Circulating mitochondrial DNA signature in cardiometabolic patients by Alessandro Mengozzi, Silvia Armenia, Nicolò De Biase, Lavinia Del Punta, Federica Cappelli, Emiliano Duranti, Virginia Nannipieri, Rossana Remollino, Domenico Tricò, Agostino Virdis, Stefano Taddei, Nicola Riccardo Pugliese, Stefano Masi

“…Circulating mitochondrial DNA (mtDNA) profiles could refine risk stratification, but current methods do not account for different fractions of circulating mtDNA. …”
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Genomic and clinical characterization of HER2 exon 20 mutations in non-small cell lung cancer: insights from a multicenter study in South China by Yating Hou, Xingyang Xue, Zhuoyun Zhang, Dahai Mai, Wei Luo, Mingyu Zhou, Zichuan Liu, Yisheng Huang

“…Abstract Background The objective of this study was to investigate the clinical and genetic characteristics and clinical relevance of HER2 exon 20 oncogenic variants in non-small cell lung cancer (NSCLC) patients. Methods This prospective study analyzed 51 NSCLC patients with HER2 mutations, identified via next-generation sequencing (NGS) of tissue, blood, cerebrospinal fluid, or pleural effusion samples. …”
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Incorporating social determinants of health into agent-based models of HIV transmission: methodological challenges and future directions by Anna L. Hotton, Pedro Nascimento de Lima, Arindam Fadikar, Nicholson T. Collier, Aditya S. Khanna, Darnell N. Motley, Eric Tatara, Sara Rimer, Ellen Almirol, Harold A. Pollack, John A. Schneider, John A. Schneider, John A. Schneider, Robert J. Lempert, Robert J. Lempert, Jonathan Ozik

“…Using examples from our ongoing work, we will discuss Uncertainty Quantification and Robust Decision Making methods to address some of the above-mentioned challenges and suggest directions for future methodological work in this area.…”
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Validity and Reliability of the Dental Neglect Scale in German by Katharina Marilena Weil, Theresa Marie Weßlau, Laura Agnes Ingrid Magerfleisch, Hannah Tröger, Lisa Irmscher, David Bantel, Clara Theres Meyer-Probst, Katja Petrowski, Hendrik Berth

“…Further validation with other samples should be conducted.…”
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Prediction of Cytokine Storm and Mortality in Patients with COVID-19 Admitted to ICU: Do Markers Tell the Story? by Rashid Nadeem, Ashraf Mahmoud Elhoufi, Naheed Elahi Iqbal, Zainab Abdulameer Obaida, Doaa Mohamed Elgohary, Mukesh Kumar Singh, Shymaa Farouk Zoraey, Rami M. Abdalla, Sara Yousif Eltayeb, Crystal Sharon Danthi, Nouha Azaza, Waleed Mohamed Ahmed, Muzammil Hafeez, Maryam AlSada, Fatima Farid Mir

“…Ferritin, CRP, and D-dimers were recorded daily if available for the whole ICU stay, and all other variables were recorded on admission day to ICU. Results: The sample includes 235 records. More than 95% of patients have all markers on the day of admission to ICU were ferritin (median 1,278; IQR 1,424), D-dimer 1.21 (3.4), and CRP 129.5 (121). …”
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Evaluating dental students’ understanding of oral complications and care management for head and neck cancer patients by Faisal Mehsen Alali, Mohammad Zakaria Nassani, Bassel Tarakji, Nasser Raqe Alqhtani, Ali Robaian, Abdullah Saad Alqahtahni, Faisal S. Alhedyan, Abdullah bin nabhan, Adel Alenzi, Khalid Ayidh Alqahtani, Ali Alrafedah, Maram Alagla, Mohammed A. S. Abuelqomsan, Belal Alsalhani, Anas B. Alsalhani

“…The aim of this study is to serve as a foundation to assess the knowledge base of senior dental students and dental interns in Saudi Arabi regarding their preparedness to manage oral health challenges in cancer patients. Methods A cross-sectional study was conducted through an online Google Forms questionnaire targeting a sample of dental students of the fourth and fifth year as well as dental interns (n = 506), from both private and public universities in Saudi Arabia. …”
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Genomic insights into multidrug-resistant Enterobacter hormaechei isolates from seafood at retail carrying the mcr-9 gene and other resistance determinants on IncHI2 plasmids by Valeria Michelacci, Silvia Pieralisi, Elisa Albini, Francesca Romana Massacci, Gabriele Angelico, Paola Chiani, Manuela Marra, Maria Carollo, Chiara Francesca Magistrali, Francesca Leoni

“…ABSTRACT: Objectives: We aimed to characterise the genomic features of two multidrug-resistant (MDR) isolates from retail seafood samples. Methods: Antimicrobial susceptibility was determined by minimum inhibitory concentration (MIC) tests. …”
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Sex disparity in adult asthma—A potential immunomodulatory role of let‐7 family microRNAs by Carina Malmhäll, Jenny Calvén, Julie Weidner, Kristina Johansson, Patricia Ramos‐Ramírez, Emma Boberg, Linda Ekerljung, Roxana Mincheva, Bright Nwaru, Hannu Kankaanranta, Henric Olsson, Christopher McCrae, Madeleine Rådinger

“…Previous findings from animal models have revealed sex‐related differences in inflammatory pathways that may contribute to asthma pathogenesis, but human studies are limited. Methods Airway and blood samples (n = 55 and n = 85 respectively) were collected from adult females and males with asthma and healthy subjects. …”
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Surgery/anesthesia may cause monocytes to promote tumor development by Yang-Yang Wang, Rui-Lou Zhu, En-Qiang Chang, Xiao-Zhuan Liu, Guang-Zhi Wang, Ning-Tao Li, Wei Zhang, Jun Zhou, Ming-Yang Sun, Xin Zou, Jie Hao, Jia-Qiang Zhang

“…Their peripheral blood samples were collected pre operation, 0, 24, and 48 h post operation, and then PBMCs were extracted, followed by single cell sequencing. …”
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Conformity of Tourism Higher Education with Tourism Development Goals: Focusing on Tourism Undergraduate Program in Iran by Faranak Ranjbar Motalegh

“…Methodology This research employs an archival study approach, with qualitative content analysis as the primary method for analyzing textual secondary data. The study is designed in four steps. …”
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Assessment and prediction of diabetic kidney disease in patients with type 2 diabetes mellitus by using an advanced biomarkers by Alyaa Hliel, Huda Ahmed, Hiba Hasan

“…Microalbuminuria has limited diagnostic role in early-stage diabetic kidney disease, because renal damage usually occurs before proteinuria. Therefore, more sensitive and specific biomarkers are needed for early detection of DKD. …”
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In situ rubidium–strontium geochronology of white mica in young metamafic and metasomatic rocks from Syros: testing the limits of laser-ablation triple-quadrupole inductively coupl... by J. Muñoz-Montecinos, A. Giuliani, A. Giuliani, S. Oesch, S. Volante, B. Peters, W. Behr

“…The former is typically expected for unaltered metamafic materials, whereas the latter is interpreted to reflect fluid–rock interaction along shear zones, with fluids derived from or having interacted with more radiogenic lithologies. These atypical values suggest that a commonly assumed value of 0.703 for mafic rocks may not always be representative. …”
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Assessment and prediction of diabetic kidney disease in patients with type 2 diabetes mellitus by using an advanced biomarkers by Alyaa Hliel, Huda Ahmed, Hiba Hasan

“…Microalbuminuria has limited diagnostic role in early-stage diabetic kidney disease, because renal damage usually occurs before proteinuria. Therefore, more sensitive and specific biomarkers are needed for early detection of DKD. …”
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Genetic counseling workforce diversity, inclusion, and capacity in Australia and New Zealand by Anaita Kanga-Parabia, Lucas Mitchell, Renee Smyth, Trisha Kapoor, Jaitika Duggal, Amy Pearn, Rachel Williams, Eliza Courtney, Emma Edwards, Michelle Bowman, Mithila Belekar, Clara Gaff, Amy Nisselle, Amy Nisselle, Amy Pearn, Anaita Kanga-Parabia, Ben Lundie, Claire Wong, N.S.W. Health, Clara Gaff, Australian Genomics, Helen Mountain, Jaitika Duggal, Jason Pinner, Lauren Hunt, Lyndon Gallacher, Rachel Williams, Sebastian Lunke, Yemima Burman, Alex Blackwell, Ana Rakonjac, Anaita Kanga-Parabia, Eliza Courtney, Emma Edwards, Emma Harrison, Janette Hayward, Lucas Mitchell, Lyndon Gallacher, Michelle Bowman, Michelle Cao, Mithila Belekar, Rachel Williams, Renee Smyth, Saraya Hogan, Trisha Kapoor

“…Quantitative data were analyzed using descriptive statistics, 1-sample proportion z-tests, 2-sample z-tests, and χ2 tests. …”
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Traditional ecological knowledge for great ape conservation in Gabon by Mohamed H. Mohamed-Djawad, Neil M. Longo-Pendy, Serge Ely Dibakou, Costanza Puppo, Jean Nzue-Nguema, Désiré Otsaghe-Ekore, Patrice Makouloutou-Nzassi, Cyr Moussadji-Kinga, Alain P. Kouga, Barthelemy Ngoubangoye, Pape Ibnou Ndiaye, Larson Boundenga

“…Samples (n = 637) were preserved in RNAlater® and later assigned to species by 12S rRNA mitochondrial sequencing. …”
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Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age by Michael H Green, Veronica Lopez-Teros, Joanne Balmer Green, Georg Lietz, Sika M Kumordzie, Anthony Oxley, Ahmed D Fuseini, K Winifred Nyaaba, Emily Becher, Jennie N Davis, K Ryan Wessells, Seth Adu-Afarwuah, Reina Engle-Stone, Marjorie J Haskell

“…Objectives: Objectives were to apply population-based (“super-subject”) modeling to determine retinol kinetics in nonpregnant Ghanaian women of reproductive age and to use RID to predict TBS in the group and its individuals. Methods: Women (n = 89) ingested a dose of [2H6]retinyl acetate and blood samples (3/woman) were collected from 6 h to 91 d, with all participants sampled at 14 d, about half at either 21 or 28 d, and each at one other time. …”
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Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques by Denise Margarita Rivera-Rivera, Gabriela Elizabeth Quintanilla-Villanueva, Donato Luna-Moreno, Araceli Sánchez-Álvarez, José Manuel Rodríguez-Delgado, Erika Iveth Cedillo-González, Garima Kaushik, Juan Francisco Villarreal-Chiu, Melissa Marlene Rodríguez-Delgado

“…This review highlights the potential of biosensors as advanced analytical methods, including a section on prospects that address the challenges that could lead to significant advancements in environmental monitoring, highlighting the necessity of testing the new sensing developments under real conditions (composition/matrix of the samples), which are often overlooked, as well as the study of peptides as a novel recognition element in microplastic sensing.…”
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Evaluation of bronchial hyperresponsiveness in asthmatic paediatric patients using mannitol challenge test – Impacts of body mass index by Sharon S. Y. Leung, Helen S. L. Tsang, Jasmine Chan, Oliver Y. H. Kui, Ping Zeng, Yin Ting Cheung, James-Wesley Cheng, Kate C. C. Chan, Michelle Yu, Patricia Tang, John D. Brannan, Jenny K. W. Lam, Hak-Kim Chan, Albert M. Li

“…Background Increasing epidemiological studies reported that overweight/obese asthma patients had more frequent and severe symptoms and exacerbations, indicating their asthma management may not be sufficient. …”
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Five abdominal computer tomography characteristics facilitate diagnosis of spontaneous perforation of pyometra in women with acute abdomen: a case control study by Yingying He, Chaoran Li, Fang Long, Zhigang Sun, Yangzong Cidan, Jing Li, Penglong Cao, Rui Ma, Weiwei Wang, Xiaoguang Xu, Zhen Xiao

“…Conclusions: The above five CT characteristics and the developed dignostic algorithm could be used as a tool to facilitate the preoperative diagnosis of spontaneous perforation of pyometra, although more tests are needed in large samples of cases.…”
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Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination by Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska

“…Vaccines allow us to save more than 2.5 million lives each year; however, up to 10% of vaccinated individuals may not develop sufficient protective antibody levels. …”
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