Aggressive Versus Moderate Fluid Replacement for Acute Pancreatitis: An Updated Systematic Review and Meta‐Analysis by Muhammad Ehsan, Aamna Badar Ahmad, Haseeba Javed, Afra Zahid, Hafiz Sheheryar Aamir, Huzaifa Ahmad Cheema, Muhammad Ayyan, Biah Mustafa, Abia Shahid, Muhammad Abdullah Ilyas, Kamal Kandel, Rehmat Ullah Awan, Sana Iqbal

“…Conclusions Aggressive fluid resuscitation is associated with higher mortality as compared to moderate fluid replacement in patients with acute pancreatitis. RCTs with larger sample sizes are needed to provide greater statistical power and establish more definitive conclusions.…”
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Enhancing Immunoglobulin G Goat Colostrum Determination Using Color-Based Techniques and Data Science by Manuel Betancor-Sánchez, Marta González-Cabrera, Antonio Morales-delaNuez, Lorenzo E. Hernández-Castellano, Anastasio Argüello, Noemí Castro

“…Traditional laboratory methods used to measure IgG concentrations, such as ELISA or RID, are reliable but costly and impractical for many farmers. …”
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“We’ve wanted to vaccinate against it and now we can”: views of respiratory syncytial virus disease and immunisation held by caregivers of Aboriginal children in Perth, Western Aus... by Samantha J. Carlson, Charlie Holland, Valerie Swift, Catherine Hughes, Peter Richmond, Hannah C. Moore

“…We conducted a pilot qualitative study identifying disease knowledge and willingness to immunise following the changing immunisation landscape for infant RSV in 2024. Methods: Yarning groups were held with a convenience sample of parents/carers of Aboriginal children attending playgroup at a metropolitan Aboriginal Health Service in Western Australia. …”
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Debriefing Methodologies in Nursing Simulation: An Exploratory Study of the Italian Settings by Sonia Lomuscio, Emanuele Capogna, Stefano Sironi, Marco Sguanci, Sara Morales Palomares, Giovanni Cangelosi, Gaetano Ferrara, Stefano Mancin, Antonio Amodeo, Anne Destrebecq, Mauro Parozzi, Susy Dal Bello

“…In Italy, although simulation has been used in nursing education for more than 20 years, there is a general lack of data regarding the elements of debriefing. …”
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Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre st... by Rémy Nicolle, Cindy Canivet, Laurent Palazzo, Bertrand Napoléon, Mira Ayadi, Camille Pignolet, Jérôme Cros, Sophie Gourgou, Janick Selves, Jérôme Torrisani, Nelson Dusetti, Pierre Cordelier, Louis Buscail, Barbara Bournet, Barbara Bournet, Cindy Canivet, Louis Buscail, Nicolas Carrère, Fabrice Muscari, Bertrand Suc, Rosine Guimbaud, Corinne Couteau, Marion Deslandres, Pascale Rivera, Emily Alouany, Nadim Fares, Karl Barange, Janick Selves, Anne Gomez-Brouchet, Adrian Culetto, Guillaume Le Cosquer, Marion Jaffrelot, Bertrand Napoléon, Bertrand Pujol, Fabien Fumex, Jérôme Desrame, Christine Lefort, Vincent Lepilliez, Rodica Gincul, Pascal Artru, Léa Clavel, Anne-Isabelle Lemaistre, Laurent Palazzo, Jérôme Cros, Sarah Tubiana, Nicolas Flori, Pierre Senesse, Pierre-Emmanuel Colombo, Emmanuelle Samalin-Scalzi, Fabienne Portales, Sophie Gourgou, Lise Roca, Claire Honfo Ga, Carinne Plassot, Marc Ychou, Pierre Guibert, Christelle De La Fouchardière, Mathieu Sarabi, Patrice Peyrat, Séverine Tabone-Eglinger, Caroline Renard, Guillaume Piessen, Stéphanie Truant, Alain Saudemont, Guillaume Millet, Florence Renaud, Emmanuelle Leteurtre, Patrick Gelé, Eric Assenat, Jean-Michel Fabre, François-Régis Souche, Marie Dupuy, Anne-Marie Gorce-Dupuy, Jeanne Ramos, Jean-François Seitz, Jean Hardwigsen, Emmanuelle Norguet-Monnereau, Philippe Grandval, Muriel Duluc, Dominique Figarella-Branger, Véronique Vendrely, Clément Subtil, Eric Terrebonne, Jean-Frédéric Blanc, Jean-Philippe Merlio, Dominique Farges-Bancel, Jean-Marc Gornet, Daniela Geromin, Geoffroy Vanbiervliet, Anne-Claire Frin, Delphine Ouvrier, Marie-Christine Saint-Paul, Philippe Berthélémy, Chelbabi Fouad, Stéphane Garcia, Nathalie Lesavre, Mohamed Gasmi, Marc Barthet, Vanessa Cottet, Cyrille Delpierre

“…Methods: 397 patients with proven pancreatic adenocarcinoma were included and followed up in a multicentre prospective study. …”
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Identification of Pyroptosis-Relevant Signature in Tumor Immune Microenvironment and Prognosis in Skin Cutaneous Melanoma Using Network Analysis by Yun Zhu, Dan Han, Hongjue Duan, Qi Rao, Yike Qian, Qiaoyun Chen, Xiao Du, Huanyu Ni, Siliang Wang

“…Later, this study established PPRS based on the expression of 8 PAGs (namely, GBP2, HPDL, FCGR2A, IFITM1, HAPLN3, CCL8, TRIM34, and GRIPAP1), which was highly associated with OS, oncogene mutations, tumor stemness, immune infiltration degrees, IC levels, treatment responses, and multiple biological processes (including cell cycle and immunoinflammatory response) in training and test set samples. Conclusions. Based on our observations, analyzing modification patterns associated with pyroptosis among diverse cancer samples via PPRS is important, which can provide more insights into TIME infiltration features and facilitate immunotherapeutic development as well as prognosis prediction.…”
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Prevalence and risk factors of schistosomiasis among primary school children in four selected regions of The Gambia. by Ebrima Joof, Abdoulie M Sanyang, Yaya Camara, Alhagie Papa Sey, Ignatius Baldeh, Sharmila Lareef Jah, Serign Jawo Ceesay, Sana M Sambou, Saikou Sanyang, Christopher M Wade, Bakary Sanneh

“…In the parent study, ten schools were selected randomly from each region. Urine and stool samples collected from 25 boys and 25 girls (7-14 years) in each school were examined for urinary schistosomiasis (Schistosoma haematobium infection) and intestinal schistosomiasis (Schistosoma mansoni infection) using urine filtration, dipstick and Kato-Katz methods.…”
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Tririum in urine in residents of Ozyorsk, the Chelyabinsk region in 2016 by L. V. Finashov, V. V. Vostrotin, A. Yu. Yanov

“…In order to develop models of dependency of tritium volume activity in urine of the residents from continuous and/or category variables we used correlation and regression methods of analysis. In order to compare two samples by mean value of tritium volume activity Student t-criterion was used. …”
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Carbapenemases Produced by Multidrug-Resistant Strains of <i>Klebsiella Pneumoniae</i> Isolated from Intensive Care Patients by T. V. Chernenkaya, L. A. Borisova, T. Yu. Vorobieva, M. A. Godkov, A. K. Shabanov

“…To date, K. pneumoniae is considered one of the main “distributors” of clinically important antibiotic resistance genes.Aim of the study To study the frequency of occurrence of the most common carbapenemase genes in multiresistant K.pneumoniae strains isolated from patients of intensive care units in an emergency hospital.Material and methods 4708 samples of various types of clinical material from patients of 5 intensive care units of the N.V. …”
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Rapid Syndromic Testing: A Key Strategy for Antibiotic Stewardship in ICU Patients with Pneumonia by Silvana Vulpie, Monica Licker, Oana Izmendi, Delia Muntean, Diana Lungeanu, Beatrice Sarah Zembrod, Iasmina Maria Hancu, Ovidiu Bedreag, Dorel Sandesc, Romanita Jumanca, Luminita Mirela Baditoiu

“…<b>Results</b>: Of the results generated using Unyvero/HPN, 51% were fully concordant with those obtained via culture, 48% were partially concordant, and only 1% represented failure. It was also more efficient in identifying multiple organisms in a single sample than the SoC culture (1.32 versus 1.1 per sample). …”
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Age influences the circulating immune profile in pediatric sepsis by Grace Fisler, Grace Fisler, Grace Fisler, Mariana R. Brewer, Mariana R. Brewer, Mariana R. Brewer, Omar Yaipen, Clifford S. Deutschman, Clifford S. Deutschman, Clifford S. Deutschman, Matthew D. Taylor, Matthew D. Taylor, Matthew D. Taylor

“…Children with sepsis had more regulatory CD4+ T cells and memory CD4+ T cells and less CD4+IL-10+ and CD8+T-bet+ T cells than healthy children. …”
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Voice as a biomarker: exploratory analysis for benign and malignant vocal fold lesions by Phillip Jenkins, Rylan Harrison, Steven Bedrick, Lisa Karstens, Bridge2AI-Voice Consortium, William Hersh, Yael Bensoussan, Olivier Elemento, Anais Rameau, Alexandros Sigaras, Satrajit Ghosh, Maria Powell, Vardit Ravitsky, Jean Christophe Belisle-Pipon, David Dorr, Phillip Payne, Alistair Johnson, Ruth Bahr, Donald Bolser, Frank Rudzicz, Jordan Lerner-Ellis, Kathy Jenkins, Shaheen Awan, Micah Boyer, William Hersh, Andrea Krussel, Steven Bedrick, Toufeeq Ahmed Syed, Jamie Toghranegar, James Anibal, Duncan Sutherland, Enrique Diaz-Ocampo, Elizabeth Silberhoz, John Costello, Alexander Gelbard, Kimberly Vinson, Tempestt Neal, Lochana Jayachandran, Evan Ng, Selina Casalino, Yassmeen Abdel-Aty, Karim Hanna, Theresa Zesiewicz, Elijah Moothedan, Emily Evangelista, Samantha Salvi Cruz, Robin Zhao, Mohamed Ebraheem, Karlee Newberry, Iris De Santiago, Ellie Eiseman, JM Rahman, Stacy Jo, Anna Goldenberg

“…Acoustic features including fundamental frequency, jitter, shimmer, and harmonic-to-noise ratio (HNR) were extracted from standardized speech recordings and compared using nonparametric statistical methods. Among the overall sample, significant differences were identified in HNR and fundamental frequency between benign lesions and both healthy controls and laryngeal cancer. …”
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Effect of DNA target size on the efficiency of chimerism measurement in circulating free plasma DNA by E. E. Nikulina, N. V. Risinskaya, O. E. Dubova, O. V. Sumtsova, Ya. G. Moysyuk, V. A. Vasilieva, M. V. Soloveva, A. A. Yushkova, I. S. Fevraleva, A. S. Skripkina, A. A. Makarik, A. B. Sudarikov

“…To investigate the effect of target length on the amplification efficiency of Y-chromosome markers from cfDNA.Material and methods. Fifty cfDNA samples were obtained from 39 patients: patients after liver transplantation (n=19), patients with acute leukemia after allogeneic hematopoietic stem cell transplantation (n=10), and pregnant women (n=10). …”
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How to Implement Digital Clinical Consultations in UK Maternity Care: the ARM@DA Realist Review by Catrin Evans, Georgia Clancy, Kerry Evans, Andrew Booth, Benash Nazmeen, Candice Sunney, Mark Clowes, Nia Wyn Jones, Stephen Timmons, Helen Spiby

“…Phase 2 involved testing these theories by looking in-depth at more evidence. In phase 3, the quality and relevance of the evidence was assessed and more information gathered where necessary. …”
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Clinical efficacy of metagenomic next-generation sequencing for the detection of pathogens in peritoneal dialysis-related peritonitis: a prospective cohort study by Qingyan Zhang, Yuan Feng, Yangyang Xia, Qiuyuan Shao, Min Zhao, Pengfei Xu, Tianfeng Tang, Jing Liu, Bo Jin, Sixiu Liu, Chunming Jiang

“…Among the 30 samples that tested positive by both methods, 27 (90%) showed completely (13 cases) or partly (14 cases) matched results between mNGS and culture. …”
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Clinical application of metagenomic next-generation sequencing in etiologic diagnosis of severe pneumonia in adults by Zhen-Chuan Xing, Hua-Zheng Guo, Peng Zhen, Ting Ao, Ming Hu

“…The sensitivity and accuracy of mNGS in bacterial detection were significantly higher than traditional methods (P&lt;0.05). Compared to culture, mNGS detected more Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Escherichia coli, and had a significant advantage in the detection of Mycobacterium tuberculosis complex, Nontuberculous mycobacterial, Legionella pneumophila, Chlamydia psittaci, Pneumocystis jirovecii and Aspergillus. …”
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Comparative efficacy of conventional pap smear and liquid based cytology for screening of cervical cancer in women of reproductive age group in a tertiary care centre in rural Madh... by Shambhavi, Suresh Kumar Sutrakar, Lokesh Tripathi, Parul Singh Rajpoot, Priyanka Agrawal, Uday Raj Singh, Jagannath Jatav, Deepti Tiwari, Pushpkunjika Sharma

“…Results: CPS showed a sensitivity of 59.62%, specificity of 94.19%, and sample adequacy of 93.3%, while LBC exhibited higher sensitivity (89.09%), comparable specificity (91.43%), and better sample adequacy (95.8%). …”
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Manifestation of a complex of Fusarium solani (Mart.) Sacc. species on seeds and seedlings of cereals, legumes, oilseeds and cereals by T. Rozhkova, L. Biliavska, H. Iutynska, L. Tytova, N. Leonova, M. Loboda, A. Sylchuk, Ye. Rozhkova

“…To establish the peculiarities of infection of seeds and seedlings of cereals, legumes, oilseeds and cereals by a complex of FSSC species, to determine the factors influencing the spread of the pathogen. Methods. Laboratory methods: germination of crop seeds in different soil samples and study of seedling development; identification of fungal species that formed mycelium layers during seed germination; analysis of soil mycobiota; determination of drug efficacy. …”
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Burnout and its Factors in Healthcare Workers Involved in Providing Health Care for Patients With COVID-19 at Different Stages of the Pandemic by A. B. Kholmogorova, S. S. Petrikov, A. Y. Suroyegina, O. Y. Mikita, A. A. Rakhmanina, A. P. Roy

“…To compare them with the indicators of a mixed sample of medical workers from different institutions and regions surveyed in the first months of the pandemic (March–April), and also to highlight the main factors of distress and protective factors.Material and methods. …”
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Machine learning-driven prediction model for cuproptosis-related genes in spinal cord injury: construction and experimental validation by Yimin Zhou, Xin Li, Zixiu Wang, Liqi Ng, Rong He, Chaozong Liu, Gang Liu, Xiao Fan, Xiaohong Mu, Yu Zhou, Yu Zhou

“…However, this study has some limitations, such as unidentified SRGs, a small sample size. Future research requires more in vitro and in vivo experiments to deeply explore regulatory mechanisms and develop intervention methods.…”
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