Mass development of a filamentous and likely nitrophilous aerophytic green alga on tree bark: Apatococcus ammoniophilus sp. nov. (Chlorophyta, Trebouxiophyceae) by Ulrik Søchting, Thomas Friedl, Øjvind Moestrup, Felix Grewe, Yukun Sun, Yağmur Tarhana Çakır, Markus Ganzera, Karin Glaser, Svenja Heesch, Fabian Hammerle, Daniel Nimptsch, Birgit Olberg, Ulf Karsten, Ulf Karsten

“…However, its species identity and taxonomy remained unknown.Material and methodsSelected algal samples from various substrates were analyzed for their ribosomal DNA sequences, metagenomic, and biochemical compounds [polyols and mycosporine-like amino acids (MAAs)].ResultsPhylogenetic analyses revealed the alga’s position within the Trebouxiophyceae (Chlorophyta), forming an independent lineage within Apatococcus. …”
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One-year post lockdown trajectories of mental health and impact of COVID-19 lockdown-related factors by Mathilde Mongeau, Samantha Huo Yung Kai, Samantha Huo Yung Kai, Vanina Bongard, Vanina Bongard, Vanina Bongard, Nicola Coley, Nicola Coley, Nicola Coley, Emilie Bérard, Emilie Bérard, Jean Ferrières, Jean Ferrières, Jean Ferrières

“…IntroductionConcerns about the impact of restrictive measures on people’s wellbeing, especially mental health, were raised by the COVID-19 pandemic and related lockdown measures.MethodsIn this study, we examined longitudinal trajectories of mental health during the initial French lockdown period and up to one-year post-lockdown, among a representative sample of French adults aged over 50. …”
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A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution by Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

“…Methods Tumor, liver, and blood samples were obtained from patients undergoing resection for non-metastatic PDAC. …”
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A Comparative Study of the Perspectives of Long‐Stay Immigrants, Nurses and Cultural Mediators on Intercultural Communication: A Secondary Qualitative Analysis by Francesc Ramos‐Roure, Maria Feijoo‐Cid, Josep Maria Manresa‐Dominguez, Jordi Segura‐Bernal, Rosa García‐Sierra, Maria Isabel Fernández‐Cano, Antonia Arreciado Marañón, Eduard Moreno‐Gabriel, Clara Flamarich Gol, Pere Toran‐Monserrat

“…Design Qualitative secondary analysis of data obtained in two primary studies. Methods Two sets of data from two primary studies on nurses and long‐stay immigrants (including in total two focus groups and 15 in‐depth interviews) were merged. …”
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Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Also notable is the presence of proliferative lymphocytes, the occurrence of which positively correlates with more aggressive tumor behavior in the bulk RNA-seq cohort. …”
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PIDLF+: A Novel Adaptive PIDLF for Forestry Height Mapping Based on Single-Baseline PolInSAR Data by Dandan Li, Hailiang Lu, Mercedes E. Paoletti, Juan M. Haut, Juntao Gu, Chao Li, Weipeng Jing

“…Meanwhile, the lack of training samples imposes additional constraints on the efficacy of supervised DL-based methods. …”
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Evaluation of perioperative care and drivers of cost in geriatric thoracolumbar trauma by Omar H. Tarawneh, Rajkishen Narayanan, Michael McCurdy, Tariq Z. Issa, Yunsoo Lee, Olivia Opara, Nicholas B. Pohl, Alexa Tomlak, Matthew Sherman, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Gregory D. Schroeder, Christopher K. Kepler

“…Secondarily, we examined the variability of cost across age groups by identifying drivers of cost of care. Materials and methods: We queried the United States Nationwide Inpatient Sample(NIS) for adult patients undergoing spinal fusion for thoracolumbar fractures between 2012 and 2017. …”
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Gestational diabetes-combined excess weight gain exacerbates gut microbiota dysbiosis in newborns, associated with reduced abundance of Clostridium, Coriobacteriaceae, and Collinse... by Yunshan Xiao, Yunshan Xiao, Yunshan Xiao, Yuan Shi, Yuan Shi, Yuan Shi, Yan Ni, Meilan Ni, Yuxin Yang, Xueqin Zhang, Xueqin Zhang, Xueqin Zhang

“…The association between gestational weight gain before/after GDM diagnosis and neonatal gut microbiota characteristics is also unclear.The purpose of this study is to conduct investigation and analysis on the above-mentioned issues, providing a basis for optimizing clinical management plans.MethodsThis study involved 98 mother-infant pairs categorized into GDM and non-GDM groups. …”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…While confirming the efficacy of the holistic approach, the results reveal the need for more efficient coordination between professionals and early involvement of rehabilitation specialists. …”
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Factors associated with head circumference and indices of cognitive development in early childhood by Matthew R Grigsby, William Checkley, Tahmeed Ahmed, Zulfiqar Ahmed Bhutta, Laura Nicolaou, Pascal Bessong, Margaret Kosek, Aldo A M Lima, Sanjaya Shrestha, Ram Chandyo, Estomih R Mduma, Laura Murray-Kolb, Brooks Morgan

“…We sought to understand the relationship among various biological and socioeconomic risk factors, HC and cognitive development.Methods We analysed data across resource-poor settings in Bangladesh, India, Nepal, Peru, South Africa and Tanzania from the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development longitudinal birth cohort study. …”
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Petrology of Oligocene Lalehzar igneous rocks in the southeast of Saveh-Naein-Jiroft magmatic belt by Fatemeh Sepidbar, Bahareh Borouzi Niyat

“…Research method About 100 samples were sampled from namerous Lalehzar intrusive and volcanic outcrops Afterward, 50 granitoid and volcanic rocks were selected for mineralogical studies. 12 samples of volcanic and granitoid rocks that had little alteration were selected for major and minor elements analyzes. …”
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Youth co-production for sustainable engagement and empowerment in health (YiPEE): protocol for a cluster-randomised controlled trial of an intervention for mental health promotion... by Josefien van Olmen, Pilvikki Absetz, Mark Tomlinson, Carina King, Edwin Wouters, Josefien van Olmen, G J Melendez-Torres, Jeroen De Man, Stefan Swartling Peterson, Suresh Kumar, Mariam Claeson, Monika Martens, Frances Mathews, Christina A Laurenzi, Yoona Kim, Yeukai Chideya, Maria Niemi, Vijaya Raghavan, Jill Åhs, Anu Linnansaari, Fredric Azariah, Moitreyee Sinha, Upasana Sharma, Orlaith O’Sullivan, Yoo Na Kim, Akshaya Rajesh, Samyukta Saravanan, Nivetha Vasanthan, N P Haritha, Lander Willem, Jeroen de Man, Christina Laurenzi, GJ Melendez Torres, Matt Hughsam, Maureen Gikonyo, Joyce Arita

“…Therefore, an intervention that focuses on developing these strengths and is delivered within a school environment, through an adolescent-informed approach using creativity-focused components, has the potential to improve adolescent mental health and well-being.Methods and analysis This protocol describes the YiPEE cluster-randomised controlled trial with concurrent mixed-methods process evaluation and economic evaluation, which aims to determine the impact of a multilevel multicomponent intervention in schools in Chennai, Tamil Nadu, India. …”
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Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…This study aims to identify and characterize plasma miRNAs associated with HF and cardiovascular death. Methods: The association between 21 candidate miRNAs and HF or cardiovascular death was evaluated in 4541 patients from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes (MERLIN)-TIMI 36 trial using samples from the time of index hospitalization for ACS. …”
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Gait characteristics in people with Friedreich ataxia: daily life versus clinic measures by Hannah L. Casey, Vrutangkumar V. Shah, Vrutangkumar V. Shah, Daniel Muzyka, James McNames, James McNames, Mahmoud El-Gohary, Kristen Sowalsky, Delaram Safarpour, Patricia Carlson-Kuhta, Christian Rummey, Fay B. Horak, Fay B. Horak, Christopher M. Gomez

“…To better understand gait during daily life, we compared measures that discriminated Friedreich ataxia (FRDA) from healthy control (HC) subjects in prescribed clinic tests and free, daily-life monitoring.MethodsWe recruited 9 people with FRDA (median age: 20, IQR [12, 48] years). …”
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Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-bl... by Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

“…In this study, we conducted a randomized, double-blind investigation to examine the impact of inulin and fructooligosaccharides (FOS) on glycemic metabolism in overweight/obese and healthy adults. Methods A total of 131 adults were included, with 44 receiving inulin, 43 receiving FOS, and 44 receiving placebo over a period of 4 weeks. …”
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16S rRNA and metabolomics reveal the key microbes and key metabolites that regulate diarrhea in Holstein male calves by P. P. Cao, C. L. Hu, M. J. Li, Y. H. An, X. Feng, X. H. Ma, D. Z. Wang, Z. H. Song, G. S. Ji, D. Yang, Q. Ma, W. F. Yang, J. N. Dong, H. R. Zhang, Y. Ma, Y. F. Ma

“…This study aimed to investigate the impact of diarrhea on calf growth.MethodsHolstein male calves with similar birth weight (39.5 ± 4.2 kg) were included in this study, and key parameters such as fecal score, diarrhea incidence, and growth performance from birth to weaning were measured. …”
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Unveiling B7/CD28 family proteins in hepatocellular carcinoma: insights into communication and prognostic significance by Yan Cai, Xiaodi Liu, Xiaodi Liu, Tao He, Yangming Xu, Shuxian Chen, Xianliang Tan, Shouchao Wei, Zimeng Wu, Liying Xiao, Baoming Luo, Baoming Luo

“…Although there has been extensive research on the role of programmed cell death-ligand 1 (PD-L1) in hepatocellular carcinoma (HCC), our understanding of the effects of other inhibitory B7/CD28 family members is still limited despite advancements in prognostic tools, more specific, accurate, and robust biomarkers are required to improve HCC patient prognoses.MethodsWe acquired the single-cell sequencing data from relevant literature and selected 42 liver tissue samples, including 89,246 cells from HCC patients, to investigate the expression, localization, and intercellular communications of the B7/CD28 family in HCC. …”
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The ORVAC trial protocol: a phase IV, double-blind, randomised, placebo-controlled clinical trial of a third scheduled dose of Rotarix rotavirus vaccine in Australian Indigenous in... by Jonathan Carapetis, Tom Snelling, Mark A Jones, Julie A Marsh, Bianca Fleur Middleton, Claire S Waddington, Margaret Danchin, Carly McCallum, Sarah Gallagher, Ross Andrews, Carl Kirkwood, Nigel Cunliffe

“…Despite this, Northern Territory Indigenous children continue to be hospitalised with rotavirus at a rate more than 20 times higher than non-Indigenous children in other Australian jurisdictions, with evidence of waning protection in the second year of life. …”
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T‐Wave Alternans Measured by 24‐Hour Ambulatory Recordings Rather Than Exercise Stress Tests as a Risk Stratification Marker in Patients With Long QT Syndrome by Jing Yang, Jiangying Luo, Kun Li, Dan Li, Tingting Lv, Fulan Liu, Yuanwei Liu, Fei She, Rong He, Ping Zhang

“…Background Few small‐sample studies have quantified the T‐wave alternans (TWA) value by 24‐hour ambulatory recordings or exercise stress tests in patients with long QT syndrome (LQTS). …”
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Activated CD27+PD-1+ CD8 T Cells and CD4 T Regulatory Cells Dominate the Tumor Microenvironment in Refractory Celiac Disease Type II by Tessa Dieckman, Mette Schreurs, Ciska Lindelauf, Ahmed Mahfouz, Caroline R. Meijer, Louise Pigeaud, Vincent van Unen, Gerd Bouma, Frits Koning

“…Here, we characterized CD8 and CD4 T cells in RCDII duodenum at the single-cell level and in situ. Methods: We applied mass cytometry on CD45+ duodenal cells derived from intestinal biopsies (n = 23) and blood samples (n = 20) from RCDII patients and controls. …”
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