Methylation and gene expression patterns in adamantinomatous craniopharyngioma highlight a panel of genes associated with disease progression-free survival by Junier Marrero-Gutiérrez, Ana Carolina Bueno, Ana Carolina Bueno, Clarissa Silva Martins, Rui Milton Patrício Silva-Júnior, Antônio Carlos dos Santos, Marcelo Volpon Santos, Luiz Eduardo Wildemberg, Ximene Lima da Silva Antunes, Monica R. Gadelha, Ayrton Custodio Moreira, Ricardo Zorzetto Nicoliello Vêncio, Sonir Roberto R. Antonini, Margaret de Castro

“…IntroductionOver the past decade, advancements in next-generation sequencing have significantly enhanced our understanding of the molecular pathogenesis of adamantinomatous craniopharyngiomas (ACP).ObjectiveThis study integrated methylome and transcriptome analyses in ACP samples to explore the potential interplay between DNA methylation and RNA expression signatures for diagnostic and prognostic applications in ACP patients.MethodsThis cross-sectional study evaluated clinicopathological features, DNA methylation, and gene expression profiles in 15 patients with ACP (33% women, age range: 3–55 years, 53% diagnosed before 18 years) treated at Ribeirao Preto Medical School, University of São Paulo.ResultsMultidimensional scaling and principal component analysis identified two distinct clusters (ACP-A: n=9, ACP-B: n=6) with consistent composition across DNA methylation and gene expression profiles. …”
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Effectiveness of interventions for improving educational outcomes for people with disabilities in low‐ and middle‐income countries: A systematic review by Xanthe Hunt, Ashrita Saran, Howard White, Hannah Kuper

“…(6) Is there evidence of cumulative effects of interventions? Search Methods The search for studies followed two steps. …”
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Anti-ALK autoantibodies in patients with ALK-positive Non-Small Cell Lung Cancer (NSCLC): A monocentric experience by Claudia Parisi, José Carlos Benitez, Hélène Lecourt, Filippo Gustavo dall’Olio, Mihaela Aldea, Felix Blanc-Durand, Véronique Vergé, Cyril Quivoron, Charles Naltet, Pamela Abdayem, Pernelle Lavaud, Maria Rosa Ghigna, Luc Friboulet, Yohann Loriot, Stéphane De Botton, Vincent Ribrag, Andrea Ardizzoni, David Planchard, Jean-Charles Soria, Fabrice Barlesi, Benjamin Besse

“…Progression-free survival, overall survival, and time to BM were analyzed using Kaplan-Meier methods. Results: We found an anti-ALK a-abs titer in 5 (9 ​%) pts. anti-ALK a-abs did not contribute to prolongation of survival. …”
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Clinical characteristics of AATD-related COPD patients vary with age at diagnosis: data from the EARCO international registry by Dilek Karadoğan, María Torres-Duran, Hanan Tanash, Carlota Rodríguez-García, Jens-Ulrik Stæhr Jensen, Angelo Guido Corsico, José Luis López-Campos, Kenneth Chapman, Christian Clarenbach, Catarina Guimaraes, Eva Bartošovská, Maria Sucena, Juan Luis Rodríguez-Hermosa, José María Hernández-Pérez, Tahsin Gökhan Telatar, Yelda Varol, İpek Özmen, Seda Tural, Alice M Turner, Paul Ellis, for the EARCO study group

“…Multivariate analysis showed that; compared to never-smokers, former smoking (OR: 0.08; 95% CI: 0.03–0.23) and current smoking (OR: 0.43; 95% CI: 0.27–0.70) were negatively associated with a diagnosis at age ≥ 65 in all sample. Compared to the Pi*ZZ genotype, among all sample, Pi*SS was associated with more than a 3-fold increased likelihood of diagnosis at age ≥ 65 and when considering only index cases Pi*SZ was associated with diagnosis age of ≥ 65 (OR: 2.01, 95%CI: 1.01–4.04). …”
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The Lived Experience of Women Regarding Family-Centric Roles in the Southern Neighbourhoods of Tehran by Fatemeh Farhadi babadi, Mehrdad Navabakhsh, Talieh Khademian

“…Following each interview, the conversations were transcribed and analysed using the Van Manen method. In phenomenological research, greater reliability relies on the richness of the collected information and the researcher's ability to analyse and interpret it. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Statistical analysis Primary analysis of the primary outcome used the intention-to-treat (ITT) population with the multiple imputation technique being implemented to deal with missing data in instances where participants were missing any of the HDRS-17 scores. Qualitative methods and analysis A purposive sample was collected of participants and non-participants to explore facilitators and barriers to participation in the trial, and the acceptability of the trial treatments. …”
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Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…Therefore, it is of great importance to analyze the genomic profiles of colorectal cancer and its paraneoplastic tissues, explore the disease-causing risk genes, and search for the potential novel therapeutic targets to improve the therapeutic efficacy of colorectal cancer.MethodsTumor and adjacent tissue samples were harvested from 26 colorectal cancer patients and divided into tumor and paraneoplastic tissues. …”
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Using Nebular Near-infrared Spectroscopy to Measure Asymmetric Chemical Distributions in 2003fg-like Thermonuclear Supernovae by J. O’Hora, C. Ashall, M. Shahbandeh, E. Hsiao, P. Hoeflich, M. D. Stritzinger, L. Galbany, E. Baron, J. DerKacy, S. Kumar, J. Lu, K. Medler, B. Shappee

“…We quantify the asymmetry of these features using five methods: velocity at peak flux, profile tilts, residual testing, velocity fitting, and comparison to deflagration–detonation transition models. …”
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Epidemiological and clinical impact of hepatitis E virus coinfection in chronic hepatitis B infected patients in Hebei, China by Yuzhu Shi, Yuzhu Shi, Yuchen Xie, Yuchen Xie, Ying Chen, Li Yang, Huixia Gao, Yun Guo, Fumin Feng, Jianhua Lu, Erhei Dai

“…However, epidemiological data on HBV/HEV coinfection in the Hebei region are scarce, necessitating further investigation.MethodsWe conducted a multicenter cross-sectional study for infectious diseases across six tertiary hospitals. …”
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Prognostic value of tertiary lymphoid structures in triple-negative breast cancer: integrated analysis with the tumor microenvironment and clinicopathological features by Florence Boissière-Michot, Marie-Christine Chateau, Simon Thézenas, Virginie Lafont, Evelyne Crapez, Evelyne Crapez, Priyanka Sharma, Angélique Bobrie, Angélique Bobrie, Pascal Roger, Séverine Guiu, Séverine Guiu, William Jacot, William Jacot, William Jacot, William Jacot

“…Tertiary lymphoid structures (TLS) are an important TILs source, but they are not integrated in the current prognostic criteria.MethodsIn this retrospective study, TLS were assessed in hematein-eosin-saffron-stained (HES) histological sections from 397 early, chemotherapy-naive TNBC samples after primary surgical resection. …”
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An outbreak investigation of a highly fatal Lassa Fever in Bo District, Sierra Leone, 2023 by Ibrahim Conteh, Hassan Swarray, Gbessay Saffa, Amara Alhaji Sheriff, Solomon Aiah Sogbeh, Umaru Sesay, Kassim Kamara, Anna Jammeh, Adel Hussein Elduma, Gebrekrstos Negash Gebru

“…Trainees of the Sierra Leone Field Epidemiology Training Program were deployed to confirm the diagnosis, assess the magnitude, and identify possible sources of infection and routes of transmission. Methods: We adapted the Lassa fever surveillance case definition, and a suspected case of Lassa Fever was any person who presented with gradual onset of one or more of the following: malaise, fever, headache, cough, nausea, vomiting, myalgia, chest pain, hearing loss and either history of contact with excreta or urine of rodents or history of contact with confirmed Lassa fever case from January 1 to March 14, 2023. …”
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Myocardial infarction in the population of some Russian regions and its prognostic value by S. A. Shalnova, O. M. Drapkina, V. A. Kutsenko, A. V. Kapustina, G. A. Muromtseva, E. B. Yarovaya, Yu. A. Balanova, S. E. Evstifeeva, A. E. Imaeva, E. V. Shlyakhto, S. A. Boytsov, Z. T. Astakhova, O. L. Barbarash, O. A. Belova, Yu. I. Grinshtein, A. Yu. Efanov, O. N. Kalachikova, N. V. Kulakova, S. V. Nedogoda, O. P. Rotar, I. A. Trubacheva, T. M. Chernykh on behalf of the ESSE-RF study participants.

“…To study the prevalence of myocardial infarction (MI) in the population of Russian regions and its contribution to cardiovascular events.Material and methods. The analysis material was representative samples of the population aged 35-64 years from 11 Russian regions,  examined within the multicenter study “Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions  of Russian Federation”. …”
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Risk Factors of Portal Vein Thrombosis in Patients with Different Child-Pugh Classes Liver Cirrhosis by M. Yu. Nadinskaia, Kh. B. Kodzoeva, K. A. Gulyaeva, M.-D. E. Khen, D. I. Koroleva, M. A. Privalov, A. Kh. Tekaeva, V. R. Fedorov, S. G. Prokofev

“…Aim: to evaluate the frequency of portal vein thrombosis (PVT) and build predictive models of the development of PVT for patients with liver cirrhosis (LC) of A and B/C classes by Child-Pugh.Materials and methods. Research design is a case-control. The Case group included 130 patients with newly diagnosed PVT not caused by invasive hepatocellular carcinoma (HCC); 29 patients were assigned to class A, 101 patients were assigned to class B/C. …”
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ASSOCIATION OF BLOOD GENE EXPRESSIONS IN RHEUMATOID ARTHRITIS PATIENTS WITH CLINICAL AND LABORATORY PARAMETERS BEFORE AND AFTER METHOTREXATE THERAPY by E. V. Chetina, N. V. Demidova, D. E. Karateev, G. A. Markova, M. A. Makarov, V. V. Kolomatsky, A. L. Logunov, E. A. Naryshkin, M. M. Lipina, S. A. Makarov, A. N. Kuzin

“…Furthermore, blood and knee articular cartilage samples from 21 patients (mean age, 50.4 years) with late-stage RA and cartilage samples from 25 healthy individuals were investigated. …”
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Role of hormonal factor in development of primary and secondary tumorous process in the brain by O. I. Kit, V. A. Bandovkina, E. M. Frantsiyants, E. E. Rostorguev, I. V. Balyazin-Parfenov, N. D. Cheryarina

“…In various periods of life the influence effect exerted by steroids on nervous cells can change the morphofunctional state of the brain and manifests as altering myelinization, neuronal growth, and differentiation of nerve cells.The present study was aimed at comparing the level of certain some hormones in tissue of glioblastomes, metastases of breast cancer into the brain and meningiomas, as well as the respective peritumoral zones.Materials and methods. Examined were samples of tissue obtained from a total of 56 patients admitted for operative treatment to our Department. …”
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PTSD Coach as an early mobile intervention to improve cancer-related anxiety and psychosocial oncology uptake in patients newly diagnosed with head and neck cancer: pilot randomize... by Laurence Ducharme, Chris Lo, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Michael Antoni, Eric Kuhn, Jason E. Owen, Daren Heyland, Robert Platt, Fabienne Fuehrmann, Nader Sadeghi, Zeev Rosberger, Saul Frenkiel, Khalil Sultanem, George Shenouda, Fabio Cury, Melissa Henry

“…This included assessing the acceptability and potential usefulness of the PTSD Coach mobile app as an early self-management intervention that gives information about anxiety symptoms, offers self-assessment of symptoms with feedback, tools to self-manage anxiety, and connects to support. Methods A three-arm randomized controlled trial was conducted. …”
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Evaluation of the Prebiotic Effect of Spirulina platensis Algal Extract on Lactobacillus acidophilus Survival and Physicochemical Properties of Feta Cheese by Ahmad Yazdani, Hamidreza Kazemeini, Ahmad Nazaktabar

“…Therefore, this study aimed to investigate the prebiotic effect of Spirulina platensis algal extract on Lactobacillus acidophilus bacteria survival and the physical, chemical, and sensory properties of feta cheese during storage at 4 °C for49 days. Methods: S. platensis extract was purchased, ground, and shaken for 48 h. …”
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Support on four paws—does the integration of a therapy dog reduce anxiety and increase positive affect in spider phobics during in vivo exposure therapy?: study protocol for a para... by Tanja Michael, Moritz Nicolai Braun, Monika Equit, Johanna Lass-Hennemann

“…(H5) The treatment in the dog group is not inferior to the treatment in the control group.Methods and analysis In this parallel randomised controlled trial of two groups, n=88 participants (spider phobics without: a current diagnosis of a mental disorder other than a specific phobia, insect bite allergy, dog hair allergy, fear of dogs, current psychopharmacological treatment, and current psychotherapeutic treatment; the sample size calculation is based on the results from our previous study) are randomly allocated (with a 1:1 allocation as per a computer-generated randomisation schedule) to either an ambulant one-session in vivo exposure treatment of spider phobia with a therapy dog (dog group) or without a dog (control group). …”
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Violence prevention accelerators for children and adolescents in South Africa: A path analysis using two pooled cohorts. by Lucie D Cluver, William E Rudgard, Elona Toska, Siyanai Zhou, Laurence Campeau, Yulia Shenderovich, Mark Orkin, Chris Desmond, Alexander Butchart, Howard Taylor, Franziska Meinck, Lorraine Sherr

“…Consequently, governments are requesting additional evidence to inform which 'accelerator' provisions can simultaneously reduce multiple types of violence against children.<h4>Methods and findings</h4>We pooled data from two prospective South African adolescent cohorts including Young Carers (2010-2012) and Mzantsi Wakho (2014-2017). …”
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Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study by Ana Checa-Ros, Antonella Locascio, Owahabanun-Joshua Okojie, Pablo Abellán-Galiana, Luis D’Marco

“…Methods/Results An observational study was performed at UNIRENAL Center (Venezuela), from January to November 2015. …”
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