Ge-SAND: an explainable deep learning-driven framework for disease risk prediction by uncovering complex genetic interactions in parallel by Lihang Ye, Liubin Zhang, Bin Tang, Junhao Liang, Ruijie Tan, Hui Jiang, Wenjie Peng, Nan Lin, Kun Li, Chao Xue, Miaoxin Li

“…This challenge may be further exacerbated by the curse of dimensionality when considering large-scale pairwise genetic combinations with limited samples. Overcoming these limitations could transform biomedicine by providing deeper insights into disease mechanisms, moving beyond black-box models and single-locus analyses, and enabling a more comprehensive understanding of cross-disease patterns. …”
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Retrospective analysis and modern spatiotemporal characteristics of tularemia in the territory of the West Kazakhstan and North Kazakhstan regions by U. A. Izbanova, L. Yu. Lukhnova, T. V. Meka-Mechenko, N. S. Maykanov, V. P. Sadovskaya, V. G. Meka-Mechenko, A. A. Yusupov, A. B. Makulova

“…We used descriptive statistics methods, relative and absolute indicators of the tularemia incidence in the population for the analysis. …”
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Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review by Xueli Zhang, Mingqiu Chen, Yanfei Zhang, Jieer Zhou, Tingyan Wei, Zhangbin Yu, Zhangbin Yu, Yuqin Yan, Yuqin Yan, Zhangxing Wang

“…Application of the quality criteria of the quality improvement showed that all the interventions were considered to be of medium to high quality, with the lowest score being 8 and 13 of the interventions having scores more than 10. The studies had heterogeneity with significant variations in intervention characteristics, implementation units, personnel, sample size, time, and outcomes.ConclusionQIIs resulted in reductions in the incidence and severity of NEC in preterm infants in some but not all settings. …”
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Milk traits characterization and association studies with DGAT1 polymorphisms in Bagnolese sheep by Maria Giulia Pugliano, Gianfranco Cosenza, Emanuele D‘Anza, Andrea Fulgione, Nicoletta Murru, Marika Di Paolo, Sara Albarella, Vincenzo Peretti, Francesca Ciotola

“…The aim of this study was to investigate milk production traits in Bagnolese sheep and the variability of diacylglycerol acyltransferase 1 (DGAT1) gene and its effects on milk production. Methods Milk quantity was recorded during the morning milking, while Kjeldahl and Gerber methods were used to assess protein and fat percentage (w/v) of collected milk samples. …”
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Getting under the skin of the menopausal hot flush: a protocol to examine skin function and structure in symptomatic postmenopausal women by Kirsty A. Roberts, Kirsty A. Roberts, Abigail Doyle, Helen Jones, Helen Jones, David A. Low, David A. Low

“…This trial aims to examine the function and structure of skin blood vessels and sweat glands in premenopausal and postmenopausal women.Methods and analysisThis is a single-centre multi-cohort observational study. …”
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Methodology and content for the design of basketball coach education programs: a systematic review by Josep Alemany-Iturriaga, Josep Alemany-Iturriaga, Josep Alemany-Iturriaga, Julio Calleja-González, Jeisson Mosquera-Maturana, Álvaro Velarde-Sotres, Álvaro Velarde-Sotres, Álvaro Velarde-Sotres

“…After inclusion and exclusion criteria, the final sample was 23 articles. These studies maintained a high standard of quality. …”
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Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT) by Manuel Hecht, Anette Blümle, Harald Binder, Martin Schumacher, Nadine Binder

“…We further investigated the impact of publicly and commercially sponsored RCTs on clinical practice guidelines by measuring direct and indirect impactful citations and the time to guideline impact. Methods We considered the sample from the IMPACT study, where a total of 691 RCTs (120 German investigator-initiated trials (IITs), 200 international IITs, 171 German industry-sponsored trials (ISTs) and 200 international ISTs) was sampled from registries (DFG–/BMBF-Websites, the German Clinical Trials Register, and from ClinicalTrials.gov) and followed prospectively. …”
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INVESTIGATION OF A ROLE OF THE IMMUNOGENICITY OF INFLIXIMAB IN THE THERAPY OF ANKYLOSING SPONDYLITIS by O. A. Rumyantseva, A. G. Bochkova, M. M. Urumova, M. V. Cherkasova, E. N. Aleksandrova, S. K. Solovyev, Sh. F. Erdes

“…There is a need for further investigation of the causes of secondary INF insufficiency and methods for its overcoming.…”
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Do leaf traits shape herbivory in tropical montane rainforests? A multispecies approach by Jana E. Schön, Raya Keuth, Jürgen Homeier, Oliver Limberger, Jörg Bendix, Nina Farwig, Roland Brandl

“…We established nine 1‐ha square plots evenly distributed over three different forest types in Ecuadorian tropical montane rainforests where we estimated herbivory as the leaf area loss (in square centimeters) of 20 (±5) leaves sampled from the canopies of 380 tree individuals belonging to 51 tree species (7 ± 1 individuals/species) using lab‐ and spectral‐sensing‐based methods. …”
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Puncture Reduction in Percutaneous Transforaminal Endoscopic Discectomy with HE's Lumbar LOcation (HELLO) System: A Cadaver Study. by Guoxin Fan, Xiaofei Guan, Qi Sun, Annan Hu, Yanjie Zhu, Guangfei Gu, Hailong Zhang, Shisheng He

“…Repeated puncture will lead to more radiation exposure and reduce the beginners' confidence.…”
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Integrated prognostic assessment of apoptosis and chemotherapy related gene in bladder cancer: a prognostic signature by Keyuan Zhao, Gang Xu, Jing Jin, Chao Peng, Jiajun Chen, Yulei Li, Weihao Wang, Shouhua Pan

“…This comprehensive approach aims to enhance our ability to predict the prognosis of BC patients and optimize treatment strategies. Methods We extracted 412 BC patients and 19 healthy humans RNA-seq samples from the TCGA database and loaded 1416 apoptosis and chemotherapy related genes from the GeneCards website. …”
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Characteristics and innovative points of clinical trials of radiotherapy combined with immune checkpoint inhibitors in NSCLC over the past decade by Mengting Li, Mengting Li, Mengting Li, Peng Ding, Peng Ding, Peng Ding

“…This study focuses on the combination of different radiotherapy methods with immune checkpoint inhibitors (ICIs), minimizing attention to new immunotherapeutic drugs. …”
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AI4Food Project: Application of Personalised Nutrition Integrating Artificial Intelligence in Nutritional Interventions Focused on Weight Loss by Isabel Espinosa-Salinas, Gala Freixer, Sergio Romero-Tapiador, Blanca Lacruz Pleguezuelos, Ruben Tolosana, Javier Ortega-Garcia, Enrique Carrillo-De Santa Pau

“…Although the aetiology of obesity has been simplified as an energy imbalance, multiple factors contribute to its development, making its treatment complex. Current methods for diagnosing obesity and overweight have significant limitations therefore, a more personalised approach to nutritional guidance is needed to account for differences in response to dietary affected by environmental and genetic factors. …”
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The effects of active play interventions on children’s fundamental movement skills: a systematic review by Xinmiao Zhang, Changhao Tang, Miao Geng, Kai Li, Cong Liu, Yujun Cai

“…Information on countries and regions, study types, experimental designs, sample characteristics, measurement methods, and intervention effects of the included literature were extracted for the included literature. …”
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Comparison of the Efficacy of Elastodontic Devices and Aligners in Dentoalveolar Transverse Expansion: A Randomized Open Label Clinical Trial by Eleonora Ortu, Mariano Lacarbonara, Samuele Cova, Elena Gigliozzi, Maria Ausilia D’Angelo, Annalisa Monaco, Davide Pietropaoli

“…Specifically, it is intended to determine which of the two methods is more effective in terms of dentoalveolar expansion in a sample of children with mixed dentition. …”
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Association of workplace support for health with occupational health literacy and illness avoidance: moderated mediation by functioning through a salutogenic lens by Nestor Asiamah, Isaac Aidoo, Etornam Doamekpor, Emelia Sarpong, Emelia Danquah, Cosmos Yarfi, Eric Eku, Usman Yaw Baidoo, Christiana Afriyie Manu, Rita Sarkodie Baffoe

“…Aim This study aimed to investigate whether there is a moderated mediation by functioning in the relationship between WSH, OHL, and illness avoidance. Methods A cross-sectional design with sensitivity analyses and measures against common methods bias was adopted. …”
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Chronic Hepatitis С in Siberian Federal District: Analysis of a Case Rate and Evolution of Genotypes of the Originator by E. D. Savilov, S. I. Malov, I. V. Malov, O. B. Ogarkov, V. A. Astafev, N. N. Chemezova, I. A. Miroshnichenko

“…In distribution of the main genotypes of HCV significant depression of the first and augmentation of the third of genotypes of the chronic hepatitis C originator is observed in recent years.Conclusions. 1 Siberian federal district is the territory of risk for chronic hepatitis C. 2 The generalized case rate indicator reflects implications of epidemic process more objectively. 3 The offered methodical approach, besides a case rate, can be used for profound assessment and other indicators. 4 Processes of globalization and social conditions promote evolution in distribution of the main genotypes of HCV.…”
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Role of Salivary Biomarkers IL-1β and MMP-8 in Early Detection and Staging of Periodontal Disease by Liliana Sachelarie, Corina Laura Stefanescu, Rodica Maria Murineanu, Mircea Grigorian, Agripina Zaharia, Ioana Scrobota, Loredana Liliana Hurjui

“…Each participant provided unstimulated saliva samples, which were analyzed using ELISA methods to quantify IL-1β and MMP-8 levels. …”
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PSYCHOLOGICAL CHARACTERISTICS IN PATIENTS WITH CHRONIC HEART FAILURE WAITING FOR HEART TRANSPLANTATION by R. Yu. Shindrikov, A. A. Velikanov, E. A. Demchenko, V. M. Tishkova, O. Yu. Shchelkova

“…The authors’ structured interviews and psychodiagnostic methods were used in the study: «The index of well-being», (WHO, 1999), «The Brief Neuropsychological Cognitive Examination» (BNCE), «The Zung Self-Rating Depression Scale» (SDS), «The State-Trait Anxiety Inventory» (STAI), «Test the Big Five» (BIG V). …”
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Prevalence and associated factors of adolescent fatherhood in Ethiopia: A multilevel analysis using the 2016 Ethiopian demographic health survey data. by Misganaw Gebrie Worku, Getayeneh Antehunegn Tesema, Achamyeleh Birhanu Teshale

“…A total weighted sample of 4455 adolescent men was included for the final analysis. …”
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