Aging associated immunosenescence in rheumatoid arthritis identified by machine learning and single cell profiling by Xinxin Ji, Lingyun Li, Yuanzhuo Jiao, Hui Cheng

“…Abstract Rheumatoid arthritis (RA) is increasingly prevalent among older adults, who often experience more severe symptoms and face significant treatment challenges. …”
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Meta-analysis of cinacalcet plus calcitriol for the treatment of secondary hyperparathyroidism in hemodialysis patients by Feng Hui-ling, Zhang Lian, Zhang Jin-ming, Wu Xiao-yan

“…ObjectiveTo evaluate the efficacy and adverse reactions of cinacalcet plus calcitriol in the treatment of secondary hyperparathyroidism in hemodialysis patients.MethodsClinical trial of cinacalcet plus calcitriol in the treatment of secondary hyperparathyroidism in dialysis patients were retrieved from the databases of PubMed，Embase，Cochrane Library，China National Knowledge Internet，Wangfang and VIP.Two researchers independently screened the literatures and extracted the relevant data according to Cochrane Systematic Evaluator's Manual 5.1.0.The included randomized controlled trials were Meta-analyzed by RevMan5.3 software.ResultsA total of 30 articles were retrieved.The total sample size was 2497 people.Meta-analysis indicated that the effective rate of combined drug group significantly improved as compared with single drug group.And the effects of reducing the levels of serum phosphorus concentration，alkaline phosphatase，fibroblast growth factor 23 and parathyroid hormone and lowering parathyroid volume were more significant.The incidence of adverse reactions was lower in combined drug group than that in single cinacalcet group and there was no difference with single calcitriol group.The level of serum calcium was higher in combined drug group than single cinacalcet group and lower than that in single calcitriol group.The level of serum calcium-phosphorus product was higher in combined drug group than single cinacalcet group and lower than that in single calcitriol group.ConclusionBased upon current evidence，cinacalcet plus calcitriol in the treatment of secondary hyperparathyroidism offers a better clinical efficacy and a lower incidence of adverse reactions as compared with single medication in hemodialysis patients.…”
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The use of a two-tiered testing strategy for the simultaneous detection of small EGFR mutations and EGFR amplification in lung cancer. by Marzena Anna Lewandowska, Karol Czubak, Katarzyna Klonowska, Wojciech Jozwicki, Janusz Kowalewski, Piotr Kozlowski

“…Our analysis showed high concordance between these two methods. With the use of this two-tier strategy, we reliably determined the frequency of EGFR mutations and EGFR, MET and ERBB2 amplifications in over 200 lung cancer samples. …”
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Estimation of Copula Density Using the Wavelet Transform by Fatimah Hashim Falhi, Munaf Yousif Hmood

“… This paper proposes a new method to estimate the copula density function using wavelet decomposition as a nonparametric method, to obtain more accurate results and address the issue of boundary effects that nonparametric estimation methods suffer from. …”
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Experiences of Professionalism Attributes among Undergraduates Nursing Students and Nurses by Lobna K. Mohamed, Shereen R. Dorgham, Walaa M. Eid

“…Aim: This research aimed to assess the main attributes of professionalism among undergraduates nursing students and nurses. Methods: This study utilized a descriptive comparative correlational design. …”
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Synchronous citizen science with dogs by Madeline H. Pelgrim, Zachary Tidd, Molly Byrne, Angie M. Johnston, Daphna Buchsbaum

“…Abstract Citizen science approaches have grown in popularity over the years, partly due to their ability to reach a wider audience and produce more generalizable samples. In dogs, these studies, though, have been limited in their controls over materials or experimental protocols, with guardians typically reporting results without researcher supervision. …”
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Adult children’s status quo and their non-cohabiting parents’ depressive symptoms among community-dwelling Chinese by Yue-Hui Yu, Yi-Yi Yang

“…This study investigated this issue and examined rural-urban differences. Methods This study used data from the China Health and Retirement Longitudinal Survey 2020. …”
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Perspectives and attitudes of South African medical professionals towards active euthanasia by Willem-Johan Steyn, Mukinay C. Bondo

“…This study aimed to explore the views of medical professionals towards active euthanasia to gain a better understanding of this phenomenon in South Africa. Methods: A descriptive-interpretive qualitative research design, using semi-structured in-depth interviews of purposively sampled South African medical professionals, was used to collect the data. …”
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Artificial intelligence use in diagnosis, grading, and segmentation of neuro-oncology: a narrative review by Adham Al-Rahbi, Tariq Al-Habsi, Abir Al-Suli, Tariq Al-Saadi

“…Chattopadhyay's study, which diagnoses using MRI and CNN-based deep learning methods, has the highest sample size, 2473, among all included articles. …”
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Analysis of Consumer Behavioral Factors Between Online Shopping and Physical Store Experience in the M-Commerce Era by Ovidiu-Aurel Ghiuță, Andreea Nistor

“…Thus, our analysis aims to identify the variables influencing consumer preferences and to assess the statistical significance of these differences using quantitative methods and relevant statistical tests. The collected data came from a valid sample of 456 respondents for the general analysis and 271 valid cases for the online shopping analysis. …”
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The Attitudes of Relatives of ICU Patients toward Informed Consent for Clinical Research by Rania Mahafzah, Karem H. Alzoubi, Omar F. Khabour

“…This study aimed to assess the attitudes and preferences of relatives of ICU patients toward informed consent in biomedical research in Jordan. Subjects and Methods. A sample of 184 relatives with a critically ill next of kin in the ICU was anonymously surveyed regarding their attitudes and preferences toward giving informed consent for biomedical research on behalf of their patients. …”
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The Impact of Organisational Climate on Staff Creativity: An Empirical Study of the Interplay by Marta Juchnowicz, Hanna Kinowska, Hubert Gąsiński

“…Further research could look more closely at the impact of individual organisational climate components on staff creativity. …”
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Comparative histochemical and morphometric analysis of muscle fibers of the psoas muscle in individuals of both genders with ageing by Antić Vladimir, Stojiljković Nenad, Antić Milorad

“…The aim of this study was to determine the presence and distribution of types I and II muscle fibers in the human psoas muscle in individuals of different ages and genders. Methods. The material consisted of tissue samples of the right iliopsoas muscle taken from 30 adult cadavers (18 males and 12 females), aged from 30 to 90 years, divided into three age groups. …”
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A Comparative Study of Conventional vs. Endoscopic Septoplasty by Bhagyesh Lalitchandra Darji

“…Aims and Objectives: To compare conventional and endoscopic techniques of Septoplasty and to find out which technique is better on the basis of various intraoperative and postoperative objectives. Material and Methods: A prospective randomized comparative study was conducted with a sample size of total 60 patients; 30 in each group. …”
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Auditory Efferent Pathway Functioning in Individuals with Misophonia by Sajana Aryal, Prashanth Prabhu

“…However, it is essential to note that the generalizability of these findings may be limited due to the relatively small sample size used in our study. Therefore, further research involving a more extensive and diverse population is needed to validate and generalize these conclusions. …”
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Ecoacoustic Baseline of a Successional Subarctic Ecosystem Post-Glaciation Amidst Climate Change in South-Central Alaska by Timothy C. Mullet, Almo Farina

“…Low-frequency geophonies were prevalent throughout the sonoscape with more natural sounds at greater distances from the road. …”
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Study Regarding Calves Health Practice from Birth to Weaning on Romanian Dairy Buffalo Farms, Considering Farm Size by Elena Raducanu, Roxana Elena Stefan (Vasiliu), Remus Ioan Chiorean, Livia Vidu

“…However, due to the small sample size, the availability of comprehensive statistical data was limited. …”
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Cervical Musculoskeletal Impairments and Temporomandibular Disorders by Susan Armijo-Olivo, David Magee

“…Thus this project was designed to investigate the association between cervical musculoskeletal impairments and Temporomandibular Disorders. Material and Methods: A sample of 154 subjects participated in this study. …”
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Ocular bacterial flora and antibiotic sensitivity among Filipino patients undergoing routine cataract surgery by Terrence L. Cham, MD, Mario J. Valenton, MD, Ruben Lim Bon Siong, MD

“…The specimens were cultured using standard technique and those with bacterial growth were tested for antibiotic sensitivity and resistance using the disc-diffusion method. Results: Sixty eyes of 30 patients were sampled, 17 females (57%) and 13 males (43%), with a mean age of 61.4  12.5 years (range, 37 to 84). …”
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Comparative molecular study of Enterococcus faecalis in endodontic treatment pre and postdiode laser application by Israa Hadi Hashim, Fatima Abood Malik, Ahmed Ghanim Mahdi

“…Objective: To detect and measure the level of Enterococcus faecalis in infected root canals during traditional cleaning techniques and after diode laser application by using real-time polymerase chain reaction (RT-PCR). Materials and Methods: Ninety samples were collected from 30 participant patients complaining of acute or chronic pulpitis with an age range of 18–50 years old; the teeth indicated endodontic treatment, including both anterior and posterior teeth. …”
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