Spatial distribution and factors associated with HIV testing among adolescent girls and young women in Sierra Leone by Augustus Osborne, Camilla Bangura, Samuel Maxwell Tom Williams, Alusine H. Koroma, Lovel Fornah, Regina M. Yillah, Bright Opoku Ahinkorah

“…This study investigated the spatial distribution of HIV testing and its associated factors among adolescent girls and young women in Sierra Leone. Methods Data from the 2019 Sierra Leone Demographic and Health Survey was used for the study. …”
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First trimester circulating miR-208b-3p and miR-26a-1-3p are relevant to the prediction of gestational hypertension by Andrée-Anne Clément, Cécilia LÉGARÉ, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Michelle S. Scott, Pierre-Étienne Jacques, William D Fraser, Patrice Perron, Renée Guérin, Marie-France Hivert, Anne-Marie Côté, Luigi Bouchard

“…We thus aimed to identify first trimester circulating miRNAs associated with GH and to build a miRNA-based algorithm to predict GH incidence. Methods We quantified miRNAs using next-generation sequencing in plasma samples collected at first trimester of pregnancy in Gen3G (N = 413, including 28 GH cases) and 3D (N = 281, including 21 GH cases) prospective birth cohorts. …”
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Comparison of Conventional Palliative Radiotherapy Fractionation Schedule with Quad Shot Regimen in Locally Advanced Head and Neck Cancer Patients: A Randomised Clinical Trial by Srishti Puraiya, Jitendra Kumar, Arun Kumar Yadav, Afroz Kahkashan Zaidi, Rajendra Kumar, Geeta Singh

“…Aim: To compare the QS regimen administered over two consecutive days versus the Conventional Palliative Regimen in the treatment of locally advanced HNC, in terms of treatment response, acute toxicities and QoL. Materials and Methods: In this prospective randomised clinical trial conducted from May 2023 to July 2024 in the Department of Radiation Oncology at King George's Medical University (KGMU), Lucknow, Uttar Pradesh, India, patients with biopsy-proven locally advanced carcinoma of the head and neck were recruited, with a sample size of 50 in each of the study Group B and control Group A arms. …”
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Omics data integration analysis identified new biological insights into chronic antibody-mediated rejection (CAMR) by Maurizio Bruschi, Simona Granata, Francesca Leone, Laura Barberio, Giovanni Candiano, Paola Pontrelli, Andrea Petretto, Martina Bartolucci, Sonia Spinelli, Loreto Gesualdo, Gianluigi Zaza

“…However, the full biological machinery underlying CAMR has only been partially defined, likely due to the fact thatsingle-omics technologies capture only specific aspects of the biological system and fail to provide a comprehensive understanding of this clinical complication. Methods This study integrated mass spectrometry-based proteomic profiling of serum samples from 19 patients with clinical and histological evidence of CAMR and 26 kidney transplant recipients with normal graft function and histology (CTR) with transcriptomic analysis of peripheral blood mononuclear cells (PBMCs) from an independent cohort of 10 CAMR and 8 CTR patients. …”
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Co‐designing a theory‐informed, multicomponent intervention to increase vaccine uptake with Congolese migrants: A qualitative, community‐based participatory research study (LISOLO... by Alison F. Crawshaw, Lusau M. Kitoko, Sarah L. Nkembi, Laura M. Lutumba, Caroline Hickey, Anna Deal, Jessica Carter, Felicity Knights, Tushna Vandrevala, Alice S. Forster, Sally Hargreaves

“…Participatory research approaches and behaviour change theory hold the potential for developing tailored vaccination interventions that address these complex barriers in partnership with communities and should be explored further. Methods This study used a theory‐informed, community‐based participatory research approach to co‐design a culturally tailored behaviour change intervention aimed at increasing COVID‐19 vaccine uptake among Congolese migrants in London, United Kingdom (2021–2022). …”
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Abstract 040: Hemorrhagic Conversion Patterns After Transition of Stroke Thrombolysis from Alteplase to Tenecteplase; Real‐World Experience by Mohamad Ezzeldin, Courtney Hill, Eryn Percenti, Ali Kerro, Adam Delora, Juan Santos, Hamza Saei, Lisa Greco, Rime Ezzeldin, Mohammad Elghanem, Yazan Alderazi, Yana Kim, Cathleen Poitevint, Osman Mir

“…Objective: We are reporting the rate of symptomatic intracranial hemorrhage(sICH) in TNK and tPA treated stroke populations across two large hospital systems. Methods Design: Retrospective cohort observational study. …”
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Polymorphisms of CYP1A1, CYP1A2, CYP19, and SULT1A1 genes in women with early miscarriage by I. N. Noskova, N. V. Artymuk, L. F. Gulyaeva

“…To determine the frequency of the polymorphisms within the genes encoding estrogen metabolism enzymes: CYP1A1 (rs4646903), CYP1A2 (rs762551), CYP19 (rs700519) and SULT1A1 (rs9282861) in women with early miscarriage.Materials and Methods. We recruited 103 consecutive women who experienced early miscarriage (< 12 weeks of pregnancy, n = 103) and 257 women without past medical history of adverse pregnancy outcomes. …”
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Cardiac Rehabilitation for Fontan Circulation Patients: A Systematic Review, and Meta-Analysis by Luna van de Ven, Ana Clara Félix, Joana Suarez, Jorge Dias, Fátima F. Pinto, Sérgio Laranjo

“…This systematic review and meta-analysis aimed to evaluate the safety, efficacy, and optimal exercise modalities for Fontan patients. <i>Materials and Methods:</i> A systematic search of PubMed, Scopus, Web of Science, and Cochrane Library was conducted on 24 August 2023. …”
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Effectiveness of Therapeutic Plasma Exchange in Paediatric Atypical Haemolytic Uremic Syndrome: A Cohort Study in a Transplant Institute of Gujarat, India by Pooja Yuvraj Modi, Amitkumar Vishnubhai Prajapati, Kamal V Kanodia, Anshuman Saha, Kinnari B Vala

“…However, given the small sample size and retrospective nature of the study, more robust prospective studies and clinical trials are needed to draw general conclusions.…”
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Germicidal Efficiency of 272 nm LED in Relation to the Hospital Strain of Klebsiella Pneumoniae by A. S. Kamrukov, T. V. Chernenkaya, L. Yu. Volodin, S. S. Petrikov, K. A. Popugaev, V. V. Bagrov, I. V. Bukhtiyarov, E. V. Zibarev, K. A. Semenov, V. I. Krylov

“…OF STUDY To evaluate the bactericidal efficacy of 272 nm LED radiation against hospital strains of Klebsiella pneumoniae bacteria characterized by multidrug resistance.Materials and Methods. The studies were carried out with an experimental sample of the LED apparatus for UV irradiation. …”
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Temporal Relationship Between Treatment Burden and Self-Care and Its Impact on Systolic Blood Pressure and Hypertension Control by Jia Z, Niu Z, Xie YJ, Su Z, Wang JJ, Hernandez J, Li YT, Wang HHX

“…The nature of such association opens the door for further primary care research on developing more sustainable hypertension management strategies.Keywords: treatment burden, self-care, systolic blood pressure, hypertension control, cross-lagged panel model, mediation analysis…”
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Dalpiciclib combined with pyrotinib and endocrine therapy in women with ER-positive, HER2-positive advanced breast cancer: A prospective, multicenter, single-arm, phase 2 trial. by Jian Zhang, Yanchun Meng, Biyun Wang, Xinhong Wu, Hongmei Zheng, Jing Hu, Wei Liu, Wenyan Chen, Leiping Wang, Jun Cao, Zhonghua Tao, Ting Li, Sujie Ni, Zhengyan Yu, Lichun Sun, Yun Wang, Qiang Peng, Song Wang, Xin Hu, Jianfei Wang, Yijia Wu, Xichun Hu

“…<h4>Background</h4>Combination of HER2-targeted therapy and endocrine therapy offers a more tolerable alternative to HER2-targeted chemotherapy regimens for estrogen receptor (ER)-positive, HER2-positive advanced breast cancer (ABC), but with compromised efficacy. …”
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Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1 by Jiali Wang, Yunlong Jia, Tianxu Liu, Xinyan Liu, Shuxian Yin, Jiaqi Chen, Xiaoqing Xu, Yi Zhang, Lihua Liu

“…While BIN1 is recognized as a tumor suppressor gene, its role in shaping the tumor microenvironment in NSCLC has yet to be fully clarified. Methods To investigate the relationship between BIN1 expression and CD8+T cell infiltration in NSCLC, we performed a comprehensive data analysis utilizing clinical information from NSCLC patients. …”
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Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial by Taylor B Thompson, Todd W Rice, Guy N Brock, Jonathan Peters, Elliott D Crouser, Matthew Exline, Sonal R Pannu, Jamie Zimmer, Jeffrey C Horowitz

“…We aim to develop a novel approach to targeted oxygenation that collectively uses the accuracy of SaO2 and the feasibility of SpO2 to mitigate occult hypoxaemia and prevent hyperoxaemia.Methods and analysis The Optimization of Inspired Oxygen during Mechanical Ventilation trial is a pragmatic stepped wedge, open label, cluster-randomised controlled trial of an algorithm-based SpO2-SaO2 electronic alert-based oxygen titration protocol. …”
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Efficacy and safety of non-pharmacological therapies for primary insomnia: a network meta-analysis by Qin-hong Zhang, Qin-hong Zhang, Yong-jian Liu, Guanhu Yang, Guanhu Yang, Guanhu Yang, Mei-yi Zhu, Jia-hui Yang, Lun Li, Xiu-mei Yan, Qi-lin Liu, Jin-huan Yue, Xiao-ling Li, Yi-ming Li, Tian-cheng Xu, Fan Jiang

“…This study systematically evaluates the efficacy and safety of various non-pharmacological therapies for adult PI through a network meta-analysis, providing evidence-based guidance for clinicians.MethodsWe analyzed 53 randomized controlled trials (RCTs) involving 4,181 adults with PI. …”
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Abstract 005: Outcomes of Heparin Induced Thrombocytopenia Type II in Aneurysmal Subarachnoid Hemorrhage Patients by Galadu Subah, Aiden K. Lui, Fangyi Lin, Rasheed Hosein‐Woodley, Anaz Uddin, Alexandria Naftchi, Sauson Soldozy, Chirag D. Gandhi, Fawaz Al‐Mufti

“…This study aims to investigate the incidence, complications, and outcomes of SAH patients who develop HIT. Methods ICD‐9‐CM and ICD‐10‐CM codes were used to query the National Inpatient Sample for patients with SAH between 2010 and 2019. …”
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Oestrogen suppresses the adipogenesis of fibro/adipogenic progenitors through reactivating the METTL3–ESR1‐mediated loop in post‐menopausal females by Hao Zhou, Shujing Feng, Jinkui Cai, Xiexiang Shao, Siyuan Zhu, Han Zhou, Yongmin Cao, Ru Wang, Xingzuan Lin, Jianhua Wang

“…This study aimed to investigate the detailed mechanism underlying the excessive muscular fatty infiltration in postmenopausal females. Methods Supraspinatus muscle samples were collected from female patients with or without menopause, and from mice with or without ovariectomy (OVX), to evaluate muscular fatty infiltration and isolated FAPs. …”
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Diagnostic Performance of Clinical Metagenomic Next-Generation Sequencing for Suspected Central Nervous System Infections in a Municipal Hospital: A Retrospective Study in China by Wang H, Zhao J, Wang X, Li M, Hu T, Xu H, Dong M, He W, Che Z

“…With technical improvements for mNGS sample processing to increase throughput and reduce costs, clinicians may use mNGS more widely in municipal hospital laboratories.Keywords: CNS infections, mNGS, CSF, conventional microbiological tests, CMT…”
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Real-time blood gas management: evaluating quantum perfusion system’s accuracy against a standard blood gas analysis in CPB by Bahi Hyasat, Amjad Bani Hani, Ali Al Saraireh, Rana Al Kirmeen, Dina Sabha, Saif Yamin, Islam Massad, Ayman Hammoudeh

“…This non-inferiority study evaluates the Quantum Perfusion System by Spectrum Medical, which features continuous online blood gas monitoring through Quantum workstation (QWS) and Quantum ventilation module (QVM) without the use of cuvettes, against the standard blood gas analysis (BGA) analyzer to assess real-time clinical accuracy. Methods This retrospective study included a sample of 40 patients, monitored continuously with the QPS and compared at intervals against standard BGA measurements. …”
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Glomerular Filtration Rate, its Association with Risk Factors and Cardiovascular Diseases. The Results of the ESSE-RF-2 Study by S. A. Shalnova, S. A. Maksimov, Yu. A. Balanova, S. E. Evstifeeva, A. E. Imaeva, A. V. Kapustina, G. A. Muromtseva, V. I. Tarasov, I. A. Viktorova, A. N. Redko, N. N. Prishchepa, S. S. Yakushin, O. M. Drapkina

“…To study the influence of social determinants on the frequency of glomerular filtration rate (GFR) categories of various levels, as well as associations with a number of cardiovascular diseases (CVD) and cardiovascular risk factors among the population of four Russian regions included in the ESSE-RF-2.Material and methods. The study was performed as part of a multicenter epidemiological study “Epidemiology of cardiovascular diseases in the regions of the Russian Federation. …”
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