Robust molecular subgrouping and reference-free aneuploidy detection in medulloblastoma using low-depth whole genome bisulfite sequencing by Dean Thompson, Jemma Castle, Martin Sill, Stefan M. Pfister, Simon Bailey, Debbie Hicks, Steven C. Clifford, Edward C. Schwalbe

“…Low-pass WGBS performs equivalently to array-based methods at comparable cost. Finally, its ascertainment of the full methylome enables elucidation of additional biological complexity and inter-tumoural heterogeneity that has hitherto been inaccessible. …”
Get full text

Potentially inappropriate medication prescribing among elderly patients with cardiovascular diseases by Stojanović Goran, Đurić Dušan, Jakovljević Biljana, Turnić-Nikolić Tamara, Maričić Milena, Stojanović Svetlana, Milovanović Olivera

“…In relation to gender, it was more frequent in female elders. The mean number of prescribed drugs was similar for 2016 and 2017, 7.2 and 7.3, respectively. …”
Get full text

E-Mental Health Interventions in Inpatient Care: Scoping Review by Alexander Diel, Isabel Carolin Schröter, Anita Robitzsch, Christoph Jansen, Martin Teufel, Alexander Bäuerle

“…Studies involving greater sample sizes and studies with more diverse patient groups need to be planned in the future. …”
Get full text

Microbiome of the Proximal Small Intestine in Patients with Acute Pancreatitis by Vladimir V. Kiselev, Stanislav I. Koshechkin, Alexey V. Kurenkov, Vera E. Odintsova, Maria S. Zhigalova, Alekxandr V. Tyakht, Sergey S. Petrikov, Petr A. Yartsev, Ilya V. Dmitriev

“…Currently, due to the complexity of obtaining samples, specific features of laboratory processing and analysis of the results, there is a lack of data on the microbial signature of the small intestine in healthy and diseased states of the upper gastrointestinal tract. …”
Get full text

Indicators of Obesity and Cardiorespiratory Fitness in Croatian Children by Marko Badrić, Leona Roca, Vladan Pelemiš, Dragan Branković, Vladimir Živanović

“…The findings will emphasize the need to determine CRF and BMI as important factors that should be addressed from early school years in order to prevent future cardiovascular diseases. Methods: The total sample consisted of 423 students, including 212 girls and 211 boys, from the continental and Adriatic regions of the Republic of Croatia, with an average age of 10.32 years. …”
Get full text

Disentangling the gut microbiota of Aldabra giant tortoises of different ages and environments by Douaa Zakaria, Camillo Sandri, Monica Modesto, Caterina Spiezio, Donatella Scarafile, Allen Cedras, Luigimaria Borruso, Paolo Manghi, Paolo Trevisi, Nicola Segata, Paola Mattarelli, Masanori Arita

“…The Aldabra giant tortoise (Aldabrachelys gigantea) is an ideal species for this study due to its exceptionally long lifespan of over 100 years. Methods Using 16S rRNA gene amplicon analysis, we analyzed 52 fecal samples from giant tortoises in Seychelles (Curieuse and Mahé islands) and in a zoological park in Italy, from very young individuals to those of >100 years old. …”
Get full text

Natural history of the aortic wall changes in adults with the degenerative tricuspid aortic valve stenosis: The morphometric proofs and implications for echocardiography by Borović Saša D., Labudović-Borović Milica M., Todorović Vera N., Rakočević Jelena T., Marinković-Erić Jelena M., Kostić Jelena V., Trifunović Zoran, Milojević Predrag S.

“…The aim of this study was to grade the histopathological changes in the wall of the nonseverely dilated ascending aorta in patients with the severe, calcific TAV stenosis and to correlate them with the echocardiographic parameters in order to analyze when the ascending aorta should be replaced simultaneously with the aortic valve replacement (AVR). Methods. The samples from 37 patients subjected to the AVR and the samples from the control group were analyzed morphologically. …”
Get full text

Confirmatory mapping for lymphatic filariasis in districts previously considered nonendemic in Ghana by Joseph L. Opare, Dziedzom K. de Souza, Bright Alomatu, Ernest Mensah, Emmanuel Nyarko, Odame Asiedu, Judith Saare, Charles Brown-Davies, Irene D. Dzathor, Achille Kabore, Ernest O. Mensah

“…Districts were classified as endemic if more than three positive cases were identified out 480 sampled. …”
Get full text

Optical Coherence Tomography of Van Der Waals Heterostructures Using Extreme Ultraviolet Light by Felix Wiesner, Johann J. Abel, Muhammad Hussain, Vipin Krishna, Alisson R. Cadore, Juan P. G. Felipe, Ana M. Valencia, Martin Wünsche, Julius Reinhard, Marco Gruenewald, Caterina Cocchi, Gerhard G. Paulus, Giancarlo Soavi, Silvio Fuchs

“…Abstract New experimental methods with high out‐of‐plane spatial sensitivity combined with ultrafast temporal resolution can revolutionize the understanding of charge‐ and heat‐transfer dynamics occurring at interfaces. …”
Get full text

Immunological features of the bone marrow microenvironment and assessment of bone marrow lesions in patients with classical Hodgkin lymphoma by A. A. Melnikova, F. M. Abbasbeyli, T. Yu. Mushkarina, M. A. Vernyuk, P. A. Zeynalova, L. Yu. Grivtsova, S. A. Ivanov, A. D. Kaprin

“…At the same time, immunological methods for detecting tumor cells using multicolor flow cytometry are more available. …”
Get full text

Culture-independent detection of Mycobacterium tuberculosis complex DNA using targeted next generation sequencing in African buffalo (Syncerus caffer) oronasal swabs in South Afric... by Sinegugu Kholeka Mhlophe, Charlene Clarke, Giovanni Ghielmetti, Giovanni Ghielmetti, Megan Matthews, Tanya Jane Kerr, Michele Ann Miller, Wynand Johan Goosen, Wynand Johan Goosen

“…Mycobacterium tuberculosis complex DNA, along with various NTM species, were identified in 8/19 samples. The methods described support a more robust interrogation of the buffalo oronasal mycobacteriome. …”
Get full text

Obstructive Sleep Apnea in Pediatrics and Adolescent Women: A Systematic Review of Sex-Based Differences Between Girls and Boys by Sofía Romero-Peralta, Cristina Rubio, María Castillo-García, Pilar Resano, Miguel Alonso, Esther Solano-Pérez, Laura Silgado, Esther Viejo-Ayuso, Leticia Álvarez-Balado, Olga Mediano

“…Exclusion criteria: (1) studies carried out with individuals aged 18 years and older; (2) studies involving a sample size of fewer than 10 patients; and (3) editorials, letters and case reports. …”
Get full text

Parental Attitudes, Motivators and Barriers Toward Children’s Vaccination in Poland: A Scoping Review by Krystyna Szalast, Grzegorz Józef Nowicki, Mariola Pietrzak, Agnieszka Mastalerz-Migas, Aleksander Biesiada, Elżbieta Grochans, Barbara Ślusarska

“…Objectives: The aim of this scoping review was to synthesize data on parental attitudes toward vaccination and identify factors influencing the motivators and barriers to children’s vaccination based on Polish studies. Methods: The scoping review process and reporting were based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScRs) checklist. …”
Get full text

Pneumonia after Major Cancer Surgery: Temporal Trends and Patterns of Care by Vincent Q. Trinh, Praful Ravi, Abd-El-Rahman M. Abd-El-Barr, Jay K. Jhaveri, Mai-Kim Gervais, Christian P. Meyer, Julian Hanske, Jesse D. Sammon, Quoc-Dien Trinh

“…To examine trends, factors, and mortality of postoperative pneumonia following major cancer surgery (MCS). Methods. From 1999 to 2009, patients undergoing major forms of MCS were identified using the Nationwide Inpatient Sample (NIS), a Healthcare Cost and Utilization Project (HCUP) subset, resulting in weighted 2,508,916 patients. …”
Get full text

Co-Infection of Lophomonas blattarum and Pneumocystis jirovecii in Patients with Respiratory Disorders in Northeastern Iran by Fariba Berenji, Hossein Zarrinfar, Ali Gholizadeh, Fatemeh Sargazi, Jamshid Jamali, Mahmoud Parian Noghabi, Ghodratollah Salehi Sangani, Bibi Razieh Hosseini Farash

“…Bronchoalveolar lavage (BAL) samples were collected from all patients and analyzed microscopically and molecularly. …”
Get full text

Histopathological study of round cell tumors of the head and neck region in a tertiary care hospital: A retrospective study by Zhuvi Zhuvithsii, Anupam Sarma, Shiraj Ahmed, Lopa Mudra Kakoti, Jagannath Dev Sharma, Tarali Pathak, Sawmik Das, Amal Chandra Kataki

“…Their diagnosis is challenging using conventional histopathologic approaches because of indistinct features in small biopsy samples and hence immunohistochemistry is a must. …”
Get full text

Effect of Lactobacillus rhamnosus AB-GG combined with phototherapy on neonatal jaundice indicators, intestinal microbiota and metabolism by Yanhan Yuan, Jiayi Chen, Tianyu Liu, Juanjuan Chen, Feng Zhang, Zhe Shi, Jinping Zhang

“…ObjectivesTo assess whether Lactobacillus rhamnosus AB-GG supplementation has a treatment effect on the neonatal jaundice of infants receiving phototherapy.MethodsIn this study, 11 and 10 neonates in experimental and control groups were recruited, respectively (upon the follow-up of experimental groups at 7–14 days after discharge, stool frequency was decreased commonly. …”
Get full text

Determination of anti-pertussis antibodies in schoolchildren with long-term cough by T. A. Skirda, O. Yu. Borisova, A. B. Borisova, S. Yu. Kombarova, A. S. Pimenova, N. T. Gadua, I. A. Chagina, M. S. Petrova, L. I. Kafarskaya

“…Active pertussis infection, established based on the detection of IgM, IgG, IgA antibodies above thresholds in blood serum samples, prevailed in children 12–15 years old, accounting for more than 60% in children with prolonged cough. …”
Get full text

Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD): Trends, Mortality, and Socioeconomic Disparities in the U.S., 1998–2020 by Paul Wasuwanich, Joshua M. So, Mustafa Sadek, Chaowapong Jarasvaraparn, Songyos Rajborirug, Ruben E. Quiros-Tejeira, Wikrom Karnsakul

“…Background/Objectives: We aim to describe the changing inpatient epidemiology of NAFLD in the U.S. and identify major risk factors associated with mortality in the disease among hospitalized pediatric patients. Methods: Hospitalization data from the 1998–2020 National Inpatient Sample were utilized. …”
Get full text

Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease by Shangpei Wang, Yajie Cai, Yibin Zhao, Yongqiang Yu, Xianwen Chen, Longsheng Wang

“…Conclusions: Besides dopamine, perfusion alterations in SMA of PD patients were more probably correlated with serotonin and noradrenaline. …”
Get full text