Abstract 071: Oral Contraceptive Use and Development of Acute Ischemic Stroke: A Population‐Based Retrospective Cohort Study by Alis J. Dicpinigaitis, Giana Dawod, Bridget A. Nolan, Catherine A. Morse, Jon Rosenberg, Gurmeen Kaur, Ji Y. Chong, Stephan A. Mayer, Chirag D. Gandhi, Fawaz Al‐Mufti

“…Modern OCP formulations contain lower doses of estrogen, the putative causative agent for AIS in this population, and underscores the need to re‐evaluate the risk initially demonstrated in older formulations containing higher levels of estrogen. Methods Hospitalizations for female patients aged 15‐50 were identified in the National Inpatient Sample (NIS) registry from 2015‐2020, excluding admissions associated with pregnancy or the postpartum period. …”
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Incidence and Severity of Acute Myocardial Injury after Thoracic Surgery: Effects of Nicorandil by K. V. Protasov, O. A. Barahtenko, E. V. Batunova, E. A. Rasputina

“…We calculated the incidence of acute myocardial injury in the groups, which was diagnosed in cases of postoperative hs-cTnI increase of more than one 99th percentile of the upper reference limit. …”
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Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study. by Shanquan Chen, Benjamin R Underwood, Peter B Jones, Jonathan R Lewis, Rudolf N Cardinal

“…Lithium-exposed patients were more likely to be married, cohabiting or in a civil partnership, to be a current/former smoker, to have used antipsychotics, and to have comorbid depression, mania/bipolar affective disorder (BPAD), hypertension, central vascular disease, diabetes mellitus, or hyperlipidemias. …”
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Schema-Informed Digital Mental Health Intervention for Maladaptive Cognitive-Emotional Patterns: Randomized Controlled Trial by Seohyun Jeong, Hyeonseong Kim, Silvia Kyungjin Lho, Inae Hwang, Seongjun Mun, Soohyun Kim, Hyejin Lim, Hyeonhee Kim, Min-Sup Shin, Woori Moon

“…The intervention group was also more likely than the waitlist to seek external mental health services (t216=2.59; P=.01; mean difference=0.45; 95% CI 0.12-0.80). …”
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The prognostic significance and Immunomodulatory role of SCGB3A1 expression in stage I lung adenocarcinoma by Xin Zhang, ShiNing Li, Yujin Lv, XinYu Liu, Yong Ao, LeQi Zhong, Yi Hu

“…We propose that SCGB3A1 may offer a novel treatment approach for lung adenocarcinoma patients who do not respond well to targeted therapies. Methods We obtained RNA sequencing data from 539 lung adenocarcinoma samples, 59 normal tissues, and 2 metastatic cancer tissues from The Cancer Genome Atlas database. …”
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Intimate partner violence during pregnancy against 601,534 women aged 15 to 49 years in 57 LMICs: prevalence, disparities, trends and associated factors using Demographic and Healt... by David Jean Simon, Vénunyé Claude Kondo Tokpovi, Adama Ouedraogo, Kassoum Dianou, Ann Kiragu, Comfort Z. Olorunsaiye, Bénédique Paul

“…We also examined changes in IPVDP in LMICs and associated factors. Methods: Data for this study were extracted from Demographic and Health Surveys conducted in 57 LMICs from 2000 to 2024. …”
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Vertical bacterial variability in oxidation ponds in the tropical zone by C. Tudsanaton, T. Pattamapitoon, O. Phewnil, W. Wararam, K. Chunkao, P. Maskulrath, M. Srichomphu

“…The purpose of this study is to examine the vertical variability of bacteria in natural treatment oxidation ponds in tropical zones.METHODS: Wastewater samples were collected from an oxidation pond at 3 different depths (0–0.6, 0.6–1.5 and more than 1.5 meter), and their chemical, physical and biological qualities were analysed. …”
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Análisis del tiempo de clase en EF y propuestas para su optimización (Analysis of class time in physical education and proposals for optimization) by Celia María Ruiz Heredia, Amador Jesús Lara Sánchez, Francisco José López Gallego, Javier Cachón Zagalaz, Pedro Valdivia Moral

“…The sample constituted of two groups of fifth-graders from a primary school, out of which 3 students were extracted. …”
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Results of various somatic mutations detection in patients with chronic myeloid leukemia by E. A. Kuzmina, E. Yu. Chelysheva, B. V. Biderman, O. A. Shukhov, E. A. Stepanova, E. P. Gadzhieva, A. N. Petrova, I. S. Nemchenko, A. V. Bykova, M. A. Guryanova, A. V. Kokhno, A. G. Turkina, A. B. Sudarikov

“…In order to assess clonal evolution, additional samples were examined at a retrospective point in time closest to the primary CML diagnosis.Results. …”
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A Data-Driven Approach to Assessing Hepatitis B Mother-to-Child Transmission Risk Prediction Model: Machine Learning Perspective by Dung Nguyen Tien, Huong Thi Thu Bui, Tram Hoang Thi Ngoc, Thuy Thi Pham, Dac Trung Nguyen, Huyen Nguyen Thi Thu, Thi Thu Hang Vu, Thi Lan Anh Luong, Lan Thu Hoang, Ho Cam Tu, Nina Körber, Tanja Bauer, Lam Khanh Ho

“…These findings offer actionable insights to support the development of more targeted and effective HBV MTCT prevention strategies.…”
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Usefulness of Interventions Using a Smartphone Cognitive Behavior Therapy Application for Children With Mental Health Disorders: Prospective, Single-Arm, Uncontrolled Clinical Tria... by Shinichiro Nagamitsu, Ayumi Okada, Ryoichi Sakuta, Ryuta Ishii, Kenshi Koyanagi, Chizu Habukawa, Takashi Katayama, Masaya Ito, Ayako Kanie, Ryoko Otani, Takeshi Inoue, Tasuku Kitajima, Naoki Matsubara, Chie Tanaka, Chikako Fujii, Yoshie Shigeyasu, Michiko Matsuoka, Tatsuyuki Kakuma, Masaru Horikoshi

“…However, a higher-intensity CBT program is necessary for more severely depressed children.…”
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Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China by ZHENG Xin, XUE Yuanye, WANG Haobiao, WU Litiao, LI Ran, DANG Yingnan, CHEN Tingting, XU Xiaoxuan, ZENG Xuezhen, ZENG Jinfeng

“…[Objective] To conduct a retrospective statistical comparison of alanine aminotransferase (ALT) test values in blood donors prior to blood collection, aiming to analyze the objective characteristics of the population with elevated ALT levels (ALT>50 U/L) and provide reference data for adjusting the screening eligibility threshold for ALT. [Methods] The preliminary ALT screening data of 30 341 blood donor samples collected prior to blood donation from three smart blood donation sites at the Shenzhen Blood Center between 2022 and 2023 were extracted and compared with data from a health examination department of a tertiary hospital in Shenzhen (representing the general population, n=24 906). …”
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The application of antibiotic-loaded bone cement in preventing periprosthetic joint infection: an umbrella review by Yangbin Cao, Peiyuan Tang, Hua Chai, Wenbo Ma, Bin Lin, Ying Zhu, Ahmed Abdirahman, Wenfeng Xiao, Jun Zhang, Yusheng Li, Shuguang Liu, Ting Wen

“…Abstract Objectives The purpose of this study was to provide thorough, understandable and precise evidence for the clinical use of antibiotic-loaded bone cement (ALBC) in preventing periprosthetic joint infection (PJI). Methods We evaluated the effectiveness of ALBC in preventing PJI by conducting an umbrella review of existing meta-analysis. …”
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Compliance of extended infusion of piperacillin/tazobactam with the desired pharmacokinetic/pharmacodynamic index in septic patients by Tomić Nataša, Vukmirović Saša, Sabo Stanislav, Uvelin Arsen, Popović Radmila, Vicković Sanja, Tomić Ljiljana, Tomić Zdenko

“…The portion of the dosing interval during which antibiotic concentrations are above the minimal inhibitory concentration – MIC (fT>MIC) or, even more, four times higher than the MIC (fT>4xMIC), represents the pharmacokinetic indices that best correlate with the clinical outcome. …”
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Study of novel 1,4-dihydropyridine derivatives as prospective anti-inflammatory remedies: a randomised controlled trial by E. Yu. Bibik, D. S. Krivokolysko, G. A. Batishcheva, A. A. Samokish, Yu. S. Venidiktova, A. V. Myazina, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko

“…A study of the anti-inflammatory action of novel compounds, 1,4-dihydropyridine derivatives, in a classical formalin-induced paw oedema test in white rats.Methods. Originally synthesised 1,4-dihydropyridine derivatives were preliminarily subjected to virtual screening using the SwissTargetPrediction toolkit. …”
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Favorable pattern of arterial stiffness and vascular aging in a unique cohort of offspring of early life famine survivors by K. M. Tolkunova, D. A. Usoltsev, E. V. Moguchaia, M. A. Boyarinova, A. M. Erina, E. P. Kolesova, S. V. Kibkalo, E. Yu. Vasileva, N. N. Artemov, O. P. Rotar, A. O. Konradi, E. V. Shlyakhto

“…The proportion of men in the samples was also comparable — 43,4% vs 42,3% (p=0,88). …”
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New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma by Sophie Deshayes, Christophe Blanquart, Erwan Mortier, Judith Fresquet, Noémie Joalland, Agnès Quéméner, Romain Humeau, Mike Maillasson, Héloïse LeBihan, Apolline Salama, Séverine Remy, Carole Guillonneau, Ignacio Anegon

“…Thus, there is a need for a more specific and yet integrative approach.Methods A human mutated form of the extracellular portion of CSF-1R was in silico modelized to trap both IL-34 and CSF-1 with higher affinity than the wild-type CSF-1R by replacing the methionine residue at position 149 with a Lysine (M149K). …”
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Bioassay Guided Fractionation Protocol for Determining Novel Active Compounds in Selected Australian Flora by Janice Mani, Joel Johnson, Holly Hosking, Beatriz E. Hoyos, Kerry B. Walsh, Paul Neilsen, Mani Naiker

“…A large variety of unique and distinct flora of Australia have developed exceptional survival methods and phytochemicals and hence may provide a significant avenue for new drug discovery. …”
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Trends in sensor-based health metrics during and after pregnancy: descriptive data from the apple women's health studyAJOG Global Reports at a Glance by Anshuman Mishra, PhD, Jihyun Park, PhD, Ian Shapiro, PhD, Tyler Fisher-Colbrie, MBA, Donna D. Baird, PhD, Sanaa Suharwardy, MD, Shunan Zhang, PhD, Anne Marie Z. Jukic, PhD, Christine L. Curry, MD, PhD

“…Wearable technology provides an opportunity to understand physiologic and behavioral changes across pregnancy with greater detail, more frequent measurements, and improved accuracy. …”
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Cross-sectional study of the association between diet and physical inactivity with obesity, diabetes and hypertension among older adults in Sierra Leone by Justine Davies, Oyinlola Oyebode, Haja Wurie, Maria Lisa Odland, Miles Witham, Rashid Ansumana, Tahir Bockarie, Joseph Lamin, Ankit Shanker, Mohamed B Jalloh, Alhaji M Kamara

“…Obesity was associated with urban living (OR=1.66, 95% CI (1.59 to 1.72)), high salt intake from two or more sources (OR=1.21, 95% CI (1.17 to 1.25)) and low physical activity (OR=1.30, 95% CI (1.22 to 1.39)). …”
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