Rationale and design of the preserved versus reduced ejection fraction biomarker registry and precision medicine database for ambulatory patients with heart failure (PREFER-HF) stu... by James L Januzzi, Hanna K Gaggin, Megan Welch, Daniel A Zlotoff, Kevin Wei, Andrew Abboud, Austin Nguonly, Asher Bean, Kemar J Brown, Roy F Chen, David Dudzinski, Neyat Fiseha, Melvin Joice, Davis Kimaiyo, Mackenzie Martin, Christy Taylor

“…A multidimensional characterisation of ambulatory patients with and without HF across LVEF groups is needed to better understand and manage patients with HF in a more precise manner.Methods and analysis To date, the first cohort of 1313 out of total planned 3000 patients with and without HF has been enroled in this single-centre, longitudinal observational cohort study. …”
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MLAR-Net: A Multilevel Attention-Based ResNet Module for the Automated Recognition of Emotions Using Single-Channel EEG Signals by M. Maithri, U. Raghavendra, Anjan Gudigar, Samir Kumar Praharaj, Karthikeyan Sriram, Massimo Salvi, Chai Hong Yeong, Filippo Molinari, U. Rajendra Acharya

“…This performance surpasses existing state-of-the-art methods for single-channel EEG-based emotion recognition. …”
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Correlation between T cell immunity and the duration of EGFR-TKI resistance acquisition in patients harboring EGFR mutations by Atsuto Mouri, Kyoichi Kaira, Ou Yamaguchi, Ayako Shiono, Yu Miura, Kosuke Hashimoto, Satoshi Yamasaki, Fuyumi Nishihara, Hisao Imai, Kunihiko Kobayashi, Hiroshi Kagamu

“…Blood samples were collected prior to and following 4 weeks of EGFR-TKI administration. …”
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Auto Machine Learning and Convolutional Neural Network in Diabetes Mellitus Research—The Role of Histopathological Images in Designing and Exploring Experimental Models by Iulian Tătaru, Simona Moldovanu, Oana-Maria Dragostin, Carmen Lidia Chiţescu, Alexandra-Simona Zamfir, Ionut Dragostin, Liliana Strat, Carmen Lăcrămioara Zamfir

“…Images were acquired from vaginal, uterine, and ovarian samples from both MD and AD_DC specimens. The experiment received the approval of the Medical Ethics Committee of the “Gr. …”
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Occurrence of Alleles of the <i>HLA-A/B/C/DPB1/DQB1/DRB1</i> Genes in Autoimmune Hepatitis (Results of a Single-Center Study) by M. D. Chanyshev, Yu. G. Sandler, N. V. Vlasenko, N. A. Bodunova, A. G. Glushchenko, A. S. Chegodar, A. V. Vykhodtseva, E. V. Vinnitskaya, K. F. Khafizov, V. G. Akimkin

“…Aim: determination of alleles of HLA genes associated with autoimmune hepatitis (AIH) and overlap syndrome (OS) in the Russian population.Materials and methods. The study included 160 adult patients with a verified diagnosis of AIH or OS. …”
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Incidence, outcomes, and mortality risk factors of acute kidney injury in critically ill children: a tertiary care center study in Saudi Arabia by Tareq Alayed, Abdulaziz Alansary, Mohammed Al-Nahdi, Abdullah Alotaibi, Raghad Alhuthil, Moath Al Abdulsalam, Fahad Aljofan, Abdullah Alturki, Tariq Alofisan

“…DESIGN: Retrospective cohort SETTING: A PICU PATIENTS AND METHODS: The study included children (aged 4 weeks to 14 years) who were admitted to the PICU from (2016 to 2019) and developed AKI at King Faisal Specialist Hopsital and Research Centre. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…This study examines how SIRT1 protein levels correlate with clinicopathological characteristics and survival outcomes in patients with breast cancer. Methods: A total of 407 BC formalin-fixed paraffin-embedded (FFPE) samples were collected from King Abdulaziz University Hospital, Saudi Arabia. …”
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Cytokine profiling identifies circulating IL-2, IL23 and sPD-L1 as prognostic biomarkers for treatment outcomes in non-small cell lung cancer patients undergoing anti-PD1 therapy by Kriti Jain, Anika Goel, Deepa Mehra, Deepak Kumar Rathore, Akshay Binayke, Shyam Aggarwal, Surajit Ganguly, Amit Awasthi, Evanka Madan, Nirmal Kumar Ganguly

“…Baseline serum samples were collected prior to ICI initiation and profiled using a multiplex cytokine panel. …”
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Computer adaptive testing to assess impairing behavioral health problems in emergency department patients with somatic complaints by Lauren M. O'Reilly, Azhar I. Dalal BS, Serena Maag MS, Matthew T. Perry BS, Alex Card DO, Max B. Bohrer BS, Jackson Hamersly BS, Setarah Mohammad Nader MD, Kelli Peterson RN, David G. Beiser, Robert D. Gibbons, Brian M. D'Onofrio, Paul I. Musey

“…Individuals who had 2 or more ED visits in the prior year had 62% increased odds of being in the intermediate‐high suicide risk category (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.07–2.44) compared to those with zero prior ED visits. …”
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Characterising developmental dynamics of adult epigenetic clock sitesResearch in context by Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil

“…This knowledge could be used to optimise healthy ageing well before the onset of age-related conditions. Methods: We leveraged results from two longitudinal population-based cohorts (N = 5019 samples from 2348 individuals) to characterise trajectories of adult clock sites from birth to early adulthood. …”
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Serum trihalomethanes and cognitive decline: investigating environmental risk factors for neurodegenerative diseases by Jianping Liu, Sufang Wang, Yuanying Song, Rong Luo, Lijian Han, Lijian Han

“…A final analytic sample of 743 participants aged 60 years or older was analyzed. …”
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Lipids, Apolipoproteins, Lipid‐Lowering Drugs, and the Risk of Cerebral Small Vessel Disease: A Mendelian Randomization Study by Yi Xie, Shuai Liu, Xinyue Wang, Hao Huang, Minghuan Wang, Wensheng Qu, Zhiyuan Yu, Wei Wang, Xiang Luo

“…Specifically, the genetically determined expressions of lipid fractions in various size‐defined lipoprotein particles were more closely related to the risk of SVS than WMH. …”
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Sex‐ and age‐specific effect of known type 2 diabetes mellitus on incident mild cognitive impairment five years later: Results from the population‐based Heinz Nixdorf Recall study... by Anna Lena Platzbecker, Janine Gronewold, Sara Schramm, Susanne Moebus, Andreas Stang, Börge Schmidt, Christian Weimar, Martha Jokisch, the Heinz Nixdorf Recall Study Investigative Group

“…Abstract Introduction As studies on the association between type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI), including amnestic (aMCI) and non‐amnestic (naMCI) subtypes, vary by sex and age, we investigated the sex‐ and age‐specific effects of T2DM on incident MCI after five years in a population‐based sample. Methods A total of 145 participants with T2DM and 1322 without T2DM were included. …”
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Anopheles mosquitoes in Mondulkiri forest, Cambodia: abundance, distribution, seasonal patterns and Plasmodium prevalence by Sebastien Boyer, Bros Doeurk, Antsa Rakotonirina, Sophy Chy, Chantrea Vong, Eakpor Piv, Baura Tat, Malen Ea, Chansophea Chhin, Sreyvouch Phen, Nimol Kloeung, Sopheakvatey Ke, Jean Popovici, Patrice Piola, Benoit Witkowski, Pierre-Olivier Maquart, Amélie Vantaux

“…Anopheles species were more prevalent during the late rainy season (August to November), with year-round activity observed. …”
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Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma by Yang Peng, Jing Yang, Jixing Ao, Yilin Li, Jia Shen, Xiang He, Dihong Tang, Chaonan Chu, Congrong Liu, Liang Weng

“…However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood. Methods: We performed single-cell RNA sequencing on 11 samples of ADC tumor tissues, with other 4 SCC samples served as controls. …”
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Molecular and serological evidence of chikungunya virus among dengue suspected patients in Sri Lanka by Mya Myat Ngwe Tun, Maurine Mumo Mutua, Shingo Inoue, Yuki Takamatsu, Satoshi Kaneko, Takeshi Urano, Rohitha Muthugala, Lakkumar Fernando, Menaka Hapugoda, YINS Gunawardene, Kouichi Morita

“…To address the gap in surveillance, this study aimed to determine the prevalence of CHIKV among patients suspected of dengue fever during the 2017–2019 DENV outbreak in Sri Lanka. Methods: Serum samples were collected from 295 patients at Kandy National Hospital and 300 patients at Negombo Hospitals, presenting with dengue-like symptoms such as fever, rash, and arthralgia. …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…Children and young people with a learning disability experience negative life events and adversity more frequently. The construct of emotional literacy has been shown to be a distinct and moderating factor of how life stress affects mental health and well-being. …”
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Immunological landscape of children with Mycoplasma pneumoniae pneumonia in the post-COVID-19 era reveals distinctive severity indicators by Ran Jia, Haiyan Guo, Aizhen Lu, Caiyan Zhang, Yuanyuan Qi, Dingmei Wang, Wen He, Qing Wang, Zimei Cheng, Yajing Gao, Guoping Lu, Libo Wang, Xiaowen Zhai, Jin Xu, Xiaobo Zhang, Yi Wang, Yufeng Zhou

“…Their blood samples were analyzed using flow cytometry, multi-cytokine assays, and antibody detection methods. …”
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Comparison of Rumen Fluid pH by Continuous Telemetry System and Bench pH Meter in Sheep with Different Ranges of Ruminal pH by Leonardo F. Reis, Antonio H. H. Minervino, Carolina A. S. C. Araújo, Rejane S. Sousa, Francisco L. C. Oliveira, Frederico A. M. L. Rodrigues, Enoch B. S. Meira-Júnior, Raimundo A. Barrêto-Júnior, Clara S. Mori, Enrico L. Ortolani

“…The telemetry system was able to detect smaller changes in rumen fluid pH and was more accurate in diagnosing both subacute ruminal lactic acidosis and acute ruminal lactic acidosis in sheep.…”
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Plasma and Urine Metabolites Associated with Microperimetric Retinal Sensitivity in Age-Related Macular Degeneration by Krupa Sourirajan, Kevin Mendez, Ines Lains, Gregory Tsougranis, Haemin Kang, Georgiy Kozak, Augustine Bannerman, Roshni Bhat, Hanna Choi, Archana Nigalye, Ivana K. Kim, Demetrios G. Vavvas, David M. Wu, Liming Liang, John B. Miller, Joan W. Miller, Jessica Lasky-Su, Deeba Husain

“…This study sought to analyze the associations between plasma and urine metabolites and microperimetry in AMD. Methods: We included data on 363 eyes (95 controls, 268 AMD). …”
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