Hepatoprotective Effect of Silymarin Peptide on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Ananda, Tsend-Ayush Damba, Xiulan Su, Khurelbaatar Nyamdavaa

“…Silymarin Peptide refers to specific peptides derived from silymarin. These peptides have more enhanced bioavailability and activity of effect compared to the whole silymarin compound. …”
Get full text

Feasibility, acceptability, and preliminary efficacy of a blended transdiagnostic group CBT for the treatment of emotional disorders by Noelia Jiménez-Orenga, Amanda Díaz-García, Rosa Lorente-Català, Alberto González-Robles, Macarena Paredes-Mealla, Azucena García-Palacios, Juana Bretón-López

“…This study aimed to analyze the feasibility, acceptability, and preliminary efficacy of a blended transdiagnostic group CBT for ED. Methods: A single-group, open-trial design with three measurement points: pre-treatment, post-treatment and 3-month follow-up. …”
Get full text

Effects of hemodilution on coagulation function during prolonged hypotensive resuscitation in a porcine model of severe hemorrhagic shock by Clifford G Morgan, Leslie E Neidert, Emily N Hathaway, Sylvain Cardin, Jacob J Glaser, Peter J Hemond, Michael M Tiller

“…Background Although hemorrhage remains the leading cause of survivable death in casualties, modern conflicts are becoming more austere limiting available resources to include resuscitation products. …”
Get full text

Molecular Characterization of Extended-Spectrum ß-Lactamases-Producing <i>Escherichia coli</i> Isolated from a Greek Food Testing Laboratory by Aikaterini Dikaiou, Nikolaos Tzimotoudis, Daniel Sergelidis, Emmanouil Papadogiannakis, Panagiota Giakkoupi

“…This study seeks to investigate the molecular characteristics of ESBL-producing <i>E. coli</i> strains isolated from food of animal origin, with a focus on chromosomal typing, plasmid typing, and the description of the associated resistance genes’ genetic environment. <b>Methods:</b> Ninety-seven food of animal origin samples were tested for <i>E. coli</i> isolates resistant to cefotaxime. …”
Get full text

Prevalence and factors associated with intimate partner violence among women in Tanzania: evidence from Tanzanian demographic and health survey 2022 by Pankras Luoga, Siri A. Abihudi, Jovinary Adam, Magreth Thadei Mwakilasa

“…Therefore, this study is timely for addressing this gap in Tanzania. Methods The study used a nationally representative secondary data that employed a cross-sectional design. …”
Get full text

An updated comparison of standard and novel FEV1 indices' association with all-cause mortality. by Stephen T Russell, Mohleen Kang, Jordan A Kempker

“…Two sensitivity analyses were performed, one after applying NHANES sample weighting and one including lower quality spirometry. …”
Get full text

The effectiveness of vedolizumab in advanced therapy-experienced ulcerative colitis patients: Real world data from the Inflammatory Bowel Disease of the Middle East (IBD-ME) Regist... by Nahla Azzam, Othman Alharbi, Mansour Altuwaijri, Yazed Alruthia, Heba Alfarhan, Suliman Alshankiti, Faris Nafisah, Qusay Ajlan, Abdulrahman Aljebreen, Majid Almadi, Mahmoud H. Mosli

“…Future studies with larger sample sizes and more robust study designs should be conducted to further validate the results of this study.…”
Get full text

Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case–control study with MDM2/CDK4 immunos... by Kentaro Nomura, Masato Tomita, Kishio Kuroda, Masakazu Souda, Ko Chiba, Akihiko Yonekura, Makoto Osaki

“…Thus, MDM2 FISH should be used more proactively, not only for lesions with obvious morphological abnormalities, but also for lipomatous tumors that are clinically suggestive of ALT/WDLPS.…”
Get full text

Sphingolipid metabolism-related genes for the diagnosis of metabolic syndrome by integrated bioinformatics analysis and Mendelian randomization identification by Weidong Li, Qixing Zhong, Naisheng Deng, Xinhao Zhou, Haitao Wang, Jun Ouyang, Zhifen Guan, Bohao Cheng, Lijun Xiang, Yueming Huang, Yao Wang

“…Abstract Background The rising global incidence of metabolic syndrome (MetS) highlights the need for more effective diagnostic and therapeutic tools. …”
Get full text

A Preliminary Study on Sinus Fungus Ball with MicroCT and X-Ray Fluorescence Technique. by Zidong Jiang, Kai Zhang, Wanxia Huang, Qingxi Yuan

“…The origin of zinc ion was also studied through elements test for different fungal ball samples using x-ray fluorescence technique.<h4>Methods</h4>Specimens including fungal ball material and sinus mucosa from patients confirmed by pathological findings were extracted after surgery. …”
Get full text

Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway by Cong Li, Ye Shen, Patrick Collins, Lingming Liang, Olivier Nolan-Stevaux, Jason S Eng, Flordeliza Fajardo, Donato Tedesco

“…While signs of clinical activity have been demonstrated, efficacy of T-cell engagers (TCEs) in solid tumors settings, molecular determinants of response, and underlying mechanisms of resistance to BiTE therapy require more investigation.Methods To uncover cancer cell-intrinsic genetic modifiers of TCE-mediated cytotoxicity, we performed genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loss-of-function and CRISPRa (CRISPR activation) gain-of-function screens using TCEs against two distinct tumor-associated antigens (TAAs). …”
Get full text

Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease by Gabriel L Ketron, Felix Grun, Joshua D Grill, Howard H Feldman, Robert A Rissman, Gregory J Brewer

“…Characterization of nicotinamide’s pharmacokinetics and metabolites in the blood and CSF is needed. Methods In these post hoc, blinded analyses of plasma and CSF samples from the completed two-site placebo controlled randomized trial testing of 1500 mg PO BID oral nicotinamide, we used mass spectroscopy to measure nicotinamide and its inactive metabolite 1-methyl-nicotinamide in plasma at baseline, 6, and 12 months and in CSF at baseline and 12 months from 23 participants on drug and 24 on placebo. …”
Get full text

Association between urinary albumin-to-creatinine ratio and all-cause and cardiovascular-cause mortality among MASLD: NHANES 2001–2018 by Zhengjin Wang, Zhangxin Chen, Zhangxin Chen, Hanxu Zhuang

“…This study aimed to investigate the association between UACR and all-cause and cardiovascular disease (CVD)-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).MethodsIn this prospective cohort study, we included sample of 3,412 MASLD enrolled in the National Health and Nutrition Examination Survey 2001–2018. …”
Get full text

Muscle growth and anabolism in intensive care survivors (GAINS 2.0): Protocol for a multi-centre randomised; placebo controlled clinical trial of nandrolone in deconditioned adults... by Matthew Anstey, Ed Litton, Maryam Habibi, Lisa Van der Lee, Robert Palmer, Natalie Tran, Bianca Mammana, Stacey Scheepers, Annamaria Palermo, Xavier Fiorilla, Bhaumik Mevavala, Adrian Regli, Angela Jacques, Bradley Wibrow

“…<h4>Research question</h4>This project aims to test whether a synthetic testosterone (nandrolone) improves muscle strength in ICU survivors compared to placebo.<h4>Methods</h4>GAINS 2.0 is a multicentre, randomised, double blinded placebo-controlled trial which will allocate ICU patients in a 1:1 ratio to nandrolone compared to placebo which commenced recruitment in July 2023. …”
Get full text

What contributes the most to the breast cancer patients’ quality of life during the therapy - clinical factors, functional and affective state or social support? by Novakov Ivana, Popović-Petrović Svetlana, Ilinčić-Zlatar Sonja, Tatić Milanka, Ševo Mirjana

“…Our results indicate that psychological and social resources are more important in predicting QOL compared to clinical and functional factors. …”
Get full text

Anoikis in prostate cancer bone metastasis gene signatures and therapeutic implications by Wei Xia, Miao Ye, Bo Jiang, Gang Xu, Guancheng Xiao, Qingming Zeng, Ruohui Huang

“…Immune landscape analysis suggested high-risk patients might benefit more from chemotherapy than immunotherapy based on their risk score. …”
Get full text

Pre-ART levels of inflammation and coagulation markers are strong predictors of death in a South African cohort with advanced HIV disease. by Lotty Ledwaba, Jorge A Tavel, Paul Khabo, Patrick Maja, Jing Qin, Phumele Sangweni, Xiao Liu, Dean Follmann, Julia A Metcalf, Susan Orsega, Beth Baseler, James D Neaton, H Clifford Lane, Project Phidisa Biomarkers Team

“…In addition, for a random sample of 100 patients, biomarkers were measured at baseline and 6 months following randomization to determine whether ART altered their levels.…”
Get full text

Trimester Specific Effect of Pregnancy on Maternal Cognitive Function using Critical Flicker Fusion Frequency: A Cross-sectional Study by J Roshni, S Anu, M Ramji

“…Conclusion: The CFFF measurements could provide a useful tool for identifying individuals at risk of more severe cognitive decline or sensory processing difficulties during pregancy and take appropriate measures.…”
Get full text

Bone marrow mesenchymal stem cells overexpressing stromal cell- derived factor 1 aid in bone formation in osteoporotic mice by Yanghao Wang, Ya Xiao, XinYu Yang, Fei He, Jun Hu, Guang Yang, Weizhou Wang

“…We aimed to investigate if the increased SDF1 concentration facilitated cell migration to the bone. Methods We used lentivirus to construct BMSCs overexpressing SDF1 or knocking down CXCR4. …”
Get full text

Reducing Repeat Emergency Department Visits for Low-Acuity Patients Using a Healthcare Connection Program by Mitchell Hoyer, Kimberly A. Stanford, Ernestina Perez, Rachel Nordgren, Laura Markin, Melanie Francia, Zain Abid, Marika Kachman, Brenda Battle, Thomas Spiegel

“…Results: In total 5,482 ED patients enrolled in the program were included in the sample, 537 of whom were enrolled more than once. …”
Get full text