Novel coronaviruses and mammarenaviruses of hedgehogs from Russia including the comparison of viral communities of hibernating and active specimens by A. V. Lukina-Gronskaya, I. K. Chudinov, I. K. Chudinov, E. V. Korneenko, E. V. Korneenko, S. D. Mashkova, T. A. Semashko, M. A. Sinkova, L. N. Penkin, E. M. Litvinova, N. Yu Feoktistova, A. S. Speranskaya

“…IntroductionSmall mammals, especially rodents and bats, are known reservoirs of zoonotic viruses, but little is known about the viromes of insectivorous species including hedgehogs (order Eulipotyphla), which often live near human settlements and come into contact with humans.MethodsWe used high-throughput sequencing and metaviromic analysis to describe the viromes of 21 hedgehogs (Erinaceus sp.) sampled from summer 2022 to spring 2023. …”
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Exploring co-occurring conditions in Iraqi children with autism spectrum disorder: prevalence, characteristics, and potential risk factors by Ahmed Kamil Toman, Ahmed Kamil Toman, Ahmed Kamil Toman, Hulla Raoof AbdulRasool, Hulla Raoof AbdulRasool, Faris Lami, Faris Lami, Shatha Mohammed Jasim, Shatha Mohammed Jasim, Osamah Abbas Jaber, Osamah Abbas Jaber, Nahid Dehghan Nayeri, Nahid Dehghan Nayeri, Mahdi Shafiee Sabet, Mahdi Shafiee Sabet, Ghaith Al-Gburi, Ghaith Al-Gburi

“…For Iraqi children, local healthcare systems tend to place more emphasis on the management of ASD itself while neglecting co-occurring conditions.ObjectivesThis study aims to investigate the prevalence, characteristics, and potential risk factors of co-occurring epilepsy, sleep, and weight issues among Iraqi children with ASD.MethodsA multicenter cross-sectional study was conducted from January 24 to August 7, 2024, including children from Imam Hussein Centre, Al-Subtain Academy for Autism and Neurodevelopmental Disorders, and Baghdad’s National Centre for Autism and Child Psychiatry. …”
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Comparison of sedentary time, number of steps and sit-to-stand-transitions of desk-based workers in different office environments including working from home: analysis of quantitat... by Martha Sauter, Eva Backé, Carina Pfab, Michaela Prigge, Claudia Brendler, Falk Liebers, Peter von Löwis, Andrea Pfeiffer, Falko Papenfuss, Janice Hegewald

“…We also aimed to determine if the behaviors differ between both working environments (ie, working from home versus the office) and the office concepts (OPO versus AFO). METHODS: We conducted a cross-sectional study to measure sedentary time, sit-to-stand-transitions (STS), standing, and physical activity (time spent physically active and steps) in different working environments with activPAL3. …”
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Parasite contamination of soil in different Peruvian locations and outside built environments by Carlos Pineda, Maritza Dalí Camones Rivera, Eddyson Montalva Sabino, Lucia Estela Mejia, Katherine Elizabeth Keegan, Lizbet Pilar Patricio Alvarez, Javier Jorge Mora, Fernanda Espinoza Vega, Emilio Rey Mejia, Patrick Olivas Herrera, Elisa Palomino Pando, Zhen Zeng, Athos Silva De Oliveira, Maria Jose Villar Mondragon, Barton Slatko, Eric J. Wetzel, Rojelio Mejia

“…We surveyed soil parasite prevalence, burden, and diversity in several different Peruvian environmental ecologies to catalog current parasite presence and provide a baseline for future surveys. Methods A total of 198 soil samples from 43 locations across three Peruvian regions—Tingo María (TM) (Amazon rainforest), Andabamba/Marabamba (A/M) (Andean highlands), and Huánuco city parks—were analyzed using multi-parallel quantitative real-time polymerase chain reaction (qPCR) to detect soil-transmitted helminths (STH) and protozoan DNA from entry, patio, and latrine sites. …”
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Chemical composition, in vitro gas production, and nutrient degradability of carob leaves as a sustainable feed for ruminants in Tunisia and Palestine by Soha Ghzayel, Soha Ghzayel, Soha Ghzayel, Hajer Ammar, Halimeh Zoabi, Halimeh Zoabi, Halimeh Zoabi, Bassem Abou Aziz, Bassem Abou Aziz, Bassem Abou Aziz, Ahmed E. Kholif, Ahmed E. Kholif, Moyòsore J. Adegbeye, Rym Ben Abdallah, Mario de Haro-Martí, Secundino Lopez, Secundino Lopez, Mireille Chahine

“…This study aimed to evaluate the nutritive value of carob leaves collected from Tunisia and Palestine untreated or treated with urea or sodium hydroxide (NaOH), or supplemented with polyethylene glycol (PEG) on chemical composition and in vitro ruminal fermentation.MethodsCarob leaf samples were collected from either Palestine or Tunisia, and were used either untreated (control) or treated with urea, NaOH at 4% or PEG at 100 mg/g (dry matter (DM) basis), and analyzed for chemical composition. …”
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Evaluating the effectiveness of field-based probiotic treatments for stony coral tissue loss disease in southeast Florida, USA by Kelly A. Pitts, Mackenzie Scheuermann, Jonathan S. Lefcheck, Blake Ushijima, Blake Ushijima, Natalie Danek, E. Murphy McDonald, Aaron R. Milanese, Monica D. Schul, Julie L. Meyer, Kathryn A. Toth, Zachary Ferris, Yesmarie T. De La Flor, Thomas DeMarco, Hunter K. G. Noren, Brian K. Walker, Valerie J. Paul

“…We developed and tested two probiotic deployment methods: (1) the injection of a probiotic in seawater suspension into a weighted bag placed over the coral to treat the whole colony; and (2) a sodium alginate-based paste that was applied directly to each disease lesion. …”
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HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol by Neil Ashman, Ben Caplin, David Wheeler, Tahseen Ahmad Chowdhury, Kieran Mccafferty, Sinead Knight, Paul Hockings, Stanley L Fan, Johannes Hulthe, Robert Kleta, Vasilios Papastefanou, Hemal Mehta, Alan Salama, Sinela Hadzovic, Lisa Jarl, Robert Unwin, Benjamin Challis, Anna K Sundgren, Muhammad Magdi Yaqoob

“…Our primary objective is to identify histological features of DKD associated with kidney endpoints in a cohort of patients diagnosed with type 1 and type 2 DM, proteinuria and kidney impairment.Methods and analysis HEROIC is a longitudinal observational study that aims to recruit 500 patients with DKD at high-risk of renal and cardiovascular events. …”
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Comparing Patient’s Confidence in Clinical Capabilities in Urology: Large Language Models Versus Urologists by Nicolas Carl, Lisa Nguyen, Sarah Haggenmüller, Martin Joachim Hetz, Jana Theres Winterstein, Friedrich Otto Hartung, Britta Gruene, Jakob Nikolas Kather, Tim Holland-Letz, Maurice Stephan Michel, Frederik Wessels, Titus Josef Brinker

“…Through hands-on experience, the study sought to reduce potential biases due to an anticipated lack of AI experience in a real-world urological patient sample. Methods: A total of 300 patients scheduled for counseling were enrolled from February to July 2024. …”
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Early child development in England: Cross-sectional analysis of ASQ®-3 records from the 2-2½-year universal health visiting review using national administrative data (Community Ser... by Jayu Jung, Sarah Cattan, Claire Powell, Jane Barlow, Mengyun Liu, Amanda Clery, Louise Mc Grath-Lone, Catherine Bunting, Jenny Woodman

“…Results Among the 226,505 children from 64 local authorities in the sample with complete ASQ®-3 data, 86.2% met expected level of development. …”
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New Onset of DiabetEs in aSsociation with pancreatic ductal adenocarcinoma (NODES Trial): protocol of a prospective, multicentre observational trial by Péter Hegyi, Andrea Szentesi, Katalin Márta, László Czakó, Noémi Zádori, Dóra Illés, Emese Ivány, Gábor Holzinger, Klára Kosár, M Gordian Adam, Beate Kamlage, Gábor Zsóri, Máté Tajti, Márk M Svébis, Viktor Horváth, Ilona Oláh, Szilárd Váncsa, Bálint Czakó

“…The proposed screening programme may allow the detection of PDAC in the early, operable stage. Diagnosing more patients in the curable stage might decrease the morbidity and mortality rates of PDAC and additionally reduce the burden of the healthcare.Methods and analysis This is a prospective, multicentre observational cohort study. …”
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Investigating mental health disparities in rural sexual and gender minority adults: protocol for the rural exploration and approaches to LGBTQ + Mental Health (REALM) prospective c... by Shoshanna L. Fine, Kalai Willis, Iaah L. Lucas, Kirsten F. Siebach, Jennifer L. Glick, Mariah Valentine-Graves, Savannah Winter, Michael Smith, Thomas Waltz, Gina Bailey Herring, Marissa Hannah, Holly C. Wilcox, Travis Sanchez, Stefan D. Baral, Sarah M. Murray

“…This paper describes the protocol for a prospective cohort study, “Rural Exploration and Approaches for LGBTQ + Mental Health (REALM),” that will explore minority stress in relation to mental health conditions and suicidal behaviors among rural SGM adults. Methods Online processes will be used to recruit and enroll a diverse sample of up to 2,500 SGM adults aged 18 + living in rural counties and small metropolitan areas in the United States to complete an online baseline survey. …”
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Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression by Silvia Di Agostino, Davide La Padula, Vittoria Rago, Caterina Gabriele, Francesco Conforti, Elio Aprigliano, Lidia Urlandini, Elvira Parrotta, Danilo Lofaro, Francesca Vescio, Andrea Sacconi, Valeria Cernaro, Giuseppe Currò, Angela Alibrandi, Girolamo Ranieri, Valeria Zuccalà, Antonio Ieni, Marco Gaspari, Giovanni Cuda, Michele Ammendola, Vittorio Abbonante

“…Stromal cells pre-conditioned with M2-like macrophages upregulated PDPN and more effectively supported the growth of three colon adenocarcinoma cell lines. …”
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Characterization of tongue coating microbiome from patients with colorectal cancer by Qubo Chen, Xiaoting Huang, Haiyan Zhang, Xuanting Jiang, Xuan Zeng, Wanhua Li, Hairong Su, Ying Chen, Fengye Lin, Man Li, Xiangyu Gu, Huihui Jin, Ruohan Wang, Dechang Diao, Wei Wang, Jin Li, Sufen Wei, Weizheng Zhang, Wofeng Liu, Zhiping Huang, Yusheng Deng, Wen Luo, Zuofeng Liu, Beiping Zhang

“…However, little is known on the relationship between tongue coating microbiome and colorectal cancer (CRC).Methods Metagenomic shotgun sequencing was performed on tongue coating samples collected from 30 patients with CRC, 30 patients with colorectal polyps (CP), and 30 healthy controls (HC). …”
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Prevalence, risk factors, and zoonotic implications of gastrointestinal parasites in urban cats in Kazakhstan: A cross-sectional multicity study by Lyudmila A. Lider, Vladimir Kiyan, Dinara M. Seitkamzina, Altay Ussenbayev, Botakoz E. Akmambaeva, Rabiga S. Uakhit, Nellya E. Mannapova, Igor Sytnik, Christian Bauer

“…This study aimed to determine the prevalence, species diversity, and risk factors of intestinal parasitic infections in urban cat populations across five major cities in Kazakhstan, thereby supporting the One Health framework for the prevention of zoonotic diseases. Materials and Methods: A cross-sectional survey was conducted from August 2023 to January 2025, involving 1,301 fecal samples collected from both client-owned and stray cats in Almaty, Astana, Oral, Qostanai, and Shymkent. …”
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Analyzing the Influence of Company's Business Strategy and Its Components as a Factor of Information Risk on Excess Stock Returns by Alireza Rahrovi Dastjerdi, Daryoosh Forooghi, Zahra Moradi

“…Materials & MethodsTo address the research objectives, two hypotheses were formulated to investigate the relationship between a company's business strategy and its excess stock returns, considering information risk as a key factor. …”
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Effects of chemoradiotherapy on surface PD-L1 expression in esophageal cancer and its implications for immunotherapy by Lovis Hampe, Stefan Küffer, Tim Niemeier, Niklas Christian Scheele, Laetitia Zoe Hampe, Anna Luisa Riedl, Laura Anna Fischer, David Alexander Ziegler, Martin Leu, Leif Hendrik Dröge, Alexander König, Michael Ghadimi, Friederike Braulke, Stefan Rieken, Hanibal Bohnenberger, Rami A. El Shafie

“…Higher irradiation doses were more effective in inducing PD-L1 expression, while Paclitaxel alone did not consistently increase PD-L1. …”
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Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis-2 (AuToDeCRA-2) study: protocol for a single-centre, experimental medicine study investigating the route of delivery... by Ema-Louise Long, James Stanway, Michael White, Nicola Goudie, Julia Phillipson, Miranda Morton, Asma Abdul Malek, Philip Brown, Geoff Hide, Ralph Jackson, Colin Nice, John Tuckett, Julie Diboll, Amy Anderson, Arthur Pratt, Catharien M. U. Hilkens, John Isaacs

“…Establishing this and developing a biomarker profile to demonstrate favourable immunomodulation is the focus of AuToDeCRA-2. Methods AuToDeCRA-2 is a non-commercial, phase IIa, 5-arm, randomised, unblinded, single-centre study. …”
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Genetic alterations affect immune contexture of non-small cell lung cancer: Ukrainian study by Denys Kozakov, Denys Kozakov, Nazarii Kobyliak, Nazarii Kobyliak, Sofiia Livshun, Oleksii Seleznov, Oleksii Seleznov, Olena Koshyk, Olena Koshyk, Alina Matvieieva, Yaroslav Shparyk, Oleksii Kolesnik, Oleksii Kolesnik, Yuliia Moskalenko, Oleksandr Vynnychenko, Roman Moskalenko, Serhii Kropyvko, Anna Khmel, Bogdana Shkarupii, Bogdana Shkarupii, Oksana Sulaieva, Oksana Sulaieva, Oksana Sulaieva

“…IntroductionAlthough the role of various genetic alterations was highlighted among factors affecting the response to immunotherapy in non-small cell lung cancer (NSCLC), the relations between oncogenic driver variants and changes in the cancer immunity cycle are still unclear.AimThe study aimed to discover the links between the molecular and immune context of NSCLC.Materials and methodsThis cohort study included 254 cases of NSCLC (193 Lung Adenocarcinomas) (LUAD; 76%), and 61 squamous cell carcinomas (SCC; 24%), with pathology reports and next-generation sequencing (NGS) data available. …”
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A multicentre implementation trial of an Artificial Intelligence-driven biomarker to inform Shared decisions for androgen deprivation therapy in men undergoing prostate radiotherap... by Eric Wegener, Michael Ng, Mario Guerrieri, Timothy N. Showalter, Jeremy de Leon, Sagar Ramani, Marcus Dreosti, Tee Lim, Bradley Wong, Michael Chao, Kathryn Hogan, Avi Raman, Scott McClintock, Darren Foreman, Matthew Brown, Stephen McCombie, Kevin McMillan, Kieran Beattie, Mark Frydenberg, Lih-Ming Wong, Dickon Hayne, John Yaxley, Phillip Stricker, Jarad Martin

“…However, its clinical utility in real-world settings has yet to be measured prospectively. Methods This multicentre implementation trial aims to collect real-world data on the use of the previously validated Artera MMAI-driven prognostic and predictive biomarkers in men with intermediate-risk prostate cancer undergoing curative radiotherapy. …”
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Lifestyle factors and urine levels of organophosphorus flame retardants in endometrial cancer: insights from a case-control study by Yu-Che Ou, Fu-Jen Cheng, Wan-Ting Huang, Wen-Chin Lee, Hung-Chun Fu, Chen-Hsuan Wu, Ying-Yi Chen, Kuo-Chung Lan, Xuan-Ping Liou, Hao Lin, Chia-Te Kung

“…This study aimed to investigate the association between urine levels of OPFRs and endometrial cancer (EC), and to explore the correlation between concentrations of parent OPFR compounds and their metabolites. Methods: Urine samples from 76 EC patients and 76 healthy controls were collected and analyzed for the levels of five common parent OPFRs and their respective metabolites. …”
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