Relationship between stressors and job burnout: Moderating role of job well-being by Jie WU, Fengmin CHENG, Ruotong YI, Weiqian YU, Chunyan LIU, Mengyu OU

“…Compared to medical staff at general hospitals, medical staff at oncology hospitals are more prone to job burnout, yet few studies in China have focused on job burnout among employees in oncology hospitals.ObjectiveTo propose a hypothetical model in which job well-being moderates the relationship between stressors and occupational burnout, to explore how stressors influence burnout and potential moderating role of job well-being, and to provide better understanding of job burnout and motivate employees based on the double-edge sword effect of stressors.MethodsA cross-sectional survey was conducted in May 2022 at a tertiary oncology specialty hospital in Chongqing, China. …”
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Knowledge, Attitudes, and Behaviors Related to Dementia Prevention and Caregiving Among Korean Americans (the KIMCHI Project): Pre- and Posttest Evaluation Study by Van Ta Park, Bora Nam, Daren Huang, Stacy W Yun, Nicole Phan, Eun Jeong Lee, Hye-Won Shin

“…Most workshop participants expressed interest in learning more about ADRD-related health topics (186/209, 89%). …”
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Study of anatomy-diagnostic features of leaves of <i>Cynara scolymus</i> L. grown under the conditions of the Kyrgyz Republic by S. C. Chubakova, N. T. Farmanova, N. V. Bobkova, T. A. Mamatov

“…Stomata of the upper epidermis are oval, those of the lower epidermis are more rounded. Stomata are surrounded by 4–5 epidermal cells. …”
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Trends and factors associated with anemia among women of reproductive age in Mali: analysis of data from 2001 to 2018 Mali demographic and health surveys by Ebenezer Kwesi Armah-Ansah, Eugene Budu, Charity Oga-Omenka, Marina Kolosnitsyna

“…We included a total weighted sample of 18,096 women of reproductive age who had participated in the hemoglobin test. …”
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High Adherence to Mediterranean Diet and Fish Intake Are Inversely Associated with Depressive Symptoms in Older Women: Findings from the Cross-Sectional NutBrain Study by Federica Prinelli, Silvia Conti, Nithiya Jesuthasan, Elena Perdixi, Matteo Cotta Ramusino, Alfredo Costa, Sara Bernini

“…The main outcome measure was a CES-D score of 16 or more. Statistical analyses were performed using a logistic regression model controlling for potential confounders. …”
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ADORA2B promotes proliferation and migration in head and neck squamous cell carcinoma and is associated with immune infiltration by Pian Li, Ke-ling Pang, Shuang-jing Chen, Dong Yang, Ai-tao Nai, Gui-cheng He, Zhe Fang, Qiao Yang, Man-bo Cai, Jun-yan He

“…High ADORA2B expression was associated with a more immunosuppressive tumor microenvironment (TME), characterized by lower immune and stromal scores and reduced immune cell infiltration. …”
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Uncovering women's healthcare access challenges in low- and middle-income countries using mixed effects modelling approach: Insights for achieving the Sustainable Development Goals... by Bewuketu Terefe, Belayneh Shetie Workneh, Gebreeyesus Abera Zeleke, Enyew Getaneh Mekonen, Alebachew Ferede Zegeye, Agazhe Aemro, Berhan Tekeba, Tadesse Tarik Tamir, Mulugeta Wassie, Mohammed Seid Ali

“…A weighted sample of 1,722,473 women was included in the study using R-4.4.0 version software. …”
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Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing by Peikai Ding, Shengbin Pei, Yi Zhai, Zheng Qu, Yazhe Yang, Xiaolong Feng, Qiang Liu, Xiangyu Wang, Wenxiang Zhang, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang

“…Objective This study aims to characterize the cellular heterogeneity and unique TME of primary breast angiosarcoma using single-cell RNA sequencing (scRNA-seq), to identify potential therapeutic targets and improve clinical outcomes. Methods Tumor samples were obtained from a patient with bilateral primary breast angiosarcoma and two patients with invasive breast cancer. …”
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Behaviour change interventions to promote physical activity in people with intermittent claudication: the OPTIMA systematic review by Ukachukwu O Abaraogu, Philippa Dall, Chris Seenan, Sarah Rhodes, Trish Gorely, Joanna McParland, Julie Brittenden, Ebuka M Anieto, Lorna Booth, Cathy Gormal, Jeremy Dearling, Candida Fenton, Sarah Audsley, Kimberley Fairer, Lindsay Bearne, Dawn A Skelton

“…Systematic review 2: quantitative, qualitative, mixed-methods research on patient/provider experiences. …”
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Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…Therefore, it is of great importance to analyze the genomic profiles of colorectal cancer and its paraneoplastic tissues, explore the disease-causing risk genes, and search for the potential novel therapeutic targets to improve the therapeutic efficacy of colorectal cancer.MethodsTumor and adjacent tissue samples were harvested from 26 colorectal cancer patients and divided into tumor and paraneoplastic tissues. …”
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Geospatial Distribution of Pedestrian Injuries and Associated Factors in the Greater Kampala Metropolitan Area, Uganda by Frederick Oporia, Nazarius Mbona Tumwesigye, John Bosco Isunju, Rebecca Nuwematsiko, Abdulgafoor Mahmood Bachani, Angela Nakanwagi Kisakye, Mary Nakafeero, Qingfeng Li, Fiston Muneza, George Kiwanuka, Nino Paichadze, Olive Kobusingye

“…We established the geospatial distribution of pedestrian injuries and associated factors in GKMA, Uganda. Methods: We conducted a mixed methods cross sectional study in three districts of GKMA. …”
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Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review by Betina Franceschini Tocchetto, Betina Franceschini Tocchetto, Andrea Cristiane Janz Moreira, Andrea Cristiane Janz Moreira, Álvaro de Oliveira Franco, Álvaro de Oliveira Franco, Iraci L. S. Torres, Felipe Fregni, Wolnei Caumo, Wolnei Caumo, Wolnei Caumo

“…The present systematic review aims to summarize the evidence on rs-FC in individuals with MDD and FM compared with healthy controls and explore overlapping connectivity patterns and their relationships with clinical symptoms.MethodsA systematic search of the EMBASE, PubMed, Scopus and ScienceDirect databases was conducted according to PRISMA guidelines. …”
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Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia by Bingxin Zhang, Shuxia Zhu, Dong Zheng, Xinyi Zhang, Wenxia Xie, Shujuan Zhou, Sisi Zheng, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Zixing Chen, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma

“…However, the relationship between cuproptosis and acute lymphoblastic leukemia (ALL) remains to be further elaborated. Methods In ALL, 12 cuproptosis-related genes (CRGs) were analyzed at genetic and single-cell levels. …”
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Impact of a massive earthquake on adherence to antiretroviral therapy, mental health, and treatment failure among people living with HIV in Nepal. by Bharat Singh Negi, Sunil Kumar Joshi, Minato Nakazawa, Tomohiro Kotaki, Anup Bastola, Masanori Kameoka

“…Therefore, the objectives of this study were i) to assess the association of antiretroviral therapy (ART) adherence with mental health problems, and social behaviors, ii) to examine factors affecting treatment failure, and iii) to investigate changes in ART adherence and post-traumatic stress disorder (PTSD) among people living with HIV 6 and 12 months after the disaster.<h4>Methods</h4>Study was conducted 6 months after the earthquake in 2015 with a sample size of 305 earthquake victims with HIV and followed after 12 months of the earthquake. …”
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Ertapenem+meropenem including double carbapenem therapy (EMDCT) versus meropenem+imipenem including double carbapenem therapy (MIDCT) in the therapy of carbapenem-resistant Klebsie... by Merve Mert Vahabi, Deniz Akyol, Deniz Dağ, Gamze Şanlıdağ, Şevket Yeniyol, Arda Kaya, Dilşah Başkol, Seichan Ketentzi, Buğra Özkara, Şükrü Dirik, Gökhan Vatansever, Derya Kaya, Meltem Tüğdür, Hüseyin Aytaç Erdem, Feriha Çilli, Hilal Sipahi, Hüsnü Pullukçu, Meltem Taşbakan, Bilgin Arda, Oğuz Reşat Sipahi

“…BACKGROUND-AIM: In this retrospective matched cohort study, we aimed to compare the clinical outcomes of EMDCT including therapy receiving cases with MIDCT receiving CRKPI cases. MATERIALS/METHODS: This study was performed at a 1800+ bedded tertiary-care hospital.Adult patients with culture proven CRKPI(bacteremia,pneumonia,UTI,other)treated with EMDCT or MIDCT including regimens between August 2016 and October 2023 were included in the study.Matching was performed as one MIDCT matched to minimum 1 or 2 EMDCT when n is possible i)according to the sample infecting strain was yielded (bacteremia vs.bacteremia etc.)ii)being in the clinic or intensive care unit at the time of the first Infectious Diseases consultation. …”
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Age-linked DNA methylation and gene expression patterns in parameningeal head and neck alveolar rhabdomyosarcoma reveal CDK9 as a promising therapeutic target by Sara Patrizi, Silvia Vallese, Sabina Barresi, Matteo Cassandri, Isabella Giovannoni, Lucia Pedace, Luana Abballe, Flavia Vinciarelli, Celeste Antonacci, Alessandra Stracuzzi, Barbara Mancini, Ida Russo, Angela Di Giannatale, Rossella Rota, Rita Alaggio, Franco Locatelli, Giuseppe Maria Milano, Evelina Miele

“…Methods: We conducted whole-genome DNAm and transcriptome analyses on 10 parameningeal head and neck ARMS patients, including 4 patients under 1 year old and 6 over 10 years old. …”
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Updates from a single-center phase 2 study of PD-1 inhibitor combined with hypomethylating agent plus CAG regimen in patients with relapsed/refractory acute myeloid leukemia by Hui-Sheng Zhou, Hui-Sheng Zhou, Yong-Feng Su, Jun Wang, Ya-Lei Hu, Ya-Lei Hu, An Wang, Lei Xu, Yi-Zhi Wang, Xuan Zheng, Yu-Qing Li, Yu-Qing Li, Kai-Li Min, Kai-Li Min, Chun-Ji Gao, Dai-Hong Liu, Dai-Hong Liu, Xiao-Ning Gao, Xiao-Ning Gao

“…Our study aimed to analyze the effectiveness and safety of combining tislelizumab with a hypomethylating agent (HMA) plus CAG regimen in treating patients with r/r AML, with an increased sample size and in comparison, with a historical control group for more reliable data support (ClinicalTrials.gov identifier NCT04541277).MethodsThe study included a total of 37 patients with r/r AML who received the tislelizumab + HMA + CAG regimen.ResultsThe overall response rate was 69.4%, with a median overall survival of 12.1 months and event-free survival of 6.2 months. …”
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High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1 by Roberta Lucianò, Maurizio Colecchia, Maurizio Colecchia, Francesca Sanvito, Irene Locatelli, Chiara Venegoni, Alessia Di Coste, Davide Danilo Zani, Angelica Stranieri, Chiara Giudice, Antonella Rigillo, Matteo Gambini, Francesco Montorsi, Francesco Montorsi, Andrea Salonia, Andrea Salonia, Marco Moschini, Massimo Alfano

“…The aim of this study was to investigate the expression of the α5β1 integrin and its specificity in high-grade UC in humans and dogs, a marker recently reported in the human bladder in situ carcinoma and murine model of orthotopic bladder cancer.MethodsExpression of integrin α5β1 was established by immunohistochemistry in 67 human bladder samples [four non-tumor tissues, 10 low-grade, 10 intermediate-grade, and 43 high-grade non-muscle invasive bladder cancer (NMIBC)] and 12 canine bladder tumor specimens.ResultsThe α5β1 integrin was not expressed by urothelial cells in the conditions of inflammatory cystitis, actinic cystitis, benign hyperplasia, and low/intermediate grade NMIBC; it was identified as a specific marker expressed only by the malignant cells in the urothelium in 81% of human and all canine high-grade NMIBC.ConclusionsThe expression of α5β1 integrin is a specific marker of high-grade UC located in the urothelium of humans and dogs and might be tested for targeted delivery of contrast agents or drugs. …”
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High-throughput quantitation of human neutrophil recruitment and functional responses in an air-blood barrier array by Hannah Viola, Liang-Hsin Chen, Seongbin Jo, Kendra Washington, Cauviya Selva, Andrea Li, Daniel Feng, Vincent Giacalone, Susan T. Stephenson, Kirsten Cottrill, Ahmad Mohammad, Evelyn Williams, Xianggui Qu, Wilbur Lam, Nga L. Ng, Anne Fitzpatrick, Jocelyn Grunwell, Rabindra Tirouvanziam, Shuichi Takayama

“…Dysregulated neutrophil recruitment drives many pulmonary diseases, but most preclinical screening methods are unsuited to evaluate pulmonary neutrophilia, limiting progress toward therapeutics. …”
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Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal B... by Nigel Curtis, Susan Donath, Dan Casalaz, Petra Zimmermann, Anne-Louise Ponsonby, Nicole L Messina, Kaya Gardiner, Katie Flanagan, Frank Shann, Roy Robins-Browne, Bridget Freyne, Veronica Abruzzo, Clare Morison, Lianne Cox, Susie Germano, Christel Zufferey, Katie J Allen, Peter Vuillermin, Mike South

“…Introduction BCG vaccination reduces all-cause infant mortality in high-mortality settings by more than can be attributed to protection against tuberculosis. …”
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