Neutrophil extracellular traps mediated by platelet microvesicles promote thrombosis and brain injury in acute ischemic stroke by Xin Gao, Xinyi Zhao, Jiacheng Li, Chang Liu, Wenqiang Li, Junjie Zhao, Zhixi Li, Nan Wang, Fang Wang, Jiawei Dong, Xiuwei Yan, Jiheng Zhang, Xueyan Hu, Jiaqi Jin, Ge Mang, Ruishuang Ma, Shaoshan Hu

“…The purpose of our study was to investigate the potential mechanism and role of NETs formation in the AIS process. Methods As well as 45 healthy subjects, 45 patients with AIS had ELISA tests performed to detect NET markers. …”
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Parents’ perceptions of core outcomes in neonatal research in two Nigerian neonatal units by Ian Sinha, Melissa Gladstone, Janneke van de Wijgert, Kevin Mortimer, Sarah Kathryn Read, Aisha Jibril, Olukemi Tongo, Abimbole Akindolire, Isa Abdulkadir, Helen Nabwera, Stephen Allen, Olusegun Akinyinka, Dominic Umoru, Chinyere Ezeaka, Ireti Fajolu, Beatrice Ezenwa, Zainab Imam, Martha Mwangome, Alison Talbert, Pauline Andang’o, Walter Otieno, Grace Nalwa, Graham Devereux, Ismaela Abubakar, Nicholas Embleton

“…Participants were purposively sampled to include parents of babies with common neonatal problems such as prematurity.Results We conducted 31 interviews. …”
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Association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64 year-old male population (international epidemiological HAPIEE and WHO MONICA programs) by V. V. Gafarov, E. A. Gromova, D. O. Panov, V. N. Maximov, I. V. Gagulin, A. V. Gafarova

“…Objective: to study the association of DRD2/ANKK1 Taq1A polymorphism with depression in an open 45–64-year-old male population from Novosibirsk.Patients and methods. A representative sample of an open 45–64-year-old male population (n=781) was surveyed within Screening IV of the international HAPIEE program and the WHO MONICA-psychosocial program in 2003–2005. …”
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Data augmentation using SMOTE technique: Application for prediction of burst pressure of hydrocarbons pipeline using supervised machine learning models by Afzal Ahmed Soomro, Ainul Akmar Mokhtar, Masdi B. Muhammad, Mohamad Hanif Md Saad, Najeebullah Lashari, Muhammad Hussain, Abdul Sattar Palli

“…Machine learning (ML) models have supplanted traditional methods in recent years. However, small and imbalanced datasets are the big challenge to build a ML model that can generate more accurate results. …”
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Cleaning protocols to enhance bond strength of fiberglass posts on root canals filled with bioceramic sealer: an in vitro comparative study by Thiago Bessa Marconato Antunes, Juliana Delatorre Bronzato, Joice Graciani, Ana Cristina Padilha Janini, Rocharles Cavalcante Fontenele, Francisco Haiter Neto, Brenda Paula Figueiredo de Almeida Gomes, Marciano Marina Angélica

“…The samples were kept at 37ºC and 95% humidity for 28 days. …”
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Comparative Validation and Misclassification Diagnosis of 30-Meter Land Cover Datasets in China by Xiaolin Xu, Dan Li, Hongxi Liu, Guang Zhao, Baoshan Cui, Yujun Yi, Wei Yang, Jizeng Du

“…However, their classification accuracy depends more on selecting training samples and feature variables.…”
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Music as an ergogenic aid in team sports: a systematic review by Eduard Bezuglov, Timur Vakhidov, Elizaveta Kapralova, Georgiy Malyakin, Mikhail Vinogradov, Sergey Chyogin, Mikhail Butovskiy, Mikhail Butovskiy

“…Future studies should include more detailed information on music usage protocols and involve larger sample sizes, particularly including adult elite athletes.…”
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Development of crystal optics for X-ray multi-projection imaging for synchrotron and XFEL sources by Valerio Bellucci, Sarlota Birnsteinova, Tokushi Sato, Romain Letrun, Jayanath C. P. Koliyadu, Chan Kim, Gabriele Giovanetti, Carsten Deiter, Liubov Samoylova, Ilia Petrov, Luis Lopez Morillo, Rita Graceffa, Luigi Adriano, Helge Huelsen, Heiko Kollmann, Thu Nhi Tran Calliste, Dusan Korytar, Zdenko Zaprazny, Andrea Mazzolari, Marco Romagnoni, Eleni Myrto Asimakopoulou, Zisheng Yao, Yuhe Zhang, Jozef Ulicny, Alke Meents, Henry N. Chapman, Richard Bean, Adrian Mancuso, Pablo Villanueva-Perez, Patrik Vagovic

“…The technique is developed for high-brilliance light-source facilities, aiming to address known limitations of state-of-the-art imaging methods in the acquisition of 4D sample information, linked to their need for sample rotation. …”
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Investigating STLV-1 infection in African green monkeys: a model for understanding HTLV-1 pathogenesis by Víctor Â. Folgosi, Liliane A. Carneiro, Sabri S. Sanabani, Felipe B. Freitas, Mayara N. S. da Silva, Amanda L. Silva, Gerlane N. Noronha, Ariela S. Farias, Hebert F. Culler, Carlos F. Apoliano, Luciano Lopes, Juliana Pereira, Luís Alberto P. C. Lage, Igor B. Costa, Camila M. Romano, Shirley V. Komninakis, Jorge Casseb

“…STLV-1 infections in non-human primates serve as valuable models to study HTLV-1 pathogenesis.MethodsThis study investigated STLV-1 infection in captive green monkeys (Chlorocebus aethiops) in Brazil. …”
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C-Reactive Protein Levels in the Brugada Syndrome by Aimé Bonny, Joelci Tonet, Manlio F. Márquez, Antonio De Sisti, Abdou Temfemo, Caroline Himbert, Fatima Gueffaf, Fabrice Larrazet, Ivo Ditah, Robert Frank, Françoise Hidden-Lucet, Guy Fontaine

“…To assess the level of inflammation in BrS patients. Methods. All studied BrS patients underwent blood samples drawn for C-reactive protein (CRP) levels at admission, prior to any invasive intervention. …”
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Comprehensive chemical and bioactive investigation of Chinese peony flower: a case of valorization of by-products as a new food ingredient from Chinese herb by Meng-ling Peng, Ming-Jiong Gong, Jing Zhang, Anastassiya V. Gadetskaya, Qian-Wen Liang, Pei-Wen He, Xiao-Hui Qiu, Zhi-Hai Huang, Wen Xu, Wen Xu

“…IntroductionIn the present study, the flower of Chinese peony (CPF), major waste by-product of Chinese Herb Radix paeoniae, was comprehensively investigated for the first time.MethodsA validated UHPLC Orbitrap Mass spectrometry combined a three-levels characterization strategy were used to analyze CPF samples from four representative cultivars. …”
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THE IMPORTANCE OF GLOMERULAR C3 ACCUMULATION IN ELDERLY PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY by Özgür Akın Oto, Şafak Mirioğlu, Ahmet Burak Dirim, Seda Şafak, Nurana Güller, Erol Demir, Ayşe Serra Artan, Mesude Yasemin Özlük, Ali Rıza Uçar, Lala Soltanova, Kanan Nuriyev, Halil Yazıcı, Yaşar Kerem Çalışkan

“…Objective: The purpose of this study was to investigate the impact of glomerular C3 accumulation density on clinical, histopathological parameters and outcomes in elderly (>60 years) individuals with primary membranous nephropathy (PMN). Material and Methods: In this study, we examined the patients (n=105) in two groups according to the C3 staining density in kidney biopsy samples as low intensity (C3: 1+; LI group) and high intensity (C3: 2+ or C3: 3+; HI group). …”
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Intratonsillar Immunotherapy: A Convenient and Effective Alternative to Subcutaneous Immunotherapy for Allergic Rhinitis by Tian Gu, Wei Zhang, Lu Tan, Rong Xiang, Peiqiang Liu, Jingyu Huang, Qin Deng, Yuqin Deng, Zezhang Tao, Shiming Chen, Yu Xu

“…Allergen-specific immunotherapy (AIT) is the only treatment that addresses the root cause of immunoglobulin E (IgE)-mediated allergies, but conventional methods face challenges with treatment duration, patient compliance, and adverse effects. …”
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Direct Discrimination and Growth Estimation of Foodborne Bacteria in Raw Meat Using Electronic Nose by Wellington Belarmino Gonçalves, Wanderson Sirley Reis Teixeira, Aryele Nunes da Cruz Encide Sampaio, Otávio Augusto Martins, Evelyn Perez Cervantes, Mateus de Souza Ribeiro Mioni, Jonas Gruber, Juliano Gonçalves Pereira

“…From the graphical analysis of the PCA, on day 1, the clusters were close to each other for beef, chicken, and pork, while on days 2 and 3, more separated bacteria clusters were obtained regardless of the meat type, allowing for the discrimination of the samples for the latter days. …”
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Application of Metagenomic and Targeted Next-Generation Sequencing in Diagnosis of Pulmonary Tuberculosis in Bronchoalveolar Lavage Fluid by Yang Z, Liu Q, Hu Y, Geng S, Ni JX

“…Additionally, these techniques identified mixed microbial species in 52.13% of the BALF samples. Although both mNGS and tNGS demonstrated similar diagnostic rates, tNGS proved to be faster, more cost-effective, and incorporated a tuberculosis-specific wall-breaking technology, thereby suggesting greater clinical utility.Conclusion: BALF mNGS and tNGS technologies quickly and accurately detect PTB patients with greater sensitivity and specificity than traditional MTB methods. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Statistical analysis Primary analysis of the primary outcome used the intention-to-treat (ITT) population with the multiple imputation technique being implemented to deal with missing data in instances where participants were missing any of the HDRS-17 scores. Qualitative methods and analysis A purposive sample was collected of participants and non-participants to explore facilitators and barriers to participation in the trial, and the acceptability of the trial treatments. …”
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Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures by Paunović Zoran, Stanojević Ivan, Abazović Džihan, Rakić Mia, Stanković Nikola, Đukić Mirjana, Milutinović Sanja, Starčević Srđan, Šupić Gordana, Vojvodić Danilo, Jović Milena, Marić Dušan

“…In the control group, girls had significantly more leptin than boys. Leptin value was significantly influenced by anatomical localization since boys and girls with humerus fracture and girls with femur fracture had the highest average leptin concentration in the initial sample. …”
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Single-cell RNA sequencing of appendiceal adenocarcinoma reveals a low proportion of epithelial cells and a fibroblast enriched tumor microenvironment by B.B. Gunes, N.J. Hornstein, M. Wang, M. Yousef, M.M. Fanaeian, A. Yousef, S. Chowdhury, M.A. Zeineddine, C. Haymaker, B. Helmink, K. Fournier, J.P. Shen

“…Results: Traditional k-means clustering analysis of >30 000 cells revealed three canonical compartments and 11 major cell types. AA samples were mostly comprised of stromal cells (56%), while healthy appendix samples had significantly more immune and epithelial cells. …”
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Heavy Metals Pollution in Drinking Water Sources: A Case Study from Kulim Hi-Tech Park, Malaysia by Muhamad Radzi Zainon, Mohd Yusmaidie Aziz, Ahmad Razali Ishak, Muhamad Azwat Abdullah, Abdul Rohim Tualeka, Rafeezul Mohamed, Hisham Atan Edinur, Siti Aisyah Mualif, Muhammad Azrul Zabidi, Maisarah Nasution Waras

“…Given industrial impact on Kulim’s water quality, this study determined the concentrations of iron (Fe), manganese (Mn), zinc (Zn), cadmium (Cd), and nickel (Ni) in various water sources around Kulim Hi-Tech Park (KHTP) and assess associated with chronic heath risks. Methods: We measured these five heavy metals in 30 water samples from tap water, rivers, and ponds, within and around Kulim Hi-Tech Park (KHTP), using Atomic Absorption Spectroscopy. …”
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Association of skipping breakfast with depression: a systematic review and meta-analysis by Junwen Tan, Qingwei Meng, Cheng Luo, Shipeng Zhang, Enjie Tang, Yanjie Jiang, Sijing Cheng, Xueying Li, Ling Li

“…High heterogeneity may stem from differences in dietary culture and assessment methods. In the future, more research is needed to explore the mechanism and increase studies in different regions.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier PROSPERO CRD42024583486.…”
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