Vascular-related biological stress, DNA methylation, allostatic load and domain-specific cognition: an integrated machine learning and causal inference approach by Reem Waziry, Olajide A Williams, Henning Tiemeier, Caleb Miles

“…Objective to determine the role of vascular-related biological Stress, DNA methylation-based biological aging and Allostatic Load in the relationship between vascular disorders and major cognitive domains including global cognition, episodic memory and executive function in a representative sample of adults across the age span. Methods The present study included participants from MIDUS refresher sample. …”
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Microbiome-based prediction of allogeneic hematopoietic stem cell transplantation outcome by Oshrit Shtossel, Adi Eshel, Shalev Fried, Mika Geva, Ivetta Danylesko, Ronit Yerushalmi, Noga Shem-Tov, Joshua A. Fein, Marco Fabbrini, Avichai Shimoni, Sondra Turjeman, Yoram Louzoun, Arnon Nagler, Omry Koren, Roni Shouval

“…Using the RATIO model, we found that microbiome features from early time points (weeks 1–2) were most predictive of short-term complications such as acute GVHD, while later samples (weeks 36–70) were more informative for long-term outcomes, including overall survival. …”
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Clinical utility of the FilmArray® meningitis/encephalitis panel in children with suspected central nervous system infection in a low-resource setting – a prospective study in Sout... by Reza Rasti, Elias Kumbakumba, Deborah Nanjebe, Phuthumani Mlotshwa, Milly Nassejje, John Mzee, Stephen Businge, Gilbert Akankwasa, Dan Nyehangane, Jesper Gantelius, Yap Boum, Andreas Mårtensson, Juliet Mwanga-Amumpaire, Tobias Alfvén, Giulia Gaudenzi

“…Results Of 212 enrolled children, CSF was sampled from 194. All samples underwent bacterial culture, of which 193 also underwent FA-ME analyses. …”
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The Effect of “Carvacrol” on Ischemia-Reperfusion Injury in the Skeletal Muscles of Rats by Barış Mardin, Abdullah Özer, Başak Koçak, Ayşegül Küçük, Mustafa Hakan Zor, Şaban Cem Sezen, Mustafa Kavutçu, Mustafa Arslan, Gürsel Levent Oktar

“…Therefore, we contend that more experimental cohort investigations are needed to examine the impact of the Car molecule on preventing I/R injury.…”
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The effect of dental caries and restorative biomaterials on IL-1 β and TNF-α levels in the gingival crevicular fluid by Stefanović Vladimir, Taso Ervin, Kanjevac Tatjana, Abazović Džihan, Rakić Mia, Petković-Ćurčin Aleksandra, Acović Aleksandar, Vojvodić Danilo

“…This paper aimed to estimate the concentrations of the proinflammatory cytokines (IL-1β and TNF-α) in the GCF and to correlate them with caries extension, tooth position, and different restorative biomaterials. Methods. GCF samples were collected from 90 periodontally healthy patients demonstrating at least one tooth with proximal caries and one intact tooth, at the baseline, 7 and 30-days post-treatment. …”
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Stakeholder perspectives on digital wellbeing in Saudi Arabia: a cross-sectional survey by Saud Abdulaziz Alomairah, Michelle Colder Carras, Dahlia Aljuboori, Juliann Saquib, Nazmus Saquib, Mayank Date, Kyeongwon Kim, Faisal Aldayel, Michelle R. Kaufman, Laura K. Clary, Vincent G. van der Rijst, Anouk Tuijnman, Antonius J. van Rooij, Nahlah Alsogaih, Faisal Z. Al-Zabidi, Fahad S. Albeyahi, Johannes Thrul

“…Objective This study aimed to gather insights from societal stakeholders, including youth, parents, policymakers, industry leaders, clinicians, educators, and digital media users, to inform culturally tailored interventions for digital well-being in Saudi Arabia. Methods A purposeful non-random sample of 92 participants representing different stakeholder groups was recruited to complete an online survey, answering questions about their experiences and perspectives on digital media use. …”
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Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma by Yang Peng, Jing Yang, Jixing Ao, Yilin Li, Jia Shen, Xiang He, Dihong Tang, Chaonan Chu, Congrong Liu, Liang Weng

“…However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood. Methods: We performed single-cell RNA sequencing on 11 samples of ADC tumor tissues, with other 4 SCC samples served as controls. …”
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Enteritisin Apostichopus japonicus in Cage Culture Areas in the Fujian Dongwuyang Bay: Pathogenic Characteristics and Bacterial Community Structure by Jinjin WANG, Yingeng WANG, Bin LI, Xiaojun RONG, Meijie LIAO, Jianlong GE, Qiang HUANG, Lu WANG, Guojun SHI

“…The relative abundance of Vibriococcaceae was 34.99% and a mixed diet led to the highest environmental sample abundance. Principal co-ordinates analysis (PCoA) and unweighted pair-group method with arithmetic mean (UPGMA) cluster analyses indicated that the samples of each group were well grouped, and the microbiota types of the mixed diet were similar to that of the intestinal flora. …”
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Evaluation of bronchial hyperresponsiveness in asthmatic paediatric patients using mannitol challenge test – Impacts of body mass index by Sharon S. Y. Leung, Helen S. L. Tsang, Jasmine Chan, Oliver Y. H. Kui, Ping Zeng, Yin Ting Cheung, James-Wesley Cheng, Kate C. C. Chan, Michelle Yu, Patricia Tang, John D. Brannan, Jenny K. W. Lam, Hak-Kim Chan, Albert M. Li

“…Background Increasing epidemiological studies reported that overweight/obese asthma patients had more frequent and severe symptoms and exacerbations, indicating their asthma management may not be sufficient. …”
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Five abdominal computer tomography characteristics facilitate diagnosis of spontaneous perforation of pyometra in women with acute abdomen: a case control study by Yingying He, Chaoran Li, Fang Long, Zhigang Sun, Yangzong Cidan, Jing Li, Penglong Cao, Rui Ma, Weiwei Wang, Xiaoguang Xu, Zhen Xiao

“…Conclusions: The above five CT characteristics and the developed dignostic algorithm could be used as a tool to facilitate the preoperative diagnosis of spontaneous perforation of pyometra, although more tests are needed in large samples of cases.…”
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Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination by Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska

“…The aim of this study was to investigate the epigenetic drift in the response to HBV vaccine in isolated B cells. <b>Methods</b>: Epigenetic drift was measured by counting rare DNA methylation variants. …”
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Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…Current FHAA analysis normally identify free FHAAs that bind surface-bound FH using ELISA techniques. These methods require well-equipped laboratories and qualified staff, and do not measure FH-FHAA complexes, which can make it difficult to correlate titers with clinical outcomes. …”
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COVID-19’s Influence on Ocular Emergency Visits at a Tertiary Referral Center and Its Relationship to Emergency Indications by the American Academy of Ophthalmology by Sharon Armarnik, Michael Kinori, Amir Abd Elkader, Sharon Blum Meirovitch, Noa Kapelushnik, Shiran Madgar, Hila Goldberg, Oded Sagiv, Tamara Wygnanski-Jaffe, Ayelet Priel

“…To examine the trends of ocular emergency admissions during the COVID-19 pandemic at a tertiary care center. Methods. The study’s sample consisted of all patients who were seen in the ophthalmic emergency room (OER) between March 15 and April 15, 2020 (during the COVID-19 pandemic) and in the same time frame of the previous year. …”
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Prenatal thallium exposure and child neurodevelopment at 2 years: a birth cohort study in China by Mingyang Wu, Yanling Shu, Lulu Song, Youjie Wang

“…Objective: To investigate the trimester-specific associations of maternal thallium exposure with early childhood neurodevelopment. Methods: A total of 423 mother-child pairs, with trimester-specific urinary samples, were followed up until the children reached 2 years of age. …”
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Prevalence of Extended-Spectrum β-Lactamase-Producing <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i> and <i>Enterobacter cloacae</i> in Wastewater Effluent in Blantyre, Mala... by Edna Ibrahim, Charity Mkwanda, Edward Masoambeta, Luigia Scudeller, Tomislav Kostyanev, Hussein H. Twabi, Yohane K. Diness, Jobiba Chinkhumba, Janelisa Musaya, Rajhab S. Mkakosya, Surbhi Malhotra-Kumar, Chantal M. Morel, Save Kumwenda, Chisomo L. Msefula

“…<b>Results</b>: A total of 288 samples were collected between April 2023 and March 2024, and 97.6% (281/288) yielded one or more presumptive ESBL isolates. …”
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Highly antimicrobial-resistant Nontyphoidal Salmonella from retail meats and clinical impact in children, Taiwan by Yi-Jung Chang, Mi-Chi Chen, Ye Feng, Lin-Hui Su, Hsin-Chieh Li, Hsin-Ping Yang, Min-Jia Yu, Chyi-Liang Chen, Cheng-Hsun Chiu

“…Background: The epidemiology of nontyphoidal Salmonella (NTS) resistant to ciprofloxacin or ceftriaxone and its impact on patients’ clinical course are rarely reported. Methods: Children with culture-proven salmonellosis treated in a medical center in northern Taiwan in 2017 were enrolled. …”
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Suicidal risk among adolescent psychiatric inpatients: the role of insomnia, depression, and social-personal factors by Valentina Baldini, Martina Gnazzo, Martina Maragno, Rebecca Biagetti, Camilla Stefanini, Francesco Canulli, Giorgia Varallo, Cristina Donati, Giovanni Neri, Andrea Fiorillo, Giuseppe Plazzi

“…Methods We conducted a cross-sectional study on 95 adolescent inpatients (54 suicide attempters, 41 non-attempters) to explore their sociodemographic and clinical variables, including insomnia, depression, and social-personal factors as history of bullying. …”
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Prevalence and predictors of chronic disease among rural and medically underserved populations using smokeless tobacco by Elaine Sang, Elaine Sang, Susan Silva, Sarah Grenon, Courtney Swinkels, Shamatree Shakya, Salsa Deshmukh, Laura J. Fish, Laura J. Fish, Mariana Da Costa, Leigh Ann Simmons, Herbert H. Severson, Kathryn I. Pollak, Kathryn I. Pollak, Devon Noonan, Devon Noonan

“…Inequities in use exist as rural and other medically underserved populations use SLT more than that of the general population. Our study examined prevalence of chronic disease and identified associated risk factors among rural and medically underserved populations using smokeless tobacco.MethodsWe conducted a cross-sectional analysis of baseline data (N = 532) from a clinical trial promoting SLT cessation among adults living in rural and/or medically underserved areas and examined the rates of eight chronic diseases: cancer, lung disease, heart disease, stroke, mental health conditions, diabetes, arthritis/orthopedic conditions, and hypertension. …”
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Employment and the youth mental health crisis in Canada: distinct influences across phases of the school-to-work transition by Véronique Dupéré, Véronique Dupéré, Véronique Dupéré, Mathieu Caron-Diotte, Mathieu Caron-Diotte, Nancy Beauregard, Nancy Beauregard, Clémentine Courdi, Clémentine Courdi, Jiseul Sophia Ahn, Jiseul Sophia Ahn, Elizabeth Olivier, Elizabeth Olivier, Kristel Tardif-Grenier, Kristel Tardif-Grenier, David Litalien

“…This study addresses this gap, considering how the role of employment might vary depending on young adults’ educational status and level.MethodsA representative sample of 6,700 young adults (18–30 y.o.) drawn from Statistics Canada’s Longitudinal and International Study of Adults (2012–2020) was used to examine links between working hours and employment in a study-related job and mental health (life satisfaction, global mental health, psychological distress), beyond prior mental health and background characteristics. …”
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Isolation and identification of strawberry anthracnose and fungicide screening in Henan province by SUN Wenbin, ZHANG Jingjing, SONG Yanhong, ZHAO Xia, LI Gang, ZHOU Houcheng, LIU Lifeng

“…Given the lack of effective agents specifically designed for controlling strawberry anthracnose in agricultural production, the mycelial growth rate method was utilized for indoor virulence testing and to evaluate the efficacy of ten selected fungicides. …”
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