Impact of HIF-1α, LOX and ITGA5 Synergistic Interaction in the Tumor Microenvironment on Colorectal Cancer Prognosis by Hayriye Tatlı Doğan, Mehmet Doğan, Seda Kahraman, Doğukan Çanakçı, Mehmet Ali Nahit Şendur, Mustafa Tahtacı, Fazlı Erdoğan

“…We aimed to investigate the relationships between the expression status of the HIF-1α, LOX and ITGA5 proteins and clinicopathologic parameters. <b>Methods</b>: HIF-1α, LOX and ITGA5 antibodies were applied immunohistochemically to tissue microarrays prepared from tumor samples. …”
Get full text

The Dynamics of Acute Renal Impairment Markers During a Surgery for Kidney Cancer by E. M. Frantsiyants, N. D. Ushakova, O. I. Kit, D. A. Rozenko, S. N. Dimitriadi, A. N. Shevchenko, Yu. A. Pogorelova, N. D. Cheryarina, L. S. Kozlova

“…Based on the baseline cystatin С level, the patients in each group were divided into 2 subgroups: subgroup 1 —cystatin C is 1000 ng/ml and lower; subgroup 2 — more than 1000 ng/ml. The statistical processing of the findings was performed using the Statistica 6.0 software based on the t-test for two independent samples. …”
Get full text

Investigation of genetic causes in non-obstructive azoospermic patients by Bulut Dural, Ilhan Gecit, Emre Aykanli, Cemal Ekici, Fatih Oguz, Ahmet Koc

“…Male factor infertility is responsible for approximately more than half of all cases of infertility. About 15% of men and 10% of women with infertility may have genetic abnormalities, including chromosomal abnormalities and single gene mutations. …”
Get full text

Examination of non-conventional dysplasias adjacent to colorectal adenocarcinoma in patients with IBD by Szintia Almási, Zsófia Balajthy, Bence Baráth, Zsófia Krisztina Török, Panna Szaszák, Tamás Lantos, Bence Kővári, Anita Sejben

“…As multiple recent publications reported evidence of a worse prognosis and more common flat morphology compared to conventional dysplasias, their recognition is of great importance, and stricter follow-up with random biopsy samples may be considered.…”
Get full text

Differential associations between education and blood pressure by gender and race by Lucia Pacca, Amanda M Irish, Catherine dP Duarte, Alicia R Riley, Mark J Pletcher, Zinzi D Bailey, Anusha M Vable

“…In this population-based study, we investigate the association between education and blood pressure overall and across race-by-gender subgroups. Methods Our analytic sample included participants aged 50 + to the US Health and Retirement Study data from 2006 to 2008 (N = 24,526). …”
Get full text

Parameters of Body Composition Predict Clinical Course in Acute Colonic Diverticulitis by Alexey Surov, Mattes Hinnerichs, Iram Shahzadi, Nina P. Haag, Jan Robert Kröger, Berthold Gerdes, Saleem Elhabash, Jan Borggrefe

“…Our purpose was to analyse associations between the occurrence of complications and parameters of body composition in patients with ACD in a large sample. Methods This retrospective study included 646 patients with ACD. …”
Get full text

Two-thirds of older people is interested in information meetings on end-of life care to stimulate advance care planning: a national survey by Tessa D. Bergman, Annicka G. M. van der Plas, Bregje D. Onwuteaka-Philipsen, H. Roeline W. Pasman

“…This study aims to explore which older people are interested, whether this is associated with previous ACP behaviour, and their preferences regarding the content and organisation of information meetings. Methods A cross-sectional study was conducted on a randomly drawn sample of 1242 Dutch older people (≥ 65 years; response 93.2%) from a nationwide panel. …”
Get full text

Prevalence, socio-demographic and environmental determinants of asthma in 4621 Ghanaian adults: Evidence from Wave 2 of the World Health Organization's study on global AGEing and a... by Justice Moses K Aheto, Emilia A Udofia, Eugene Kallson, George Mensah, Minicuci Nadia, Naidoo Nirmala, Somnath Chatterji, Paul Kowal, Richard Biritwum, Alfred E Yawson

“…A final sample of 4621 individuals residing in 3970 households was used in analytical modelling. …”
Get full text

Evaluating long-term outcomes after cytoreductive surgery for colorectal peritoneal metastasis: do long survivors really exist? by Giorgio D’Annibale, Matteo Aulicino, Carlo Abatini, Cecilia Orsini, Lorenzo Barberis, Claudio Lodoli, Miriam Attalla El Halabieh, Andrea Di Giorgio, Federica Ferracci, Maria Alessandra Calegari, Fabio Pacelli, Francesco Santullo

“…The median OS for the entire sample was 52 months. Among the 63 patients with at least 4 years of follow-up, 32 were identified as part of the average survival group (AS-G), while 31 were classified in the long-survival group (LS-G). …”
Get full text

Thyroid function profiles in small versus appropriate for gestational age stable neonates with implications for screening cutoffs: a retrospective cross-sectional study by Monisha Rameshbabu, Shiba Subramanian, Giridhar Sethuraman

“…Elevated TSH (>10 mIU/L) requiring recall was more frequent in SGA than AGA neonates (18% vs. 8%, p < 0.01). …”
Get full text

Offset analgesia as a marker of dysfunctional pain modulation in episodic and chronic migraine by Giuseppe Cosentino, Elisa Antoniazzi, Camilla Cavigioli, Elena Guaschino, Natascia Ghiotto, Matteo Castaldo, Massimiliano Todisco, Roberto De Icco, Cristina Tassorelli

“…Conclusions Episodic and chronic migraine patients exhibit disrupted top-down pain modulation pathways, with more significant alterations in chronic migraine without MOH. …”
Get full text

Evaluation of the tubular penetration of two different types of nanoparticle root canal sealers over apically separated files: a scanning electron microscopic study (in vitro study... by Alaa H. Nagdi, Nayera A. Mokhless, Mahmoud R. Aboelseoud

“…Conclusions Under the parameters of this in vitro study, conventional bioceramic sealer and resin-based sealer modified with silver nanoparticles exhibit more tubular penetration depth over apically separated file compared to conventional resin-based sealer and bioceramic sealer modified with bioactive glass nanoparticles.…”
Get full text

Bridging urban-rural disparities in malaria care during pregnancy in Senegal: evidence from household and health facility surveys by Yongsheng Jiang, Di Liang, Jinkou Zhao, Shailendra Prasad, Medoune Ndiop, Serigne Amdy Thiam, Ibrahima Diallo, Doudou Sene, Rose Mpembeni, Jiayan Huang

“…Using sample domain linkage to link the databases at the regional level. …”
Get full text

The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study by Yu Yang, Rong Luo, Shilei Qin, Wenkai Zhu, Minyan Yang, Dandan Zhu, Ping Zhang, Jia Wang, Hongshan Ge

“…To confirm this conclusion, more thorough, prospective randomized controlled studies of sizable sample sizes with good design are required.…”
Get full text

Acculturation and Plasma Fatty Acid Concentrations in Hispanic and Chinese-American Adults: The Multi-Ethnic Study of Atherosclerosis. by Cassandra S Diep, Rozenn N Lemaitre, Tzu-An Chen, Tom Baranowski, Pamela L Lutsey, Ani W Manichaikul, Stephen S Rich, David E St-Jules, Brian T Steffen, Michael Y Tsai, David S Siscovick, Alexis C Frazier-Wood

“…We investigated the cross-sectional relationship between acculturation and plasma phospholipid fatty acids in a diverse sample of Hispanic- and Chinese-American adults.<h4>Methods and findings</h4>Participants included 377 Mexican, 320 non-Mexican Hispanic, and 712 Chinese adults from the Multi-Ethnic Study of Atherosclerosis, who had full plasma phospholipid assays and acculturation information. …”
Get full text

Parental emotional adjustment as a primary target for parenting programs: a cross-sectional study by Haley M. LaMonica, Victoria Loblay, Qaisar Khan, Gabrielle Hindmarsh, Yun J. C. Song, Mahalakshmi Ekambareshwar, Laura Ospina-Pinillos, Ian B. Hickie

“…Our results highlight that better emotional adjustment is associated with more positive parenting practices, suggesting that interventions that support a parent’s ability to cope with the parenting role will increase the use of responsive and nurturing childrearing practices. …”
Get full text

Efficacy and safety of YQFM (YiQiFuMai lyophilized injection) on acute ischemic stroke (FAST): rationale and design for a randomized, double-blind, placebo-controlled trial by Yingzhi Xu, Li Sun, Zhaoyou Meng, Xinxing Lai, Dayong Ma, Yuqiu An, Boxuan Du, Qiaosheng Ren, Ying Gao, Kegang Cao

“…Clinical trial registration ChiCTR2300074125 was registered on 31 July, 2023. For more information, please visit Clinical Trials.gov at https://www.chictr.org.cn/showproj.html?…”
Get full text

Determinants of induced abortion among second-trimester pregnant women attending Dessie City health facilities, Northeast Ethiopia: a case-control study by Elsabeth Addisu, Bitya Admassu, Wolde Melese Ayele, Kassawmar Angaw, Bezawit Adane

“…A total sample of 390 patients were included in the study, with a ratio of 1 : 2 (case : controls). …”
Get full text

Association of the AGT rs699 and ACE rs1799752 Gene Polymorphisms with Obesity and COVID-19 Severity in a Cohort of Syrian Patients by Majd Mhd Nassouh Aljamali, Lama Ali Youssef

“…., hypertension and obesity). Study Subjects and Methods: We interviewed 54 subjects who had been previously diagnosed with COVID-19. …”
Get full text

Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer by Tianyue Sun, Yan Chen, Ying-Xuan Chen

“…Using this score, 23 additional CRC samples were classified into high and low AA score groups. …”
Get full text