Does Area Deprivation Index Predict Worse Initial Preoperative Patient-Reported Outcomes in Patients Who Underwent Microfracture for Osteochondral Lesions of the Talus? by Warren Austin, Kenzo M. Cotton BS, Garcia Findlay BS, Marfred Munoz Umanes MS, Richard Michael Smith MD, Cortes Brown MD, Warren Austin, Lauren Lewis MD MPH, Jarrett D. Cain DPM MSc, Macalus V. Hogan MD, MBA

“…Patients who experience more social deprivation may have an initial presentation that is objectively worse compared to patients with a higher socioeconomic status. …”
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Current research progress of tranexamic acid in the management of patients with traumatic injuries in emergency settings by Gengwei Zhang, Juan Liu, Zhang Wen, Zhang Wen, Jia He, Haifeng Chang

“…This review aims to synthesize current evidence on TXA's efficacy, mechanisms, and clinical applications in the trauma management, identify research gaps, and propose future directions to optimize its use.MethodsA comprehensive literature search was conducted using PubMed, Embase, and Cochrane Library up to April 2025. …”
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Anxiety and burnout in infectious disease nurses: the role of perceived stress and resilience by Yalan Huang, Zonghua Wang, Yongguang Li, Zhihan Zhao, Weiyi Wang, Changxia Cai, Xiushuang Wu, Li Liu, Mengting Chen

“…The perceived stress and emotional exhaustion were more serious when resilience levels were lower. Conclusion Anxiety was identified as a critical risk factor for burnout among nurses in infectious disease units. …”
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The Ways of Using Social Media for Health Promotion Among Adolescents: Qualitative Interview and Focus Group Study by Elizabeth Zimmermann, Samuel Tomczyk

“…Future research should explore broader and more diverse participant profiles to improve generalizability.…”
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Analysis of the Consumption of Medicinal Products Associated with a High Risk of Drug-Induced Liver Injury in Patients with COVID-19 by V. I. Petrov, A. Yu. Ryazanova, N. S. Tokareva

“…The study aimed to analyse the annual consumption of medicinal products associated with a high risk of drug-induced liver injury (DILI) used as part of combination therapy in COVID-19 patients and to review a number of medication administration records in order to develop measures to prevent DILI.MATERIALS AND METHODS. The study used the ATC/DDD methodology to study consumption data for 2020, 2021, and 2022 and analysed a sample of 1250 inpatient medical records and medication administration records of COVID-19 patients treated in a Volgograd region hospital converted into a COVID-19 care centre. …”
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Psychometric Hepatic Encephalopathy Score in the Diagnosis of Minimal Hepatic Encephalopathy in Cirrhosis of Liver: A Cross-sectional Study by Mounika Maragari, Ninad Mulimani, Mallanna S Mulimani, Shravankumar Potkar

“…Aim: To establish normal values for the PHES and assess its diagnostic efficacy for MHE in patients with liver cirrhosis. Materials and Methods: A cross-sectional study was conducted at BLDE (DU) Medical College, Vijayapura, Karnataka, India, from May 2023 to December 2024, with a sample of 166 participants (cases and controls). …”
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Body image dissatisfaction and disordered eating behaviors in Chinese female undergraduate students: the mediating role of emotional regulation strategies by Danli He, Harvinder Kaur Gilcharan Singh, Masoumeh Alavi, Hui Chin Koo, Muhamad Nur Fariduddin, Lei Hum Wee, Ching Sin Siau

“…Covariance-based structural equation modeling (CB-SEM) technique was employed, with the hypothesized parallel mediation model tested using 10,000 bootstrap samples. Results More than half of the participants (60.5%, n = 1063) reported body image dissatisfaction and demonstrated high levels of disordered eating behaviors, including uncontrolled eating (52.5%, n = 922), emotional eating (54.0%, n = 948), and cognitive restraint (57.4%, n = 1008). …”
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CNA landscape of HER2-negative breast cancer during administration of taxane-containing schemes of neoadjuvant chemotherapy by M. K. Ibragimova, E. A. Kravtsova, M. M. Tsyganov, N. V. Litviakov

“…Evaluation of when and how to include taxanes in preoperative chemotherapy is becoming more important in the era when molecular and genetic approaches allow to develop biologically targeted therapeutic medications and select patients who can benefit from certain cytotoxic agents.Aim. …”
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Determinants of early resumption of postpartum sexual intercourse in sub-Saharan Africa: A systematic review and meta-analysis by Habtamu Gebrehana Belay, Enyew Dagnew Yehuala, Simegnew Asmer Getie, Alemu Degu Ayele, Tigist Seid Yimer, Besfat Berihun Erega, Wassie Yazie Ferede, Mulugeta Dile Worke, Gedefaye Nibret Mihretie

“…This suggests that a large proportion of women are more vulnerable to unwanted pregnancies and sexual health problems. …”
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Impact of Obstructive Sleep Apnea in Patients with Acute Heart Failure: A Nationwide Cohort Study by Abdulmajeed Alharbi, Nahush Bansal, Anas Alsughayer, Momin Shah, Waleed Alruwaili, Mohammed Mhanna, Halah Alfatlawi, Eun Seo Kwak, Ayman Salih, Mohanad Qwaider, Ragheb Assaly

“…This study analyzes the impact of OSA on the outcomes in patients admitted with acute decompensated heart failure. Methods: We conducted a retrospective cohort study using the National Inpatient Sample database (NIS) 2020, focusing on patients admitted with acute heart failure. …”
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Bidirectional association between cardiovascular disease and hip fracture: a systematic review and meta-analysis by Jinyi Wu, Yan Zhang, Junwen Wang, Qingsong Zhang, Jun Jiang, Qingwu Jiang, Yibiao Zhou

“…Abstract Background The aim of this study was to comprehensively analyze the bidirectional association between cardiovascular disease (CVD) and hip fracture (HF). Methods We searched PubMed, EMBASE, Web of Sciences, Cochrane Library, ScienceDirect and China National Knowledge Infrastructure for relevant studies. …”
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From parental education to under-5 mortality: how antenatal care and hand hygiene mediate the pathway mechanisms by Tapas Mazumder, Itismita Mohanty, Danish Ahmad, Theo Niyonsenga

“…Therefore, building on the existing evidence, this research investigated the effect of one of the key predictors, parental education, on under-5 mortality (U5M) mediated through antenatal care (ANC) and the availability of hand washing stations. Methods This study conducted weighted mediation analyses using the Bangladesh Demographic and Health Survey data from 2011, 2014 and 2017–18, with sample sizes 4,658, 4,367, and 4,826, respectively, and estimated a generalised structural equation model. …”
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Optimising a multi-strategy implementation intervention to improve the delivery of a school physical activity policy at scale: findings from a randomised noninferiority trial by Cassandra Lane, Luke Wolfenden, Alix Hall, Rachel Sutherland, Patti-Jean Naylor, Chris Oldmeadow, Lucy Leigh, Adam Shoesmith, Adrian Bauman, Nicole McCarthy, Nicole Nathan

“…It is a cost-efficient alternative also likely to be a more suitable approach to supporting large scale implementation of school physical activity policies. …”
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Molecular Crosstalk Between SIRT1, Wnt/β-Catenin Signaling, and Inflammatory Pathways in Renal Transplant Rejection: Role of miRNAs, lncRNAs, IL-1, IL-6, and Tubulointerstitial Inf... by Nurhak Aksungur, Murat Kizilkaya, Necip Altundaş, Eda Balkan, Salih Kara, Elif Demirci, Abdullah Uyanik

“…<i>Background/Objectives</i>: This study aimed to evaluate the relationship between sirtuin family members (SIRT1, SIRT3, and SIRT6) and Wnt/β-catenin pathways with inflammation during the rejection process following kidney transplantation, as well as to explore their potential roles as candidate biomarkers. <i>Materials and Methods</i>: Blood samples were collected from 35 kidney transplant rejection patients and 30 healthy controls. …”
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Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial. by Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Dilip Patel, Will Mungall, Timothy J Kendall, Adrian Thomson, Ross J Lennen, Maurits A Jansen, Carmel M Moran, Antonella Pellicoro, Prakash Ramachandran, Isaac Shaw, Rebecca L Aucott, Thomas Severin, Rajnish Saini, Judy Pak, Denise Yates, Neelesh Dongre, Jeremy S Duffield, David J Webb, John P Iredale, Peter C Hayes, Jonathan A Fallowfield

“…The clinical study's main limitations were the relatively small sample size and stable, well-compensated population.…”
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Metabolic syndrome and the risk of cardiovascular and all-cause mortality: data of 14-year prospective cohort study in Siberia by G I Simonova, S V Mustafina, O D Rymar, L V Scherbacova, T I Nikitenko, M Bobak, S K Malyutina

“…To study the risk of cardiovascular and all-cause mortality in patients with metabolic syndrome (MS) according to a 14-year prospective cohort study in Siberia.Material and methods. Based on the data from the Russian arm of the HAPIEE project, we assessed all-cause deaths occurred by 2017 in the population cohort examined at baseline in 2003-2005 (n=9273). …”
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Effects of Pomegranate Seed Oil on Lower Extremity Ischemia-Reperfusion Damage: Insights into Oxidative Stress, Inflammation, and Cell Death by Ümmü Gülşen Bozok, Aydan İremnur Ergörün, Ayşegül Küçük, Zeynep Yığman, Ali Doğan Dursun, Mustafa Arslan

“…<i>Aim</i>: This study sought to clarify the therapeutic benefits and mechanisms of action of pomegranate seed oil (PSO) in instances of ischemia–reperfusion (IR) damage in the lower extremities. <i>Materials and Methods</i>: The sample size was determined, then 32 rats were randomly allocated to four groups: Control (C), ischemia–reperfusion (IR), low-dose PSO (IR + LD, 0.15 mL/kg), and high-dose PSO (IR + HD, 0.30 mL/kg). …”
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Association between ERCC2 Lys751Gln, Asp312Asn, and Arg156Arg polymorphisms and gynecological cancer susceptibility: a meta-analysis by Fen Chen, Jiayang Yu, Chun-Guang Wang

“…Therefore, we performed this meta-analysis to estimate these associations more precisely.ObjectIn this paper, we summarized a larger sample for meta-analysis to explored the relationship between the polymorphisms of the ERCC2 Lys751Gln, Asp312Asn, and Arg156Arg and gynecological tumors.MethodsWe conducted a systematic search for relevant case-control studies in PubMed, the Cochrane Library, Embase, and the Web of Science databases, covering studies up to October 2024. …”
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Sociodemographic disparities in diabetic retinopathy: Analysis of the 2021 behavioral risk factor surveillance system by Dawsyn Smith, S. Mackenzee Hester, Ryan Emmert, Juliana Bryant, Micah Hartwell

“…Design: We conducted a cross-sectional study using data from the Behavioral Risk Factor Surveillance System, a phone-based survey conducted in the United States and surrounding territories by the Centers for Disease Control, and assessed the prevalence of DR by various sociodemographic factors. Methods: A sample of 21,905 individuals was drawn from survey data based on self-reported diabetes status. …”
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A novel cross-validated machine learning based Alertix-Cancer Risk Index for early detection of canine malignancies by Hanan Sharif, Hanan Sharif, Reza Arabi Belaghi, Kiran Kumar Jagarlamudi, Sara Saellström, Liya Wang, Henrik Rönnberg, Staffan Eriksson, Staffan Eriksson

“…., Alertix-Cancer Risk Index (Alertix-CRI) which incorporates canine TK1 protein, CRP levels in conjunction with an age factor.MethodsA total of 287 serum samples were included in this study, consisting of 67 healthy dogs and dogs with different tumors (i.e., T-cell lymphoma n = 24, B-cell lymphoma n = 29, histiocytic sarcoma n = 47, hemangiosarcoma n = 26, osteosarcoma n = 26, mastocytoma n = 40, and mammary tumors n = 28). …”
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