Xylazine prevalence and concentration in the Los Angeles fentanyl market, 2023–2025 by Joseph Friedman, Caitlin A. Molina, Adam J. Koncsol, Ruby Romero, Morgan E. Godvin, Elham Jalayer, Spider Davila, Oscar Arellano, Amanda Cowan, Brian Hurley, Chelsea L. Shover

“…Compared to xylazine-negative samples, xylazine-positive samples were more likely to contain bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate (BTMPS) [46.60 % vs 17.30 %], and lidocaine (65.0 % vs 29.6 %), and had lower average fentanyl concentration (6.12 % vs 10.7 %). …”
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A Comprehensive LC–MS Metabolomics Assay for Quantitative Analysis of Serum and Plasma by Lun Zhang, Jiamin Zheng, Mathew Johnson, Rupasri Mandal, Meryl Cruz, Miriam Martínez-Huélamo, Cristina Andres-Lacueva, David S. Wishart

“…In an effort to both expand the coverage and improve the accuracy of metabolite quantification in targeted metabolomics, we decided to develop a comprehensive liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay that could quantitatively measure more than 700 metabolites in serum or plasma. <b>Methods:</b> The developed assay makes use of chemical derivatization followed by reverse phase LC–MS/MS and/or direct flow injection MS (DFI–MS) in both positive and negative ionization modes to separate metabolites. …”
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Get BusActive!: Protocol of a single-blinded randomised controlled trial incentivising public transport use for physical activity gain among young people and adults by Melanie J. Sharman, Oliver Stanesby, Kim A. Jose, Stephen Greaves, Anna Timperio, Elizabeth Reid, Lisa Stafford, Petr Otahal, Verity J. Cleland

“…Compared with private motor vehicle users, public transport users tend to be more physically active and financial incentives may encourage more public transport use, but these relationships are under-investigated. …”
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Epigenetic Study of Cohort of Monozygotic Twins With Hypertrophic Cardiomyopathy Due to MYBPC3 (Cardiac Myosin‐Binding Protein C) by Alfonso Peñarroya, Rebeca Lorca, José Julián Rodríguez Reguero, Juan Gómez, Pablo Avanzas, Juan Ramon Tejedor, Agustín F. Fernandez, Mario F. Fraga

“…In this study we aimed to establish a possible correlation between the peripheral blood DNA methylation patterns and left ventricular hypertrophy severity in patients with hypertrophic cardiomyopathy, evaluating the potential impact of lifestyle variables and providing a biological context to the observed changes. Methods and Results Methylation data were obtained from peripheral blood samples (Infinium MethylationEPIC BeadChip arrays). …”
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Continuous local anaesthetic wound infusion in infants undergoing thoracic or abdominal surgery: A systematic review by Jeewan Jyoti, Eva Sloukova, Kaye Spence, Annabel Webb, Albert Shun, Himanshu Popat

“…Objective: To determine whether continuous local anaesthetic wound infusion (CLAWI) provides more effective pain relief and decrease the need for systemic opioids compared to other analgesic agents in term or preterm newborn infants undergoing thoracic or abdominal surgery. …”
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Changes in LEND trainees’ understanding and application of diversity, equity, inclusion, and justice principles by Allison P. Fisher, Lisa M. Gies, Stephanie Weber, Stephanie Weber, Tanya Froehlich, Tanya Froehlich, Simon Abimosleh, Neeraja Ravindran, Jennifer Smith, Jennifer Smith

“…Changes in trainees’ responses were examined using paired-samples t-tests.ResultsThirty-six (78%) participants identified as White, 7 (15%) as Black, 2 (4%) as Asian, and 2 (4%) as more than one race. …”
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Occurrence of Endoparasites in Creole Goats Under an Extensive Production System on the Southern Coast of Peru by Emmanuel Sessarego, Jhony Soca-Jorge, Jose Teran, María Dávalos-Almeyda, Justo Valdivia-Zevallos, Jose Ruiz, Juancarlos Cruz, Danny Julio Cruz

“…Mixed infestations were predominant (65.9%), occurring more frequently in Independencia (75.9%) than in San Clemente (57.7%) (OR: 2.26, <i>p</i> < 0.05). …”
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Predictors of Success in Horizontal Strabismus Surgery: Insights from a Prospective Study by Aurellia Valmai Tjujitno, Reni Prastyani, Joni Susanto, Rozalina Loebis, Luki Indriaswati, Lely Retno Wulandari

“…While the preoperative angle of strabismus did not significantly impact success, a trend emerged (p=1), indicating a potential threshold effect for more significant angles. Conclusion: Knowing the significance of age and duration of misalignment on the success rate of strabismus surgery allows for enhanced preoperative assessments, optimized timing of surgery, and developed predictive models to assist in clinical decision-making, ultimately leading to more efficient and successful surgical outcomes.…”
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An assessment of the role of buttress roots in the carbon stocks of tropical forests by Xu Wang, Xu Wang, Brian Njoroge Mwangi, Brian Njoroge Mwangi, Guangyi Zhou, Guangyi Zhou, Mengmeng Yang, Mengmeng Yang, Yuelin Li, Yuelin Li

“…This study aims to address this knowledge gap.MethodsThis study collected soil samples and made physical measurements of buttressed, control, and non-buttressed trees in a tropical forest from 2020 to 2022. …”
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mRNA expression of chemosensitivity genes as a predictor of response to neoadjuvant chemotherapy in non-small cell lung cancer by M. M. Tsyganov, I. V. Deryusheva, E. O. Rodionov, L. A. Efteev, S. V. Miller, M. K. Ibragimova, E. E. Perminova, O. V. Cheremisina, I. G. Frolova, S. A. Tuzikov, N. V. Litviakov

“…Low (less than 0.2) and high (more than 1.2) BRCA1 expression levels were associated with low rates of NAC response compared with patients whose expression level was between the lower and upper quartiles. …”
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Adolescent developmental assets and longitudinal weight status and psychosocial health outcomes: Exploratory analysis from a youth cohort study in Taiwan by Meng-Che Tsai, Jennifer M.T. Ng, Yi-Fang Yu, Carol Strong, Yi-Ping Hsieh, Yi-Ching Lin, Chung-Ying Lin

“…This study aims to extend the current knowledge regarding the effects of positive youth development on weight status and psychosocial health outcomes in young adulthood using a large representative longitudinal sample. Methods: Data were retrieved from the Taiwan Youth Project that comprised a longitudinal cohort of adolescents (N = 2688) surveyed at grades 7, 8, 9, and 12, and at age 22. …”
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Religious Service Attendance, COVID-19 Vaccine Attitudes, and COVID-19 Vaccination Status: A Vaccine Safety Datalink Member Survey, 2022–2023 by Joshua T.B. Williams, MD, Kate Kurlandsky, BA, Kristin Breslin, MPH, Hannah Cruz, MPH, Amy Stein, PhD, Jo Ann Shoup, PhD, Liza M. Reifler, MPH, Matthew F. Daley, MD, Bruno Lewin, MD, DTMH, Kristin Goddard, MPH, Michelle L. Henninger, PhD, Jennifer C. Nelson, PhD, Gabriela Vazquez-Benitez, PhD, MSC, Kayla E. Hanson, MPH, Candace C. Fuller, PhD, MPH, Simon J. Hambidge, MD, PhD

“…The aim of this study was to examine the associations between religious service attendance, COVID-19 attitudes, and COVID-19 vaccination at the midpoint of the COVID-19 public health emergency. Methods: A survey of Vaccine Safety Datalink members, purposefully sampled by race, ethnicity, language, and pregnancy status (N=2,856), was administered from November 2022 through February 2023. …”
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TO JUSTIFY A DIFFERENTIATED APPROACH TO PRESERVATION OF THIRD MOLARS DURING ORTHODONTIC TREATMENT BY DETERMINING THEIR CONDITION AND POSITION IN THE JAW by S.І. Doroshenko, I.S. Kuzmenko, K.V. Storozhenko, S.V. Irkha, Kh.M. Demianchuk

“…Additional methods of the study included analysis of diagnostic model measurements (by Pont Korkhaus method). …”
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Older Fallers’ Comprehensive Neuromuscular and Kinematic Alterations in Reactive Balance Control: Indicators of Balance Decline or Compensation? A Pilot Study by Ringo Tang-Long Zhu, Timmi Tim Mei Hung, Freddy Man Hin Lam, Jun-Zhe Li, Yu-Yan Luo, Jingting Sun, Shujun Wang, Christina Zong-Hao Ma

“…Previous studies have compared postural sways or stepping strategies between older adults with and without fall histories to identify factors associated with falls. However, more in-depth neuromuscular/kinematic mechanisms have remained unclear. …”
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Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model by Marloes IJff, Xionge Mei, Enzo M. Scutigliani, Hans M. Rodermond, Gregor G. W. van Bochove, Przemek M. Krawczyk, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Johannes Crezee, Arlene L. Oei

“…The aim of our present study was to test efficacy of different combinations of treatment modalities radiotherapy, cisplatin, hyperthermia and PARP1-inhibitors using in vitro tumor models, ex vivo treated patient samples and in vivo tumor models.Materials and Methods: In vitro clonogenic survival curves (0–6 Gy) show that PARP1-i (4–5 M Olaparib) enhances both chemoradiotherapy (0.3–0.5 µM cisplatin) and thermoradiotherapy (42 °C for 1 h) in SiHa, CaSki and HeLa cells. …”
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Prognostic significance of perioperative circulating CD56bright NK cell and recovery of NK cell activity in patients with colorectal cancer undergoing radical surgery by Jeng-Fu You, Cheng-Chi Lee, Yun-Shien Lee, Yih-Jong Chern, Chun-Kai Liao, Hung-Chih Hsu

“…Venous blood samples were collected preoperatively and on postoperative day 3 (POD3) and 30 (POD30). …”
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ICalled-DIY Device for Hands-On and Low-Cost Adapted Emergency Call Learning: A Simulation Study by Luis Castro-Alonso, Sheila Vázquez-Álvarez, Santiago Martínez-Isasi, María Fernández-Méndez, Luz Rey-Fernández, María García-Martínez, Adriana Seijas-Vijande, Roberto Barcala-Furelos, Martín Otero-Agra

“…<b>Objective</b>: To assess the efficacy of a low-cost, Do-It-Yourself training material for emergency call simulation training, compared to a more traditional approach. <b>Methods</b>: A quasi-experimental design without pre-test was used. …”
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Endodontic Tendencies in a Very-Low-Income Population Area of Northeastern Brazil by Maria Tereza Pedrosa Albuquerque, Joice Velames Silva, David Junio Oliveira Poppe, Crislaine Santana Santos, Tainá Pires Santos, Eliseu Aldrigh Münchow, Juliana Yuri Nagata

“…Lastly, the professionals who attended (p<0.05) to a continuous education program in Endodontics were more frequently associated to performing incisors and molars RCT in one clinical appointment (p<0.05).Conclusions. …”
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CYTOTOXIC PROPERTIES OF NANOSTRUCTURES BASED ON ALUMINUM OXIDE AND HYDROXIDE PHASES IN RELATION TO TUMOR CELLS by A. S. Lozhkomoev, O. V. Bakina, S. O. Kazantsev, L. Yu. Ivanova, A. V. Avgustinovich, S. G. Afanasyev, L. V. Spirina, A. Yu. Dobrodeev

“…Γ-al2o3 had 6.5 times more basic centers than acidic ones, which determined its ability to exhibit more pronounced antacid properties, i.e. …”
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Association between calprotectin and volatile fatty acids in patients with inflammatory bowel diseases by Yu. M. Stepanov, I. A. Klenina, O. M. Tatarchuk, M. V. Stoikevych, Т. S. Tarasova, N. S. Fedorova, O. P. Petishko

“…Calprotectin detection in fecal samples was carried out using a kit “Immundiagnostik”, Germany. …”
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