Few-Shot Segmentation Using Multi-Similarity and Attention Guidance by Ehtesham Iqbal, Sirojbek Safarov, Seongdeok Bang, Sajid Javed, Yahya Zweiri, Yusra Abdulrahman

“…Few-shot segmentation (FSS) methods aim to segment objects of novel classes with relatively few annotated samples. …”
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INBRX-106: a hexavalent OX40 agonist that drives superior antitumor responses via optimized receptor clustering by William L Redmond, Yoshinobu Koguchi, Melissa J Kasiewicz, Annah S Rolig, Nisha Holay, Bryan Becklund, Anya Polovina, Sae Jeong Ahn, Brendan P Eckelman, Rashi Yadav, Thi Staebler, Noah D Simons, Yaiza Diaz de Durana

“…Clinical pharmacodynamic analysis in blood samples from patients treated with INBRX-106 showed heightened T-cell activation and proliferation, particularly in central and effector memory subsets, validating our preclinical findings.Conclusions Our data establish hexavalent INBRX-106 as a differentiated and more potent OX40 agonist, showcasing its ability to overcome the limitations of conventional bivalent therapies by inducing superior receptor clustering and multimeric engagement. …”
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Investigation of the Protective Effects of Dexmedetomidine, Midazolam, Propofol, and Intralipid on Oxidative Stress and Inflammation in Rats with Lidocaine-Induced Toxicity by Kucun MK, Guler EM, Saracoglu A, Yildirim M, Demirtas C, Serdogan F, Beyaztas H, Aktas S, Kacan M, Gaszynski T, Ratajczyk P, Saracoglu KT

“…Despite an increase in oxidative stress in brain tissue samples across all groups, it was found that all groups exhibited antioxidant protective effects (p < 0.05). …”
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Relationship between personal anxiety and genes associated with eating disorders in women aged 45-64 by V. V. Gafarov, E. A. Gromova, I. V. Gagulin, V. N. Maksimov, A. V. Gafarova

“…To study the possible relationship between personal anxiety and polymorphic variants of genes associated with eating disorders (rs17782313 MC4R, rs1800497 DRD2, rs9939609 FTO) in women aged 45-64 in Novosibirsk.Material and methods. A random representative sample of women aged 45-64 years (n=1074, mean age, 54,27±0,2 years) was examined in 2003-2005 at the Research Institute of Internal and Preventive Medicine, a branch of the Institute of Cytology and Genetics, within the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) project. …”
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High salt intake in the Russian population: prevalence, regional aspects, associations with socio-demographic characteristics, risk factors and diseases. Results of epidemiological... by N. S. Karamnova, S. A. Maksimov, A. V. Kapustina, S. A. Shalnova, O. B. Shvabskaya, А. N. Dotsenko, V. A. Kutsenko, Yu. A. Balanova, S. E. Evstifeeva, A. E. Imaeva, M. B. Kotova, G. A. Muromtseva, А. V. Kontsevaya, O. M. Drapkina

“…To study the characteristics of high salt intake in Russian and Moscow populations according to epidemiological studies.Material and methods. Data from representative samples of adult population aged 25-64 years (n=21922, 8372 men and 13550 women) from Russian 13 regions and persons aged &gt;18 years (n=4063, 1662 men and 2401 women) from Moscow were used. …”
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Comparative assessment of line probe assays and targeted next-generation sequencing in drug-resistant tuberculosis diagnosisResearch in context by Giovanna Carpi, Marva Seifert, Andres De la Rossa, Swapna Uplekar, Camilla Rodrigues, Nestani Tukvadze, Shaheed V. Omar, Anita Suresh, Timothy C. Rodwell, Rebecca E. Colman

“…Comparative evaluations of molecular diagnostic assays in high-burden settings are essential for informing clinical decision-making for DR-TB treatment. Methods: The Seq&Treat clinical study previously evaluated the performance of two targeted next-generation sequencing (tNGS) workflows, GenoScreen Deeplex Myc-TB and Oxford Nanopore Technologies Tuberculosis Drug Resistance Test, on direct sediment samples from persons at risk for DR-TB. …”
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PhyloFunc: phylogeny-informed functional distance as a new ecological metric for metaproteomic data analysis by Luman Wang, Caitlin M. A. Simopoulos, Joeselle M. Serrana, Zhibin Ning, Yutong Li, Boyan Sun, Jinhui Yuan, Daniel Figeys, Leyuan Li

“…We provide PhyloFunc as an open-source Python package (available at https://pypi.org/project/phylofunc/ ), enabling efficient calculation of functional beta-diversity distances between a pair of samples or the generation of a distance matrix for all samples within a dataset. …”
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The preventive effect of sodium-glucose co-transporter-2 inhibitors on atrial fibrillation and atrial flutter in patients with chronic kidney disease: a meta-analysis by Qian Yang, Chen Wang, Wenjing Wang, Yanhong Li, Yi Dang

“…Subgroup analysis based on sample size and follow-up duration showed that SGLT2i reduced the risk of AF in trials with sample size more than 1,000 and follow-up duration longer than 2 years (0.59% vs. 0.80%; RR 0.74, 95% CI 0.55–0.99, P = 0.04). …”
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The association between gut microbiota composition and cardiometabolic parameters in healthy adults by Seyda Silan Okalin, Nazli Arslan, Ebru Demiray Gürbüz, Mine Arayıcı, Nevin Deniz Kırca, Duygu Ozel Demiralp, Didem Dereli-Akdeniz, Pınar Akan, Ayse Aydan Ozkutuk

“…Fecal and blood samples were collected from all participants. Bacterial DNA from fecal samples was extracted, and the full-length 16 S rRNA was amplified. …”
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Immunological characterization of pleural effusions in pediatric patients by Luca Flögel, Elisabeth Kaiser, Muriel Charlotte Hans, Sybelle Goedicke-Fritz, Michelle Bous, Hashim Abdul-Khaliq, Martin Poryo, Michael Zemlin, Regine Weber

“…This study provides the first comprehensive immunological characterization of paired blood and pleural effusion samples, utilizing combined cell and cytokine analyses in pediatric patients undergoing cardiac surgery.MethodsIn 30 pediatric patients (median age: 22 months) with pleural effusion after cardiac surgery for congenital heart defects, corresponding peripheral blood and pleural effusion samples were analyzed for their immune response. …”
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Numerical and experimental evaluation of shear strength and consolidation properties of cohesive soils in high water table areas by Nauman Izhar, Muhammad Adeel Khan, Muhammad Salman Khan, Asad Khan, Mahmood Ahmad, Mahmood Ahmad, Mohanad Muayad Sabri Sabri, Muriuzs Necurzac, Abdullah Alzlfawi

“…The numerical results from PLAXIS offered a more accurate understanding of soil behavior compared to the traditional Meyerhof and Vesic methods, highlighting the necessity of integrating advanced numerical techniques with conventional approaches. …”
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Are neurasthenia and depression the same disease entity? An electroencephalography study by Ge Dang, Lin Zhu, Chongyuan Lian, Silin Zeng, Xue Shi, Zian Pei, Xiaoyong Lan, Jian Qing Shi, Nan Yan, Yi Guo, Xiaolin Su

“…Compared with the MDD group, patients with neurasthenia reported more somatic symptoms and less emotional symptoms (p < 0.05). …”
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SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper by João Pedro Ferreira, Francisco Vasques‐Nóvoa, Francisca Saraiva, Ana C. Oliveira, Jorge Almeida, Ana Beatriz Batista, Arsénio Barbosa, Ana Filipa Ferreira, Cátia Costa, Diogo Santos‐Ferreira, Fernando Friões, Cândida Goncalves, João Tiago Guimarães, Marta Leite, Pedro Marques, Joana Mascarenhas, Maria Inês Matos, Catarina Pereira, Pedro Rodrigues, Abhinav Sharma, Gualter Silva, Inês Pereira‐Sousa, Carla Sousa, Faiez Zannad, Joana Pimenta, Ricardo Fontes‐Carvalho, Adelino Leite‐Moreira

“…Compared to other HFmr/pEF trials, SOGALDI‐PEF patients were older, were more frequently women, had a high prevalence of atrial fibrillation, and had more often a preserved ejection fraction. …”
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Liver fibrosis progression analyzed with AI predicts renal decline by Dan-Qin Sun, Jia-Qi Shen, Xiao-Fei Tong, Ya-Yun Ren, Hai-Yang Yuan, Yang-Yang Li, Xin-Lei Wang, Sui-Dan Chen, Pei-Wu Zhu, Xiao-Dong Wang, Christopher D. Byrne, Giovanni Targher, Lai Wei, Vincent W.S. Wong, Dean Tai, Arun J. Sanyal, Hong You, Ming-Hua Zheng

“…In addition, liver fibrosis changes in the central vein and pericentral regions were more strongly associated with eGFR decline than in periportal, zone 2 and portal tract regions. …”
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Head circumference and intelligence, schooling, employment, and income: a systematic review by Marina B O Freire, Rebeccah Slater, Thiago M Santos, Bruna G C da Silva, Luke Baxter, Ana M B Menezes

“…Despite the relatively large number of included articles, more than 80% presented serious limitations such as lack of adjustment for confounding and severe selection bias. …”
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Risk prediction models for ovarian hyperstimulation syndrome: a systematic review and meta-analysis by Jinghui Liu, Fangli Liu, Wenqi Xu, Luwen Zhang, Qingmi Tian, Libaihe Du, Siyuan Li, Mingyang Zhang

“…As infertility rates rise and assisted reproductive technology (ART) becomes more common, the risk of OHSS increases. Therefore, early identification of high-risk patients and timely intervention are crucial. …”
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The Impact of Rapid Molecular Diagnostics for Influenza on Antibiotic Stewardship in the Emergency Department—An Observational Retrospective Study by Elisa Roth, Marco Cattaneo, Yvonne Hollenstein, Maja Weisser, Stefano Bassetti, Sarah Tschudin Sutter, Roland Bingisser, Christian H. Nickel, Adrian Egli

“…We evaluated the impact of rapid diagnostic results, such as an influenza-specific PCR, blood sample results, and radiological imaging, on antibiotic prescription rates. …”
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Pelvic floor‐related sexual functioning in the first 24 months postpartum: Findings of a large cross‐sectional study by Carsten Hagenbeck, Jan Kössendrup, Johannes Soff, Fabinshy Thangarajah, Nadine Scholten

“…Material and Methods We conducted a cross‐sectional online survey and recruited via social media women up to 24 months after birth of their last child. …”
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From Cell Lines to Patients: Dissecting the Proteomic Landscape of Exosomes in Breast Cancer by Aleksei Shefer, Lyudmila Yanshole, Ksenia Proskura, Oleg Tutanov, Natalia Yunusova, Alina Grigor’eva, Yuri Tsentalovich, Svetlana Tamkovich

“…Since the diagnosis and treatment of BC have been improved substantially with exosomes, in this study, we isolated breast carcinoma cell-derived exosomes, primary endotheliocyte-derived exosomes, and blood exosomes from BC patients (BCPs) in the first stage of disease and investigated their proteomic profiles. <b>Methods</b>: Exosomes were isolated from the samples by ultrafiltration and ultracentrifugation, followed by mass spectrometric and bioinformatics analyses of the data. …”
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Trends in medically serious suicide attempts before and after COVID-19: a four-year retrospective analysis (2018–2022) by Anna Beneria, Luis Marte, Marta Quesada-Franco, Sara García-González, Damià Restoy, Citlalli Pérez-Galbarro, Olga Santesteban-Echarri, Rosa Ramos, Josep Antoni Ramos-Quiroga, María Dolores Braquehais

“…Sixty-eight patients with MSSA were admitted during the first period, and 93 during the COVID period (OR = 1.4 ; CI 95% = 1–1.9 ; p < 0.05). MSSA patients were more likely to be admitted to an intensive care unit during the COVID period than during the pre-COVID period (OR = 3.5; CI 95% = 1.7–6.9; p < 0.001). …”
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