Health care utilization among Medicare beneficiaries with newly diagnosed back pain by Maria Isabel Barros Guinle, BA, Thomas Johnstone, BS, Gabriela D. Ruiz Colón, MD, Yingjie Weng, MHS, Ella A. Nettnin, BS, John K. Ratliff, MD

“…No previous study has characterized health care costs and treatment patterns of LBP among Medicare beneficiaries. Methods: This retrospective cohort study quantifies health care utilization costs among Medicare beneficiaries with newly diagnosed LBP, compares costs between patients managed operatively and nonoperatively, identifies costs associated with treatment guideline nonadherence, and characterizes opioid prescribing patterns. …”
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Characterization of medical device randomized controlled trials with adaptive designs by Gui Su, Dan Shen, Dongyuan Deng, Qianqian Bai, Hui Xie

“…We aimed to characterize medical device RCTs with adaptive designs. Materials & methods:We searched for adaptive RCTs in the following databases: ClinicalTrials.gov, International Clinical Trials Registry Platform and the International Standard Randomised Controlled Trial Number registry. …”

Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study by Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt

“…Here we investigated effects of CAR-T cells on the innate immune system which is an important contributor to pathology in SSc. Methods Longitudinal analysis of peripheral blood mononuclear cells from an Scl70 + SSc patient treated with CAR-T cells sampled over 18 months by 29-color spectral flow cytometry, in vitro experiments using sera from patient cohorts. …”
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Effects of different mind-body exercises on pain in patients with knee osteoarthritis: A pairwise, network, and dose-response meta-analysis by Bei Wu, Wenyu Liu, Shuang Wang, Huimin Li, Meng Yin

“…Sex and age may affect treatment effects, with women responding more significantly to tai chi. Due to the limitations of risk of bias and low confidence level, future studies should expand the sample size, conduct strict blinding control, etc. to improve the reliability and applicability of research evidence. …”
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First experience of using alginate polymer polysaccharide hemostatic hydrogel in complex endoscopic treatment of unstable gastroduodenal ulcer bleeding: Clinical cases by S. V. Barannikov, E. F. Cherednikov, G. V. Polubkova, A. K. Vorontsov, Yu. V. Maleev, A. E. Bolkhovitinov, G. V. Prokhorov

“…However, the present paper describes only the first experience of the clinical use of hemostatic alginate polymer polysaccharide hemostatic hydrogel, which is to be analyzed in more details on a larger sample of patients.…”
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Magnitude, distribution and determinants of non-utilization of antenatal care services among women in low- and middle-income countries: Insights for implementation of WHO recommend... by Tadesse Tarik Tamir, Deresse Abebe Gebrehana, Alebachew Ferede Zegeye, Bewuketu Terefe, Berhan Tekeba

“…This study was aimed to assess the magnitude, spatial distribution, and determinants of non-utilization of ANC services in LMICs.<h4>Methods</h4>This study analyzed data from the most recent Demographic and Health Surveys conducted between 2015 and 2024, encompassing a total of 47 LMICs. …”
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Emergency department visits among rural and urban older adults: disparities in ambulatory and emergency care sensitive conditions by Cameron J. Gettel, Courtney Kitchen, Craig Rothenberg, Yuxiao Song, Ryan Koski-Vacirca, Katherine Schaffer, Alexander T. Janke, Nicholas M. Mohr, Margaret Greenwood-Ericksen, Arjun K. Venkatesh

“…Methods We conducted a pooled cross-sectional analysis of 2016–2020 Medicare Current Beneficiary Survey data, assessing ED visitation rates for ACSCs and ECSCs. …”
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Staying afloat on a realm of shifting sands: carers navigating palliative care in their rural settings by Bonnie Zhu, Peter Lin, Heidi Bevan, Anne Croker, Karin Fisher

“…Locating our research in the interpretive paradigm, we sought to develop a conceptual framework to inform reflections and discussions to provide meaningful support for carers involved in palliative care in rural areas. Methods: Our qualitative research, undertaken in the interpretive paradigm, was informed by philosophical hermeneutics. …”
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Digital Cognitive Behavioral Therapy–Based Treatment for Insomnia, Nightmares, and Posttraumatic Stress Disorder Symptoms in Survivors of Wildfires: Pilot Randomized Feasibility Tr... by Fadia Isaac, Britt Klein, Huy Nguyen, Shaun Watson, Gerard A Kennedy

“…Future research studies should aim at evaluating the intervention in a more definitive trial with a larger sample size. …”
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No Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population by Amanda D. Rocha, Suzane Garcia, Andressa B. Santos, José C. C. Eduardo, Claudio T. Mesquita, Jocemir R. Lugon, Jorge P. Strogoff-de-Matos

“…We intended to evaluate if the race-ethnicity adjustment proposed for the sCr-based CKD-EPI equations is appropriate for the Brazilian population. Methods. CKD outpatients had blood samples collected for determination of sCr and serum cystatin C (sCys) levels. …”
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Microwave ablation of non-small cell lung cancer enhances local T-cell abundance and alters monocyte interactions by Run-Qi Guo, Yuan-Ming Li, Zhi-Xin Bie, Jin-Zhao Peng, Xiao-Guang Li

“…Objective The present study was conducted to identify changes in immune cell populations and analyse dysregulated genes in immune cells after MWA in NSCLC microenvironment. Methods The patients received fractionated MWA in two treatments separated by 3 weeks. …”
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Hospitalizations for Infective Endocarditis in Children: 15-Year Analysis by Margarida Dias, Rita Amorim, Ana Luísa Correia, Marisa Pereira, Ana Correia-Costa, Ana Reis-Melo, Margarida Tavares

“…Streptococci are still described as the most prevalent etiology, but Staphylococci are known to become more frequent, as shown in our sample. Awareness of IE in patients with heart disease and implanted prosthetic material is crucial. …”
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Salivary pH Levels at Three Different Time Intervals after Application of Silver Diamine Fluoride in Children with Severe Early Childhood Caries: A Quasi-experimental Study by Umapathy Thimmegowda, Sanchitha Venkatahanumaiah, Pradnya Dhamnekar, Pallavi Nagappa Kuri, Gadigi Sampreetha

“…This alkaline solution is known to be more resistant to acidic environments than hydroxyapatite. …”
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The Impact of Training Given to Nulliparous Pregnant Women for Attaining Identity and being Satisfied with the Maternal Role by Soghra Jamshidbeiki, Zohreh Khakbazan, Mehrnaz Geranmayeh, Siyamak Tahmasebi, Abbas Mehran

“…Objective: This study aimed at determining the impact of training on nulliparous Pregnant women in attaining identity and satisfaction with the maternal role. Materials and Methods: This is a quasi-experimental intervention study. …”
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Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization by Weisheng Li, Baoguo Xia, Weixin Chu, Likui Lu, Xuedong Liu

“…Although prostate cancer is common, little is known about its causes, which makes treatment more difficult. Studies suggest that immunity and inflammation are linked to prostate cancer. …”
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Multiple deprivations as drivers of suboptimal basic child vaccination in Latin America and the Caribbean: cross-sectional analysis of household survey data for 18,136 children acr... by Fato Fene, Mira Johri, Manassé Eliantus Michel, Hortensia Reyes-Morales, Blanca Estela Pelcastre-Villafuerte

“…This study provides an up-to-date cross-sectional analysis of prevalence, subnational variation, and key determinants of suboptimal basic child vaccination (BCV). Methods We produced weighted estimates of suboptimal BCV prevalence at the national and subnational levels via harmonized data from household surveys spanning a 12-year period (2011–2022) in the LAC region. …”
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Investigation of Lassa Fever outbreak in Grand Bassa County, Liberia, 2021 by Phebe Jackson Thomas, Dora Dadzie, Irene Amedzro, Ernest Kenu, Janjay Hilary Glay

“…The County Surveillance Office organized a joint (District, County, and a resident of the Ghana Field Epidemiology and Laboratory Training Program (GFELTP)) rapid response team to investigate with aimed to confirm the outbreak, describe its magnitude and implement control and preventive measures. Methods: The investigation covered March to June 2021 in Grand Bassa County District. …”
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Significance of the peripheral blood Treg/Th17 ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma and its correlation with 1q21 gain/amplification by Jingjing Wen, Qiaolin Zhou, Fang Xu, Jing Yue, Ya Zhang, Yiping Liu, Jing Su, Xiaogong Liang

“…Despite advances in immunotherapy, current risk stratification lacks immune biomarkers.MethodsWe collected the peripheral blood and bone marrow samples from MM patients to investigate the relationships among 1q21 gain/amplification, the Treg/Th17 ratio, and MYC gene abnormalities at diagnosis, remission, and relapse. …”
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Effects of exercise intensity and diet on cardiac tissue structure and FGF21/β-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD + STZ induced type 2 dia... by Sevda Moharamzadeh, Majid Kashef, Mojtaba Salehpour, Meysam Torabi, Samira Vesali, Zakieh Samsonchi, Ensiyeh Hajizadeh-Saffar

“…Finally, the tissue and serum samples were collected and analyzed by two-way ANOVA. …”
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Morphological Changes Depending on the Contentof Clozapine and its Metabolites in the Lungs and Serum (Experimental Study) by O. L. Romanova, D. V. Sundukov, A. M. Golubev, M. I. Blagonravov

“…The purpose of the study: to assess the morphological changes in the lungs depending on the content of clozapine and its metabolites in the lungs and serum.Materials and methods. The experiments were performed on male outbred rats weighing 290-350 g at the age of 20 weeks (n=15). …”
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