Safety and efficacy of rotigotine in patients with frontotemporal dementia: a phase 2, double-blind, randomized, placebo-controlled, multicenter trialResearch in context by Giacomo Koch, Martina Assogna, Yasmine Gadola, Antonella Alberici, Francesco Di Lorenzo, Sonia Bonnì, Ilaria Borghi, Emanuele Cerulli Irelli, Lucia Mencarelli, Michele Maiella, Romina Esposito, Elias Paolo Casula, Valentina Pezzopane, Alessia D'Acunto, Francesca Candeo, Matteo Ferraresi, Gisella Guerrera, Luca Battistini, Enrico Premi, Valeria Bracca, Silvia Lucchini, Francesco Bertagna, Pasquale Romano, Andrea Ludovici, Antonio Daniele, Caterina Motta, Clarissa Ferrari, Alessandro Martorana, Barbara Borroni

“…Adverse events were mild in all groups and more common in the rotigotine (4 mg: 4/25; 6 mg: 3/26) than in the placebo (1/24) group. …”
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Response‐adapted zanubrutinib and tislelizumab as a potential strategy to enhance CD19 CAR T‐cell therapy in relapsed/refractory large B‐cell lymphoma: A retrospective observationa... by Rong Shen, Wei‐Guo Cao, Li Wang, Ling‐Shuang Sheng, Yi‐Lun Zhang, Wen Wu, Peng‐Peng Xu, Shu Cheng, Meng‐Ke Liu, Yan Dong, Yue Wang, Xiang‐Qin Weng, Xu‐Feng Jiang, Qi Song, Hong‐Mei Yi, Lei Li, Sheng Chen, Zi‐Xun Yan, Wei‐Li Zhao

“…This regimen functions independently of genetic subtypes, rendering it more applicable for clinical practice with CAR T‐cell therapy. …”
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The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…This strategy fails to adequately capture the full impact of treatment in heterogenous neurological conditions like SCI. A more patient-centric analysis requires assessment of neurological function, functional capacity, and quality of life, incorporating meaningful patient-reported outcomes. …”
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Analysis of the Impact of Effectiveness of Media (Seda-va-Sima) Advertisement on the Extent of Consumers’ Urge to Consume National Commodities by Abolfazl Danaei

“…Consequently, adversaries have recognized that economic sanctions against Iran could more effectively achieve their objectives (Motaqi & Motaqi, 2013). …”
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Exploring the effect of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study by Frauke Beyer, Lukas Kleine, Andrea Zülke, Melanie Luppa, Toralf Mildner, Jochen Gensichen, Thomas Frese, David Czock, Birgitt Wiese, Hans-Helmut König, Hanna Kaduszkiewicz, Wolfgang Hoffmann, Jochen René Thyrian, Arno Villringer, Steffi Riedel-Heller, A.Veronica Witte

“…All other markers progressed similarly across groups, however sample size was smaller than expected. In exploratory analyses, cerebral blood flow increased more in the intervention group and this change was associated with decreases in systolic blood pressure. …”
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Sex differences in psychosocial functioning and neurocognition in bipolar disorder: a systematic review and meta-analysis by Maria Serra-Navarro, Derek Clougher, Vincenzo Oliva, Clàudia Valenzuela-Pascual, Michele De Prisco, María Florencia Forte, Marina Garriga, Brisa Solé, Jose Sánchez-Moreno, Norma Verdolini, Giulia Menculini, Alfonso Tortorella, Miquel Bernardo, J. Antoni Ramos-Quiroga, Anabel Martinez-Aran, Eduard Vieta, Silvia Amoretti, Carla Torrent

“…Results Twenty studies published between 2005 and 2023 with a total sample size of 2286 patients with BD were included. …”
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Effects of Supplementation of Synbiotic (DiPro Plus) on Growth Performance, Health Status, Skeletal parameters and Blood Parameters in Holstein Suckling Calves by Vahid Vahedi, Mehrab Hamdam, Taher Yalchi, Sayyad Seifzadeh

“…Synbiotics, a combination of prebiotics and probiotics, may offer synergistic health benefits, improving the survival and colonization of beneficial microorganisms in the GIT more effectively than either prebiotics or probiotics alone. …”
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Superstitious Ideas of Coved 19 among students of Salahaddin University - Erbil by Saza Hussen Rasul, Diyar Mohialdeen Sadeq

“… The current research aims to identify The level of superstitious ideas of Coved 19 among students of Salahaddin  University - Erbil, and according to gender variables (males - females) and specialization variables (scientific - humanitarian), the research sample reached (560) male and female students, of which (160) as a primary research sample, and (400) male and female students for the final research sample, The search scale was prepared by the researchers and the number of its items was (37 items), and after verifying the psychometric properties of the scale (Face validity, Discrimination coefficient and   Reliability), the scale became in (27) items for the final application, the Reliability of scale  was extracted by two methods, Test and Re test way,  and  Alfa Cronbach way, after applying the scale to the final sample of the research, All statistics processing done by  using the statistical bag of social sciences (SPSS), the results showed that The level of superstitious ideas for Coved 19 among students of Salahaddin University - Erbil in general is high, and the level of superstitious ideas of Coved 19 for students (females) and  (humanities) are  more level. …”
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Etiologic Characteristics of Influenza Epidemics on the Territory of Russia in the Period of Pandemic COVID-­19 in 2020–2023 by P. A. Petrova, N. I. Konovalova, A. Y. Boyarintseva, D. M. Danilenko, A. D. Vasilieva, T. N. Shelepanova, A. V. Prokopets, M. Y. Eropkin

“…Establish the etiological nature of influenza epidemics in 2020–2023 in Russia and the antigenic properties of influenza viruses of the types A and B which circulated on its territory in 2020–2023. Methods. Isolation of influenza viruses from PCR+-clinical materials (nazo-pharingeal swabs and post-mortem tissue samples) in the cell lines MDCK and MDCK-Siat1; antigenic analysis by means of the reaction of hemagglutination-inhibition (HI) and micro-neutralization (MN) with the cell-ELISA detection using the post-infectious ferret antisera and rat polyclonal antisera; antigenic cartography. …”
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TERTp Mutation and its Prognostic Value in Glioma Patients Under the 2021 WHO Classification: A Real‐World Study by Hao Xing, Delin Liu, Junlin Li, Yulu Ge, Xiaopeng Guo, Wenlin Chen, Dachun Zhao, Yixin Shi, Yilin Li, Yaning Wang, Yuekun Wang, Yu Xia, Jiaming Wu, Tingyu Liang, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Siying Guo, Huanzhang Li, Tianrui Yang, Kun Zhang, Yu Wang, Wenbin Ma

“…ABSTRACT Background The 2021 WHO Classification of Central Nervous System Tumors introduces more molecular markers for glioma reclassification, including TERT promoter (TERTp) mutation as a key feature in glioblastoma diagnosis. …”
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Endothelial damage and complement dysregulation in fetuses from pregnancies complicated by preeclampsia by Alex Ramos, Lina Youssef, Patricia Molina, Julia Martinez‐Sanchez, Ana Belen Moreno‐Castaño, Miquel Blasco, Blanca De Moner, Marta Tortajada, Marta Camacho, Maria Borrell, Francesca Crovetto, Marc Pino, Gines Escolar, Enric Carreras, Eduard Gratacos, Maribel Diaz‐Ricart, Marta Palomo, Fatima Crispi

“…Abstract Introduction Our objective was to evaluate the endothelial function profile and complement system in fetuses from preeclamptic pregnancies using ex vivo and in vitro approaches. Material and Methods A total of 66 singleton pregnancies were prospectively recruited comprising 34 cases of preeclampsia and 32 normotensive pregnancies matched for baseline characteristics. …”
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Investigating The Performance Of Local And Indigenous Businesses In Times Of Economic Recession With Emphasis On Developing The Capabilities Of Cooperatives In Sistan And Baluchest... by Ali Asghar Tabavar, Abdoulnaser Derakhshan, Sahar Arefi

“…In general, it can be said that cooperatives, as economic and social organizations, have the necessary power and capacity to organize different classes and groups of people to create sustainable human development, and during the economic recession, they play an effective role in creating stable employment and income generation (Shadmehri, Ahmad 2005).Case studyThe statistical population of the research included the collection of managers, supervisors, and employees of cooperatives located in Sistan and Baluchistan province in the number of 345 people, out of which 182 people were randomly selected as the sample group.Materials and methodsThe current research is of an applied type, Also, this research is one of the empirical research in the field of management. …”
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Dependence of Indicators of Daily Blood Pressure Monitoring on Activity of Pathological Process in Patients with Systemic Lupus Erythematosus by Abrahamovych O., Abrahamovych U., Kushyna A., Guta S., Synenkyi O.

“…The identified patterns of changes of DMAT are also preserved throughout the period of 24 hours, and according to the results of their separate evaluation during a nighttime and daytime so that during a passive periods these figures are significantly more often lower than the reference values, especially in patients of first and second groups.…”
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GDF15 and its receptors as pathways mediating smoking related weight changeResearch in context by Alexander C. Tinworth, Andri Iona, Pang Yao, Iona Y. Millwood, Hannah Fry, Jonathan Clarke, Baihan Wang, Mohsen Mazidi, Christiana Kartsonaki, Robin G. Walters, Huaidong Du, Canqing Yu, Yiping Chen, Dianjianyi Sun, Ling Yang, Dan Valle Schmidt, Jun Lv, Daniel Avery, Liming Li, Derrick A. Bennett, Richard Peto, Robert Clarke, Fiona Bragg, Zhengming Chen, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Daniel Avery, Maxim Bernard, Derrick Bennett, Ruth Boxall, Ka Hung Chan, Yiping Chen, Charlotte Clarke, Jonathan Clarke, Huaidong Du, Ahmed Edris Mohamed, Hannah Fry, Simon Gilbert, Pek Kei Im, Andri Iona, Maria Kakkoura, Christiana Kartsonaki, Hubert Lam, Kuang Lin, James Liu, Mohsen Mazidi, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Maryam Rahmati, Paul Ryder, Dan Schmidt, Becky Stevens, Iain Turnbull, Baihan Wang, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Xiao Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Dianjanyi Sun, Canqing Yu, Lang Pan, Zengchang Pang, Ruqin Gao, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, Xiaocao Tian, Hua Zhang, Yaoming Zhai, Feng Ning, Xiaohui Sun, Feifei Li, Silu Lv, Junzheng Wang, Wei Hou, Wei Sun, Shichun Yan, Xiaoming Cui, Chi Wang, Zhenyuan Wu, Yanjie Li, Quan Kang, Huiming Luo, Tingting Ou, Xiangyang Zheng, Zhendong Guo, Shukuan Wu, Yilei Li, Huimei Li, Ming Wu, Yonglin Zhou, Jinyi Zhou, Ran Tao, Jie Yang, Jian Su, Fang Liu, Jun Zhang, Yihe Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jiangchao Liu, Mei Lin, Zhenzhen Lu, Lifang Zhou, Changping Xie, Jian Lan, Tingping Zhu, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Yulu Qin, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Mingqiang Yuan, Xia Wu, Xiaofang Chen, Wei Jiang, Jiaqiu Liu, Qiang Sun, Faqing Chen, Xiaolan Ren, Caixia Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Kai Kang, Shixian Feng, Huizi Tian, Lei Fan, XiaoLin Li, Huarong Sun, Pan He, Xukui Zhang, Min Yu, Ruying Hu, Hao Wang, Xiaoyi Zhang, Yuan Cao, Kaixu Xie, Lingli Chen, Dun Shen, Xiaojun Li, Donghui Jin, Li Yin, Huilin Liu, Zhongxi Fu, Xin Xu, Hao Zhang, Jianwei Chen, Yuan Peng, Libo Zhang, Chan Qu

“…SomaScan_GDF15 partially mediated the associations of smoking with all adiposity measures, while Olink_GDF15 mediated the association with body fat percentage. The GDF15/RET ratio more robustly mediated the smoking-adiposity relationships than GDF15 alone in both platforms. …”
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A large-scale ENIGMA multisite replication study of brain age in depression by Laura K.M. Han, Richard Dinga, Ramona Leenings, Tim Hahn, James H. Cole, Lyubomir I. Aftanas, Alyssa R. Amod, Bianca Besteher, Romain Colle, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Konstantin V. Danilenko, Paola Fuentes-Claramonte, Ali Saffet Gonul, Ian H. Gotlib, Roberto Goya-Maldonado, Nynke A. Groenewold, Paul Hamilton, Naho Ichikawa, Jonathan C. Ipser, Eri Itai, Sheri-Michelle Koopowitz, Meng Li, Go Okada, Yasumasa Okamoto, Olga S. Churikova, Evgeny A. Osipov, Brenda W.J.H. Penninx, Edith Pomarol-Clotet, Elena Rodríguez-Cano, Matthew D. Sacchet, Hotaka Shinzato, Kang Sim, Dan J. Stein, Aslihan Uyar-Demir, Dick J. Veltman, Lianne Schmaal

“…However, the estimated neuroimaging-derived “brain age gap” has varied from study to study, likely driven by differences in training and testing sample (size), age range, and used modality/features. …”
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Evaluation of porosity, permeability, and reservoir quality of the Asmari Formation using sedimentary facies and diagenesis data in the Ahvaz oil field by Akbar Heidari, Narges Shokri, Milad Faraji

“…This study's results show the evidence from sedimentary environment and diagenesis, but the effect of diagenetic processes was relatively more important. Therefore, the studied succession can be considered a diagenetic reservoir. …”
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The impact of methylome analysis on the diagnosis and treatment of CNS tumours in children and adolescents: A population-based study in Greece by Maria Filippidou, Stavros Glentis, Ilona Binenbaum, Martin Sill, Kleoniki Roka, Antonia Vlachou, Georgia Avgerinou, Jonas Ecker, Florian Selt, Martin Hasselblatt, Mirjam Blattner-Johnson, Kathrin Schramm, Clio Trougkou, Dimitrios Doganis, Nikolaos Katzilakis, Vita Ridola, Evgenia Papakonstantinou, Vassilios Papadakis, Emmanouel Hatzipantelis, Eleftheria Kokkinou, Roser Pons, Christina Kanaka-Gantenbein, Dominik Sturm, Steffen Hirsch, Nicola Dikow, Kristian W. Pajtler, Cornelis M. van Tilburg, Michael C. Frühwald, Till Milde, Olaf Witt, David T.W. Jones, Andreas Von Deimling, Felix Sahm, Kalliopi Stefanaki, Stefan M. Pfister, Antonis Kattamis

“…Additional t-distributed stochastic neighbour embedding (t-SNE) analysis allowed the possible classification of twelve tumours. Nine more samples reached high Cs using the newer brain tumour classifiers, since available. …”
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A Phase I Dose-Escalation Clinical Trial of Bronchoscopic Cryoimmunotherapy in Advanced-Stage NSCLC by Jun-Chieh J. Tsay, MD, MS, Antonio Velez, MD, Destiny Collazo, BS, Isaac Laniado, MD, Jamie Bessich, MD, Vivek Murthy, MD, Andrew DeMaio, MD, Samaan Rafeq, MD, Benjamin Kwok, MD, Fares Darawshy, MD, Ray Pillai, MD, Kendrew Wong, MD, Yonghua Li, MD, PhD, Rosemary Schluger, RN, Alena Lukovnikova, BS, Sofia Roldan, BS, Matt Blaisdell, BS, Fernanda Paz, Kelsey Krolikowski, BS, Katherine Gershner, MD, Yong Liu, PhD, Judy Gong, BA, Sara Borghi, PhD, Fang Zhou, MD, Aristotelis Tsirigos, PhD, Harvey Pass, MD, Leopoldo N. Segal, MD, MS, Daniel H. Sterman, MD

“…Pre- and post-BCI blood samples were collected to explore changes in the systemic immune profile. …”
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Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design... by Kengo Kusano, Ayako Okada, Koji Miyamoto, Eizo Tachibana, Wataru Shimizu, Masato Murakami, Tomoo Harada, Kojiro Tanimoto, Takeshi Kato, Satoru Sakagami, Katsuhito Fujiu, Tatsuya Hayashi, Yasuo Okumura, Kazuhiro Satomi, Tomoyuki Shiozawa, Hideki Kobayashi, Michifumi Tokuda, Teiichi Yamane, Ryohsuke Narui, Seigo Yamashita, Satoru Miyanaga, Ikutaro Nakajima, Hidehira Fukaya, Hajime Kihara, Shiro Nakahara, Koichi Nagashima, Kenta Murotani, Shinya Suzuki, Ryuta Watanabe, Katsuaki Yokoyama, Hidemori Hayashi, Yu-ki Iwasaki, Yuhi Fujimoto, Yasushi Mukai, Koichiro Ejima, Takayuki Otsuka, Masaomi Kimura, Masahide Harada, Junjiroh Koyama, Hideharu Okamatsu, Mitsuru Takami, Morio Shoda, Kenichi Hiroshima, Tadashi Fujino, Keijiro Nakamura, Koji Kumagai, Yuji Watari, Mina Hatsuno, Kazuki Iso, Kazumasa Sonoda, Yoshiyasu Aizawa, Akio Chikata, Masaru Inoue, Hitoshi Minamiguchi, Nobuhiko Makino, Yoshinao Yazaki, Hideshi Aoyagi, Makoto Ichikawa, Hironori Haruta, Takafumi Hiro, Kimie Okubo, Ken Arima, Taiki Tojo, Yoshiaki Fukuda, Koji Oiwa, Tamami Fujiishi, Masashi Akabane, Norikazu Ishikawa, Haruna Tabuchi, Kenjiro Miyamoto, Hiroshi Mase

“…Results of the study will be published in one or more peer-reviewed journals.Trial registration number UMIN000047023.…”
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Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well by Maxie Liebscher, Silke White, Simon Hass, Anne Chocat, Florence Mezenge, Brigitte Landeau, Marion Delarue, Oriane Hébert, Anne-Laure Turpin, Natalie L. Marchant, Gaël Chételat, Olga Klimecki, Géraldine Poisnel, Miranka Wirth, Claire André, Pierre Champetier, Léa Chauveau, Fabienne Collette, Sophie Dautricourt, Robin de Flores, Vincent De La Sayette, Harriet Demnitz-King, Séverine Fauvel, Francesca Felisatti, Victor Ferment, Eglantine Ferrand-Devouge, Julie Gonneaud, Antoine Garnier-Crussard, Anaïs Hamel, Sacha Haudry, Pierre Krolak-Salmon, Elizabeth Kuhn, Valérie Lefranc, Antoine Lutz, Valentin Ourry, Cassandre Palix, Anne Quillard, Géraldine Rauchs, Eric Salmon, Edelweiss Touron, Patrik Vuilleumier, Tim Whitfield

“…The identification of sex-specific patterns in these associations may inform the development of more effective and tailored interventions.…”
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