METTL14 mediates the m6A methylation of miR-29a-3p, thereby activating the MAP2K6 signaling pathway and exacerbating the inflammatory response associated with spinal tuberculosis by Lijun Feng, Mengqi Zhu, Xu Zhang, Ningkui Niu, Zhiyun Shi

“…Objective This study aimed to validate the expression levels of METTL14 and miR-29a-3p in spinal tuberculosis and explore the regulatory role of METTL14 in mediating miR-29a-3p via the MAP2K6 signaling pathway during spinal tuberculosis-associated inflammation. Methods Twenty cases of peripheral blood samples from patients with spinal tuberculosis and normal individuals were collected respectively. …”
Get full text

Classifying the Information Needs of Survivors of Domestic Violence in Online Health Communities Using Large Language Models: Prediction Model Development and Evaluation Study by Shaowei Guan, Vivian Hui, Gregor Stiglic, Rose Eva Constantino, Young Ji Lee, Arkers Kwan Ching Wong

“…When suboptimal results were observed, we generated additional samples of the misclassified ones to give them more attention. …”
Get full text

Assessment of the effectiveness and safety of fixed-dose combination of alogliptin and pioglitazone in real clinical practice: results of the PROsperity study by M. V. Shestakova, M. I. Kharakhulakh, Y. A. Belolipetsky

“…The maximum reduction in HbA1C (-2,8%) was seen in patients with baseline HbA1C >9,0% (n=300, which is 15% of the total sample). Overall, 70,2 % of patients achieved goal HbA1C (<7,0%), including 80,1 % of those treated with Incresync 25 mg+30 mg (n=915, which is 46% of the total sample). …”
Get full text

Effect of Nickel Content and Cooling Rate on the Microstructure of as Cast 316 Stainless Steels by Lei Chen, Yang Wang, Yafeng Li, Zhengrui Zhang, Zhixuan Xue, Xinyu Ban, Chaohui Hu, Haixiao Li, Jun Tian, Wangzhong Mu, Kun Yang, Chao Chen

“…The austenite-forming element nickel of three different industrial samples is 10%, 12%, and 14%, respectively. The effect of the cooling rate on the ferrite content and precipitation phases of the high Ni content of the 316 stainless steel casting (H-316) is studied by remelting experiments and different methods of quenching of liquid steel. …”
Get full text

Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker by Jason-Alexander Hörauf, Amit Singh, Maika Voth, Hamed Moheimani, Cora Rebecca Schindler, Borna Relja, Liudmila Leppik, Ingo Marzi, Dirk Henrich

“…Future research with a large sample size should investigate whether other miRNAs can more accurately predict liver injury and the extent of hepatocellular injury, particularly in the acute post-traumatic phase.…”
Get full text

The role of CPAP as a potential bridge to invasive ventilation and as a ceiling-of-care for patients hospitalized with Covid-19-An observational study. by Jonathan Walker, Shaman Dolly, Liji Ng, Melissa Prior-Ong, Kalpana Sabapathy

“…Patients receiving a ceiling of care more than 24 hours after admission (N = 6) were excluded from the analysis. …”
Get full text

Genetic surveillance shows spread of ACT resistance during period of malaria decline in Vietnam (2018-2020) by Johanna Helena Kattenberg, Mathijs Mutsaers, Van Hong Nguyen, Thi Hong Ngoc Nguyen, Arlette Umugwaneza, Maria Lara-Escandell, Xuan Xa Nguyen, Thi Huong Binh Nguyen, Anna Rosanas-Urgell

“…IntroductionVietnam’s goal to eliminate malaria by 2030 is challenged by the further spread of drug-resistant Plasmodium falciparum malaria to key antimalarials, particularly dihydroartemisinin-piperaquine (DHA-PPQ).MethodsThe custom targeted NGS amplicon sequencing assay, AmpliSeq Pf Vietnam v2, targeting drug resistance, population genetic- and other markers, was applied to detect genetic diversity and resistance profiles in samples from 8 provinces in Vietnam (n = 354), in a period of steep decline of incidence (2018–2020). …”
Get full text

Impact of prenatal triclosan exposure on ADHD-like symptoms in school-aged children by Jingjing LI, Xiaomeng CHENG, Yan ZHANG, Luanluan LI, Xiaodan YU, Ying TIAN, Yu GAO

“…TCS concentrations in early pregnancy urine samples were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). …”
Get full text

Plasma metabolomics of immune-related adverse events for patients with lung cancer treated with PD-1/PD-L1 inhibitors by Juan Chen, Jun-yan Liu, Fan Yang, Ting Zou, Zhan Wang, Jia-Si Liu, Lei She, Xiang-Ping Li, Zhaoqian Liu

“…This study aims to explore the potential metabolic biomarkers to predict risk of irAEs and to investigate the association of plasma metabolites level with survival in patients with lung cancer receiving PD-1/PD-L1 inhibitor treatment.Methods The study collected 170 plasmas of 85 patients with lung cancer who received immune checkpoint inhibitors (ICIs) treatment. 58 plasma samples of 29 patients with irAEs were collected before ICIs treatment and at the onset of irAEs. 112 plasma samples of 56 patients who did not develop irAEs were collected before ICIs treatment and plasma matched by treatment cycles to onset of irAEs patients. …”
Get full text

Pornography-Watching Disorder and Its Risk Factors Among Young Adults: Cross-Sectional Survey by Csaba Erdős, Oguz Kelemen, Dávid Pócs, Edit Paulik, András Papp, Edina Horváth, Arbel Golan, Krisztián Széll

“…The use of an anonymous web-based questionnaire likely reduced the influence of stigma, resulting in more accurate self-reporting of sensitive behaviors. …”
Get full text

Mortality, ethnicity, and country of birth on a national scale, 2001-2013: A retrospective cohort (Scottish Health and Ethnicity Linkage Study). by Raj S Bhopal, Laurence Gruer, Genevieve Cezard, Anne Douglas, Markus F C Steiner, Andrew Millard, Duncan Buchanan, S Vittal Katikireddi, Aziz Sheikh

“…Smoking and diabetes data were from a primary care sub-sample (about 53,000 people). Males and females in most minority groups had lower age-adjusted mortality RRs than the White Scottish group. …”
Get full text

Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation by Dun Li, Jing Lin, Hongxi Yang, Lihui Zhou, Yujian Li, Zhe Xu, Li Sun, Xinyu Zhang, Weili Xu, Yaogang Wang

“…However, the causal associations of modifiable factors with CMDs and CMM remains to be systematically investigated. Methods In this study, a three-stage design Mendelian randomization (MR) investigation was conducted, using two-sample MR with potential sample overlap correction and multiple testing, multivariable MR analysis, and multi-response MR, with modifiable factors covering domains of socioeconomic factors, behavioral factors, biochemical factors, and physical measures as exposures, and CMM and CMDs as outcomes. …”
Get full text

Transcriptomic and histological characteristics of innate immune activation in brain parenchyma in a rat model of neonatal intraventricular hemorrhage by Miriam Zamorano, Sanjna Udtha, Aidan M. Collier, Erica Underwood, Razan El Sayed, Ankit Agarwal, Devin S. Hatchell, Chunfeng Tan, Paul J. Nietert, Scott D. Olson, Brandon A. Miller

“…RNAseq and CD68 counts are more sensitive to differences between groups than morphological immune cell analysis. …”
Get full text

Community burden of Respiratory Viruses infections during influenza seasons from 2016/2017 to 2023/2024, Apulia region (Southern Italy) by Dr Alfredo Marziani, Dr Valentina Annachiara Orlando, Dr Francesca Centrone, Dr Anna Sallustio, Dr Daniele Casulli, Dr. Daniela Loconsole, Prof. Maria Chironna

“…According to other studies, RVs were more likely to be detected in the under-5 age group. …”
Get full text

Correlation between mixed exposure to several heavy metals during early pregnancy and fetal low birth weight: Possible mediating effect of mitochondrial DNA copy number by Zhanyue Zheng, Tianao Sun, Minli Yang, Qitao Tan, Minglian Pan, Yingjie Zhou, Yongjie Ma, Yan Sun

“…Urine and blood samples were collected during early pregnancy, along with placental and umbilical cord blood samples at delivery. …”
Get full text

Imminent meningitis outbreak prevented by early warning and response action: Nadowli-Kaleo District, Upper West Region, Ghana-2017 by Gyesi Razak Issahaku, Daniel Amobtiwon Amoatika, Donne Kofi Ameme, Delia Akosua Bandoh, Samuel Oko Sackey, Ernest Kenu

“…Dominant aetiologic agent was Neisseria meningitidis isolated from 17 (58.6%) of 29 culture-positive CSF samples. Compared to controls, meningitis case-patients had higher odds of living in single window rooms (adjusted odds ratio (aOR) =5.05; 95% confidence interval (CI) =1.35-11.66), or in rooms inhabited by more than two people (aOR=3.28, CI=1.57-7.73). …”
Get full text

IMMUNOLOGICAL AND MORPHOLOGICAL PREDICTORS OF CLINICAL HETEROGENEITY OF PATIENTS WITH GRAVES' DISEASE (BASED ON RESEARCH OF THE THYROID GLAND OPERATIONAL MATERIAL) by T. V. Saprina, T. S. Prokhorenko, N. V. Ryazantseva, I. N. Vorozhtsova, S. Yu. Martynova, A. N. Dzyuman, A. P. Zima, O. S. Popov, I. A. Khlusov, K. T. Kasoyan, I. P. Shabalova

“…The goal of the research was to establish immunologic and morphologic predictors of clinical course and functional outcomes of Graves’s disease (GD).Material and methods. We examined 45 patients with GD (14 men and 31 women) aged 18–55 years (47.0 (35.0–53.0)) years, matching the following criteria: a verified diagnosis GD, accommodation in Tomsk oblast and the Tomsk not less than 10 years, the patient's consent for the study. …”
Get full text

Clinicopathological characteristics and diagnostic performance of metagenomic pathogen detection technology in mycobacterial infections among HIV patients by Man Li, Jiamin Chen, Liang Zhang, Xiangmei Chen, Jianfeng Zhou, Feifei Liu, Xingang Zhou, Jiang Xiao, Kun Yang, Liming Qi, Xiaoyi Han, Ting Liu, Hongxin Zhao, Zhen Zhou, Xiaoyou Chen, Lei Sun

“…This study evaluated diagnostic techniques for mycobacterial identification and compared clinicopathological features between HIV-positive and HIV-negative patients.MethodsWe analyzed 88 tissue samples (with 41 matched blood and 28 sputum samples) using histopathology (HE and acid-fast staining), bacterial culture, MTB-PCR (sputum/biopsy), PCR-reverse dot blot hybridization (RDBH), and metagenomic pathogen detection technology (MetaPath™). …”
Get full text

Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in... by Neil Parry, Andrew Beckett, Jo Carroll, Homer Tien, Jeannie Callum, Andrew Petrosoniak, Damon Scales, Luis Teodoro da Luz, Keyvan Karkouti, Paul T Engels, Hans-Peter Hucke, Deep Grewal, Bruce Schwartz, Henry Peng

“…However, there is a knowledge gap on their use compared with the standard of care, the transfusion of plasma.Methods and analysis The factors in the initial resuscitation of severe trauma 2 trial is a multicentre, randomised, parallel-control, single-blinded, phase IV superiority trial. …”
Get full text

A splice donor variant in SLAMF1 is associated with canine atopic dermatitis by Oliver P. Forman, Jamie Freyer, Abigail Kerr, Julia D. Labadie, Michael Denyer, Debbie J. Gow, Janet Alexander, Michelle Daya, Yaindrys Rodriguez Olivera, Cecilia Lozoya, Christian Leutenegger, Christian Savard, Jason T. Huff, Rebecca Chodroff Foran

“…Further analysis of additional genome sequences and RNA samples from the MARS PETCARE BIOBANK confirmed that the SLAMF1 splice variant is a strong potential contributor to an increased risk of atopic dermatitis.DiscussionThe discovery represents the first compelling genetic variant associated with CAD to be validated in more than one breed of dog. …”
Get full text