Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients by Yushi Nagaki, MD, PhD, Satoru Motoyama, MD, PhD, Yusuke Sato, MD, PhD, Akiyuki Wakita, MD, PhD, Hiromu Fujita, MD, PhD, Kohei Kemuriyama, MD, Ryohei Sasamori, MD, Shu Nozaki, MD, Kyoko Nomura, MD, PhD, Yoshihiro Minamiya, MD, PhD

“…In addition, several studies have suggested that chemotherapy and radiotherapy may convert cold tumors to hot tumors. Methods:. Of 105 ESCC patients who underwent surgery after NACRT between 2010 and 2018 at our hospital, 99 whose biopsy tissue samples were obtained were enrolled. …”
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Metabolic Characterization of Deceased Donor Kidneys Undergoing Hypothermic Machine Perfusion Before Transplantation Using 13C-enriched Glucose by Kamlesh Patel, PhD, Jay Nath, PhD, Thomas Smith, PhD, Tom Darius, PhD, Alpesh Thakker, PhD, Sarah Dimeloe, PhD, Nicholas Inston, PhD, Andrew Ready, MD, Christian Ludwig, PhD

“…This study aimed to describe de novo metabolism in ex vivo human kidneys undergoing HMP before transplantation using 13C-labeled glucose as a metabolic tracer. Methods. Cadaveric human kidneys were perfused with modified clinical-grade perfusion fluid (kidney perfusion solution [KPS-1], Organ Recovery Systems), in which glucose was uniformly enriched with the stable isotope 13C ([U-13C] glucose). …”
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Plate waste in hospital canteens: a nutritional and environmental analysis in north-eastern Italy by Federica Fiori, Diana Menis, Peter Cautero, Peter Cautero, Daniela Zago, Daniela Zago, Marco Driutti, Marco Driutti, Lucia Lesa, Alessandro Conte, Enrico Scarpis, Laura Brunelli, Laura Brunelli, Maria Parpinel

“…The aim of this study was to quantify and characterize plate waste generated by users in three hospital worksite canteens in Italy.MethodsUser’s trays were photographed before and after lunch consumption on 5 days. …”
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Osteosarcopenia as a risk factor for depression: Longitudinal findings from the SHARE study by Nicola Veronese, Francesco Saverio Ragusa, Shaun Sabico, Ligia Juliana Dominguez, Mario Barbagallo, Gustavo Duque, Lee Smith, Nasser Al-Daghri

“…Methods: Osteosarcopenia was defined as the concomitant presence of osteoporosis and sarcopenia; depressive symptoms in the SHARE study were self-reported using the EURO-D scale. …”
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Prevalence of Dental Fear and Its Association with Oral Health Status Among School Children in Bosnia and Herzegovina: A Cross-Sectional Study by Jelena Eric, Bojana Davidovic, Rasa Mladenovic, Marko Milosavljevic, Ivana Dmitruk Miljevic, Ljiljana Bjelovic, Svjetlana Jankovic, Olivera Dolic, Brankica Davidovic

“…<i>Background and Objective</i>: This study aimed to examine the prevalence of dental fear among schoolchildren in Bosnia and Herzegovina, analyze the distribution of dental anxiety by gender, age, and place of residence in relation to perceived sources of fear, and evaluate its association with oral health status. <i>Materials and Methods</i>: The sample included 355 schoolchildren between the ages of 12 and 15. …”
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Evidence for Evolutionary Pathway-dependent Black Hole Scaling Relations by Jonathan H. Cohn, Emmanuel Durodola, Quinn O. Casey, Erini Lambrides, Ryan C. Hickox

“…However, BH masses in high- z AGN are generally estimated from single-epoch measurements, which carry large systematic uncertainties. More reliable M _BH detection methods like dynamical measurements are currently only possible in the local Universe or with strongly lensed systems. …”
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Assessing Microplastic Contamination in Shellfish: Insights from Pantai Remis Kuala Selangor, Strait of Malacca, Malaysia by Aliyah Abdul Aziz, Mohamed Syazwan Osman, Nadiah Wan Rasdi, Farah Ayuni Shafie, Nur Azalina Suzianti Feisal, Muhamaad Afiq Zaki, Siti Rohana Mohd Yatim

“…To effectively mitigate this environmental concern and comprehend the long-term ecological ramifications of MP intake by shellfish, more research is required.…”
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Streptococcus pyogenes in Neonates and Postpartum Women: First Report on Prevalence, Resistance, emm Typing, and Risk Factors in Khyber Pakhtunkhwa by BASIT ABDUL, HUSSAIN MUBBASHIR, QASIM MUHAMMAD, KHAN TAJ ALI, NAVEED HASSAN, REH-MAN ABDUL, SHAH MIAN MUFARIH, FATIMA MADIHA, ALZAHRANI KHALID J., ALSHARIF KHALAF F.

“…S. pyogenes isolates were identified using standard microbiological methods, and antibiotic susceptibility was assessed via the Kirby–Bauer disk diffusion assay. …”
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Systemic Health Characteristics and Self-Reported Xerostomia among Nursing Facility Residents in Iowa-US and Sao Paulo-Brazil by Erica Recker, Mariana Sarmet Smiderle Mendes, Derec Blanchette, Deborah V Dawson, Howard Cowen, Jennifer Hartshorn, Jarbas Francisco Fernandes dos Santos, Leandro Notari Chester, Daniel Caplan, Leonardo Marchini

“… Objective: To describe and compare potential differences in systemic health characteristics and xerostomia among residents in American and Brazilian nursing facilities (NF). Material and Methods: This secondary analysis used data from a study in NF located in Iowa-USA (n=81) and Sao Paulo (SP)-Brazil (n=119). …”
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Virus-like Particle Vaccine for Feline Panleukopenia: Immunogenicity and Protective Efficacy in Cats by Tongyan Wang, Hongchao Wu, Yanwei Wang, Yang Guan, Yujiao Cao, Lulu Wang, Mengyue Wang, Feifei Tan, Wenqiang Pang, Kegong Tian

“…Methods: Sf9 insect cells were infected with recombinant baculovirus to express VP2 protein. …”
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Chemoresistance of PRAME-expressing melanoma cell can be resolved with help of bortezomib by V. A. Misyurin, D. V. Kalenichenko, A. A. Rudakova, Yu. P. Finashutina, N. A. Lyzhko, V. V. Tikhonova, L. A. Kesaeva, O. N. Solopova, A. Е. Misyurina, A. N. Velikanov, M. А. Baryshnikovа, A. V. Misyurin

“…We hypothesized that this phenomenon determines chemoresistance of PRAME-expressing cell, which can be overcome by NF-κB inhibitors, such as bortezomib.Materials and methods. We incubated A875 melanoma cells with cisplatin, bortezomib and dexamethasone, as well as with a mixture  of cisplatin with bortezomib and cisplatin with dexamethasone within 24 hours. …”
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Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany by Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand

“…This study aimed to assess the distribution of different C. difficile RTs in hospitals in the Berlin-Brandenburg area, and to analyse the heterogeneity within isolates of different ribotypes using WGS. Methods Between February 2020 and November 2021, stool samples from patients with laboratory-confirmed CDI were collected from 22 hospitals (approximately 13,900 beds) in Berlin and Brandenburg. …”
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Differential effects of work and socioeconomic status on breastfeeding duration in times of crisis by Chadia Haddad, Paula Hage Boutros, Hala Sacre, Rana Rizk, Cosette Fakih EL Khoury, Bahia Abdallah, Joanne Karam, Pascale Salameh

“…Methods A cross-sectional study was conducted among Lebanese mothers who have recently breastfed. …”
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FAT1 mutation-related signature predicts survival risk and tumor immunogenicity in lung adenocarcinoma by Lifeng Gao, Xueying Wang, Yixin Xu, Aimin Wang, Wenjing Zhang, Qinghua Wang, Yanfeng Ren

“…In this study, we aim to identify a FAT1 mutation-related transcriptomic risk signature to assess the survival risks and immune status of LUAD patients.MethodsA total of 2528 LUAD samples, which included both gene expression profiles and clinicopathologic data, were collected from 12 datasets. …”
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Milk Donation Awareness of Parents, Health Workers and Lactation Consultants: Survey Findings by Olga L. Lukoyanova, Tatyana E. Borovik, Irina A. Belyaeva, Leyla S. Namazova-Baranova, Galina V. Yatsyk, Elena V. Shepkina, Ulyana M. Lebedeva, Vladimir I. Phurtsev, Yakov Ya. Yakovlev, Lyudmila N. Sophronova, Liliana A. Dautova, Olga V. Nodvikova, Anna L. Karpova, Nonna V. Klyueva

“…Today, in Russia there is no practice of using donor milk in hospitals, while abroad it is a common technique of caring for premature and low-weight infants.Objective: Our aim was to study the milk donation awareness of parents of children under the age of 1, health workers and lactation consultants.Methods. A sample survey was carried out.Results. …”
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Apolipoprotein E gene polymorphisms: a relationship with the risk of coronary artery disease and the effectiveness of lipid-lowering therapy with rosuvastatin by M. I. Churilin, S. I. Kononov, Yu. V. Luneva, Yu. E. Azarova, E. Yu. Klesova, A. V. Kharchenko, S. N. Zhabin, O. Yu. Bushueva, S. V. Povetkin, G. S. Mal, M. A. Solodilova, A. V. Polonikov, V. A. Kazanov

“…To analyze the associations of apolipoprotein E (APOE) gene polymorphisms (rs7412 and rs4420638) with the risk of coronary artery disease (CAD) and the effectiveness of lipid-lowering therapy with rosuvastatin.Material and methods. The study involved the analysis of deoxyribonucleic acid samples and phenotypic data of 1700 unrelated individuals of Slavic origin, natives of Central Russia. …”
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Psychological and cultural correlates of illness conception and menopausal symptoms: a cross-sectional and longitudinal comparative study of Mosuo, Yi, and Han women by Limin Gao, Limin Gao, Jinyi Wang, Ying Zhang, Xudong Zhao, Xudong Zhao, Haojie Fu, Haojie Fu

“…ObjectiveThis study explores the differences in menopausal symptoms, illness conception, and health-seeking behaviors among Mosuo, Yi, and Han women in China, analyzes the key factors behind these differences, and conducts a longitudinal comparison.MethodsThis study collected data from Mosuo, Yi, and Han women in Yongning Township, Ninglang County, Yunnan Province, through a questionnaire survey. …”
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“I always wondered if my baby is able to feel my love for them” -  Development and pilot testing of two behavioural feedback strategies designed to improve maternal self-efficacy [... by Rebecca M Pearson, Shane A Norris, Alessandra Prioreschi, Antonia Smith, Deborah M James, Kirsten L Rennie

“…Most mothers had two or more children, and lived in informal housing (such as shacks and small, temporary prefabricated structures) with only outdoor toilet facilities available. …”
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Immunoenhancing effects of Gynostemma Pentaphyllum Extract on mucosal immunity against porcine epidemic diarrhea virus by Yanxiang Zhang, Ruihan Tang, Ruihan Tang, Yuanqing Liu, Zhihui Hao, Zhihui Hao, Zhihui Hao, Kai Fan, Shanshan Xie, Bo Tang, Shuaiyu Wang, Shuaiyu Wang, Shuaiyu Wang

“…IntroductionThis study investigated the mucosal immunoadjuvant effects of Gynostemma Pentaphyllum Extract (Gynostemma P.E), the bioactive constituents of Gynostemma pentaphyllum, against porcine epidemic diarrhea virus (PEDV).MethodsTwenty-four mice were randomly divided into four groups: a negative control group (intranasal administration of antigen only), a Gynostemma P.E-antigen mixture test group (intranasal administration), and two positive control groups (intramuscular injection of antigen or inactivated homemade vaccine, respectively). …”
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Structure of anxiety and stress as factors of COVID-19 vaccine acceptance by M. Y. Sorokin, N. B. Lutova, G. E. Mazo, N. G. Neznanov, E. D. Kasyanov, G. V. Rukavishnikov, O. V. Makarevich, M. А. Khobeys

“…Threats to life and health, the public health crisis associated with the COVID-19 pandemic, have led to 1) accelerated development of vaccines, 2) adverse psychological reactions in the population.Aim: to identify differences in stress, anxiety, protective behavior strategies, and the socio-demographic characteristics of online survey participants, who reported opposing attitudes to SARS-CoV-2 vaccination.Materials and Methods. In December 2020-January 2021, 131 respondents were assessed (men—21.4%). …”
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