Gait characteristics in people with Friedreich ataxia: daily life versus clinic measures by Hannah L. Casey, Vrutangkumar V. Shah, Vrutangkumar V. Shah, Daniel Muzyka, James McNames, James McNames, Mahmoud El-Gohary, Kristen Sowalsky, Delaram Safarpour, Patricia Carlson-Kuhta, Christian Rummey, Fay B. Horak, Fay B. Horak, Christopher M. Gomez

“…A comparative healthy control (HC) subject cohort of 9 was sampled using propensity matching on age (median age: 18 [13, 22] years). …”
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Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-bl... by Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

“…Blood and fecal samples were collected before and after the intervention, and various metabolic parameters, gut microbiota composition, and metabolites were analyzed. …”
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16S rRNA and metabolomics reveal the key microbes and key metabolites that regulate diarrhea in Holstein male calves by P. P. Cao, C. L. Hu, M. J. Li, Y. H. An, X. Feng, X. H. Ma, D. Z. Wang, Z. H. Song, G. S. Ji, D. Yang, Q. Ma, W. F. Yang, J. N. Dong, H. R. Zhang, Y. Ma, Y. F. Ma

“…This study aimed to investigate the impact of diarrhea on calf growth.MethodsHolstein male calves with similar birth weight (39.5 ± 4.2 kg) were included in this study, and key parameters such as fecal score, diarrhea incidence, and growth performance from birth to weaning were measured. …”
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Unveiling B7/CD28 family proteins in hepatocellular carcinoma: insights into communication and prognostic significance by Yan Cai, Xiaodi Liu, Xiaodi Liu, Tao He, Yangming Xu, Shuxian Chen, Xianliang Tan, Shouchao Wei, Zimeng Wu, Liying Xiao, Baoming Luo, Baoming Luo

“…Although there has been extensive research on the role of programmed cell death-ligand 1 (PD-L1) in hepatocellular carcinoma (HCC), our understanding of the effects of other inhibitory B7/CD28 family members is still limited despite advancements in prognostic tools, more specific, accurate, and robust biomarkers are required to improve HCC patient prognoses.MethodsWe acquired the single-cell sequencing data from relevant literature and selected 42 liver tissue samples, including 89,246 cells from HCC patients, to investigate the expression, localization, and intercellular communications of the B7/CD28 family in HCC. …”
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The ORVAC trial protocol: a phase IV, double-blind, randomised, placebo-controlled clinical trial of a third scheduled dose of Rotarix rotavirus vaccine in Australian Indigenous in... by Jonathan Carapetis, Tom Snelling, Mark A Jones, Julie A Marsh, Bianca Fleur Middleton, Claire S Waddington, Margaret Danchin, Carly McCallum, Sarah Gallagher, Ross Andrews, Carl Kirkwood, Nigel Cunliffe

“…Despite this, Northern Territory Indigenous children continue to be hospitalised with rotavirus at a rate more than 20 times higher than non-Indigenous children in other Australian jurisdictions, with evidence of waning protection in the second year of life. …”
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T‐Wave Alternans Measured by 24‐Hour Ambulatory Recordings Rather Than Exercise Stress Tests as a Risk Stratification Marker in Patients With Long QT Syndrome by Jing Yang, Jiangying Luo, Kun Li, Dan Li, Tingting Lv, Fulan Liu, Yuanwei Liu, Fei She, Rong He, Ping Zhang

“…Background Few small‐sample studies have quantified the T‐wave alternans (TWA) value by 24‐hour ambulatory recordings or exercise stress tests in patients with long QT syndrome (LQTS). …”
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Activated CD27+PD-1+ CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II by Tessa Dieckman, Mette Schreurs, Ciska Lindelauf, Ahmed Mahfouz, Caroline R. Meijer, Louise Pigeaud, Vincent van Unen, Gerd Bouma, Frits Koning

“…Here, we characterized CD8 and CD4 T cells in RCDII duodenum at the single-cell level and in situ. Methods: We applied mass cytometry on CD45+ duodenal cells derived from intestinal biopsies (n = 23) and blood samples (n = 20) from RCDII patients and controls. …”
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Study of Concentration of Angiotensin-Converting Enzyme 2 Receptor Proteins in Different Age-groups and Genders with Reference to Susceptibility toward Severe Acute Respiratory Syn... by Shareef M Buvvaji, Vinod Joshi, Bennet Angel, Annette Angel, Poorna Khaneja, Monika Dheer, Bhawna Sharma, Neha Singh, Shilpa Barthwal, Ramesh Joshi, Ambreen S Khan, Nuzhat M Peer, Khushbu Kumari, Reshu Chauhan, Aarya Chitransh

“…The present study aimed to find whether age-specific disease severity was due to different concentrations of ACE2 in the patients. Materials and methods: Nasopharyngeal swab samples of different age-groups and gender from infected COVID-19 patients and healthy individuals were subjected to Enzyme-Linked Immunosorbent Assay (ELISA) for quantitative estimation of ACE2 in the upper respiratory tract. …”
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Public perception of COVID-19 in Saudi Arabia during the Omicron wave: recommendations for policy improvement by Mohammed J. Almalki, Amani A. Alotaibi, Abdulrahman M. Jabour, Ali Elamin, Wafa A Hetany, Hamza Abdullah M. Adam, Hassan N Moafa, Ahmed S. Alamer, Anwar Alsharif, Sami M. Almalki

“…This study investigates Saudi citizens’ perceptions of COVID-19 during the Omicron wave.MethodsWe conducted a cross-sectional study using an online survey and a convenience sample of 746 participants. …”
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Mass treatment with azithromycin for trachoma: when is one round enough? Results from the PRET Trial in the Gambia. by Emma M Harding-Esch, Ansumana Sillah, Tansy Edwards, Sarah E Burr, John D Hart, Hassan Joof, Mass Laye, Pateh Makalo, Ahmed Manjang, Sandra Molina, Isatou Sarr-Sissoho, Thomas C Quinn, Tom Lietman, Martin J Holland, David Mabey, Sheila K West, Robin Bailey, Partnership for Rapid Elimination of Trachoma (PRET) study group

“…The best way to treat these districts, and the optimum role of testing for infection in deciding whether to initiate or discontinue MDA, are unknown.<h4>Methods</h4>In a community randomized trial with a factorial design, we randomly assigned 48 communities in four Gambian districts, in which the prevalence of trachoma was known or suspected to be above 10%, to receive annual mass treatment with expected coverage of 80-89% ("Standard"), or to receive an additional visit in an attempt to achieve coverage of 90% or more ("Enhanced"). …”
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SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementi... by Yu Liu, Olaf Gefeller, Jian Su, Ming Zhong, Elmar Graessel, André Kratzer, Petra Scheerbaum, Julia-Sophia Scheuermann, Yaping Ding, Jianwen Lu

“…Due to the limited effectiveness of pharmacological interventions, more research on non-pharmacological interventions is needed. …”
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Association of Chronic Pain with Motor Symptom Severity in Parkinson’s Disease: An Exploratory Cross-Sectional Analysis by Niels Pacheco-Barrios, Vivian D. B. Gagliardi, Roberta R. Grudtner, Iloba Gabriel Njokanma, Ben Illigens, John D. Rolston, Felipe Fregni, Kevin Pacheco-Barrios

“…Conclusions: Chronic pain is strongly associated with MSS in PD patients, with a more pronounced effect as MSS progresses from medium to severe, supporting a dose–response relationship. …”
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Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment: Protocol for a Multicenter Cohort Study (Swiss Childhood Cancer Survivor Study FollowUp–Pulmo) by Maša Žarković, Christina Schindera, Grit Sommer, Christine Schneider, Jakob Usemann, Maria Otth, Sonja Lüer, Marc Ansari, Philipp Latzin, Claudia E Kuehni

“…The results will assist in the development of more targeted screening and risk-stratified follow-up care. …”
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Práticas e nível de conhecimento sobre doença cerebrovascular em um hospital universitário: Parte 1. Educação do corpo de enfermagem: prioridade para o tratamento do infarto cerebr... by Charles André, Mônica F. Costa, Ronir Raggio, Letícia L. Vermelho, Sérgio A. P. Novis

“…Smoking and poor monitoring of blood pressure levels were also more common in strata with the lowest levels of education and among NHCW. …”
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Impact of job crafting and work engagement on the mental and physical health of palliative care nurses by Ateya Megahed Ibrahim, Donia Elsaid Fathi Zaghamir, Mohamed Gamal Elsehrawy, Hassanat Ramadan Abdel-Aziz, Samia Eaid Elgazzar, Fathia Gamal Elsaid Hassabelnaby, Heba Ahmed Osman Mohamed, Nahed Abd Elazeem Abd Elsalam

“…As a result, higher work engagement not only enhances nurse well-being but also contributes to better patient care, as engaged nurses are more capable of providing compassionate, effective care. …”
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Delay in timing of first antenatal care utilisation among women of reproductive age in sub-Saharan Africa: a multilevel mixed effect analysis by Million Phiri, Jason Mwanza, Angel Mwiche, Musonda Lemba, Jacob R. S. Malungo

“…Thus, allowing for targeted interventions to improve maternal health outcomes. Methods Data from the most recent Demographic and Health Surveys conducted between January 2010 and December 2021 were used in this study. …”
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Prognostic Value of Genetic Markers for Efficacy Estimation of Induction Treatment Including Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma Patients by EL Nazarova, NV Minaeva, MN Khorobrykh, EE Sukhorukova, VI Shardakov, IV Paramonov, NA Zorina

“…To determine the value of polymorphisms of the immune response genes for the treatment efficacy in MM patients receiving high-dose chemotherapy and autologous hematopoietic stem cell transplantation (autoHSCT). Methods. The overall of 20 ММ patients (8 men and 12 women) were included in the study. …”
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Distribution of 10-year cardiovascular disease risk levels in Mongolia: results from nation-wide health screening program by Bayarbold Dangaa, Batzorig Bayartsogt, Ariuntuya Tuvdendorj, Enkhbold Sereejav, Khurelbaatar Nyamdavaa, Damdindorj Boldbaatar, Enkhtur Yadamsuren, Otgonbat Altangerel, Oyuntugs Byambasukh, Narantuya Davaakhuu, Tumur-Ochir Tsedev-Ochir, Mijidsuren Ganbat, Munkhtulga Gantulga, Davaalkham Dambadarjaa, Oyunsuren Enebish

“…Based on data collected from nationwide health screening program, we estimated the distribution of 10-year cardiovascular disease (CVD) risks in the general population by using the risk prediction model recently published by the World Health Organization (WHO).MethodsA representative sample of 35,769 adults aged between 40 and 80 years old participated in nationwide health screening program, which covered all 21 Mongolian provinces and 9 districts in the capital city Ulaanbaatar. …”
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Predicting the Risk of Preterm Birth Throughout Pregnancy Based on a Novel Transcriptomic Signature by Yang Pan, Yuxin Ran, Dongni Huang, Nanlin Yin, Yanqing Wen, Yan Jiang, Yamin Liu, Hongbo Qi

“…It aimed to identify the transcriptomic signature essential for the occurrence of PTB and evaluate its predictive value in early, mid, and late pregnancy and in women with threatened preterm labor (TPTL). Methods. Blood transcriptome data of pregnant women were obtained from the Gene Expression Omnibus database. …”
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Molecular signatures of preeclampsia subtypes determined through integrated weighted gene co-expression network analysis and differential gene expression analysis of placental tran... by Luhao Han, Fabricio da Silva Costa, Fabricio da Silva Costa, Anthony Perkins, Anthony Perkins, Olivia Holland, Olivia Holland

“…Severe and early-onset PE exhibit large molecular perturbations, while late-onset PE presents more subtle alterations. Aberrant placental lipid storage may contribute to disease severity and early manifestation.…”
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