Effectiveness and Safety of DLBS3233 in Newly Diagnosed Type 2 Diabetes Mellitus: A 12-week Clinical Trial by Heri Nugroho, Nurmilawati Nurmilawati, Diana Novitasari, Lidia Rombeallo, Rambu Farah Effendi, Reski Reski, Intan Surayya, Nugroho Agung Daryanto, Solomon Putera, Raymond Rubianto Tjandrawinata

“…Further research with larger samples and more prolonged duration is warranted to comprehensively explore DLBS3233’s potential in T2DM management.…”
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Outcomes of Out‐of‐Hospital Cardiac Arrest at Centers With and Without On‐Site Coronary Angiography: A Nationwide Analysis by Shayan Ebrahimian, Troy Coaston, Amulya Vadlakonda, Joseph Hadaya, Sara Sakowitz, Ali Nsair, Radoslav Zinoviev, Boback Ziaeian, Eric H. Yang, Gregg C. Fonarow, Olcay Aksoy, Peyman Benharash

“…However, national data evaluating outcomes of OHCA admission to such centers remain limited. Methods Using the 2021 National Inpatient Sample, we identified all direct OHCA hospitalizations across US facilities. …”
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Effectiveness and Safety of DLBS3233 in Newly Diagnosed Type 2 Diabetes Mellitus: A 12-week Clinical Trial by Heri Nugroho, Nurmilawati Nurmilawati, Diana Novitasari, Lidia Rombeallo, Rambu Farah Effendi, Reski Reski, Intan Surayya, Nugroho Agung Daryanto, Solomon Putera, Raymond Rubianto Tjandrawinata

“…Further research with larger samples and more prolonged duration is warranted to comprehensively explore DLBS3233’s potential in T2DM management. …”
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Addressing the gap in preterm resuscitation practices in high-income and low-middle income countries: a multicenter survey of the Asian neonatal network collaboration by Rinawati Rohsiswatmo, Rizalya Dewi, Jennie Sutantio, Zubair Amin, Young-Ah Youn, Sae Yun Kim, Su Jin Cho, Yun Sil Chang, Satoshi Kusuda, Fuyu Miyake, Tetsuya Isayama

“…This study aimed to evaluate the resuscitation practices of high-risk infants in a large multi-country sample of healthcare facilities among HICs and LMICs in Asia under the AsianNeo Network.MethodsIn 2021, a customized 6-item online survey on resuscitation practices of infants born at <29 weeks gestation (or birth weight <1,200 g) was sent by the representative of each country's neonatal network to all the Neonatal Intensive Care Units (NICUs) participating in AsianNeo network. …”
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Tumor Invasion Distance Based on MRI Is a Novel Prognostic Indicator for I-IIIB Cervical Cancer Patients Treated with Radiotherapy by Linying Liu, Jie Lin, Anyang Li, Ning Xie, Jianfeng Zheng, Youping Xiao, Xuefen Lin, Shizhong Wu, Haijuan Yu, Yang Sun

“…The new risk stratification system based on TID could complement the 2018 FIGO staging system in identifying high-risk patients for more intense treatment and care. Further prospective research with larger samples is warranted to confirm the significance of TID for CC patients treated with RT.…”
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The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis by Erik Hellbacher, Erik Hellbacher, Vincent van Hoef, Alina Johansson, Ann Knight, Ann Knight, Iva Gunnarsson, Iva Gunnarsson, Annette Bruchfeld, Annette Bruchfeld, Per Eriksson, Sophie Ohlsson, Solbritt Rantapää-Dahlqvist, Johanna Dahlqvist, Johanna Dahlqvist

“…This study aimed to identify key molecular signaling pathways activated in AAV and to elucidate molecular distinctions between AAV with proteinase 3 ANCA (PR3-AAV) and AAV with myeloperoxidase ANCA (MPO-AAV).MethodsPlasma samples from 41 cases with active PR3-AAV, 24 with active MPO-AAV and 138 population controls were analyzed for 185 proteins using proximity extension assay and Luminex. …”
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Serum Krebs von den Lungen-6 as a potential biomarker for early diagnosis of silicosis: a case-control study by Qiying Nong, Xuehua Zhu, Lin Zhong, Ying Li, Liang Yao, Zhiming Hu, Shan Wu, Ziping Zou, Cong Li, Zhifang Liu, Kengkeng Chen, Bizhu Zhang, Wei Wei, Yiru Qin, Yongshun Huang, Na Zhao, Lihua Xia

“…This study aims to evaluate the levels of Krebs von den Lungen-6 (KL-6) in patients with early-stage silicosis and explore its potential as a diagnostic biomarker. Methods Blood samples were collected from 40 stage I silicosis patients, 57 dust-exposed workers (DEWs), and 70 healthy controls (HCs). …”
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(Fear of) SARS-CoV-2 infection and psychological distress: a population-based cohort study in southern Switzerland by C. Sculco, B. Bano, G. Piumatti, R. Amati, C. Barbui, L. Crivelli, M. Purgato, E. Albanese

“…Results In our sample, 84.3% of the participants (mean age of 51.30 years, SD = ±.93) were seronegative at baseline. …”
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Comparison of Patellar Tracking Following Kinematic Alignment Versus Mechanical Alignment Total Knee Arthroplasty via the Mini‐Subvastus Approach by Bochen Sun, Yiyang Xu, Guiguan Wang, Long Chen, Fenqi Luo, Guoyu Yu, Yuan Lin, Jie Xu

“…This study aimed to compare radiological parameters of patellar tracking and clinical outcomes between KA‐TKA and MA‐TKA via the mini‐subvastus approach. Methods This prospective randomized controlled study included 234 patients who underwent KA‐TKA and MA‐TKA from January 2022 to October 2023. …”
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Dynamic circulating tumor DNA indicates pathological benefits of additional neoadjuvant chemoimmunotherapy courses for locally advanced non-small-cell lung cancer patients by Dong Lin, Liang Wu, Pei Wang, Xiaolong Li, Xiaolan Wang, Yiran Cai, Kangli Xiong, Xi Chen, Fu Yang, Wei Huang, Xing Wang, Jiang Fan

“…This study introduced minimal residual disease (MRD) based on circulating tumor DNA (ctDNA), and investigated the association between ctDNA-MRD and NCI cycles and pathological response.Materials and methodsThis study was based on a phase III trial (NCT05157776). …”
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Transition experiences of adolescents and young adults working with a patient navigator by Daniella San Martin-Feeney, Sophie Samborn, Brooke Allemang, Megan Patton, Zoya Punjwani, Ken Pfister, Laurel Ryan, Gregory M.T. Guilcher, Lorraine Hamiwka, Scott Klarenbach, Eddy Lang, Kerry McBrien, Alberto Nettel-Aguirre, Danièle Pacaud, Jorge Pinzon, Shannon D. Scott, Lonnie Zwaigenbaum, Curtis Perrott, John Andersen, Gail Andrew, Andrew S. Mackie, Susan Samuel, Gina Dimitropoulos

“…A patient navigator (PN) intervention may mitigate transition-related barriers. Methods: A qualitative study was conducted within a pragmatic randomized controlled trial. …”
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Series 2: Development of a Multiplex Amplicon Next Generation Sequencing Assay for Rapid Assessment of Resistance-Associated Mutations in <i>M. tuberculosis</i> Clinical Cases by Adriana Cabrera, Tracy Lee, Kathleen Kolehmainen, Trevor Hird, Danielle Jorgensen, Calvin Ka-Fung Lo, Hasan Hamze, Alan O’Dwyer, Dan Fornika, Rupinder Kaur KhunKhun, Mabel Rodrigues, Natalie Prystajecky, John Tyson, James E. A. Zlosnik, Inna Sekirov

“…This assay is now in use in our laboratory and offers significantly faster turnaround than both WGS and phenotypic methods on cultured isolates, enabling more rapid, informed treatment decisions for tuberculosis patients.…”
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Psychological Profiles in Ulcerative Colitis and Crohn’s Disease: Distinct Emotional and Behavioral Patterns by Antonio Maria D’Onofrio, Eleonora Maggio, Valentina Milo, Gaspare Filippo Ferrajoli, Daniele Ferrarese, Daniela Pia Rosaria Chieffo, Massimiliano Luciani, Antonio Gasbarrini, Gabriele Sani, Franco Scaldaferri, Rosaria Calia, Giovanni Camardese

“…<b>Methods</b>: We enrolled 29 (44.61%) UC patients and 36 (55.39%) CD patients, all aged 18 years or older. …”
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Ruminococcus gnavus and Biofilm Markers in Feces From Primary Bile Acid Diarrhea Patients Indicate New Disease Mechanisms and Potential for Diagnostic Testing by Evette B.M. Hillman, Danielle Carson, Julian R.F. Walters, Martin Fritzsche, Ryan Mate, Katie E. Chappell, Elena Chekmeneva, Maria Gomez Romero, Stephen J. Lewis, Sjoerd Rijpkema, Elizabeth M.H. Wellington, Ramesh Arasaradnam, Gregory C.A. Amos

“…This study aimed to investigate fecal changes in well-defined subjects. Methods: Fecal samples were compared in BAD patients (n = 26), diagnosed by SeHCAT testing, and healthy controls (n = 21). …”
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Real-world clinical insights and aqueous humor biomarker analysis of diabetic macular edema subtypes classified by OCT following intravitreal injections by Liangzhang Tan, Shoukuan Liu, Wenrui Linghu, Yifeng Ke, Yongtao Li, Emmanuel Eric Pazo, Xinjun Ren

“…Abstract Purpose This study aimed to observe the morphological changes and visual outcomes in diabetic macular edema (DME) subtypes based on optical coherence tomography classification following intravitreal injection. Methods Ninety-four eyes from seventy-eight patients were enrolled between July 1, 2018, and June 30, 2023. …”
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Reaction time variations in normal aging and elderly MCI patients under various cognitive load conditions by Yanfei Zhu, Yanfei Zhu, Zhuoming Chen, Zhengkun Shi, Zhengkun Shi, Junyi Chen, Junyi Chen, Qiankun Zuo, Qiankun Zuo, Zhi Yang, Wenjing Zhang, Wanting Li, Siyu Lu, Siyuan Peng, Lei Gou

“…ObjectivesTo compare reaction time parameters and accuracy rates between cognitively normal older adults and those with mild cognitive impairment (MCI) during the Stroop Color-Word Test, and to investigate how cognitive load modulates performance in MCI.MethodsSpeech audio samples (n = 1,920) were collected from 10 cognitively normal older adults and 10 MCI patients during Stroop task execution. …”
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Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review with Meta-Analysis by Juan José Valenzuela-Fuenzalida, Camila Ignacia Núñez-Castro, Valeria Belén Morán-Durán, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandra Suazo-Santibáñez, Alvaro Becerra-Farfan, Gustavo Oyanedel-Amaro, Alejandro Bruna-Mejias, Guinevere Granite, Daniel Casanova-Martinez, Juan Sanchis-Gimeno

“…To enhance outcomes, it is recommended to develop more accurate imaging tools for pre-surgical analysis, necessitating ongoing research in this area.…”
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Probiotics mitigate stress and inflammation in malnourished adults via gut microbiota modulation: a randomized controlled trial by Maryam Ahmadi-Khorram, Maryam Ahmadi-Khorram, Alireza Hatami, Alireza Hatami, Parastoo Asghari, Parastoo Asghari, Ali Jafarzadeh Esfehani, Asma Afshari, Fateme Javdan, Fateme Javdan, Mohsen Nematy, Mohsen Nematy

“…The current study examined the effects of multi-strain probiotic supplementation on stress levels in underweight individuals using the Perceived Stress Scale (PSS).MethodsA double-blind, randomized, placebo-controlled trial involved 100 underweight participants were randomized to receive either a probiotic supplement (Lactobacillus acidophilus, L. casei, L. rhamnosus; 3 × 109 CFU) or placebo for 8 weeks. …”
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Trends in management of odontoid fractures 2010–2021 by Michael J. Gouzoulis, BS, Anthony E. Seddio, BS, Albert Rancu, BS, Sahir S. Jabbouri, MD, Jay Moran, MD, Arya Varthi, MD, Daniel R. Rubio, MD, Jonathan N. Grauer, MD

“…Outcome Measures: Yearly trends and predictors of odontoid fracture management. Methods: Adult patients with odontoid fractures were abstracted from the large, national, administrative M161Ortho Pearldiver dataset. …”
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Genetic variations in the IDUA gene in Tunisian MPS I families: Identification of a novel microdeletion disrupting substrate binding and structural insights by Mariem Rebai, Yessine Amri, Chaima Sahli, Hajer Foddha, Taieb Messaoud, Hela Boudabous, Hassen Ben Abdennebi, Salima Ferchichi, Latifa Chkioua

“…This study aimed to identify genetic mutations in the IDUA gene among Tunisian families and assess their structural and functional implications. Patients and methods: Genomic DNA was extracted from blood samples of four patients including two siblings from three Tunisian families. …”
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