Polymorphisms of the <i>TPMT</i>, <i>NUDT15</i> genes and 6-mercaptopurine toxicity profile in adult patients with Ph-negative acute lymphoblastic leukemia/lymphomas on the ALL-201... by E. S. Kotova, O. A. Gavrilina, I. A. Yakutik, A. B. Sudarikov, Yu. A. Chabaeva, S. M. Kulikov, S. G. Beksaev, V. V. Troitskaya, G. A. Isinova, A. N. Sokolov, Z. T. Fidarova, I. A. Lukyanova, A. V. Abramova, V. N. Dvirnyk, I. V. Galtseva, T. N. Obukhova, E. N. Parovichnikova

“…TPMT and NUDT15 polymorphisms were detected in 11 (20 %) patients, more often in B-ALL - 7 (32 %) of 22 (p &lt;0.05). …”
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Clinical genomic profiling to identify actionable alterations for very early relapsed triple-negative breast cancer patients in the Chinese population by Liye Wang, Qinglian Zhai, Qianyi Lu, Kaping Lee, Qiufan Zheng, Ruoxi Hong, Shusen Wang

“…Comprehensive genomic profiling helps to explore the clinically relevant genomic alterations (CRGAs) and potential therapeutic targets in very-early-relapsed TNBC patients.Methods Formalin-fixed paraffin-embedded (FFPE) tumour tissue specimens from 23 patients with very-early-relapsed TNBC and 13 patients with disease-free survival (DFS) more than 36 months were tested by FoundationOne CDx (F1CDx) in 324 genes and select gene rearrangements, along with genomic signatures including microsatellite instability (MSI) and tumour mutational burden (TMB).Results In total, 137 CRGAs were detected in the 23 very-early-relapsed TNBC patients, averaging six alterations per sample. …”
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A Novel DNA Repair‐Gene Model to Predict Responses to Immunotherapy and Prognosis in Patients With EGFR‐Mutant Non‐Small Cell Lung Cancer by Fen Wang, Xue‐Wu Wei, Ming‐Yi Yang, Chang Lu, Xiao‐Rong Yang, Jia‐Yi Deng, Zhi‐Hong Chen, Qing Zhou

“…However, the role and mechanism of DDR in the genesis and progression of EGFRm NSCLC remain unclear. Methods This study included 101 EGFRm NSCLC samples from The Cancer Genome Atlas (TCGA) dataset and a GSE31210 dataset (external set) from the GEO database. …”
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Analyzing the efficacy of conservative versus surgical treatment of chronic mixed blepharitis via laser Doppler flowmetry and interferometry by Tatyana N. Safonova, Natalya P. Kintyukhina

“…Objective — To analyze and compare the efficacy of conservative vs. surgical treatment of chronic mixed blepharitis via laser Doppler flowmetry and interferometry. Materials and methods — We enrolled 42 patients (the sample of 84 eyes) with chronic mixed blepharitis in the study. …”
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Prediction of Temperature Distribution on an Aircraft Hot-Air Anti-Icing Surface by ROM and Neural Networks by Ziying Chu, Ji Geng, Qian Yang, Xian Yi, Wei Dong

“…Furthermore, the proposed model demonstrates a prediction time of no more than 5.5 ms for individual temperature samples. …”
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Digital nationalism: analyzing the role of sports in Thai identity through social media by Sid Terason, Boonyada Pahasing

“…Employing qualitative methods, including thematic analysis, we examined over 500 social media posts, comments and interactions purposively sampled from Facebook, X and Instagram during major sports events such as the Olympics, Asian Games and Southeast Asian Games. …”
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Effect of chemical treatment of multi-walled carbon nanotubes on the specific capacitance of supercapacitors by Valeriy V. Golovakhin, Ekaterina Yu. Kim, Oksana N. Novgorodtseva, Alexander G. Bannov

“…To date, the research on carbon nanomaterials has progressed rapidly. More than 400 papers were written in 2021 on the application of carbon nanomaterials in various fields. …”
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Analysis of morphological differences between natural and cultured populations of Oplegnathus fasciatus by WANG Jiahao, HU Guisen, WU Zhang, ZHU Kai, XU Kaida, WANG Haoxue, DAI Qian

“…The results of stepwise discriminant analysis showed that the correct rate of discrimination were 97.8% and 94.7%, respectively, after cross-validation based on the traditional morphometry and truss network, and the correct rate of discrimination was 99.6% after cross-validation based on the comprehensive analysis combined with the two methods. The above results showed that it is feasible to discriminate the natural and cultured populations via morphological methods, and the results of the comprehensive discrimination can be more accurate when various morphologically measurable traits were combined.…”
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Knowledge of Nurses Toward Covid-19 at Primary Health Care by Mansour Abdullah Falah

“…Results: The study revealed that more than half of the nurses possess moderate knowledge (53.28%), while less than half demonstrated good knowledge (40.72%). …”
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Unsupervised machine learning-based stratification and immune deconvolution of liver hepatocellular carcinoma by Mae Montserrat Reierson, Animesh Acharjee

“…The tumour microenvironment (TME) influences treatment response and prognosis, yet its heterogeneity remains unclear. Methods The unsupervised machine learning methods— agglomerative hierarchical clustering, Multi-Omics Factor Analysis with K-means++, and an autoencoder with K-means++ — stratified patients using microarray data from HCC samples. …”
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SHELTERED EMPLOYMENT WORKSHOPS VS. SUSTAINABILITY POLICY by Joanna Małecka, Dominik Czerkawski

“… Background and Objective: The purpose of the article is to determine the rate of change of economic aspects related to social demand for the number of Sheltered Employment Workshops (SEWs) compared to the Commercial Labour Market (CLM), taking into account the needs of people with disabilities (PwDs) and sustainable development (SD). Materials and Methods: Materials and methods: Using linear regression for fluctuation, the most effective correlation coefficient between SEW funding opportunities and existing businesses in the CLM was determined. …”
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Development and validation of a novel combinational index of liquid biopsy biomarker for longitudinal lung cancer patient management by Min-Yi Liao, Yun-Jie Hao, Ching-Shan Luo, Ching-Mei Chen, Po-Hao Feng, Hsin-Yu Yang, Da-Jeng Yao, Kang-Yun Lee, Fan-Gang Tseng

“…In this paper, a novel combinational index, P-score, was developed for monitoring and predicting the disease condition of lung cancer patients during follow-up visits. Materials and methods: There were totally 13 return patients with 54 blood samples involved in this study to examine the number of CTC and CTM. …”
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Investigating the complementarity of thermal and physical soil organic carbon fractions by A. A. Delahaie, L. Cécillon, M. Stojanova, S. Abiven, P. Arbelet, D. Arrouays, F. Baudin, A. Bispo, L. Boulonne, C. Chenu, J. Heinonsalo, C. Jolivet, K. Karhu, M. Martin, L. Pacini, L. Pacini, C. Poeplau, C. Ratié, P. Roudier, N. P. A. Saby, F. Savignac, P. Barré

“…A debate is emerging as to which of these methods should be recommended for soil monitoring. …”
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Pre-treatment Circulating Tumor Cell Associated White Blood Cell Clusters Independently Predict Poor Survival in Patients with Extensive-disease Small Cell Lung Cancer by Ying Wang, Minghang Zhang, Cen Chen, Yanxia Liu, Yuan Gao, Hongxia Li, Baohua Lu, Mingming Hu, Hongmei Zhang, Peter Ping Lin, Zhanliang Ren, Tongmei Zhang, Shaofa Xu

“…Design: This prospective, non-interventional, single-center study included 48 patients with LD-SCLC and 47 patients with ED-SCLC. Methods: A total of 95 SCLC patients were prospectively enrolled and serial blood samples were obtained before chemotherapy administration (t 0 ) and after 2 cycles of chemotherapy (t 1 ). …”
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Hospital-related healthcare expenditure of impending versus completed pathological femur fractures: a propensity score matched study of 265 patients by Tom M de Groot, Michelle R Shimizu, David Shin, Olivier Q Groot, Stein J Janssen, Kevin A Raskin, Eric T Newman, Marco L Ferrone, Santiago A Lozano-Calderon, Joseph H Schwab, Paul C Jutte

“…Patients with completed pathologic fractures were more often discharged to rehabilitation facilities (57/100, vs 30/100, P < 0.01). …”
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A Prospective Analysis of the Burden of Multi-Drug-Resistant Pathogens in Acute Appendicitis and Their Implication for Clinical Management by Faruk Koca, Sara Fatima Faqar-Uz-Zaman, Claudia Reinheimer, Michael Hogardt, Volkhard A. J. Kempf, Paul Ziegler, Andreas A. Schnitzbauer, Armin Wiegering, Wolf Otto Bechstein, Patrizia Malkomes

“…These patients required more frequent postoperative antibiotic treatment (65.5% vs. 40.8%, <i>p</i> = 0.03) and therapy adjustments (37.9% vs. 15.8%, <i>p</i> = 0.02). …”
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Features of antihypertensive therapy in the Russian population: data from the ESSE-RF3 study by Yu. A. Balanova, S. A. Shalnova, V. A. Kutsenko, A. E. Imaeva, O. E. Ivlev, S. E. Evstifeeva, A. V. Kapustina, M. B. Kotova, S. A. Maksimov, G. A. Muromtseva, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, O. A. Bashkina, S. V. Glukhovskaya, I. A. Levina, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. S. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovieva, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, E, V. Mikhailov, Yu. O. Tarabrina, M. G. Ataev, M. O. Radzhabov, Z. M. Gasanova, M. A. Umetov, I. A. Hakuasheva, i. V. Elgarova, E. I. Yamashkina, L. А. Balykova, A. A. Usanova, A. M. Nikitina, N. V. Savvina, Iu. E. Spiridonova, E. A. Naumova, V. S. Yudin, A. A. Keskinov, S. M. Yudin, A. V. Kontsevaya, O. M. Drapkina

“…To evaluate the usage of antihypertensive drugs (AHDs) and their combinations in participants aged 35 to74 years with arterial hypertension (AH) in the population-based study ESSE-RF3.Material and methods. Representative samples of the population aged 35 to 74 years from 15 regions of Russia (n=28731) with a response rate over 70% were examined in the ESSE-RF3 study. …”
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The Impact of the “Green Transition” in the Field of Food Packaging on the Behavior of Romanian Consumers by Alexandru Jurconi, Ioana Maria Popescu (Iacobescu), Daniela-Ioana Manea, Mihaela Mihai, Rodica Pamfilie

“…The validation of the research hypotheses was done with methods of non-parametric analysis of the interdependencies between the identified variables, the results obtained highlighting the need to study this issue on a representative sample, using a more complex questionnaire. 81% of the study respondents identified as the main benefit for the use of sustainable packaging the possibility of living in a less polluted environment, an essential component of the development of ecological and sustainable food systems, being identified in the ability of producers and traders to communicate the placement on the market of sustainable packaging for marketed products…”
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Realistic in silico generation and augmentation of single-cell RNA-seq data using generative adversarial networks by Matteo Marouf, Pierre Machart, Vikas Bansal, Christoph Kilian, Daniel S. Magruder, Christian F. Krebs, Stefan Bonn

“…Augmenting few real observations with generated in silico samples could lead to more robust analysis results and a higher reproducibility rate. …”
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In silico discovering relationship between bacteriophages and antimicrobial resistance by Maya Zhelyazkova, Roumyana Yordanova, Iliyan Mihaylov, Stefan Tsonev, Dimitar Vassilev

“…The approach used in our analyses consists of several different methods which assess the differential abundance of phages, their diversity across samples, the impact on AMR categories and associations with AMR genes. …”
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