Delivering a national de-adoption programme: a documentary analysis of local commissioning policy compliance with England's Evidence-based Interventions programme (EBI) by Carmel Conefrey, Nicola Farrar, Maeve Coyle, Mike Bell, Jane Blazeby, Christopher Burton, Jenny Donovan, Andy Gibson, Joel Glynn, Tim Jones, Angus McNair, Josie Morley, Amanda Owen-Smith, Ellen Rule, Gail Thornton, Victoria Tucker, Iestyn Williams, William Hollingworth, Leila Rooshenas

“…This study (which is part of the NIHR OLIVIA study, an evaluation of the EBI programme) assessed local commissioning policy compliance with EBI recommendations and identified funding mechanisms employed locally to promote enforcement. Methods A documentary analysis was conducted on a purposive sample of local commissioning policies for each of the 17 EBI surgical procedures. …”
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Eco-friendly pest management in integrated rice-fish farming systems using plant-derived biopesticides to promote sustainable agriculture by Wiratno , I.M. Trisawa, I. Taufik, I. Ardi, L. Thesiana, E. Kusrini, D. Susanti, E.W. Minarni, A. Nurawan, A. Jufri, Sukamto , Y. Apriyana, N. Sutrisna, Y. Surdianto, B. Susanto, U. Susanto

“…No insecticide residues were found in fish, soil, or water samples. Fish survival remained high (more than 90 percent), and rice yields increased by 15 percent compared to conventional practices. …”
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Identification of intratumoral bacteria that enhance breast tumor metastasis by Zachary J. Gerbec, Antonio Serapio-Palacios, Avril Metcalfe-Roach, Zakhar Krekhno, Haggai Bar-Yoseph, Sarah E. Woodward, Jorge Pena-Díaz, Oksana Nemirovsky, Shannon Awrey, Sebastian H. Moreno, Sean Beatty, Esther Kong, Nina Radisavljevic, Mihai Cirstea, Shawn Chafe, Paul C. McDonald, Sam Aparicio, B. Brett Finlay, Shoukat Dedhar

“…We tested for the presence of these bacterial genes in patient tumor samples and found they were more likely to be associated with mortality. …”
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Longitudinal Comparison of Three T-Cell Assays and Three Antibody Assays Against SARS-CoV-2 Following Homologous mRNA-1273/mRNA-1273/mRNA-1273 and Heterologous ChAdOx1/ChAdOx1/BNT1... by Hyeyoung Lee, Geon Young Ko, Jihyun Lee, Hyunjoo Bae, Ji Hyeong Ryu, Jin Jung, Hyunhye Kang, Raeseok Lee, Dong-Gun Lee, Eun-Jee Oh

“…This study compares three T-cell and three antibody assays in two vaccine groups. <b>Methods</b>: This prospective longitudinal cohort study involved 46 naïve healthcare workers: a total of 11 in the homologous mRNA-1273 group (three doses) and 35 in the heterologous ChAd group (two ChAd doses followed by a BNT booster). …”
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Factors associated with death in patients admitted with Ebola virus disease to Ebola Treatment Units in Guinea, Sierra Leone, and Liberia – December 2013 to March 2016 [version 2;... by Ralph W. Jetoh, Ajay M.V. Kumar, Alexandre Delamou, Laura Merson, Prabin Dahal, Gomathi Ramaswamy, Ibrahima Kaba, Benjamin T. Vonhm, Trokon Omarley Yeabah, Anthony D. Harries, Pryanka Relan, Adam C. Levine

“…Conclusions Although laboratory-confirmed patients admitted to ETUs fared worse than clinically-suspected patients, the latter still had a substantial risk of death and more attention needs to be paid to this group in future EVD outbreaks.…”
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Comparison of conventional culture and automated blood culture system for microbiologic diagnosis of pleural infection by Young Ho Lee, Min Seo Kang, Jinyoung Yang, Si-Ho Kim, Jae-Hoon Ko, Sun Young Cho, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Kyungmin Huh

“…Non-duplicate patients whose pleural fluid samples were tested using both conventional culture and ABCS (BACT/ALERT 3D and VIRTUO, bioMerieux) from 2001 through 2021 were included. …”
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Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival by Junier Marrero-Gutiérrez, Ana Carolina Bueno, Ana Carolina Bueno, Clarissa Silva Martins, Rui Milton Patrício Silva-Júnior, Antônio Carlos dos Santos, Marcelo Volpon Santos, Luiz Eduardo Wildemberg, Ximene Lima da Silva Antunes, Monica R. Gadelha, Ayrton Custodio Moreira, Ricardo Zorzetto Nicoliello Vêncio, Sonir Roberto R. Antonini, Margaret de Castro

“…IntroductionOver the past decade, advancements in next-generation sequencing have significantly enhanced our understanding of the molecular pathogenesis of adamantinomatous craniopharyngiomas (ACP).ObjectiveThis study integrated methylome and transcriptome analyses in ACP samples to explore the potential interplay between DNA methylation and RNA expression signatures for diagnostic and prognostic applications in ACP patients.MethodsThis cross-sectional study evaluated clinicopathological features, DNA methylation, and gene expression profiles in 15 patients with ACP (33% women, age range: 3–55 years, 53% diagnosed before 18 years) treated at Ribeirao Preto Medical School, University of São Paulo.ResultsMultidimensional scaling and principal component analysis identified two distinct clusters (ACP-A: n=9, ACP-B: n=6) with consistent composition across DNA methylation and gene expression profiles. …”
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In Vitro Antimicrobial Activity of Volatile Compounds from the Lichen <i>Pseudevernia furfuracea</i> (L.) Zopf. Against Multidrug-Resistant Bacteria and Fish Pathogens by Yasser Essadki, Adel Hilmi, Antonio Cascajosa-Lira, Mariana Girão, El Mehdi Darrag, Rosário Martins, Abderrahmane Romane, Soukaina El Amrani Zerrifi, Richard Mugani, Zakaria Tazart, El Mahdi Redouane, Angeles Jos, Ana M. Cameán, Vitor Vasconcelos, Alexandre Campos, Fatima El Khalloufi, Brahim Oudra, Mustapha Barakate, Maria de Fátima Carvalho

“…The antimicrobial activity of these compounds was assessed using disc diffusion and broth microdilution methods. Both samples demonstrated significant antimicrobial effects against multidrug-resistant human bacteria, reference microorganisms, fish pathogens, and <i>Candida albicans</i>, with minimum inhibitory concentrations (MICs) ranging from 1000 µg/mL to 31.25 µg/mL. …”
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Identification of HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome in Ambon, Indonesia by Sri Linuwih Susetyo Wardhani Menaldi, Mufqi Handaru Priyanto, Sandra Widaty, Yunia Irawati, Yulia Ariani Aswin, Dwi Anita Suryandari, Melani Marissa, Iwan Ariawan, Emiliana Kartika, Malika Sabrina Yunifananda, Hok Bing Thio

“…Cases were included if they met two or more Richardus and Smith’s criteria and were recruited from several hospital in Ambon and Tual Cities. …”
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The unintended outcome: a retrospective cross‐sectional study using a urine lateral flow assay to detect ART use reveals non‐disclosure of taking ART in South Africa's public healt... by Nsika Sithole, Indira Govender, Matthew Spinelli, Theresa Smit, Siyabonga Cibane, Mlungisi Zwane, Njabulo Phakathi, Meighan Krows, Busisiwe Nkosi, Janet Seeley, Ruanne V. Barnabas, Mark J. Siedner, Mosa Moshabela, Connie Celum, Alison Grant, Monica Gandhi, Adrienne E. Shapiro

“…If successful, this strategy may reduce duplicative care entries and promote more efficient use of resources.…”
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Gene-environment interactions and colorectal cancer risk: A case-control study on xenobiotic metabolizing enzyme polymorphisms in the Jammu& Kashmir, India population by Gowhar Rashid, Gulzar A. Bhat, Tahseen Bilal Rather, Kulsum Akhter, Ishrat Parveiz, Irfan Maqbool, Syed Nisar Ahmad, Malik Tariq Rasool, Farooq Ahmad Jan, Syed Mudassar

“…The study included 246 histopathologically confirmed colorectal cancer (CRC) cases, and an equal number of matched controls based on age (±5 years), gender, and place of residence. Blood samples were collected for DNA extraction, followed by genotyping of xenobiotic-metabolizing enzyme (XME) genes, including CYP2A13, CYP2A6, and GSTs using standard PCR-RFLP and multiplex PCR methods. …”
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The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey by Juan Yang, Mark Jit, Kathy S. Leung, Ya-ming Zheng, Lu-zhao Feng, Li-ping Wang, Eric H. Y. Lau, Joseph T. Wu, Hong-jie Yu

“…Conclusion The economic burden of influenza-associated outpatient and inpatient visits in China is substantial, particularly for young children, the elderly, and patients with underlying medical conditions. More widespread influenza vaccination would likely alleviate the economic burden of patients. …”
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Comprehensive analysis of single-cell and bulk RNA sequencing data unveils antigen-presenting and processing fibroblasts and establishes a predictive model in gastric cancer by Chenggang Zhang, Fangqi Chen, Jie Li, Yixuan He, Juan Sun, Zicheng Zheng, Guanmo Liu, Yihua Wang, Weiming Kang, Xin Ye

“…Results Compared to non-APPFs, APPFs exhibited more interactions with myeloid cells, endothelial cells, and lymphocytes via MHC-II signaling network. …”
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Rise and dine: unraveling breakfast habits among tenth graders - a cross-sectional study among 646 students in the City of Witten, Germany (GeWIT study) by Mohamed Salah Anwar Mohamed, Anwar Mohamed, Nessia Rachma Dianti, Anne-Lisa Heye, Klaus Völkel, Judith Tillmann, Oxana Klassen, Paul Wiesheu, Klaus Weckbecker, Eva Münster

“…This study aimed to assess the prevalence of breakfast skipping on the day of the survey among adolescents in Witten, Germany, and to explore its associations with selected sociodemographic characteristics, health-related behaviours, and self-reported health indicators. Methods Between November 2, 2021, and February 25, 2022, a cross-sectional, survey-based study was conducted among 10th-grade students in all nine municipally managed secondary schools in Witten. …”
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Sex differences in burnout and work-family conflict among Chinese emergency nurses: a cross-sectional study by Dongmei Diao, Dongmei Diao, Dongmei Diao, Xiaoli Chen, Xiaoli Chen, Xiaoli Chen, Luying Zhong, Luying Zhong, Luying Zhong, Hao Zhang, Hao Zhang, Hao Zhang, Jianna Zhang, Jianna Zhang, Jianna Zhang

“…This study aimed to apply sex-specific analyses to investigate the associations between dimensions of burnout and work–family role behavior conflict among Chinese emergency department nurses.MethodsThis was a cross-sectional research. A questionnaire comprising items on demographic characteristics, work–family role behavior conflict, and burnout information, was distributed among emergency department nurses from 30 tertiary hospitals across mainland China, between December 26, 2023, and January 18, 2024.ResultsThis study's sample comprised 1,540 nurses. …”
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Comparison of treatment planning for stereotactic radiosurgery and stereotactic body radiation therapy techniques with 2.5mm and 5mm multileaf collimator (MLC): A pilot study [vers... by Senthil Manikandan, Krishna Sharan, Shirley Lewis, Suresh Sukumar, Umesh V, Srinidhi G Chandraguthi, Shreekripa Rao, Rechal Nisha Dsouza, Sneha Ravichandran

“…However, the study must be extended further with more samples and multiple comparison parameters. …”
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Changing trends in oral mucosal diseases in China (2016–2024): a cross-sectional study of 316,166 patients with focus on COVID-19 impact and use of chinese patent medicines by Peiru Zhou, Xu Zhang, Yifan Chen, Jiakun Fang, Yanhong Meng, Furong Yang, Pan Wei, Hong Hua

“…It also explores trends in the use of Chinese patent medicines (CPMs) for treatment. Methods This retrospective, cross-sectional study included 316,166 patients from the Department of Oral Medicine at Peking University School and Hospital of Stomatology between 2016 and 2024. …”
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Prevalence and transmission of HIV-1 drug resistance mutations among patients with treatment failure and newly diagnosed people in Liangshan Prefecture, China, in 2021–2023 by Rong Pei, Rong Pei, Yulian Zhang, Chunnong Jike, Gang Yu, Ling Su, Ju Wang, Lin Xiao, Yubing Wang, Maogang Shen, Jiayi Liao, Yifei Zheng, Joris Hemelaar

“…A deeper understanding of HIV-1 drug resistance can lead to improvements in current treatment policies.MethodsWe conducted an analysis of HIV drug resistance mutations (DRMs) among patients with treatment failure and people newly diagnosed with HIV in Liangshan Prefecture. 8,523 blood samples were collected from people living with HIV with treatment failure and newly diagnosed individuals in all 15 counties and two cities in Liangshan Prefecture between 2021 and 2023.Results43.0% of patients with treatment failure acquired HIV through the heterosexual route, followed by injecting drug use (38.7%), while newly diagnosed individuals mainly acquired HIV through the heterosexual route (86.7%). 95.6% of patients with treatment failure were infected with HIV-1 variant CRF07_BC and 2.7% with CRF08_BC, and newly diagnosed individuals were also main infected with HIV-1 variant CRF07_BC (90.9), followed by CRF08_BC (4.0%) and CRF01_AE (2.5%). …”
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A Prospective Study of the Association Between Plasma Calprotectin Levels and New-Onset CKD in the General Population by Arno R. Bourgonje, Martin F. Bourgonje, Sacha la Bastide-van Gemert, Tom Nilsen, Clara Hidden, Ron T. Gansevoort, Douwe J. Mulder, Jan-Luuk Hillebrands, Stephan J.L. Bakker, Robin P.F. Dullaart, Harry van Goor, Amaal E. Abdulle

“…This association is mitigated after adjustment for hs-CRP, and more pronounced with new-onset CKD defined by UAE.…”
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Molecular testing for cytologically suspicious and malignant (Bethesda V and VI) thyroid nodules to optimize the extent of surgical intervention: a retrospective chart review by Jessica Hier, Galit Avior, Marc Pusztaszeri, Joshua R. Krasner, Noura Alyouha, Veronique-Isabelle Forest, Michael P. Hier, Alex Mlynarek, Keith Richardson, Nader Sadeghi, Michael Tamilia, Richard J. Payne

“…Prospective studies with larger sample sizes are required to further investigate this finding. …”
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