Evaluating the Efficacy of Gelatin-Chitosan-Tetraethyl Orthosilicate Calcium Hydroxide Composite as a Dental Pulp Medicament on  COX-2, PGP 9.5, TNF-α Expression and Neutrophil num... by Yulita Kristanti, Mh Busra Fauzi, Bidhari Pidhatika, Iwa Sutardjo Rus Sudarso, Retno Ardhani, Al-qatta Ghadah Abdulrahman, Endytiastuti Endytiastuti, Heni Susilowati, Juni Handajani

“…Alternative materials have been developed to provide more biocompatible materials with better dentin formation ability. …”
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Usability testing of EatsUp®: mobile application for monitoring balanced dietary practices and active lifestyle among adolescents—a study in Jakarta, Indonesia by Erfi Prafiantini, Erfi Prafiantini, Erfi Prafiantini, Rina Agustina, Rina Agustina, Betty Purwandari, Dian Novita Chandra, Dian Novita Chandra, Dini Rahma Bintari, Fellatinnisa Zafira Rajwadini, Jihan Farhanah, Aryono Hendarto

“…Future studies should include a more diverse population and explore features like gamification to enhance long-term engagement.…”
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Tissue specific role of ABCA1 in lung cholesterol homeostasis under high-cholesterol diet by Jian Ma, Jian Ma, Zhongwen Gong, Hong Lu, Han Yang, Shengquan Wang, Qian Zhu, Hongya Liu, Yongjia Li, Yuemei Zhang, Xuemei Lian, Xuemei Lian

“…In CYP27A1(−/−) mice, hepatic lipid accumulation was more severe with further suppression of ABCA1, whereas ABCA1 expression in the lung remained elevated. …”
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Meditation for subjective cognitive decline, mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials by Jiaxin Shi, Hao Tian, Jingwen Wei, Wenhan Xu, Qin Luo, Jin Peng, Jun Xia, Wenying Huai, Ying Xiong, Yunhui Chen

“…More large-scale and high-quality RCTs are needed to further substantiate these effects.…”
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Changes in Alcohol Consumption During and After the Covid-19 Pandemic From 2020 to 2023 in a Prospective Cohort of Italian Adults by Sonia Cerrai, Giulia Carreras, Filippo Monti, Chiara Stival, Alessandra Lugo, Cristina Bosetti, Silvia Biagioni, Tiziana Fanucchi, Giuseppe Gorini, Andrea Amerio, Luisa Mastrobattista, Claudia Mortali, Anna Odone, Sabrina Molinaro, Luc Smits, Silvano Gallus, the “Lost in Italy” and “Lost in Toscana” Study Investigators

“…Background: The lockdowns imposed by the government during coronavirus disease 2019 (COVID-19) pandemic have had a significant impact on the Italian population habits. Methods: LOckdown and lifeSTyles in Italy and in Tuscany studies collected data on a representative sample of the Italian adult population in 2020 (n = 6,003) followed up through 2023 via four additional surveys (3,000 ≤ n ≤ 6,600) through an online self-administered questionnaire. …”
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First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers by Aurélien Marabelle, Aung Naing, Funda Meric-Bernstam, Xingfeng Bao, Andrea Varga, David S Hong, Aparna Parikh, Geoffrey I Shapiro, Özlem Ataman, Larisa Reyderman, Terri A Binder, Min Ren, Mingjie Liu, Satish Dayal, Amy Y Siu, Pallavi Sachdev, Lucy Xu, Vijay Bhagawati-Prasad, Ilian Tchakov, Chean Eng Ooi

“…This first-in-human phase 1 study assessed the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose (MTD) and recommended phase 2 dose of E7046.Methods This first-in-human study enrolled 30 patients with advanced tumors of cancer types associated with high levels of myeloid infiltrates. …”
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Mass development of a filamentous and likely nitrophilous aerophytic green alga on tree bark: Apatococcus ammoniophilus sp. nov. (Chlorophyta, Trebouxiophyceae) by Ulrik Søchting, Thomas Friedl, Øjvind Moestrup, Felix Grewe, Yukun Sun, Yağmur Tarhana Çakır, Markus Ganzera, Karin Glaser, Svenja Heesch, Fabian Hammerle, Daniel Nimptsch, Birgit Olberg, Ulf Karsten, Ulf Karsten

“…However, its species identity and taxonomy remained unknown.Material and methodsSelected algal samples from various substrates were analyzed for their ribosomal DNA sequences, metagenomic, and biochemical compounds [polyols and mycosporine-like amino acids (MAAs)].ResultsPhylogenetic analyses revealed the alga’s position within the Trebouxiophyceae (Chlorophyta), forming an independent lineage within Apatococcus. …”
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Boosting Coercivity of 3D Printed Hard Magnets through Nano‐Modification of the Powder Feedstock by Philipp Gabriel, Varatharaja Nallathambi, Jianing Liu, Franziska Staab, Timileyin David Oyedeji, Yangyiwei Yang, Nick Hantke, Esmaeil Adabifiroozjaei, Oscar Recalde‐Benitez, Leopoldo Molina‐Luna, Ziyuan Rao, Baptiste Gault, Jan T. Sehrt, Franziska Scheibel, Konstantin Skokov, Bai‐Xiang Xu, Karsten Durst, Oliver Gutfleisch, Stephan Barcikowski, Anna Rosa Ziefuss

“…Microstructural analyses reveal finer grain sizes and more equiaxed nanocrystalline structures due to the modification. …”
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Impact of heteroresistance on treatment outcomes of people with drug-resistant TB by R. Crowder, M. Kato-Maeda, B. Schwem, A. dela Tonga, D.M. Geocaniga-Gaviola, E. Lopez, C.L. Valdez, A.R. Lim, N. Hunat, A.G. Sedusta, C.A. Sacopon, G.A.M. Atienza, E. Bulag, D. Lim, J. Bascuña, K. Shah, R.P. Basillio, C.A. Berger, M.C.D.P. Lopez, S. Sen, C. Allender, M. Folkerts, U. Karaoz, E. Brodie, S. Mitarai, A.M.C. Garfin, M.C. Ama, D.M. Engelthaler, A. Cattamanchi, R. Destura

“…METHODS: We used targeted deep sequencing to identify mutations associated with DR-TB and heteroresistance in culture samples of 624 people with DR-TB. …”
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A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Methods Tumor, liver, and blood samples were obtained from patients undergoing resection for non-metastatic PDAC. …”
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A Comparative Study of the Perspectives of Long‐Stay Immigrants, Nurses and Cultural Mediators on Intercultural Communication: A Secondary Qualitative Analysis by Francesc Ramos‐Roure, Maria Feijoo‐Cid, Josep Maria Manresa‐Dominguez, Jordi Segura‐Bernal, Rosa García‐Sierra, Maria Isabel Fernández‐Cano, Antonia Arreciado Marañón, Eduard Moreno‐Gabriel, Clara Flamarich Gol, Pere Toran‐Monserrat

“…The sample was extended to include a focus group of cultural mediators. …”
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Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Also notable is the presence of proliferative lymphocytes, the occurrence of which positively correlates with more aggressive tumor behavior in the bulk RNA-seq cohort. …”
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PIDLF+: A Novel Adaptive PIDLF for Forestry Height Mapping Based on Single-Baseline PolInSAR Data by Dandan Li, Hailiang Lu, Mercedes E. Paoletti, Juan M. Haut, Juntao Gu, Chao Li, Weipeng Jing

“…Meanwhile, the lack of training samples imposes additional constraints on the efficacy of supervised DL-based methods. …”
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Evaluation of perioperative care and drivers of cost in geriatric thoracolumbar trauma by Omar H. Tarawneh, Rajkishen Narayanan, Michael McCurdy, Tariq Z. Issa, Yunsoo Lee, Olivia Opara, Nicholas B. Pohl, Alexa Tomlak, Matthew Sherman, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Gregory D. Schroeder, Christopher K. Kepler

“…Secondarily, we examined the variability of cost across age groups by identifying drivers of cost of care. Materials and methods: We queried the United States Nationwide Inpatient Sample(NIS) for adult patients undergoing spinal fusion for thoracolumbar fractures between 2012 and 2017. …”
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Gestational diabetes-combined excess weight gain exacerbates gut microbiota dysbiosis in newborns, associated with reduced abundance of Clostridium, Coriobacteriaceae, and Collinse... by Yunshan Xiao, Yunshan Xiao, Yunshan Xiao, Yuan Shi, Yuan Shi, Yuan Shi, Yan Ni, Meilan Ni, Yuxin Yang, Xueqin Zhang, Xueqin Zhang, Xueqin Zhang

“…Further,LEfSe analysis identified 30 differential bacteria taxa between GDM-Total and healthy control groups, which increased to 38 between GDM+EGWG and non-GDM groups, highlighting more pronounced microbial shifts associated with EGWG. …”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…While confirming the efficacy of the holistic approach, the results reveal the need for more efficient coordination between professionals and early involvement of rehabilitation specialists. …”
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Factors associated with head circumference and indices of cognitive development in early childhood by Matthew R Grigsby, William Checkley, Tahmeed Ahmed, Zulfiqar Ahmed Bhutta, Laura Nicolaou, Pascal Bessong, Margaret Kosek, Aldo A M Lima, Sanjaya Shrestha, Ram Chandyo, Estomih R Mduma, Laura Murray-Kolb, Brooks Morgan

“…Participating children were enrolled and followed up between 2009 and 2014. A final sample of 1210 children aged 0–24 months were included in the analyses. …”
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New possibilities of using perampanel in children. Efficacy and tolerability of perampanel in the treatment of epilepsy (literature review and experience of Svt. Luka’s Association... by K. Yu. Mukhin, O. A. Pylaeva, M. Yu. Bobylova, L. Yu. Glukhova

“…Luka’s Institute of Pediatric and Adult Neurology and Epilepsy) with a focus on the order of perampanel administration (in groups of early and late additional therapy with perampanel).Materials and methods. This study included 270 patients aged 4 to 43 years (125 males and 145 females; 255 children and adolescents aged 4–18 years; 15 adult patients; mean age at the time of perampanel therapy initiation was 11.8 years) who received perampanel and for whom we managed to collect clinical data for at least 6 months.The study sample included 114 patients with structural and presumably structural focal epilepsy, 120 patients with genetic and presumably genetic epilepsy (including Dravet and Angelman syndromes, Lafora disease, mutations in genes PCDH19, PHACTR1, CDKL5, ARX, PING, SCN2A, KIAA2022, chromosomal microdeletions, etc.), and 36 patients with focal epilepsy of unknown etiology. …”
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Downregulation of the p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation by Ester Ciociola, Tanmoy Dutta, Kavitha Sasidharan, Lohitesh Kovooru, Francesca R. Noto, Grazia Pennisi, Salvatore Petta, Angela Mirarchi, Samantha Maurotti, Bernardette Scopacasa, Luca Tirinato, Patrizio Candeloro, Marcus Henricsson, Daniel Lindén, Oveis Jamialahmadi, Arturo Pujia, Rosellina M. Mancina, Stefano Romeo

“…However, there are contrasting results regarding the mechanisms that promote this protection. Methods We downregulated MARC1 in primary human hepatocytes (PHHs) using short interfering RNA (siRNA). …”
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Assessing germline TP53 mutations in cancer patients: insights into Li-Fraumeni syndrome and genetic testing guidelines by Anastasiia Danishevich, Daria Fedorova, Natalia Bodunova, Maria Makarova, Maria Byakhova, Anna Semenova, Vsevolod Galkin, Maria Litvinova, Sergey Nikolaev, Irina Efimova, Pavel Osinin, Tatyana Lisitsa, Anastasiya Khakhina, German Shipulin, Tatiana Nasedkina, Syuykum Shumilova, Oleg Gusev, Airat Bilyalov, Elena Shagimardanova, Leyla Shigapova, Marina Nemtsova, Olesya Sagaydak, Mary Woroncow, Saida Gadzhieva, Igor Khatkov

“…This study investigated the frequency and spectrum of TP53 pathogenic variants associated with Li-Fraumeni syndrome in a large cohort of mainly breast cancer patients from Russia. Methods The study analyzed 3,455 genomic DNA samples from cancer patients using next-generation sequencing panels and whole-genome sequencing. …”
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