Emergence of begomoviruses and DNA satellites associated with weeds and intercrops: a potential threat to sustainable production of cassava in Côte d’Ivoire by Aya Ange Naté Yoboué, Aya Ange Naté Yoboué, Bekanvié S. M. Kouakou, Bekanvié S. M. Kouakou, Justin S. Pita, Justin S. Pita, Boni N’Zué, William J.-L. Amoakon, William J.-L. Amoakon, Kan Modeste Kouassi, Kan Modeste Kouassi, Linda Patricia L. Vanié-Léabo, Linda Patricia L. Vanié-Léabo, Nazaire K. Kouassi, Nazaire K. Kouassi, Fatogoma Sorho, Michel Zouzou

“…This study offers insights that will inform the development of more effective control methods for sustainable cassava production in Côte d’Ivoire.…”
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Examining alterations in subjective sleep ratings in individuals with major depressive disorder receiving daily theta burst stimulation by Jennifer Cuda, David Smith, Arthur R. Chaves, Karina L. Fonseca, Jessica Drodge, Stacey Shim, Youssef Nasr, Maya El-Outa, Ram Brender, Ruxandra Antochi, Lisa McMurray, Rebecca Robillard, Sara Tremblay

“…Additionally, changes in depression more closely aligned with changes in sleep-related daytime functioning than with sleep quality per se. …”
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Thrombotic Microangiopathy After Lung Transplantation: A Retrospective Observational Multicenter Cohort Study by Pierre Gazengel, MD, Vincent Bunel, MD, Kinan El-Husseini, MD, Mohamad Zaidan, MD, Edouard Lefevre, MD, Romain Kessler, MD, Xavier Demant, MD, Loïc Falque, MD, Emmanuel Eschapasse, MD, Thomas Villeneuve, MD, Gaelle Dauriat, MD, Pauline Pradère, MD, Olaf Mercier, MD, Elie Fadel, MD, Clément Picard, MD, Jérôme Le Pavec, MD

“…In the belatacept group, renal function at one year was better but death, bacterial pneumonia, and CMV viremia were more common; none of the differences was significant, perhaps given the small sample size. …”
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Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients by Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Maria D. Pinazo-Durán, Vicente Zanón-Moreno, Vicente Zanón-Moreno, Carolina García–Villanueva, Alessio Martucci, Cristina Peris-Martínez, Cristina Peris-Martínez, Jorge Vila-Arteaga, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Jose J. García-Medina, Irene Andrés–Blasco, Irene Andrés–Blasco, Irene Andrés–Blasco, Alex Gallego–Martínez, Alex Gallego–Martínez, Carlo Nucci, Julian García–Feijoo

“…Outstanding clinical trials and animal-model study designs, innovative technology, and analytical approaches in bioinformatics are essential tools to successfully uncover novel glaucoma biomarkers with a high potential for translation into clinical practice.MethodsTo better understand the clinical and biochemical-molecular-genetic glaucoma pathogenesis, we conducted an analytical, observational, and case-comparative/control study in 358 primary open-angle glaucoma (POAG) patients and 226 comparative-control individuals (CG) to collect tears, aqueous humor, and blood samples to be processed for identifying POAG biomarkers by exploring several biological pathways, such as inflammation, neurotransmitter/neurotrophin alteration, oxidative stress, gene expression, miRNAs fingerprint and its biological targets, and vascular endothelial dysfunction, Statistics were done by using the IBM SPSS 25.0 program. …”
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Dedifferentiated liposarcomas treated with immune checkpoint blockade: the MD Anderson experience by Madeline B. Torres, Madeline B. Torres, Cheuk Hong Leung, Marianne Zoghbi, Rossana Lazcano, Davis Ingram, Khalida Wani, Emily Z. Keung, M. Alejandra Zarzour, Christopher P. Scally, Kelly K. Hunt, Anthony Conley, Andrew J. Bishop, B. Ashleigh Guadagnolo, Ahsan Farooqi, Devarati Mitra, Alison K. Yoder, Michael S. Nakazawa, Dejka Araujo, Andrew Livingston, Ravin Ratan, Shreyaskumar Patel, Vinod Ravi, Alexander J. Lazar, Alexander J. Lazar, Christina L. Roland, Neeta Somaiah, Elise F. Nassif Haddad, Elise F. Nassif Haddad

“…This study aimed to evaluate the ORR and survival of patients with DDLPS treated with ICB at a single center.MethodsWe conducted a retrospective study of 31 patients with pathologically confirmed DDLPS treated with ICB at MD Anderson Cancer Center between 2018 and 2023. …”
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AGN STORM 2. II. Ultraviolet Observations of Mrk 817 with the Cosmic Origins Spectrograph on the Hubble Space Telescope by Y. Homayouni, Gisella De Rosa, Rachel Plesha, Gerard A. Kriss, Aaron J. Barth, Edward M. Cackett, Keith Horne, Erin A. Kara, Hermine Landt, Nahum Arav, Benjamin D. Boizelle, Misty C. Bentz, Thomas G. Brink, Michael S. Brotherton, Doron Chelouche, Elena Dalla Bontà, Maryam Dehghanian, Pu Du, Gary J. Ferland, Laura Ferrarese, Carina Fian, Alexei V. Filippenko, Travis Fischer, Ryan J. Foley, Jonathan Gelbord, Michael R. Goad, Diego H. González Buitrago, Varoujan Gorjian, Catherine J. Grier, Patrick B. Hall, Juan V. Hernández Santisteban, Chen Hu, Dragana Ilić, Michael D. Joner, Jelle Kaastra, Shai Kaspi, Christopher S. Kochanek, Kirk T. Korista, Andjelka B. Kovačević, Daniel Kynoch, Yan-Rong Li, Ian M. McHardy, Jacob N. McLane, Missagh Mehdipour, Jake A. Miller, Jake Mitchell, John Montano, Hagai Netzer, Christos Panagiotou, Ethan Partington, Richard W. Pogge, Luka Č. Popović, Daniel Proga, Daniele Rogantini, Thaisa Storchi-Bergmann, David Sanmartim, Matthew R. Siebert, Tommaso Treu, Marianne Vestergaard, Jian-Min Wang, Martin J. Ward, Tim Waters, Peter R. Williams, Fatima Zaidouni, Ying Zu

“…We measure rest-frame delayed responses between the far-ultraviolet continuum at 1180 Å and Ly α λ 1215 Å ( ${10.4}_{-1.4}^{+1.6}$ days), N v λ 1240 Å ( ${15.5}_{-4.8}^{+1.0}$ days), Si iv + ]O iv λ 1397 Å ( ${8.2}_{-1.4}^{+1.4}$ days), C iv λ 1549 Å ( ${11.8}_{-2.8}^{+3.0}$ days), and He ii λ 1640 Å ( ${9.0}_{-1.9}^{+4.5}$ days) using segments of the emission-line profile that are unaffected by absorption and blending, which results in sampling different velocity ranges for each line. However, we find that the emission-line responses to continuum variations are more complex than a simple smoothed, shifted, and scaled version of the continuum light curve. …”
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Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial by Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan

“…Interventions Collection of prespecified standard clinicopathological variables and more novel imaging, genetic and immunohistochemical biomarkers, followed by 3-year follow-up to identify postoperative metastasis. …”
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Genealogy of the Arab tribes living in Syria during the Caliphate of Imam Ali (AS)Typology of the Arab Tribes Living in the Levant during the Caliphate of Imam Ali (AS) Typology... by Akram sadat Hoseini, Yahya Mirhoseini

“…However, a closer examination of the available historical propositions suggests that the reality may have been more nuanced and complex. In this research, we undertook a systematic analysis of the Levantine community by first identifying a sample of 80 Arab tribes residing in the region. …”
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Organizational readiness for change towards implementing a sepsis survivor hospital to home transition-in-care protocol by Elaine Sang, Elaine Sang, Ryan Quinn, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Jiyoun Song, Jiyoun Song, Jiyoun Song, Karen B. Hirschman, Karen B. Hirschman, Karen B. Hirschman, Sang Bin You, Sang Bin You, Katherine S. Pitcher, Katherine S. Pitcher, Nancy A. Hodgson, Nancy A. Hodgson, Nancy A. Hodgson, Patrik Garren, Melissa O'Connor, Sungho Oh, Sungho Oh, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles

“…Future research should confirm, expand, and examine underlying factors related to these findings with a larger and more diverse sample. Additional studies may assess the predictive validity of ORIC towards implementation success.…”
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Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer by Mitchell S. von Itzstein, MD, Jialiang Liu, PhD, Hong Mu-Mosley, PhD, Farjana Fattah, PhD, Jason Y. Park, MD, PhD, Jeffrey A. SoRelle, MD, J. David Farrar, PhD, Mary E. Gwin, MD, David Hsiehchen, MD, Yvonne Gloria-McCutchen, Edward K. Wakeland, PhD, Suzanne Cole, MD, Sheena Bhalla, MD, Radhika Kainthla, MD, Igor Puzanov, MD, MSCI, Benjamin Switzer, DO, MHSA, MS, Gregory A. Daniels, MD, PhD, Yousef Zakharia, MD, Montaser Shaheen, MD, Jianjun Zhang, MD, PhD, Yang Xie, PhD, David E. Gerber, MD

“…To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer. Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. …”
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O jogo como sistema de avaliação no idoso institucionalizado – um estudo piloto (El juego como sistema de evaluación en ancianos institucionalizados - estudio piloto) (Game perfo... by Marlene Rosa, Raquel Marinho, Sara Gordo, Ricardo Pocinho

“…Further studies are needed to replicate the results in larger and more heterogeneous samples. …”
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The heterogeneity of genomic alterations, metastatic patterns and immune microenvironment in metastatic ovarian cancer originating from colorectal cancer by Chao Chen, Chao Chen, Jian Wang, Binjie Sun, Yuyan Zheng, Yuyan Zheng, Xiaoxu Ge, Xiaoxu Ge, Zhiyuan Gong, Zhiyuan Gong, Haochen Gu, Zhiwei Zhang, Zhiwei Zhang, Akao Zhu, Yingkuan Shao, Yeting Hu, Lijia Ma, Yini Li, Kefeng Ding, Kefeng Ding, Da Wang, Lifeng Sun

“…The aim of this study is to explore the special molecular phenotype and dissemination patterns of CRCOM.MethodsThe whole-exome sequencing (WES) was performed on 65 matched tissue samples from 11 CRCOM patients, including 11 primary colorectal cancer (CRC) with 11 matched normal tissues, and 43 multi-site metastases (including 15 CRCOMs and 4 patients had bilateral ovarian metastases (OMs). …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…Review the feasibility study against predetermined progression criteria and ascertain whether progression to a large-scale randomised controlled trial is feasible. Methods Design Two-arm cluster (school) randomised feasibility trial of an adapted ZF programme (ZF-SEND) delivered by teachers to children in special schools. …”
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Constraining Resolved Extragalactic R21 Variation with Well-calibrated ALMA Observations by Jakob den Brok, Elias K. Oakes, Adam K. Leroy, Eric W. Koch, Antonio Usero, Erik W. Rosolowsky, Frank Bigiel, Jiayi Sun, Hao He, Ashley T. Barnes, Yixian Cao, Fu-Heng Liang, Hsi-An Pan, Toshiki Saito, Sumit K. Sarbadhicary, Thomas G. Williams

“…We find strong correlations between R _21 and various galactic parameters, particularly SFR surface density, which shows a power-law slope of 0.10–0.11 depending on the adopted binning/fitting methods. Our findings suggest that, for studies covering main-sequence galaxy samples, assuming a fixed R _21 = 0.64 does not significantly bias kiloparsec-scale molecular gas mass estimates from CO(2–1). …”
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Phase II study of rucaparib and nivolumab in patients with leiomyosarcoma by Robert G Maki, Martina Bradic, Phillip Wong, William Tap, Vicky Makker, Sandra D’Angelo, Angela Green, Mrinal M Gounder, Evan Rosenbaum, Ciara M Kelly, Jason E Chan, Ping Chi, Mark A Dickson, Mary L Keohan, Sujana Movva, Viswatej Avutu, Martee L Hensley, Maria M Rubinstein, Ronak Shah, Kenneth Seier, Karmelina Charalambous, Seth M Cohen, Lauren B Banks, Sara Saunds, Jae-Mun Cho, Robert A Lefkowitz, Joseph Erinjeri, Li-Xuan Qin

“…We therefore evaluated the combination of a PARP inhibitor, rucaparib, and the anti-programmed death receptor-1 monoclonal antibody, nivolumab, in patients with advanced LMS and investigated its effects on the tumor immune microenvironment.Methods This was an open-label, single-center, single-arm, phase II study in patients with advanced refractory LMS. …”
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Twelve-month prevalence of DSM-5 mental disorders and the psychosocial correlates- a child and adolescent psychiatric epidemiologic survey in Hong Kong SARResearch in context by Sandra S.M. Chan, Oscar W.H. Wong, Samara Hussain, Kelvin K.F. Tsoi, Karen K.Y. Ma, Steven W.H. Chau, Suk Ling Ma, Kelly Y.C. Lai, Winnie C.W. Chu, Holly H.L. Lo, Stephy W.S. Ho, Ching Chi Leung, Karen K.L. Yiu, Suzanne H.W. So, Pak C. Sham, Se Fong Hung, Patrick W.L. Leung

“…Findings: The final weighted sample consisted of 6082 participants. The 12-month prevalence of having only one DSM-5 disorder was 13.5% (95% CI: 12.6–14.3%), while the 12-month prevalence of having two or more DSM-5 disorders was 11.0% (95% CI: 10.2–11.8%). …”
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Multiomics reveals tumor microenvironment remodeling in locally advanced gastric and gastroesophageal junction cancer following neoadjuvant immunotherapy and chemotherapy by Yong Liu, Xia Wang, Rui Liu, Le Zhang, Hongli Li, Ting Deng, Lijun Ma, Yanhui Zhang, Lan Su, Yi Ba, Zhi Ji, Jiaqi Xin, Duo Zuo, Xinze Lv, Shaohua Ge, Tingting Ding

“…A detailed multiomic investigation is essential to elucidate these mechanisms.Methods We performed whole-exome sequencing, whole-transcriptome sequencing, multiplex immunofluorescence and single-cell RNA sequencing on matched pretreatment and post-treatment samples from 30 patients enrolled in an investigator-initiated Phase 2 clinical trial (NCT04908566). …”
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Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade by Pedro Rocha, Rafael Bach, Laura Masfarré, Sharia Hernandez, Nil Navarro-Gorro, Adrià Rossell, Xavier Villanueva, Mario Giner, Ignacio Sanchéz, Miguel Galindo, Raúl Del Rey-Vergara, Albert Iñañez, Beatriz Sanchéz-Espiridion, Wei Lu, Ariadna Acedo-Terrades, Pau Berenguer-Molins, Albert Sánchez-Font, Roberto Chalela, Victor Curull, Álvaro Taus, Max Hardy-Werbin, Mark Sausen, Andrew Georgiadis, James White, Jennifer B Jackson, Laura Moliner, Sergi Clavé, Beatriz Bellosillo, Ana Rovira, Ignacio Wistuba, Luisa M Solis Soto, Júlia Perera-Bel, Edurne Arriola

“…Despite widespread adoption of immune checkpoint blockade (ICB) across diverse solid tumors, the quest for a clinically informative biomarker for long-term benefit remains unmet.Methods A total of 49 patients with metastatic NSCLC treated with ICB were included. …”
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Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series by Olav Dajani, Iain Philips, Ester Kristine Størkson, Trude R. Balstad, Leo R. Brown, Asta Bye, Ross Dolan, Christine Greil, Marianne Hjermstad, Gunnhild Jakobsen, Stein Kaasa, James McDonald, Inger Ottestad, Judith Sayers, Melanie Simpson, Mariana S. Sousa, Ola Magne Vagnildhaug, Michael S. Yule, Barry J. A. Laird, Richard J. E. Skipworth, Tora S. Solheim, Mark Stares, Jann Arends, the Cancer Cachexia Endpoints Working Group

“…This review examines oncological endpoints in CC clinical trials. Methods An electronic literature search of MEDLINE, Embase and Cochrane databases (1990–2023) was performed. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…To interrogate mechanisms of divergent immune responses in obese and non-obese patients, we examined the relationship among obesity status, clinical responses, and immune profiles from a diverse, pan-tumor cohort of patients treated with ICI-based therapy.Methods From June 2021 to March 2023, we prospectively collected serial peripheral blood samples from patients with advanced or metastatic solid tumors who received ICI as standard of care at Johns Hopkins. …”
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