Associations between pathophysiological traits and symptom development in retrospective analysis of V30M and V122I transthyretin amyloidosis by Sameer U. Kini, Ha My Thi Vy, Madhav Subramanian, Parasuram M. Krishnamoorthy, Son Q. Duong, Ghislain Rocheleau, Jagat Narula, Ron Do, Girish N. Nadkarni

“…This retrospective analysis of microarray and biobank data helped establish clinical biomarkers for early hATTR detection. Methods: In a Portuguese sample of V30M carriers (n = 183), gene profiling identified dysregulated immune markers. …”
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The relationship between prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure and infant neurodevelopment: Modifying effects of DHA revised by Ting-ting Jiang, Lian-man Lei, Xia-yu Zhang, Ya-ling Li, Lu-ming Yan, Zi-shun Lu, Zi-yi Liu, Bo-lin Liu, Lian-jie Dou, An-hui Zhang, Min Yu, Min Zhu, Fei Li, Ji-an Xie, Chao Zhang, Jia-hu Hao

“…Objective: This study aimed to investigate the relationship between prenatal PFAS exposure and infant neurodevelopmental delay and evaluate the effects of postnatal DHA supplementation on infant neurodevelopment. Methods: From October 2020 to December 2022, 2415 mother–newborn pairs were enrolled in the study from China WuHu Birth Cohort Study (WH-BC). …”
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The Hannover Postinfarction Ventricular Septal Rupture Score: A New Scoring System Predicting 30-Day Mortality by Lisa Baustert, Dietmar Boethig, MD, Adelheid Görler, MD, Christian Kühn, MD, Alexander Weymann, MD, Bastian Schmack, MD, Aron-Frederik Popov, MD, Arjang Ruhparwar, MD, Bettina Wiegmann, MD

“…To address the specific conditions of patients with piVSR, the Hannover piVSR Score (HpiVSR) was developed. Methods: Between 2001 and 2019, 45 patients with piVSR underwent surgery. …”
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Adherence to a healthy lifestyle in Russia according to the ESSE-RF study: is there a COVID-19 trace? by О. M. Drapkina, M. B. Kotova, S. A. Maksimov, S. A. Shalnova, Yu. A. Balanova, A. E. Imaeva, V. A. Kutsenko, G. A. Muromtseva, N. S. Karamnova, S. E. Evstifeeva, A. V. Kapustina, O. A. Litinskaya, M. S. Pokrovskaya, E. B. Yarovaya, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, E. N. Chernysheva, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. S. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V, Khokhlova, A. V. Solovyova, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, I. V. Tantsyreva, I. N. Baryshnikova, M. G. Ataev, M. O. Radjabov, M. M. Isakhanova, M. A. Umetov, L. V. Elgarova, I. A. Khakuasheva, E. I. Yamashkina, M. V. Esina, T. A. Kunyaeva, A. M. Nikitina, N. V. Savvina, Yu E. Spiridonova, E. A. Naumova, B. M. Nazarov, A. A. Keskinov, V. S. Yudin, S. M. Yudin, A. V. Kontsevaya

“…To assess adherence to a healthy lifestyle depending on the individual and socio-economic characteristics of the Russian population (according to the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study), followed by a comparative analysis with ESSE-RF2 (2017).Material and methods. The analysis was carried out based on research data from ESSE-RF2 in 2017 and ESSE-RF3 in 2020-2022. …”
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Index pregnancy emotional fertility intention and its correlates in Ethiopia: evidence from a national women and newborns baseline survey by Solomon Abrha Damtew, Tariku Dejene Demissie, Assefa Seme, Niguse Tadele Atnafu, Fitsum Tariku Fantaye, Mahari Yihdego Gidey, Kelemua Mengesha Sene, Bezawork Ayele Kassa, Hailay Gebremichael Gebrekidan, Tariku Tesfaye Bekuma, Aynaw Amogne, Solomon Shiferaw

“…This evidence could serve as an action point to empower women regarding their reproductive health right and the control over their fertility. Methods Nationally representative cross sectional baseline data from the Ethiopian performance monitoring for action (Ethiopian PMA) cohort one survey, which enrolled and collected data from currently pregnant and 6 weeks postpartum women were used for this study. …”
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School-level variation in children’s moderate to vigorous intensity physical activity before and after COVID-19: a multilevel model analysis by Ruth Salway, Danielle House, Robert Walker, Lydia Emm-Collison, Katie Breheny, Kate Sansum, Joanna G Williams, William Hollingworth, Frank de Vocht, Russell Jago

“…Post lockdown, we collected accelerometer, individual and school data from 393 children in 23 of the same schools and 436 children in 27 of the same schools in 2021 (Wave 1) and 2022 (Wave 2), respectively. Methods Sources of variation (between-school, between-pupil and within-pupil) in child weekday moderate to vigorous physical activity at each wave were modelled using linear mixed-effects models with school-level wave random coefficients. …”
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Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomizatio... by Xiaoxiao Zhao, Jiannan Li, Shaodi Yan, Yu Tan, Runzhen Chen, Nan Li, Jinying Zhou, Chen Liu, Peng Zhou, Yi Chen, Hongbing Yan, Hanjun Zhao, Li Song

“…Conclusion CHIP mutations, particularly TET2, are more prevalent in patients with T2DM compared to individuals without diabetes. …”
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Effects of different low temperatures on postharvest physiology and storage quality in Youhou sweet persimmon by JIAO Xuan, ZHANG Huihui, REN Huihui, FENG Zhihong, GAO Zhenfeng, SHI Junfeng, WANG Rufu, ZHANG Lixin

“…The objective of this study was to investigate the storage characteristics of Youhou sweet persimmon and confirm the appropriate cold storage temperature. [Methods] Fruits of Youhou sweet persimmon (Diospyros kaki L. cv. …”
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Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study by A. Biaggi, V. Zonca, C. Anacker, V. Begni, F. Benedetti, A. Bramante, A. Braniecka, V. Brenna, M. Bulgheroni, C. Buss, L. Cavaliere, C.A.M. Cecil, A.C. Couch, D. de Barra, H. El Marroun, S. Entringer, R. Grassi-Oliveira, M. Jackowska, A. Korosi, P.J.C. Kwant, J. Lahti, K. Lekadir, I. Mansuy, F. Manuella, M. Marizzoni, U. Meyer, C. Monk, S. Nakić Radoš, C.M. Pariante, B.J.A. Pollux, K. Priestley, K. Räikkönen, J. Richetto, M.A. Riva, L.M. Rothmann, V. Simonetti, B. Vai, A.C. Vernon, M. Žutić, A. Cattaneo

“…Background: Perinatal depression is common: on average, more than 13% of women suffer from physician-diagnosed disorder and 20% report symptoms bearing clinical relevance. …”
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Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus by Joan T Merrill, Ronald F van Vollenhoven, Daniel J Wallace, Susan Manzi, Cynthia Aranow, Anca Askenase, Michelle A Petri, Jill Buyon, Rosalind Ramsey-Goldman, Ian N Bruce, Guillermo Ruiz-Irastorza, Ellen M Ginzler, Graciela S Alarcón, John G Hanly, Murray B Urowitz, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Anisur Rahman, Mary Anne Dooley, Paul R Fortin, Meggan Mackay, Andreas Jönsen, Sam Lim, Murat Inanc, Diane L Kamen, Christine A Peschken, Søren Jacobsen, Jorge Sanchez-Guerrero, David Isenberg, Marvin J Fritzler, Ann E Clarke, Sasha Bernatsky, Kenneth C Kalunian, Eugene Krustev, May Y Choi, Katherine A Buhler, Ricky Chin

“…We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort.Methods Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort. …”
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全基因组关联分析标准化流程的构建与扩展应用(Development and Extended Applications of Standardized Processes for Genome-Wide Association Studies) by 许喆1，2，石延枫1，2，张杰1，2，姜明慧1，2，刘阳1，2，李昊1，2，3，廖晓凌4，程丝1，2，3(XU Zhe1,2, SHI Yanfeng1,2, ZHANG Jie1,2, JIANG Minghui1,2, LIU Yang1,2, LI Hao1,2,3, LIAO Xiaoling4, CHENG Si1,2,3)

“…However, compared to PLINK and Regenie, SAIGE software offered more appropriate correction and relatively robust statistical testing, especially when case-control samples were biased. …”
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Quality of antidiabetic medicines in 13 sub-Saharan African countries: a cross-sectional surveyResearch in context by Marie Antignac, Roland N'Guetta, Philippe Henri Secretan, Bernard Do, Meo Stephane Ikama, Jean Bruno Mipinda, Ibrahim Ali Toure, Jean Laurent Takombe, Yves Lubenga, Mouhamadoul Mounir Dia, El Bou Isselmou Boukhary Ould, Maxwell Dalaba, Naby Moussa Balde, Amadou Kake, Ely Cheikh Ibrahima Sy, Pauline Cavagna, Marie Cécile Perier, Eugène Sobngwi, Pr Badara Cisse, Christian Boitard, J.P. Empana, I. Bara Diop, Maimouna Ndour Mbaye, Xavier Jouven

“…Out of the 1673 (of 4951 collected) drug samples randomly tested, 28·0% (n: 468, 95% CI [22·3–33·0]) failed to meet standards related to the expected content of active ingredients (B: 27·2% 95% CI [21·5–32·0]; C: 0·8% 95% CI [0·2–3·5]), with more samples showing underdosage (19·31% 95% CI [14·8–24·3]) than overdosage (8·67% 95% CI [5·3–12·5]). …”
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Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome: can we use gut bacteria as potential biomarkers to characteriz... by Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Patricia da Silva Fernandes, Otávio von Ameln Lovison, Otávio von Ameln Lovison, Giovanna de Ross Forni, Giovanna de Ross Forni, Gabriel Silva de Oliveira, Luana Cristina Viana, Dariane Castro Pereira, William Latosinski Matos, William Latosinski Matos, Miriane Melo Silveira Moretti, Fabiana Zempulski Volpato, Luciana Giordani, Luciana Giordani, Patricia Orlandi Barth, Patricia Orlandi Barth, Tarsila Vieceli, Diego Rodrigues Falci, Márcio Manozzo Boniatti, Afonso Luís Barth, Afonso Luís Barth, Afonso Luís Barth, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins

“…The characterization of the gut microbiota of these patients may inform microbiota-based interventions to mitigate antibiotic-induced dysbiosis.ObjectiveThis study aimed to identify key bacterial taxa that distinguish sepsis from non-sepsis patients.MethodsA total of 89 stool samples (51 non-sepsis, 38 sepsis) were evaluated by amplicon sequencing the 16S rRNA gene to assess microbiota diversity and differential abundance. …”
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Safety and efficacy of rotigotine in patients with frontotemporal dementia: a phase 2, double-blind, randomized, placebo-controlled, multicenter trialResearch in context by Giacomo Koch, Martina Assogna, Yasmine Gadola, Antonella Alberici, Francesco Di Lorenzo, Sonia Bonnì, Ilaria Borghi, Emanuele Cerulli Irelli, Lucia Mencarelli, Michele Maiella, Romina Esposito, Elias Paolo Casula, Valentina Pezzopane, Alessia D'Acunto, Francesca Candeo, Matteo Ferraresi, Gisella Guerrera, Luca Battistini, Enrico Premi, Valeria Bracca, Silvia Lucchini, Francesco Bertagna, Pasquale Romano, Andrea Ludovici, Antonio Daniele, Caterina Motta, Clarissa Ferrari, Alessandro Martorana, Barbara Borroni

“…Here we aimed at investigating the clinical impact of treatment with dopaminergic agonists in FTD. Methods: This was a phase IIa 24-week randomized, double-blind, multicenter, placebo-controlled study, conducted in Italy from June 16th 2021 to April 30th 2023. …”
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Response‐adapted zanubrutinib and tislelizumab as a potential strategy to enhance CD19 CAR T‐cell therapy in relapsed/refractory large B‐cell lymphoma: A retrospective observationa... by Rong Shen, Wei‐Guo Cao, Li Wang, Ling‐Shuang Sheng, Yi‐Lun Zhang, Wen Wu, Peng‐Peng Xu, Shu Cheng, Meng‐Ke Liu, Yan Dong, Yue Wang, Xiang‐Qin Weng, Xu‐Feng Jiang, Qi Song, Hong‐Mei Yi, Lei Li, Sheng Chen, Zi‐Xun Yan, Wei‐Li Zhao

“…The combination of targeted therapeutic strategies, particularly bruton tyrosine kinase inhibitor zanubrutinib and programmed death‐1 inhibitor tislelizumab, may improve clinical outcomes and modulate the tumour microenvironment (TME). Methods We studied patients with R/R LBCL who received response‐adapted zanubrutinib plus tislelizumab upon CD19 CAR T‐cell therapy between June 2021 and March 2023. …”
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CREATING THE KULTUK POLYGON FOR EARTHQUAKE PREDICTION: VARIATIONS OF (234U/238U) AND 87SR/86SR IN GROUNDWATER FROM ACTIVE FAULTS AT THE WESTERN SHORE OF LAKE BAIKAL by S. V. Rasskazov, E. P. Chebykin, A. M. Ilyasova, E. N. Vodneva, I. S. Chuvashova, S. A. Bornyakov, A. K. Seminsky, S. V. Snopkov, V. V. Chechel'nitsky, N. A. Gileva

“…These two faults that limit the Sharyzhalgai block of the crystalline basement of the Siberian craton in the south are conjugated in the territory of the Kultuk polygon (Fig 1). Forty sets of samples taken from 27 June 2012 to 28 January 2014 were analysed, and data on 170 samples are discussed in this paper.Methods. …”
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Simulación numérica de un nuevo sensor de anisotropía magnética//Numeric Simulation of a new magnetic anisotropy sensor by Gustavo Eugenio Carro-Hernández, Carlos Manuel Cruz-Inclán, Josué Arteche-Díaz, Antonio Leyva-Fabelo

“…<br /><br /><strong>Key words</strong>: magnetic anisotropy sensor, residual stress, finite element method…”
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The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical an... by Michael G. Fehlings, Karlo M. Pedro, Mohammed Ali Alvi, Ali Moghaddamjou, James S. Harrop, Ralph Stanford, Jonathon Ball, Bizhan Aarabi, Paul M. Arnold, James D. Guest, Shekar N. Kurpad, James M. Schuster, Ahmad N. Nassr, Karl M. Schmitt, Jefferson R. Wilson, Darrel S. Brodke, Faiz U. Ahmad, Albert Yee, Wilson Z. Ray, Nathaniel P. Brooks, Jason Wilson, Diana S-L. Chow, Elizabeth G. Toups, Kevin E. Thorpe, Jiaxin Huang, Peng Huang

“…This strategy fails to adequately capture the full impact of treatment in heterogenous neurological conditions like SCI. A more patient-centric analysis requires assessment of neurological function, functional capacity, and quality of life, incorporating meaningful patient-reported outcomes. …”
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Exploring the effect of multi-modal intervention against cognitive decline on atrophy and small vessel disease imaging markers in the AgeWell.de imaging study by Frauke Beyer, Lukas Kleine, Andrea Zülke, Melanie Luppa, Toralf Mildner, Jochen Gensichen, Thomas Frese, David Czock, Birgitt Wiese, Hans-Helmut König, Hanna Kaduszkiewicz, Wolfgang Hoffmann, Jochen René Thyrian, Arno Villringer, Steffi Riedel-Heller, A.Veronica Witte

“…All other markers progressed similarly across groups, however sample size was smaller than expected. In exploratory analyses, cerebral blood flow increased more in the intervention group and this change was associated with decreases in systolic blood pressure. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Staff have also highlighted the need for training to help them work more appropriately to meet these patients’ needs. …”
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