Histomorphological scoring of murine colitis models: A practical guide for the evaluation of colitis and colitis-associated cancer by Marianne Remke, Tanja Groll, Thomas Metzler, Elisabeth Urbauer, Janine Kövilein, Theresa Schnalzger, Jürgen Ruland, Dirk Haller, Katja Steiger

“…Therefore, we aimed to develop an easy-to-use and reproducible score for standardized assessment of colitis and associated cancer models. Methods: In this study, samples from three different colitis models with and without associated cancer formation were analyzed to develop a universal, robust, and reproducible score for the grading of murine colitis models using the following three parameters: 1. …”
Get full text

Within-laboratory SARS-CoV-2 real time PCR testing operations in Nepal: a simulation-based analysisResearch in context by Fannie L. Côté, Nadia Lahrichi, Erica Gralla, Hannah Bakker, Parvathy Krishnan Krishnakumari, Joaquim Gromicho, Arunkumar Govindakarnavar, Runa Jha, Lilee Shrestha, Nirajan Bhusal, Saugat Shrestha, Rashmi Mulmi, Priya Jha, Reuben Samuel, Dhamari Naidoo, Victor J. del Rio Vilas

“…We used a series of “what-if” scenarios under different levels of testing demand and staffing to investigate bottlenecks in the processing of COVID-19 samples in a simulated laboratory environment, assess the impact of potential reagent shortages and increased automation, and more generally, explore the key factors that drive the performance and resilience of the testing system. …”
Get full text

Longitudinal Analysis of Tetanus- and Influenza-Specific IgG Antibodies in Myeloma Patients by Sebastian Kobold, Tim Luetkens, Britta Marlen Bartels, Yanran Cao, York Hildebrandt, Orhan Sezer, Henrike Reinhard, Julia Templin, Katrin Bartels, Nesrine Lajmi, Friedrich Haag, Carsten Bokemeyer, Nicolaus Kröger, Djordje Atanackovic

“…We have performed a longitudinal analysis of IgG-antibody responses against influenza virus (FLU) and tetanus toxoid (TT) as surrogate markers for the B cell-mediated immunity in MM patients. Methods. 1094 serum samples of 190 MM patients and samples from 100 healthy donors were analyzed by ELISA for FLU- and TT-specific antibodies. …”
Get full text

What racial disparities exist in the prevalence of perinatal bipolar disorder in California? by Mercy Eigbike, Mercy Eigbike, Rebecca J. Baer, Rebecca J. Baer, Rebecca J. Baer, Nichole Nidey, Nancy Byatt, Xavier R. Ramirez, Hsiang Huang, Crystal T. Clark, Avareena Schools-Cropper, Scott P. Oltman, Scott P. Oltman, Scott P. Oltman, Laura L. Jelliffe-Pawlowski, Laura L. Jelliffe-Pawlowski, Laura L. Jelliffe-Pawlowski, Laura L. Jelliffe-Pawlowski, Kelli K. Ryckman, Karen M. Tabb, Karen M. Tabb

“…This study sought to examine racial differences in the odds of having a bipolar disorder diagnosis in perinatal women across self-reported racial groups in a large sample in California, USA.MethodThis cross-sectional study uses data from 3,831,593 women who had singleton live births in California, USA from 2011 to 2019 existing in a linked dataset which included hospital discharge records and birth certificates. …”
Get full text

Vegetarian diets: prevalence in the Russian population, regional accents and associations with cardiovascular risk factors. Results of the ESSE-RF, ESSE-RF2 and ESSE-RF3 epidemiolo... by O. M. Drapkina, N. S. Karamnova, S. A. Maksimov, O. B. Shvabskaya, S. A. Shalnova, A. V. Kontsevaya, Yu. A. Balanova, S. E. Evstifeeva, A. E. Imaeva, A. V. Kapustina, M. B. Kotova, G. A. Muromtseva, T. V. Repkina, T. O. Gonoshilova, A. V. Kudryavtsev, N. I. Belova, L. L. Shagrov, M. A. Samotrueva, A. L. Yasenyavskaya, E. N. Chernysheva, S. V. Glukhovskaya, I. A. Levina, E. A. Shirshova, E. B. Dorzhieva, E. Z. Urbanova, N. Yu. Borovkova, V. K. Kurashin, A. S. Tokareva, Yu. I. Ragino, G. I. Simonova, A. D. Khudyakova, V. N. Nikulin, O. R. Aslyamov, G. V. Khokhlova, A. V. Solovyova, A. A. Rodionov, O. V. Kryachkova, Yu. Yu. Shamurova, I. V. Tantsyreva, I. N. Baryshnikova, M. G. Ataev, M. O. Radjabov, M. M. Isakhanova, M. A. Umetov, L. V. Elgarova, I. A. Khakuasheva, E. I. Yamashkina, M. V. Esina, T. A. Kunyaeva, A. M. Nikitina, N. V. Savvina, Yu. E. Spiridonova, E. A. Naumova, A. A. Keskinov, S. M. Yudin, V. S. Yudin

“…To study the prevalence and characteristics of vegetarian diets in the Russian population at the present stage.Material and methods. The analysis included data from representative samples of the adult population 25-74 years old, examined within three sections of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study in 20132014, 2017 and 2020-2022. …”
Get full text

Incorporating social determinants of health into agent-based models of HIV transmission: methodological challenges and future directions by Anna L. Hotton, Pedro Nascimento de Lima, Arindam Fadikar, Nicholson T. Collier, Aditya S. Khanna, Darnell N. Motley, Eric Tatara, Sara Rimer, Ellen Almirol, Harold A. Pollack, John A. Schneider, John A. Schneider, John A. Schneider, Robert J. Lempert, Robert J. Lempert, Jonathan Ozik

“…Using examples from our ongoing work, we will discuss Uncertainty Quantification and Robust Decision Making methods to address some of the above-mentioned challenges and suggest directions for future methodological work in this area.…”
Get full text

Validity and Reliability of the Dental Neglect Scale in German by Katharina Marilena Weil, Theresa Marie Weßlau, Laura Agnes Ingrid Magerfleisch, Hannah Tröger, Lisa Irmscher, David Bantel, Clara Theres Meyer-Probst, Katja Petrowski, Hendrik Berth

“…Further validation with other samples should be conducted.…”
Get full text

Prediction of Cytokine Storm and Mortality in Patients with COVID-19 Admitted to ICU: Do Markers Tell the Story? by Rashid Nadeem, Ashraf Mahmoud Elhoufi, Naheed Elahi Iqbal, Zainab Abdulameer Obaida, Doaa Mohamed Elgohary, Mukesh Kumar Singh, Shymaa Farouk Zoraey, Rami M. Abdalla, Sara Yousif Eltayeb, Crystal Sharon Danthi, Nouha Azaza, Waleed Mohamed Ahmed, Muzammil Hafeez, Maryam AlSada, Fatima Farid Mir

“…Ferritin, CRP, and D-dimers were recorded daily if available for the whole ICU stay, and all other variables were recorded on admission day to ICU. Results: The sample includes 235 records. More than 95% of patients have all markers on the day of admission to ICU were ferritin (median 1,278; IQR 1,424), D-dimer 1.21 (3.4), and CRP 129.5 (121). …”
Get full text

Evaluating dental students’ understanding of oral complications and care management for head and neck cancer patients by Faisal Mehsen Alali, Mohammad Zakaria Nassani, Bassel Tarakji, Nasser Raqe Alqhtani, Ali Robaian, Abdullah Saad Alqahtahni, Faisal S. Alhedyan, Abdullah bin nabhan, Adel Alenzi, Khalid Ayidh Alqahtani, Ali Alrafedah, Maram Alagla, Mohammed A. S. Abuelqomsan, Belal Alsalhani, Anas B. Alsalhani

“…The aim of this study is to serve as a foundation to assess the knowledge base of senior dental students and dental interns in Saudi Arabi regarding their preparedness to manage oral health challenges in cancer patients. Methods A cross-sectional study was conducted through an online Google Forms questionnaire targeting a sample of dental students of the fourth and fifth year as well as dental interns (n = 506), from both private and public universities in Saudi Arabia. …”
Get full text

Genomic insights into multidrug-resistant Enterobacter hormaechei isolates from seafood at retail carrying the mcr-9 gene and other resistance determinants on IncHI2 plasmids by Valeria Michelacci, Silvia Pieralisi, Elisa Albini, Francesca Romana Massacci, Gabriele Angelico, Paola Chiani, Manuela Marra, Maria Carollo, Chiara Francesca Magistrali, Francesca Leoni

“…ABSTRACT: Objectives: We aimed to characterise the genomic features of two multidrug-resistant (MDR) isolates from retail seafood samples. Methods: Antimicrobial susceptibility was determined by minimum inhibitory concentration (MIC) tests. …”
Get full text

Sex disparity in adult asthma—A potential immunomodulatory role of let‐7 family microRNAs by Carina Malmhäll, Jenny Calvén, Julie Weidner, Kristina Johansson, Patricia Ramos‐Ramírez, Emma Boberg, Linda Ekerljung, Roxana Mincheva, Bright Nwaru, Hannu Kankaanranta, Henric Olsson, Christopher McCrae, Madeleine Rådinger

“…Previous findings from animal models have revealed sex‐related differences in inflammatory pathways that may contribute to asthma pathogenesis, but human studies are limited. Methods Airway and blood samples (n = 55 and n = 85 respectively) were collected from adult females and males with asthma and healthy subjects. …”
Get full text

Surgery/anesthesia may cause monocytes to promote tumor development by Yang-Yang Wang, Rui-Lou Zhu, En-Qiang Chang, Xiao-Zhuan Liu, Guang-Zhi Wang, Ning-Tao Li, Wei Zhang, Jun Zhou, Ming-Yang Sun, Xin Zou, Jie Hao, Jia-Qiang Zhang

“…In this study single-cell sequencing technology was used to investigate the effect of surgery/anesthesia on peripheral blood mononuclear cells (PBMCs) in depth during the perioperative period. Methods We performed an in-depth analysis of our previously published data, which included a total of 4 patients were recruited in this study. …”
Get full text

The Minimum Dietary Diversity For Women Indicator Can Be Extended To Children And Adolescents aged 4-15 Years As A Proxy Population Indicator For Good Micronutrient Adequacy Of Die... by Loty Diop, Aulo Gelli, Lieven Huybregts, Joanne E Arsenault, Lilia Bliznashka, Erick Boy, Megan Deitchler, Carl Lachat, Mourad Moursi, Angelica M Ochoa-Avilés, Deanna K Olney, Elodie Becquey

“…Background: The response to the global call for more data on children’s and adolescents’ diets and nutrition is limited by the lack of straightforward practical indicators to track their diet quality. …”
Get full text

Sex differences in the prevalence of high-risk oral and anal human papillomavirus infections among heterosexually active populations in Ibadan, Nigeria by Imran Morhason-Bello, Imran Morhason-Bello, Imran Morhason-Bello, Yusuf Bello, Yusuf Bello, Yusuf Bello, Deborah Oke, Deborah Oke, Deborah Oke, Adekunle Daniel, Adekunle Daniel, Akinyele Adisa, Akinyele Adisa, Adeola Fowotade, Adeola Fowotade, Yinan Zheng, Yinan Zheng, Joshua Akinyemi, Joshua Akinyemi, Isaac Adewole, Miquel A. Pavon, Robert Murphy, Lifang Hou, Lifang Hou, Suzanna C. Francis, Deborah Watson-Jones, Deborah Watson-Jones

“…PurposeTo determine sex differences in the prevalence of oral and anal high-risk HPV infections among heterosexually active males and females in Ibadan.MethodsThis was a secondary analysis from the Sexual Behavior and HPV Infections in Nigerians in Ibadan (SHINI) study that involved sexually active males and females aged 18–45 years. …”
Get full text

Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China by Yongxiang Wang, Xiaolei Han, Xianda Zhang, Zhonglin Zhang, Lin Cong, Shi Tang, Tingting Hou, Cuicui Liu, Xiaojuan Han, Qinghua Zhang, Jianli Feng, Ling Yin, Lin Song, Yi Dong, Rui Liu, Yuanjing Li, Tiia Ngandu, Miia Kivipelto, Heather Snyder, Maria Carrillo, Jonas Persson, Laura Fratiglioni, Lenore J Launer, Jianping Jia, Yifeng Du, Chengxuan Qiu

“…Participants examined for the specific modules were younger, more likely to be women, and more educated than those not examined. …”
Get full text

Machine learning and discriminant analysis model for predicting benign and malignant pulmonary nodules by Zhi Li, Wenjing Zhang, Jinyi Huang, Ling Lu, Dongming Xie, Jinrong Zhang, Jiamin Liang, Yuepeng Sui, Linyuan Liu, Jianjun Zou, Ao Lin, Lei Yang, Fuman Qiu, Zhaoting Hu, Mei Wu, Yibin Deng, Xin Zhang, Jiachun Lu

“…While a range of predictive models have been developed for the identification of MPNs, there are still some challenges in distinguishing between BPNs and MPNs. Methods We included a total of 5197 patients for the case-control study according to the preset exclusion criteria and sample size. …”
Get full text

Assessment of Microsatellite Genetic Diversity of Cultured Eriocheir sinensis Populations from Jiangsu and Anhui by Yuting HU, Jun LING, He JIANG, Huan WANG, Tingshuang PAN, Guoqing DUAN, Huaxing ZHOU, Min YANG, Tong LI

“…Therefore, the culture of Chinese mitten crabs in Jiangsu and Anhui plays a pivotal role in the country. After more than 30 years of development, China has established ecological and large-scale breeding systems for juvenile crabs. …”
Get full text

PLASMOpred: A Machine Learning-Based Web Application for Predicting Antimalarial Small Molecules Targeting the Apical Membrane Antigen 1–Rhoptry Neck Protein 2 Invasion Complex by Eugene Lamptey, Jessica Oparebea, Gabriel Anyaele, Belinda Ofosu, George Hanson, Patrick O. Sakyi, Odame Agyapong, Dominic S. Y. Amuzu, Whelton A. Miller, Samuel K. Kwofie, Henrietta Esi Mensah-Brown

“…<b>Objective:</b> Falciparum malaria is a major global health concern, affecting more than half of the world’s population and causing over half a million deaths annually. …”
Get full text

Longitudinal fecal microbiota and volatile metabolomics preceding necrotizing enterocolitis in preterm infants: a case–control study by S. el Manouni el Hassani, N. M. Frerichs, D. J. C. Berkhout, T. Nijsen, H. H. Knobel, H. Weda, M. Xu, X. Long, L. Wijnoltz, M. M. van Weissenbruch, A. H. van Kaam, V. Cossey, C. F. W. Peeters, R. A. van Lingen, C. V. Hulzebos, D. C. Vijlbrief, W. P. de Boode, B. W. Kramer, A. E. Budding, M. A. Benninga, N. K. H. de Boer, H. J. Niemarkt, T. G. J. de Meij

Get full text

Influence of Different Pigmentations and Accelerated Aging on the Hardness and Tear Strength of the A-2186 and MDX4-4210 Silicones by Estefânia Marrega Malavazi, Daniela Micheline dos Santos, Clóvis Lamartine de Moraes Melo Neto, Fernanda Pereira de Caxias, Emily Vivianne Freitas da Silva, Lisiane Cristina Bannwart, Aldiéris Alves Pesqueira, André Luiz de Melo Moreno, André Pinheiro de Magalhães Bertoz, Marcelo Coelho Goiato

“…To evaluate the influence of different pigmentations and accelerated aging on the hardness and tear strength of the A-2186 and MDX4-4210 silicones. Materials and Methods. The samples A-2186 and MDX4-4210 were manufactured without and with pigmentations (black, bronze, and pink). …”
Get full text