Proteomic profile of plasma-derived extracellular vesicles from Colombian pregnant women with Plasmodium-soil transmitted helminths coinfection by Jahnnyer A. Martínez-Moreno, Alberto Ayllon-Hermida, Alberto Ayllon-Hermida, Alberto Ayllon-Hermida, Berta Barnadas-Carceller, Berta Barnadas-Carceller, Carmen Fernández-Becerra, Carmen Fernández-Becerra, Carmen Fernández-Becerra, Hernando A. del Portillo, Hernando A. del Portillo, Hernando A. del Portillo, Jaime Carmona-Fonseca, Eliana M. Arango-Flórez, Eliana M. Arango-Flórez

“…The size range of EVs was more variable in the three infected groups (100-700 nm) compared to the size range of the uninfected groups (50-300 nm). …”
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PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…Results NSCLC-H exhibited increased expression of specific CD44 isoforms and a more aggressive phenotype, including organoid formation ability, compared to NSCLC-B. …”
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Effect of prednisolone on live birth rate in women with unexplained recurrent pregnancy loss: a study protocol for a double-blind, placebo-controlled, multicentre, randomised contr... by Saskia le Cessie, Nan van Geloven, Marie-Louise van der Hoorn, Michael Eikmans, Annemarie Mulders, Eileen Lashley, Jantien Visser, Moniek van der Zanden, Mariette Goddijn, Tess Meuleman, Salwan Al-Nasiry, Harold Verhoeve, Gijs Teklenburg, Jan-Peter de Bruin, Yentl Béquet, Renate Van der Molen, Elske van den Akker-van Marle, Marloes Vermeulen, Merel van den Berg, Astrid Cantineau, Dana Huppelschoten

“…Introduction Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more spontaneous pregnancy losses from the time of conception until 24 weeks of gestation. …”
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Liver kinase B1 expression is associated with improved prognosis and tumor immune microenvironment features in small cell lung cancer by Alessandro Dal Maso, Federica Ferrarini, Giovanni Esposito, Sonia Anna Minuzzo, Anna Maria Puggia, Federica Pezzuto, Elisabetta Zulato, Loc Carlo Bao, Loc Carlo Bao, Mattia De Nuzzo, Mattia De Nuzzo, Alessandra Ferro, Stefano Frega, Giulia Pasello, Giulia Pasello, Fiorella Calabrese, Matteo Fassan, Matteo Fassan, Federico Rea, Federico Rea, Valentina Guarneri, Valentina Guarneri, Stefano Indraccolo, Stefano Indraccolo, Laura Bonanno, Laura Bonanno

“…Unexpectedly, LKB1-negative samples were more likely to show CD8+ tumor-infiltrating lymphocytes (TILs; p = 0.013). …”
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Detecting actionable mutations from matched plasma-based versus tissue next-generation sequencing in advanced non-small cell lung cancer: a retrospective single centre analysis on... by Christophe Bontoux, Caroline Lacoux, Jonathan Benzaquen, Jacques Boutros, Guylène Rignol, Elodie Long-Mira, Sandra Lassalle, Maryline Allegra, Doriane Bohly, Mathieu Garcia, Christelle Bonnetaud, Olivier Bordone, Jean-Marc Félix, Virginie Lespinet-Fabre, Virginie Tanga, Charles-Hugo Marquette, Valérie Taly, Aurélia Baurès, Simon Heeke, Marius Ilié, Véronique Hofman, Paul Hofman

“…The value of systematically combining LB and TB next-generation sequencing (NGS) for genomic profiling in these patients remains controversial. Methods This single-centre retrospective study included 102 matched TB and LB samples collected from aNSCLC patients at diagnosis. …”
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Cocaine Cues Used in Experimental Research: A Systematic Review by Eileen Brobbin, Natalie Lowry, Matteo Cella, Alex Copello, Simon Coulton, Jerome Di Pietro, Colin Drummond, Steven Glautier, Ceyda Kiyak, Thomas Phillips, Daniel Stahl, Shelley Starr, Lucia Valmaggia, Colin Williams, Paolo Deluca

“…To advance understanding of CET for cocaine treatment, this systematic review aims to categorise the range of cocaine cues used in research. <b>Methods</b>: A systematic review of the existing literature with searches conducted on PubMed and Web of Science bibliographic databases with no time constraints in August 2024 (PROSPERO: CRD42024554361). …”
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Aflatoxin exposure and mortality in acutely ill children: results from the CHAIN network cohort by Tahmeed Ahmed, Molline Timbwa, Moses Ngari, Mohammod Jobayer Chisti, Kirkby D Tickell, Hama Diallo, Robert Bandsma, Judd L Walson, Syed Asad Ali, James Berkley, Ezekiel Mupere, Ali Faisal Saleem, Lei Xia, Wieger Voskuijl, Hang Wu, Benson Singa, Shalton Mwaringa, Christina Lancioni, Isabel Potani, Abu Sadat Mohammad Sayeem bin Shahid, Caroline Tigoi, James Njunge, Yunyun Gong, Michael N Routledge

“…We examined the role of aflatoxin exposure in inpatient and post-discharge mortality.Methods In a nested case-cohort from the CHAIN cohort, we compared aflatoxin exposure at admission and discharge with death or survival in hospital (n=755) or up to 180-days post-discharge (n=585) and with community participants (CP, n=222). …”
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Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China by Li Chen, Yi‐Chen Kong, Jia‐Wei Tian, Pei‐Yu Han, Song Wu, Chen‐Jie He, Ti‐Lian Ren, Bo Wang, Lian Qin, Yun‐Zhi Zhang

“…Patients infected with the Karp‐like exhibited significantly more severe clinical symptoms, and the Karp‐like genotype of patients was relatively common in Xiangyun County of Yunnan Province. …”
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Outcomes of Active Treatment for Localised Prostate Cancer After Holmium Laser Enucleation of the Prostate: A Systematic Review and Meta-analysis by Alberto Artiles Medina, Ana Tagalos Muñoz, Ana Domínguez Gutiérrez, Alfonso Muriel García, José Daniel Subiela, Noelia Álvarez Díaz, Guillermo Fernández Conejo, Victoria Gómez Dos Santos, Almudena Coloma del Peso, Francisco Javier Burgos Revilla

“…Limitations were scarcity of relevant studies (especially for treatments other than RP), their predominantly observational and retrospective nature, and their small sample sizes. Conclusions and clinical implications: The findings from this meta-analysis should be considered for patient counselling and management decisions, bearing in mind that patients with prior HoLEP who undergo RP have more intraoperative complications and urethrovesical anastomotic leaks and an increased postoperative incontinence rate. …”
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Fully Automated Assessment of Cardiac Chamber Volumes and Myocardial Mass on Non-Contrast Chest CT with a Deep Learning Model: Validation Against Cardiac MR by Ramona Schmitt, Christopher L. Schlett, Jonathan I. Sperl, Saikiran Rapaka, Athira J. Jacob, Manuel Hein, Muhammad Taha Hagar, Philipp Ruile, Dirk Westermann, Martin Soschynski, Fabian Bamberg, Christopher Schuppert

“…<b>Conclusions</b>: Automated cardiac chamber volume and myocardial mass quantification on non-contrast chest CT produced viable measurements in this retrospective sample. <b>Relevance Statement</b>: An automated cardiac assessment on non-contrast chest CT provides quantitative morphological data on the heart, enabling a preliminary organ evaluation that aids in incidentally identifying at-risk patients who may benefit from a more targeted diagnostic workup.…”
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Smoking cessation for people accessing homeless support centres (SCeTCH): comparing the provision of an e-cigarette versus usual care in a cluster randomised controlled trial in Gr... by Lynne Dawkins, Kirstie Soar, Francesca Pesola, Allison Ford, Caitlin Notley, Rachel Brown, Emma Ward, Lauren McMillan, Debbie Robson, Anna Varley, Charlotte Mair, Jessica Lennon, Janine Brierley, Amy Edwards, Peter Hajek, Allan Tyler, Steve Parrott, Jinshuo Li, Linda Bauld, Bethany Gardner, Sharon Cox

“…We aimed to test the effectiveness of an e-cigarette (EC) intervention designed to help people accessing homeless support services to stop smoking. Methods A two-arm cluster randomised controlled trial. …”
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Application of high-throughput sequencing in citrus virus identification and analysis of population diversity by LI Xiang, YANG Jin, HUANG Aijun, ZHOU Jun, YI Long

“…The above methods are well-suited for known viruses and can be combined with multiple methods for detection and identification. …”
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Factors influencing smoking cessation in Lebanese patients with bladder cancer: A cross sectional study by Georges Horkoss, Joey El Khoury, Rami Halabi, Anthony Kanbar, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Maher Abdessater, Rodrigue Saad, Antoine Kassis, Raghid El Khoury

“…Methods: A cross sectional study was conducted using a phone survey composed of 53 questions assessing the patients’ knowledge that they had or received from their treating physician about smoking as risk factor for BCa. …”
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Determination of T cell response against XBB variants in adults who received either monovalent wild-type inactivated whole virus or mRNA vaccine or bivalent WT/BA.4-5 COVID-19 mRNA... by Yun Sang Tang, Chee Wah Tan, Ka Chun Chong, Chunke Chen, Yuanxin Sun, Karen Yiu, Kwun Cheung Ling, Ken K.P. Chan, Malik Peiris, Chris Ka Pun Mok, David S. Hui

“…Objectives: As the SARS-CoV-2 virus evolves more rapidly than vaccines are updated, T cell immunity potentially confers protection against disease progression and death from new variants. …”
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Gut microbiota dysbiosis in people living with HIV who have cancer: novel insights and diagnostic potential by Zhiman Xie, Qianqian Huang, Qianqian Huang, Lemin Wen, Tingyan Luo, Tingyan Luo, Sufang Ai, Guangjing Ruan, Ningmei Liu, Yiru Wei, Yiru Wei, Yingji Lan, Yingji Lan, Ping Cui, Ping Cui, Qin Cao, Qin Cao, Hao Liang, Hao Liang, Li Ye, Li Ye, Jie Zhou, Jie Zhou, Jiegang Huang, Jiegang Huang

“…We conducted a pioneering study on the gut microbiota of PLWH with various types of cancer, revealing key microbiota.MethodsWe collected stool samples from 54 PLWH who have cancer (PLWH-C), including Kaposi’s sarcoma (KS, n=7), lymphoma (L, n=22), lung cancer (LC, n=12), and colorectal cancer (CRC, n=13), 55 PLWH who do not have cancer (PLWH-NC), and 49 people living without HIV (Ctrl). …”
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Simultaneous profiling of mercapturic acids, glucuronic acids, and sulfates in human urine by Jin Y. Chen, Saurin R. Sutaria, Zhengzhi Xie, Manjiri Kulkarni, Rachel J. Keith, Aruni Bhatnagar, Clara G. Sears, Pawel Lorkiewicz, Sanjay Srivastava

“…Further, we performed statistical analyses on 214 metabolites found in more than 75% of samples to examine the association between metabolites and demographic characteristics using integrated network analysis, principal component analysis (PCA), and multivariable linear regression models. …”
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α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback by Ying-Hao Hu, Ying-Hao Hu, Jun Han, Jun Han, Lin Wang, Chao Shi, Chao Shi, Yan Li, Yan Li, Opeyemi Joshua Olatunji, Xiu Wang, Xiu Wang, Jian Zuo, Jian Zuo, Jian Zuo

“…Metabolic indicators and basic clinical parameters were evaluated using samples collected on day 20 and 38 since immunization. …”
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Clinical Profile of Mortality and Treatment Profile of Survival in Patients with COVID-19 Pneumonia Admitted to Dubai Hospital by Rashid Nadeem, Ishma Aijazi, Ashraf Elhoufi, Crystal Danthi, Nouha Azaza, Mohd Kafeel Khan, Mohannad Alheraki, Muhammed Jamshaid, Asadullah Nawazani, Sadia Tariq, Sobia Siddiq, Muzammil Hafeez, Mukesh Kumar, Islam Bon, Ahmed Elsousi, Lamiaa Salama, Sahish Kamat, Rami Abdalla

“…Background: Most COVID-19 studies conclude old age and coexisting illnesses as mortality determinants owing to different populations or methodologies, or omitting factors affecting outcomes. Methods: We analyzed COVID-19 patients’ data (N = 391) of Dubai Hospital between January 1, 2020 and June 30, 2020. …”
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IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer by Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu

“…However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear. Methods The correlation between m6A and APA was analyzed by using RNA methylation sequencing of OC cells and single‐cell sequencing of clinical samples from public databases. …”
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Long-term outcomes in leucine-rich glioma inactivated-1 autoimmune encephalitis and associated biomarkers of inflammation and neuronal and glial injury by Tyler L. Borko, Tyler L. Borko, Phillip Winters, Kelli M. Money, Stefan Sillau, Sadie Eggmann, Sean Selva, Alanna Ritchie, Ryan Kammeyer, Ryan Kammeyer, Gregory P. Owens, Jeffrey L. Bennett, Jeffrey L. Bennett, Amanda L. Piquet

“…Blood-based biomarkers for inflammation and neuronal and glial injury have been evaluated as potential markers of disease severity and prognosis in AE.MethodsPatients diagnosed with LGI1 AE, confirmed by cell-based assay, were enrolled and followed prospectively to gather plasma samples for biomarker testing. …”
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