Hip fractures in Chinese TikTok (Douyin) short videos: an analysis of information quality, content and user comment attitudes by Zhuoxin Li, Zhuoxin Li, Yashi Lin, Yashi Lin, Kairou Zhang, Kairou Zhang, Ran Li, Ran Li, Mei Ju, Yanhua Chen, Jing Fu, Ruiyu Huang, Ling Zhu, Junjun Sun, Yanxia Guo, Min Gao, Yue Hu, Gang Liu, Baolu Zhang

“…While numerous Douyin videos address hip fracture, their information quality and factors affecting user comment attitudes remain uncertain.ObjectiveThis study aims to analyze the content, information quality, and user comment attitudes of videos depicting hip fractures on Chinese TikTok (Douyin).MethodsThe search term “hip fracture” was used on Douyin, which resulted in 170 samples being included. …”
Get full text

Characterization of intrahepatic B cells in acute-on-chronic liver failure by Yudong Zhao, Wei He, Chenchen Wang, Nana Cui, Changjie Yang, Zhengrui You, Bisheng Shi, Lei Xia, Xiaosong Chen

“…Previous reports were only based on immunophenotyping of peripheral blood samples. Here, we aim to dissect liver-infiltrating B-cell subpopulation in ACLF.MethodsPaired liver perfusate and peripheral blood were freshly collected from healthy living donors and recipients during liver transplantation. …”
Get full text

BRCA1 promoter hypermethylation is not associated with germline variants in Polish breast cancer patients by Karolina Prajzendanc, Paweł Domagała, Jolanta Hybiak, Wojciech Kluźniak, Cezary Cybulski, Katarzyna Białkowska, Alicja Ogrodniczak, Janusz Ryś, Aleksandra Sejda, Marek Szwiec, Joanna Tomiczek-Szwiec, Tomasz Kluz, Roksana Dwornik, Dagmara Cylwik, Jacek Gronwald, Jan Lubiński, Anna Jakubowska

“…Among BRCA1 PV carriers, the GG genotype was significantly more frequent, while the CC genotype was 10 times less common compared to non-carriers (p = 0.003). …”
Get full text

Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics by Alexander Tristancho-Baró, Ana Isabel López-Calleja, Ana Milagro, Mónica Ariza, Víctor Viñeta, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, David Badenas-Alzugaray, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…This study aims to investigate the genomic determinants associated with cefiderocol resistance in CPE isolates of human origin. <b>Methods</b>: Comparative genomic analyses were conducted between cefiderocol-susceptible and -resistant CPE isolates recovered from human clinical and epidemiological samples at a tertiary care hospital. …”
Get full text

Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism by Mai Han, Gang Cui, Yan Zhao, Xianbo Zuo, Xiaoxue Wang, Xin Zhang, Na Mi, Jiangli Jin, Chunyan Xiao, Jing Wang, Wei Wu, Yajuan Li, Jintong Li

“…Differences in system exposure were more pronounced during the terminal elimination phase than the early stage of GP1707D07 metabolism. …”
Get full text

Comparative Analysis of Long-Term Measles Immune Response After Natural Infection and Routine Vaccination in China by Sihong Zhao, Qianli Wang, Juan Yang, Qiaohong Liao, Juanjuan Zhang, Xiaoyu Zhou, Jiaxin Zhou, Zeyao Zhao, Yuxia Liang, Junteng Luo, Jingting Cai, Yanpeng Wu, Wei Wang, Hongjie Yu

“…In this study, we aimed to determine the distinct dynamics of vaccine-induced and naturally acquired antibodies, with specific focus on difference in vaccine-induced antibody responses across different birth cohorts. <b>Methods:</b> Based on two cohorts and one cross-sectional study conducted in Anhua County, Hunan Province, China, serum samples from children who followed China’s routine measles vaccination schedule (i.e., two-dose schedule at 8/18 months) and adults who acquired immunity through natural infection were tested for measles IgG antibodies using an enzyme-linked immunosorbent assay. …”
Get full text

Comparison of two combined drug therapy regimens for renal damage in patients with metastatic kidney cancer after previously performed unilateral nephrectomy by K. S. Titov, M. V. Epifanova, A. A. Alimov, O. Yu. Nesterova, E. V. Shutov, S. S. Lebedev, G. M. Zapirov

“…Combined immunotherapy with ipilimumab + nivolumab in patients with metastatic RCC in patients with a single kidney has a more pronounced deterioration in renal function compared with combined immunotherapy with pembrolizumab + axitinib.…”
Get full text

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes by Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng

“…While these subtypes share clinical, genetic, and pathological features, their transcriptomic similarities and differences remain poorly understood. Methods We applied single-nucleus RNA-sequencing (snRNA-seq) to prefrontal cortex samples from individuals with non-cognitive impairment control (NCI), and dementia subtypes (AD, DLB, and PDD) to investigate cell type-specific gene expression patterns and pathways underlying pathological similarities and differences across dementia subtypes. …”
Get full text

HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study by Irma Wati Ngadimon, Devi Mohan, Mohd Farooq Shaikh, Ching Soong Khoo, Hui Jan Tan, Yu Mey Lee, Nor Syazwani Chamhuri, Farizal Fadzil, Nursyazwana Zolkafli, Alina Arulsamy, Jegan Thanabalan, Angel Aledo‐Serrano, Wing Loong Cheong

“…This prospective longitudinal study investigated whether serum HMGB1 levels are associated with PTE development and cognitive decline over 12 months post‐TBI. Methods Serum samples were collected from 41 TBI patients, including mild and moderate to severe, at baseline, 6, and 12 months following TBI. …”
Get full text

Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk by Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma

“…Plasma samples underwent untargeted metabolomic and lipidomic profiling using liquid chromatography–mass spectrometry (LC–MS). …”
Get full text

Conception and development of a neurological registry of patients with persistent health impairments following work-related COVID-19 disease in Germany by Schwenkreis, Peter, Kozak, Agnessa, Gonschorek, Andreas, Schmehl, Ingo, Seddigh, Susann, Fürst, Andrea, Wohlfahrt, Kai, Rademacher, Corinna, Engel, Lynn, Wefers, Jacob, Kobes, Kerrin, Kleinmüller, Olaf, Wischnat, Jana, Nienhaus, Albert, Tegenthoff, Martin

“…The design of the post-COVID registry, along with a description of the study population, is detailed in this paper.Methods: The registry includes patients with an occupational disease or accident. …”
Get full text

Analysis of endophytic bacterial diversity of Puerariae thomsonii from different production areas and their correlation with secondary metabolites by Yang Xu, Yang Xu, Lihua Zeng, Lihua Zeng, Zheng Peng, Zheng Peng, Nana Chang, Nana Chang, Ye Wang, Ye Wang, Lingling Zheng, Lingling Zheng, Yan Ren, Yan Ren, Hui Li, Hui Li, Hui Li, Tielin Wang, Tielin Wang

“…The differences between endophytes and the content of five isoflavones were analyzed using high-throughput sequencing and UPLC methods. In addition, differences in endophytic bacteria across the samples from different productions were analyzed using LEfSe analysis. …”
Get full text

Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study by Yaqin Peng, Ruijie Xie, Yifeng Luo, Yifeng Luo, Yifeng Luo, Penghao Guo, Zhongwen Wu, Yili Chen, Pingjuan Liu, Jiankai Deng, Bin Huang, Kang Liao

“…BackgroundThough droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due to different ddPCR platforms with discrepant diagnostic performance. …”
Get full text

Efficacy and safety of Chinese classical prescriptions for dilated cardiomyopathy: a systematic review and Bayesian network meta-analysis by Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Xiao Xia, Yonghao Li, Deshuang Yang, Wenjie Zhang

“…Furthermore, additional larger RCTs with longer follow-up periods and standardized outcome reporting are required to give more solid evidence to support our findings due to the small sample size of the current studies and the presence of risk of bias.…”
Get full text

EVALUASI ELEMEN TEKNIS RUANG BERSAMA RUSUNAWA MAHASISWA SEBAGAI HUNIAN SEHAT DI MASA PANDEMI COVID-19 by Citra Amalia Amal, Andi Annisa Amalia, Siti Fuadillah A. Amin, Rifaldi Rifaldi

“…The results of the study found that the two samples of student flats, in general, had met the Healthy Home Principles. …”
Get full text

An examination of the associations between nutritional peaking strategies in physique sport and competitor characteristics by Kai A. Homer, Matt R. Cross, Eric R. Helms

“…For non-CHO-based strategies, drug-enhanced competitors were more likely to restrict water than non-drug enhanced, while males and professional competitors had greater odds of loading sodium than females and amateurs, respectively. …”
Get full text

Spatial distribution and factors associated with HIV testing among adolescent girls and young women in Sierra Leone by Augustus Osborne, Camilla Bangura, Samuel Maxwell Tom Williams, Alusine H. Koroma, Lovel Fornah, Regina M. Yillah, Bright Opoku Ahinkorah

“…The sample comprised 6,062 adolescent girls and young women between the ages of 15 and 24. …”
Get full text

First trimester circulating miR-208b-3p and miR-26a-1-3p are relevant to the prediction of gestational hypertension by Andrée-Anne Clément, Cécilia LÉGARÉ, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Michelle S. Scott, Pierre-Étienne Jacques, William D Fraser, Patrice Perron, Renée Guérin, Marie-France Hivert, Anne-Marie Côté, Luigi Bouchard

“…We thus aimed to identify first trimester circulating miRNAs associated with GH and to build a miRNA-based algorithm to predict GH incidence. Methods We quantified miRNAs using next-generation sequencing in plasma samples collected at first trimester of pregnancy in Gen3G (N = 413, including 28 GH cases) and 3D (N = 281, including 21 GH cases) prospective birth cohorts. …”
Get full text

Comparison of Conventional Palliative Radiotherapy Fractionation Schedule with Quad Shot Regimen in Locally Advanced Head and Neck Cancer Patients: A Randomised Clinical Trial by Srishti Puraiya, Jitendra Kumar, Arun Kumar Yadav, Afroz Kahkashan Zaidi, Rajendra Kumar, Geeta Singh

“…Aim: To compare the QS regimen administered over two consecutive days versus the Conventional Palliative Regimen in the treatment of locally advanced HNC, in terms of treatment response, acute toxicities and QoL. Materials and Methods: In this prospective randomised clinical trial conducted from May 2023 to July 2024 in the Department of Radiation Oncology at King George's Medical University (KGMU), Lucknow, Uttar Pradesh, India, patients with biopsy-proven locally advanced carcinoma of the head and neck were recruited, with a sample size of 50 in each of the study Group B and control Group A arms. …”
Get full text

Omics data integration analysis identified new biological insights into chronic antibody-mediated rejection (CAMR) by Maurizio Bruschi, Simona Granata, Francesca Leone, Laura Barberio, Giovanni Candiano, Paola Pontrelli, Andrea Petretto, Martina Bartolucci, Sonia Spinelli, Loreto Gesualdo, Gianluigi Zaza

“…However, the full biological machinery underlying CAMR has only been partially defined, likely due to the fact thatsingle-omics technologies capture only specific aspects of the biological system and fail to provide a comprehensive understanding of this clinical complication. Methods This study integrated mass spectrometry-based proteomic profiling of serum samples from 19 patients with clinical and histological evidence of CAMR and 26 kidney transplant recipients with normal graft function and histology (CTR) with transcriptomic analysis of peripheral blood mononuclear cells (PBMCs) from an independent cohort of 10 CAMR and 8 CTR patients. …”
Get full text