Clinical disorders in a post war British cohort reaching retirement: evidence from the First National Birth Cohort study. by Mary B Pierce, Richard J Silverwood, Dorothea Nitsch, Judith E Adams, Alison M Stephen, Wing Nip, Peter Macfarlane, Andrew Wong, Marcus Richards, Rebecca Hardy, Diana Kuh, NSHD Scientific and Data Collection Teams

“…This study describes the distribution and clustering of 15 common clinical disorders requiring medical treatment or supervision in a representative British cohort approaching retirement, and how health tracked across adulthood.<h4>Methods and findings</h4>The data come from a cohort of 2661 men and women, 84% of the target sample, followed since birth in England, Scotland and Wales in 1946, and assessed at 60-64 years for: cardio and cerebro-vascular disease, hypertension, raised cholesterol, renal impairment, diabetes, obesity, hypothyroidism, hyperthyroidism, anaemia, respiratory disease, liver disease, psychiatric problems, cancers, atrial fibrillation on ECG and osteoporosis. …”
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Level of awareness of parents towards pediatric lumbar punctures in Riyadh, Saudi Arabia by Nouf Bin Muammar, Norah Al Rohaimi, Banan Aleid, Aminah Al Harbi, Amal Yousif

“…This study aimed to explore and assess the level of knowledge of parents towards LPs who live in Riyadh, Saudi Arabia. Methods: This is a cross-sectional quantitative study that included a sample of parents residing in Riyadh. …”
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Investigation of the impact of commonly used medications on the oral microbiome of individuals living without major chronic conditions. by Vanessa DeClercq, Jacob T Nearing, Morgan G I Langille

“…<h4>Background</h4>Commonly used medications produce changes in the gut microbiota, however, the impact of these medications on the composition of the oral microbiota is understudied.<h4>Methods</h4>Saliva samples were obtained from 846 females and 368 males aged 35-69 years from a Canadian population cohort, the Atlantic Partnership for Tomorrow's Health (PATH). …”
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Device Substantiation for Generating Artificial Rain Drops by Pneumohydraulic Liquid Spraying by V. P. Gorobey, V. Y. Moskalevich, Z. A. Godzhaev

“…They obtained the parameters values for the designed and experimental samples development, which turned out to be significantly less than when operating in the air ejection mode: the outlet nozzle and the middle annular gap – by 16 percent, the air nozzle – by 23, the diameter of the mixing cell – by 50 percent or more. …”
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DisCo P-ad: Distance-Correlation-Based <i><b>p</b></i>-Value Adjustment Enhances Multiple Testing Corrections for Metabolomics by Debmalya Nandy, Debashis Ghosh, Katerina Kechris

“…We propose a modification to the <i>p</i>-value adjustment based on a more general measure of association between two predictors, the <i>distance correlation</i>, with a specific focus on MWAS. …”
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Viability studies of bacterial strains exposed to nitrogen oxides and light in controlled atmospheric conditions by Elena Gatta, Elena Abd El, Marco Brunoldi, Muhammad Irfan, Tommaso Isolabella, Dario Massabò, Franco Parodi, Paolo Prati, Virginia Vernocchi, Federico Mazzei

“…The experimental approach was simple but carefully controlled: before being introduced into ChAMBRe, the bacteria samples were characterized using three different methods to determine the ratio of viable to total bacteria. …”
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Nonadherence Predictors to Tuberculosis Medications among TB Patients in Gambella Region of Ethiopia by Taye Kebede, Wiw Gach Jing, Abiot Girma, Kifle Woldemichael

“…Hence, the objective of this study was to determine the determinants of nonadherence to anti-TB drug treatment among patients in Gambella regional state of Ethiopia. Methods. A case-control study was conducted on cohorts of TB patients sampled from four public health facilities in Gambella Region from January 2019 to 2020, followed by 18 months of follow-up. …”
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A Cuproptosis-Related lncRNAs Signature Could Accurately Predict Prognosis in Patients with Clear Cell Renal Cell Carcinoma by Wei Zhang, Han Wang, Wei Wang, Haoqiang Xue, Maolin Qiao, Liying Song, Shuang Wang, Zhaoyu Ren, Zhifang Ma

“…As cuproptosis, a new cell death mechanism proposed recently, differs from all other known mechanisms regulating cell death, we aimed to create prognostic markers using cuproptosis-related long non-coding ribonucleic acids (RNAs; lncRNAs) and elucidate the molecular mechanism. Methods. Data from transcriptome RNA sequencing of ccRCC samples and the relevant clinical data were downloaded from The Cancer Genome Atlas, and Pearson’s correlation analysis was implemented to obtain the cuproptosis-related lncRNAs. …”
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Characteristics of HCV co-infection among HIV infected individuals from an area with high risk of blood-borne infections in central China. by Tiejun Zhang, Damien C Tully, Sujuan Zhou, Na He

“…Serum samples were collected and HCV antibody testing, AST and ALT testing were performed. …”
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Speech-in-noise, psychosocial, and heart rate variability outcomes of group singing or audiobook club interventions for older adults with unaddressed hearing loss: A SingWell Proje... by Chi Yhun Lo, Benjamin Rich Zendel, Deniz Baskent, Christian Boyle, Emily Coffey, Nathan Gagne, Assal Habibi, Ellie Harding, Merel Keijzer, Gunter Kreutz, Bert Maat, Eva Schurig, Mridula Sharma, Carmen Dang, Sean Gilmore, Helen Henshaw, Colette M McKay, Arla Good, Frank A Russo

“…However, there is a lack of robust evidence, primarily due to the literature being based on small sample sizes, single site studies, and a lack of randomized controlled trials. …”
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Cardiac Amyloidosis Versus Other Restrictive Cardiomyopathies: A Retrospective Analysis of Cardiovascular Outcomes and Arrhythmic Burden by Andrew Sagalov, Waqas Ullah, Yevgeniy Brailovsky, Michael Buhnerkempe, Steve Scaife, Abhishek Kulkarni, Mohamed Labedi, Shruti Hegde

“…Methods and results: We queried the National Inpatient Sample (NIS) database to identify all adult patients diagnosed with cardiac amyloidosis or other RCM between the years 2016 and 2019. …”
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RNA Sequencing Identifies Novel Signaling Pathways and Potential Drug Target Genes Induced by FOSL1 in Glioma Progression and Stemness by Guo S, Sidhu R, Ramar V, Guo AA, Wang G, Liu M

“…Shanchun Guo,1 Rajveer Sidhu,2 Vanajothi Ramar,2 Alyssa A Guo,3 Guangdi Wang,1 Mingli Liu2 1RCMI Cancer Research Center and Department of Chemistry, Xavier University, New Orleans, LA, USA; 2Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, GA, USA; 3Wake Forest University School of Medicine, Winston-Salem, NC, USACorrespondence: Mingli Liu, Email mliu@msm.eduBackground: Glioblastoma is a highly aggressive brain tumor, and the transition from the proneural to mesenchymal subtype is associated with more aggressive and therapy-resistant features. However, the signaling pathways and genes involved in this transition remain largely undefined.Methods: We utilized patient-derived xenograft (PDX) samples of glioblastoma, specifically PDX-L14, which exhibit both negative and overexpressed FOSL1 expression. mRNA expression profiles were assessed by RNA sequencing in these samples, followed by gene ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and Gene Set Enrichment Analysis (GSEA). …”
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A Retrospective Analysis of the Characteristics and Clinical Outcomes of Dental Implants Placed in Romanian Patients by Bogdan Gabriel Sandu, Raluca Iulia Juncar, Abel Emanuel Moca, Paul Andrei Țenț, Mihai Juncar

“…This study aimed to assess the favorable or unfavorable progress of dental implants in a patient sample from Oradea, Romania, considering different variables. …”
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ANALYSIS OF A GENETIC COLLECTION OF TOMATO CULTIVARS AND HYBRID FORMS FOR RESISTANCE TO LEAF MOLD USING DNA MARKERS by I. N. Shamshin, M. V. Maslova, Y. V. Gryazneva

“…It allows for the time-saving analysis of breed­ing material.Materials and methods. The present work offers the results of screening more than 30 accessions from the genetic collection of tomato cultivars and hybrids of the Michurinsk State Agrarian University using the P7 molecular marker.Results and discussion. …”
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Association between diabetes and edentulism and their joint effects on health status in 40 low and middle-income countries by Lee Smith, Josep Maria Haro, Ai Koyanagi, Jae Il Shin, Louis Jacob, Guillermo F Lopez-Sanchez, Hans Oh

“…In addition, people with comorbid diabetes and edentulism had worse health status in the domains of cognition, sleep/energy, and perceived stress, compared with those with diabetes only.Conclusions Diabetes was positively associated with edentulism in this sample of more than 175 000 individuals living in LMICs. …”
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Locus-specific HERV expression associated with hepatocellular carcinoma by Hui Wen, Marcos Pérez-Losada, Lopa Mishra, Keith A. Crandall

“…For example, HERVH and ERVLE families showed consistent downregulation in tumor samples, while HERVE and HERV9 were more commonly upregulated. …”
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Prevalence and predisposing factors of retained drug needle fragments in people who inject drugs: a protocol for a preliminary cross-sectional multicentre observational study in Fi... by Markku Sumanen, Heidi Laukkala, Otso Arponen, Irina Rinta-Kiikka, Olli Pekka Oskari Nevalainen

“…After the pilot study, we aim to recruit 80 more adult participants.Ethics and dissemination We submitted the study protocol for ethics review to the Tampere University Hospital Ethics Committee and received their favourable opinion (study code: R22037). …”
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Therapeutic and protective effects of light-cured varnishes on erosive lesions: an in vitro study by Ebru Imren, Yeliz Güven

“…After initial erosion, the samples were treated with varnishes and subjected to a second 7-day erosive cycle. …”
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The association between physical activity and lung function in adolescents: a cross-sectional NHANES study by Xiaoyuan Chen, Jinhai Ma, Linghua Dong, Yan Chen, Keke Chen

“…While physical activity is known to improve respiratory health, its impact on specific lung function parameters in adolescents, particularly across different activity intensities, remains underexplored.MethodsWe analyzed the effects of varying intensities of PA on lung function parameters—specifically Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 s (FEV₁), and Forced Expiratory Flow (FEF)—in a sample of 896 adolescents aged 12–19 years. …”
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Adolescent Emoji Use in Text-Based Messaging: Focus Group Study by Matt Minich, Bradley Kerr, Megan Moreno

“…ObjectiveThis study sought to understand whether the pragmatic functions of adolescent emoji use resemble those of adults, and to gain insight into the semantic meanings of emojis sent by adolescents. MethodsWeb-based focus groups were conducted with a convenience sample of adolescents, in which participants responded to questions about their use and interpretation of emojis and engaged in unstructured interactions with one another. …”
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