New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma by Sophie Deshayes, Christophe Blanquart, Erwan Mortier, Judith Fresquet, Noémie Joalland, Agnès Quéméner, Romain Humeau, Mike Maillasson, Héloïse LeBihan, Apolline Salama, Séverine Remy, Carole Guillonneau, Ignacio Anegon

“…Thus, there is a need for a more specific and yet integrative approach.Methods A human mutated form of the extracellular portion of CSF-1R was in silico modelized to trap both IL-34 and CSF-1 with higher affinity than the wild-type CSF-1R by replacing the methionine residue at position 149 with a Lysine (M149K). …”
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Bioassay Guided Fractionation Protocol for Determining Novel Active Compounds in Selected Australian Flora by Janice Mani, Joel Johnson, Holly Hosking, Beatriz E. Hoyos, Kerry B. Walsh, Paul Neilsen, Mani Naiker

“…A large variety of unique and distinct flora of Australia have developed exceptional survival methods and phytochemicals and hence may provide a significant avenue for new drug discovery. …”
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Trends in sensor-based health metrics during and after pregnancy: descriptive data from the apple women's health studyAJOG Global Reports at a Glance by Anshuman Mishra, PhD, Jihyun Park, PhD, Ian Shapiro, PhD, Tyler Fisher-Colbrie, MBA, Donna D. Baird, PhD, Sanaa Suharwardy, MD, Shunan Zhang, PhD, Anne Marie Z. Jukic, PhD, Christine L. Curry, MD, PhD

“…Wearable technology provides an opportunity to understand physiologic and behavioral changes across pregnancy with greater detail, more frequent measurements, and improved accuracy. …”
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Cross-sectional study of the association between diet and physical inactivity with obesity, diabetes and hypertension among older adults in Sierra Leone by Justine Davies, Oyinlola Oyebode, Haja Wurie, Maria Lisa Odland, Miles Witham, Rashid Ansumana, Tahir Bockarie, Joseph Lamin, Ankit Shanker, Mohamed B Jalloh, Alhaji M Kamara

“…Data were collected using a household survey based on the validated WHO STEPs questionnaire.Methods Multivariable logistic regression analysis was performed to determine associations between behavioural risk factors (diet, physical activity and salt intake) and the presence of hypertension, diabetes and/or obesity, adjusting for sociodemographic variables.Primary outcome measure The primary outcomes were the presence of hypertension, diabetes or overweight/obesity. …”
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Study of Concentration of Angiotensin-Converting Enzyme 2 Receptor Proteins in Different Age-groups and Genders with Reference to Susceptibility toward Severe Acute Respiratory Syn... by Shareef M Buvvaji, Vinod Joshi, Bennet Angel, Annette Angel, Poorna Khaneja, Monika Dheer, Bhawna Sharma, Neha Singh, Shilpa Barthwal, Ramesh Joshi, Ambreen S Khan, Nuzhat M Peer, Khushbu Kumari, Reshu Chauhan, Aarya Chitransh

“…The present study aimed to find whether age-specific disease severity was due to different concentrations of ACE2 in the patients. Materials and methods: Nasopharyngeal swab samples of different age-groups and gender from infected COVID-19 patients and healthy individuals were subjected to Enzyme-Linked Immunosorbent Assay (ELISA) for quantitative estimation of ACE2 in the upper respiratory tract. …”
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Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing by Peikai Ding, Shengbin Pei, Yi Zhai, Zheng Qu, Yazhe Yang, Xiaolong Feng, Qiang Liu, Xiangyu Wang, Wenxiang Zhang, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang

“…Objective This study aims to characterize the cellular heterogeneity and unique TME of primary breast angiosarcoma using single-cell RNA sequencing (scRNA-seq), to identify potential therapeutic targets and improve clinical outcomes. Methods Tumor samples were obtained from a patient with bilateral primary breast angiosarcoma and two patients with invasive breast cancer. …”
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SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper by João Pedro Ferreira, Francisco Vasques‐Nóvoa, Francisca Saraiva, Ana C. Oliveira, Jorge Almeida, Ana Beatriz Batista, Arsénio Barbosa, Ana Filipa Ferreira, Cátia Costa, Diogo Santos‐Ferreira, Fernando Friões, Cândida Goncalves, João Tiago Guimarães, Marta Leite, Pedro Marques, Joana Mascarenhas, Maria Inês Matos, Catarina Pereira, Pedro Rodrigues, Abhinav Sharma, Gualter Silva, Inês Pereira‐Sousa, Carla Sousa, Faiez Zannad, Joana Pimenta, Ricardo Fontes‐Carvalho, Adelino Leite‐Moreira

“…Compared to other HFmr/pEF trials, SOGALDI‐PEF patients were older, were more frequently women, had a high prevalence of atrial fibrillation, and had more often a preserved ejection fraction. …”
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Liver fibrosis progression analyzed with AI predicts renal decline by Dan-Qin Sun, Jia-Qi Shen, Xiao-Fei Tong, Ya-Yun Ren, Hai-Yang Yuan, Yang-Yang Li, Xin-Lei Wang, Sui-Dan Chen, Pei-Wu Zhu, Xiao-Dong Wang, Christopher D. Byrne, Giovanni Targher, Lai Wei, Vincent W.S. Wong, Dean Tai, Arun J. Sanyal, Hong You, Ming-Hua Zheng

“…We used an automated quantitative liver fibrosis assessment (qFibrosis) technique to investigate the temporal changes in regional liver fibrosis. Methods: This retrospective longitudinal study included 68 MASLD patients and their paired formalin-fixed sections of liver biopsies. …”
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Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…Thus, our aim in this project was to explore the mechanism by which tricin inhibited the progression of KRAS-mutant NSCLC much more deeply.MethodsFirst of all, we detected the acute toxicity of an intraperitoneal injection of tricin in mice according to the improved up-and-down procedure. …”
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Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (<i>TRBC1</i>/2) Immunostaining as a Rapid and Cost-Effective Alternative to PCR-Based Clonality Studies for the Diagnosis o... by Elizabeth J. Soilleux, Daniel T. Rodgers, Jinlong J. Situ, Shelley C. Evans, Venkata N. Konda, Han-Chieh Yang, Jianxiong Pang, Isabella Gilbey Smith, Pete Rajesh, Maryam Salimi, Soo Weei Ng, Julia Jones, Jodi L. Miller, Rachel Etherington, Margaret Ashton-Key, Graham Ogg

“…We sought to demonstrate the feasibility of detecting TCRbeta1 and TCRbeta2 immunohistochemically in routine clinical (formalin-fixed, paraffin-embedded (FFPE)) tissue sections as a novel diagnostic strategy for T-cell lymphomas. Methods: Recombinant rabbit antibodies were validated using Western blotting and FFPE immunostaining of T-cell leukemia lines. …”
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Associations of endocrine-disrupting chemicals mixtures with serum lipid and glucose metabolism among overweight/obese and normal-weight children: A panel study by Yuanyuan Zhang, Biao Zhang, Huihua Yang, Miao Liu, Jie Wang, Lei Zhao, Wenting Guo, Meng Li, Xuefeng Lai, Liangle Yang, Xiao Meng, Cuijuan Wang, Zhihu Zhang, Xiaomin Zhang

“…Background: Endocrine-disrupting chemicals (EDCs) can disturb lipid and glucose metabolism, but few studies have explored the effects of EDC mixtures and underlying inflammation mechanisms in weight-specific children. Methods: We conducted a panel study with 3 repeated visits among 144 children aged 4–12 years. …”
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Syndemic Factors Associated with Zika Virus Infection Prevalence and Risk Factors in a Cohort of Women Living in Endemic Areas for Arboviruses in Northeast Brazil by Ligia Kerr, Carlos Sanhueza-Sanzana, Marto Leal, Italo Aguiar, Kasim Allel, Moisés H. Sandoval, Cristiane Cunha Frota, Marco Túlio Aguiar, Adriano Ferreira Martins, Livia Dias, Rosa Livia Freitas de Almeida, Francisco Herlânio Costa Carvalho, Francisco Gustavo Silveira Correia, Roberto da Justa Pires Neto, Fernanda Montenegro Araújo, Shirlene Telmos Silva de Lima, Leda Maria Simões Mello, Lucas de Lima Nogueira, Terezinha do Menino Jesus Silva Leitão, Maria da Glória Teixeira, Jeni Stolow, Guilherme Loureiro Werneck, Ivo Castelo Branco Coelho, Ronald Blanton, Ana Zaira da Silva, George W. Rutherford, Carl Kendall

“…Background: We sought to explain the seroprevalence of Zika Virus (ZIKV) as a syndemic of socioeconomic, environmental, and health factors in a cohort of women living in Brazil. Methods: This is a cohort study comprising 1498 women between 15 and 39 years of age followed up in two waves between February 2018 and August 2019. …”
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Identification of Patients With Congestive Heart Failure From the Electronic Health Records of Two Hospitals: Retrospective Study by Daniel Sumsion, Elijah Davis, Marta Fernandes, Ruoqi Wei, Rebecca Milde, Jet Malou Veltink, Wan-Yee Kong, Yiwen Xiong, Samvrit Rao, Tara Westover, Lydia Petersen, Niels Turley, Arjun Singh, Stephanie Buss, Shibani Mukerji, Sahar Zafar, Sudeshna Das, Valdery Moura Junior, Manohar Ghanta, Aditya Gupta, Jennifer Kim, Katie Stone, Emmanuel Mignot, Dennis Hwang, Lynn Marie Trotti, Gari D Clifford, Umakanth Katwa, Robert Thomas, M Brandon Westover, Haoqi Sun

“…Automated analysis of medical records through natural language processing (NLP) enables more efficient adjudication but has not yet been validated across multiple sites. …”
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Analyzing petrographic characteristics and trace element distribution of high-purity quartz deposits from the Peshawar Basin, Pakistan: insights into processing and purification te... by I. Khan, X. Yang, X. Yang, X. Yang, M. Xia, Z. Hou

“…<p>This study examined the potential of quartz vein ore from the Peshawar Basin, Pakistan, as a raw material for producing high-grade, high-purity quartz sand. These samples were purified using a combination of methods including crushing, magnetic separation, ultrasonic cleaning, flotation, high-temperature calcination, water quenching, and acid leaching. …”
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The American Transformative HIV Study: Protocol for a US National Cohort of Sexual and Gender Minority Individuals With HIV by Christian Grov, Alexa B D'Angelo, Chloe Mirzayi, Michelle Dearolf, Elena Hoeppner, Yan Guo, Nicole Richards, Rifa Ehsan, Sarah Kulkarni, Denis Nash, Viraj V Patel, Dustin T Duncan, Meredith Ray, Tyler Bartholomew, Jennifer Manuzak, Jennifer Manuel, Kathryn McCollister, Drew Westmoreland, Adam W Carrico

“… Abstract BackgroundSexual and gender minority (SGM) individuals represent 2%‐5% of the US population, yet continue to account for more than two-thirds of new HIV infections annually. …”
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Entrenamiento físico/técnico/táctico vs entrenamiento físico: efectos en la resistencia/velocidad de futbolistas prejuveniles (Physical/technical/tactical training vs physical trai... by Darley Jhosue Burgos Angulo, Kevin Andrés Sánchez Jiménez, Ronald Alberto Feraud Cañizares, Alex Arturo Perlaza Estupiñán, María Antonieta Coello Castro, Boris René Morales Fischer

“…Objective: To analyze the effects of physical/technical/tactical training and physical training in enhancing resistance/speed capacity in pre-youth soccer players. Methods: Quasi-experimental research, which compares the results in two homogeneous independent samples (Experimental Group 1: n=12; Experimental Group 2: n=13) in a 6-month intervention process, where speed resistance is measured with two performance assessment tests, additionally evaluated at the process end the effectiveness of the shot on goal. …”
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Investigating The Performance Of Local And Indigenous Businesses In Times Of Economic Recession With Emphasis On Developing The Capabilities Of Cooperatives In Sistan And Baluchest... by Ali Asghar Tabavar, Abdoulnaser Derakhshan, Sahar Arefi

“…In general, it can be said that cooperatives, as economic and social organizations, have the necessary power and capacity to organize different classes and groups of people to create sustainable human development, and during the economic recession, they play an effective role in creating stable employment and income generation (Shadmehri, Ahmad 2005).Case studyThe statistical population of the research included the collection of managers, supervisors, and employees of cooperatives located in Sistan and Baluchistan province in the number of 345 people, out of which 182 people were randomly selected as the sample group.Materials and methodsThe current research is of an applied type, Also, this research is one of the empirical research in the field of management. …”
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Impact of SARS-CoV-2 variants on COVID-19 symptomatology and severity during five waves by Bruno Belmonte Martinelli Gomes, Natasha Nicos Ferreira, Pedro Manoel Marques Garibaldi, Cassia Fernanda Sales de Lima Dias, Letícia Nakamura Silva, Maria Aparecida Alves Leite dos Santos Almeida, Glenda Renata de Moraes, Dimas Tadeu Covas, Simone Kashima, Rodrigo Tocantins Calado, Benedito Antônio Lopes Fonseca, Gustavo Jardim Volpe, Marcos de Carvalho Borges

“…This study describes the differences in COVID-19 presentation and outcomes across five variant waves. Methods: This prospective cohort was conducted in Serrana, São Paulo State, Brazil. …”
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Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome by Natalya B. Zakharzhevskaya, Olga Yu Shagaleeva, Daria A. Kashatnikova, Daria A. Kashatnikova, Anton O. Goncharov, Anton O. Goncharov, Daria V. Evsyutina, Dmitry A. Kardonsky, Elizaveta A. Vorobeva, Artemiy S. Silantiev, Viktoria D. Kazakova, Irina V. Kolesnikova, Ivan O. Butenko, Anna A. Vanyushkina, Svetlana V. Smirnova, Andrei V. Chaplin, Andrei V. Chaplin, Boris A. Efimov, Boris A. Efimov

“…It has been demonstrated that symbiont nontoxigenic Bf strains have a more effective “weapon” effect on pathogenic Bf, which is realized through the activity of effector-immune (E-I) protein pairs. …”
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Variations in the milk lipidomic profile of lactating dairy cows fed the diets containing alfalfa hay versus alfalfa silage by Kaizhen Liu, Meiqing Chen, Guoxin Huang, Chuanyou Su, Wenhao Tang, Ning Li, Jiyong Yang, Xufang Wu, Boxue Si, Shengguo Zhao, Nan Zheng, Yangdong Zhang, Jiaqi Wang

“…Previous research has shown that the storage method of grass significantly influences milk composition. …”
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