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18981
Clinical and immune evolution in neurological/psychiatric patients during the COVID-19 pandemic
Published 2025-04-01“…In this context, we evaluated the effects of COVID-19 on the subjective perception of neurological and psychiatric symptoms in patients with pre-pandemic neuropsychiatric diseases, as well as the possible association between the evolution of these symptoms and immunological factors. Methods: A cohort of neurological/psychiatric patients with (n = 99) or without (n = 42) a history of COVID-19 was included. …”
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18982
Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design...
Published 2023-02-01“…Results of the study will be published in one or more peer-reviewed journals.Trial registration number UMIN000047023.…”
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18983
Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well
Published 2025-03-01“…We examined cross-sectional associations between circulating stress biomarkers and multimodal measures of brain health and cognition susceptible to AD in older adults and sex-specific subgroups. Methods: Baseline data from 132 cognitively unimpaired participants without depression (age, mean ± SD = 74.0 ± 4.0 years, women: n = 80) in the Age-Well trial (NCT02977819) were included. …”
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18984
Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec...
Published 2025-05-01“…An inverse variance model was used with a generalised methods of moments estimate of the between-studies variance. …”
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18985
Cognitive Dysfunction in the Addictions (CDiA): protocol for a neuron-to-neighbourhood collaborative research program
Published 2025-05-01“…Project 7 uses whole-person modeling to integrate the multi-modal data generated across projects, applying clustering and deep learning methods to identify patient subtypes and drive future cross-disciplinary initiatives. …”
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18986
The impact of methylome analysis on the diagnosis and treatment of CNS tumours in children and adolescents: A population-based study in Greece
Published 2024-12-01“…Additional t-distributed stochastic neighbour embedding (t-SNE) analysis allowed the possible classification of twelve tumours. Nine more samples reached high Cs using the newer brain tumour classifiers, since available. …”
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18987
Exploring the therapeutic potential of Quercus ilex acorn extract in papillomavirus-induced lesions
Published 2024-11-01“…This study aimed to evaluate the in vivo safety and cancer chemopreventive activity of an infusion extract of Q. ilex in a transgenic mouse model of human PV (HPV)-16, which developed squamous cell carcinomas through a multistep process driven by HPV16 oncogenes. Materials and Methods: Q. ilex extract was prepared by heating in water at 90°C and then characterized by mass spectrometry. …”
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18988
Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology
Published 2025-02-01“…For both datasets, we found substantial variation in the variable selection and random effects structures among analyses, as well as in the ratings of the analytical methods by peer reviewers, but we found no strong relationship between any of these and deviation from the meta-analytic mean. …”
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18989
Impact of Y chromosome loss on the risk of Parkinson's disease and progressionResearch in context
Published 2025-07-01“…This study investigated the relationship between blood LOY levels and the risk of PD onset and progression. Methods: We estimated the LOY level for each male participant based on genome-wide arrays or whole genome sequencing data. …”
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18990
Impact of standardized immunophenotyping and MRD monitoring on early mortality reduction in childhood leukemia: a step towards addressing healthcare disparities in vulnerable popul...
Published 2025-07-01“…In 2022 the Childhood Cancer Cytomics Laboratory (CCCL) started the implementation of standardized protocols for immunophenotyping and measurable residual disease (MRD) monitoring of B-ALL patients from this region.ObjectiveTo evaluate the impact of implementing standardized immunophenotyping and MRD monitoring on early mortality in children with B-ALL treated in public hospitals in southern Mexico.MethodsA prospective cohort study was conducted between 2022 and 2024. …”
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18991
Prevalence of chronic kidney disease among Chinese adults with diabetes: a nationwide population-based cross-sectional studyResearch in context
Published 2025-02-01“…Additionally, research gaps exist in understanding the association between CKD and cardiovascular health (CVH), an integrated indicator of lifestyle and metabolic control, within a nationwide sample of Chinese adults with diabetes. Methods: A nationally community-based cross-sectional survey was conducted in 2018–2020. 58,560 residents diagnosed with diabetes aged 18–74 years nationwide were invited to participate, and 52,000 participants with complete CKD data were included in this study. …”
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18992
Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT
Published 2025-08-01“…We investigated whether H. pylori eradication would protect against aspirin-associated ulcer bleeding. Methods The Helicobacter Eradication Aspirin Trial was a randomised placebo-controlled trial (European Union Drug Regulating Authorities Clinical Trials 2011-003425-96), conducted in United Kingdom primary care using routinely collected clinical data. …”
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18993
High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs
Published 2025-05-01“…High-flow nasal cannula is easier to use, requires less nursing input and is more comfortable for children. However, few clinical trials have compared their effectiveness in sick children. …”
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