Unraveling Novel Subsets of Lymphocytes Involved in Sac Expansion in the Tertiary Lymphoid Structure Within an Abdominal Aortic Aneurysm by Itaru Hosaka, Ippei Ikegami, Takuma Mikami, Tatsuya Sato, Toshifumi Ogawa, Kei Mukawa, Marenao Tanaka, Keisuke Endo, Yukinori Akiyama, Akihito Ohkawa, Junji Nakazawa, Tsuyoshi Shibata, Tomohiro Nakajima, Yutaka Iba, Chikara Shiiku, Satoshi Sumino, Ryuji Koshima, Kenichi Takano, Shingo Ichimiya, Nobuyoshi Kawaharada, Masato Furuhashi

“…We aimed to elucidate the relationships between TLS and pathophysiology of AAA. Methods Abdominal aortic samples obtained from 37 patients with AAA (men/women: 34/3, age: 72.8±9.9 years) and 15 autopsied patients who died from non‐aortic events (men/women: 11/4, age: 65.5±9.8 years) were investigated. …”
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Changes in upper airway morphology and respiratory function of adolescent patients with mandibular retrognathism treated with clear aligner mandibular advancement: a prospective st... by Tianlu Jiang, Yizhe Qi, Yueying Zhang, Yusen Du, Qiuyue Wu, Hua Xiao, Kangping He, Jiajing Zheng, Zuolin Jin, Feifei Li

“…The increase in the anteroposterior diameter contributed more to the increase in volume and cross-sectional area than that in the lateral diameter, except for the nasopharyngeal plane. …”
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Levels and determinants of exposure to perfluoroalkyl substances in French pregnant women from the SEPAGES cohort by Nicolas Jovanovic, Anne Lise Brantsæter, Sarah Lyon-Caen, Blandine Duval, Sylvain Carras, Annabelle Bédard, Wassila Ait-Hadad, Blandine de Lauzon-Guillain, Valérie Siroux, Sam Bayat, Inger-Lise Steffensen, Rémy Slama, Line Småstuen Haug, Claire Philippat

“…Results: Seven PFAS were quantified in 83 % or more of the samples, while the remaining PFAS were quantified in less than 20 %. …”
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Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma by Valerie Chew, Tony Kiat Hon Lim, David Tai, Su Pin Choo, Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Sahil Saraf, Han Chong Toh, Benedict Tan, Harry Ho Man Ng, Ren Yuan Lee, Siting Goh, Isabel Shu Ying Tay, Xinru Lim, Sherlly Lim, Bijin Au, Josh Jie Hua Loh, John Edward Connolly, Tracy Loh, Wei Qiang Leow, Joycelyn Jie Xin Lee, Fabio Malavasi, Ser Yee Lee, Pierce Chow, Evan W Newell

“…We then investigated the association between CD38 and ICB treatment outcomes in advanced HCC.Methods Clinically annotated samples from 49 patients with advanced HCC treated with ICB were analyzed for CD38 expression using immunohistochemistry (IHC), multiplex immunohistochemistry/immunofluorescence (mIHC/IF) and multiplex cytokine analysis.Results IHC and mIHC/IF analyses revealed that higher intratumoral CD38+ cell proportion was strongly associated with improved response to ICB. …”
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Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets by Giulia Pecora, Camilla Mancini, Rossella Mazzilli, Virginia Zamponi, Stefano Telese, Stefano Scalera, Marcello Maugeri-Saccà, Ludovica Ciuffreda, Francesca De Nicola, Maurizio Fanciulli, Anna La Salvia, Massimiliano Mancini, Andrea Vecchione, Alessandra Siciliani, Mohsen Ibrahim, Diana Bellavia, Andrea Marcello Isidori, Antongiulio Faggiano, Rita Mancini, Claudia De Vitis

“…To gain deeper insights into the genomic underpinnings of lung NETs, we conducted a pilot investigation to uncover potential genetic mutations and copy number variations (CNVs) implicated in their pathogenesis. Methods Formalin-fixed, paraffin-embedded intraoperative tumor biopsies and matched peripheral blood mononuclear cell samples were collected from six consecutive patients with lung NETs. …”
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Atezolizumab plus bevacizumab in patients with unresectable or metastatic mucosal melanoma: 3‐year survival update and multi‐omics analysis by Jie Dai, Tianxiao Xu, Lifeng Li, Meiyu Fang, Jing Lin, Jun Cao, Xue Bai, Caili Li, Xiaoting Wei, Junjie Gu, Yaoyao Liu, Xuan Gao, Xuefeng Xia, Jun Guo, Yu Chen, Lili Mao, Lu Si

“…This report updates 3‐year survival outcomes and multi‐omics analysis to identify potential response biomarkers. Methods Forty‐three intention‐to‐treat (ITT) patients received intravenous administration of atezolizumab and bevacizumab every 3 weeks. …”
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Rates of colorectal cancer diagnosis and mortality in people with severe mental illness: results from Australia’s National Bowel Cancer Screening Programme by S. Kisely, K. Spilsbury, C. Bull, S. Jordan, B.J. Kendall, D. Siskind, G. Sara, M. Protani, D. Lawrence

“…These studies mostly predate the introduction of national bowel cancer screening programmes (NBCSPs) and it is unknown if these have reduced disparity in CRC-related mortality for people with SMI. Methods We compared mortality rates following CRC diagnosis at colonoscopy between a nationally representative sample of people with and without SMI who participated in Australia’s NBCSP. …”
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High‐Density Lipoprotein‐Associated Cholesterol Abnormalities in a Clinical Outcomes Study of Dysferlin‐Deficient Limb–Girdle Muscular Dystrophy Type R2 by Zoe White, Laura Rufibach, Heather Gordish Dressman, Heather Hilsden, Dan Cox, Simone Spuler, John W. Day, Kristi J. Jones, Diana X. Bharucha‐Goebel, Emmanuelle Salort‐Campana, Alan Pestronk, Maggie C. Walter, Carmen Paradas, Tanya Stojkovic, Madoka Mori‐Yoshimura, Elena Bravver, Jordi Diaz‐Manera, Elena Pegoraro, Jerry R. Mendell, the Jain COS Consortium, Volker Straub, Pascal Bernatchez

“…Transaminase levels were lower in late‐stage LGMDR2 samples, whereas bilirubin remained unchanged, suggesting a low muscular mass rather than hepatic origin and the absence of major liver damage. …”
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Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study. by Daniel B Rosoff, George Davey Smith, Nehal Mehta, Toni-Kim Clarke, Falk W Lohoff

“…The objective of this study is to use a wide range of CVD risk factors and outcomes to evaluate potential total and direct causal roles of alcohol and tobacco use on CVD risk factors and events.<h4>Methods and findings</h4>Using large publicly available genome-wide association studies (GWASs) (results from more than 1.2 million combined study participants) of predominantly European ancestry, we conducted 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) to simultaneously assess the independent impact of alcohol consumption and smoking on a wide range of CVD risk factors and outcomes. …”
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Knowledge, attitudes, and practices toward ticks and tick-borne diseases: a cross-sectional study in Rwanda by Abakundana Nsenga Ariston Gabriel, Xiao-Yang Wang, Guo-Yao Zu, Laila Jamil, Blaise Iraguha, Methode Ngabo Gasana, Bing-Bing Gu, Ntakirutimana Theoneste, Lin Zhao, Wu-Chun Cao

“…This study aimed to assess the knowledge, attitudes, and practices toward ticks and tick-borne diseases among adults in Rwanda. Methods The sample size was determined using a single-population proportion formula. …”
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Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel by Ainsley R. Davies, Ainsley R. Davies, Kristy Kwong, Kristy Kwong, Kristy Kwong, Zhijia Yu, Koula E. M. Diamand, Koula E. M. Diamand, Fei-Ju Li, Fei-Ju Li, Laurensia Kannitha, Sidra A. Ali, Abolfazl Amjadipour, Ann-Maree Padarin, Michael Devoy, Harpreet Vohra, Bahar Miraghazadeh, Simon H. Jiang, Simon H. Jiang, Anne Brüstle, Nicolas Cherbuin, Christopher J. Nolan, Christopher J. Nolan, Matthew C. Cook, Elizabeth E. Gardiner, Stuart Read, Stuart Read, Euan McNaughton, Katrina L. Randall, Katrina L. Randall, Katrina L. Randall

“…The purpose of our study was to measure many lymphocyte and monocyte populations from a single sample, with the long-term aim of validating our assay for diagnostic use in the Australian regulatory environment.MethodsWe designed and optimised a novel 30-colour lymphocyte immunophenotyping panel tailored for use on a 3-laser (V-B-R) spectral flow cytometer. …”
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In-depth assessment of BRAF, NRAS, KRAS, EGFR, and PIK3CA mutations on cell-free DNA in the blood of melanoma patients receiving immune checkpoint inhibition by Isabel Heidrich, Charlotte Rautmann, Cedric Ly, Robin Khatri, Julian Kött, Glenn Geidel, Alessandra Rünger, Antje Andreas, Inga Hansen-Abeck, Finn Abeck, Anne Menz, Stefan Bonn, Stefan W. Schneider, Daniel J. Smit, Christoffer Gebhardt, Klaus Pantel

“…Methods We conducted a prospective analysis of 241 longitudinal samples from 39 patients with unresectable stage III/IV melanoma using a SYSMEX targeted NGS panel covering 1,114 COSMIC mutations. …”
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Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis by Chun Zhang, Xiuxing Liu, Chenyang Gu, Yuhan Su, Jianjie Lv, Yidan Liu, Yuehan Gao, Hui Chen, Nanwei Xu, Jing Xiao, Zhuping Xu, Wenru Su

“…However, underlying pathogenesis of AU required to develop more efficient therapy remain unclear. Methods: We isolated peripheral blood mononuclear cells (PBMCs) from AU patients and performed single-cell RNA sequencing (scRNA-seq). …”
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Universal, school-based, interventions to improve emotional outcomes in children and young people: a systematic review and meta-analysis by Daniel Hayes, Daniel Hayes, Emre Deniz, Kirsty Nisbet, Abigail Thompson, Anna March, Anna March, Carla Mason, Joao Santos, Rosie Mansfield, Emma Ashworth, Bettina Moltrect, Bettina Moltrect, Shaun Liverpool, Hannah Merrick, Jan Boehnke, Neil Humphrey, Paul Stallard, Praveetha Patalay, Praveetha Patalay, Jessica Deighton, Jessica Deighton

“…Risk of bias was assessed using specially devised tools adopted from Cochrane.ResultsIn total, 71 unique studies with a total sample of 63,041 young people met the inclusion criteria. …”
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Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study by Xinran Song, Xinran Song, Weixin Chen, Weixin Chen, Shuang Bai, Shuang Bai, Min Lv, Min Lv, Jian Wang, Jian Wang, Ao Zhang, Ao Zhang, Jiang Wu, Jiang Wu, Wei Zhao, Wei Zhao, Wei Zhao

“…BackgroundInactivated COVID-19 vaccines exhibit more rapid declines in antibody levels than other vaccine platforms, likely owing to transient antigen exposure and limited germinal center persistence. …”
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A national survey of suicidality and non-suicidal self-injury in bipolar disorder: insights from network analysis by Lvchun Cui, Yuncheng Zhu, Yang Li, Jia Zhou, Guiyun Xu, Miao Pan, Zhiyu Chen, Wenfei Li, Zhian Jiao, Mingli Li, Yong Zhang, Jingxu Chen, Xiuzhe Chen, Na Li, Jing Sun, Jian Zhang, Shaohua Hu, Haishan Wu, Zhaoyu Gan, Yan Qin, Yumei Wang, Yantao Ma, Xiaoping Wang, Xiaohong Li, Chuangxin Wu, Yiyun Cai, Jiaye Chen, Baichuan Wu, Zuowei Wang, Daihui Peng, Yiru Fang

“…Results Of the 1,055 participants recruited, over 50% with depressive or mixed episodes had SI, more than 20% engaged in SA, and over 40% reported NSSI. …”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

“…Existing primary and secondary prevention strategies for cardiovascular disease have limitations in identifying some high-risk groups, and 1.5-level prevention aims to achieve more precise intervention by early identification of subclinical target organ damage. …”
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COVID-19 Breakthrough Infections in Immune-Mediated Inflammatory Diseases: Data from the SUCCEED (Safety and Immunogenicity of COVID-19 Vaccines in Systemic Autoimmune-Mediated Inf... by Jeremiah Tan, Sasha Bernatsky, Jennifer L. F. Lee, Paul R. Fortin, Roya M. Dayam, Anne-Claude Gingras, Ines Colmegna, Dawn M. E. Bowdish, Claudie Berger, Dora Chan, Maggie J. Larché, Dawn P. Richards, Lourdes Gonzalez Arreola, Carol A. Hitchon, Nadine Lalonde, J. Antonio Aviña-Zubieta

“…Our objective was to assess these events in IMID. <b>Methods</b>: We prospectively studied IMID participants who had received ≥three COVID-19 vaccine doses. …”
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Get strong to fight childhood cancer - an exercise intervention for children and adolescents undergoing anti-cancer treatment (FORTEe): Rationale and design of a randomized control... by Marie Astrid Neu, Elias Dreismickenbecker, Francesca Lanfranconi, Sandra Stössel, Adriana Balduzzi, Peter Wright, Stan Windsor, Joachim Wiskemann, Inaam El-Rajab, Alejandro Lucia, Carmen Fiuza-Luces, Rodolf Mongondry, Martin Kaj Fridh, Filippo Spreafico, Barbara Konda, Lidija Kitanovski, Barbara Heißerer, Marco Polak, Tobias Baader, Wilhelm Bloch, Miriam Götte, on behalf of Network ActiveOncoKids, Katie Rizvi, on behalf of Youth Cancer Europe, Christian Ruckes, Norbert W. Paul, Joerg Faber, on behalf of the FORTEe Consortium

“…Enhancing statistical power, the large sample will enable more robust analyses of the intervention’s effects in a diverse population across multiple European centers. …”
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Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation by Jessica Hernandez, Fabian Johannes Pflieger, Julia Schäffer, Leona Bähr, Jenny Schneiders, Thomas Reichel, Marita Meurer, Marita Meurer, Benjamin Lamp, Natali Bettina Bauer, Karsten Krüger, Lois Harden, Maren von Köckritz-Blickwede, Maren von Köckritz-Blickwede, Christoph Rummel, Christoph Rummel, Christoph Rummel

“…LPS-induced hypothermia was more severe in PMN-pretreated mice while other physiological parameters were only altered by LPS alone. …”
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