Comparative performance of a commercial and in-house Mp1p antigen-detecting enzyme immunoassay for the rapid diagnosis of talaromycosis. by Joseph Barwatt, Lottie Brown, Nguyen Thi Mai Thu, Paula Gonzalez, Sruthi Venugopalan, Heera Natesan Sambath, Ngo Thi Hoa, Jian-Piao Cai, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Vo Trieu Ly, Thuy Le

“…The aim of this study was to perform a head-to-head comparison of the performance of our in-house monoclonal antibody-based Mp1p antigen-detecting enzyme immunoassay (EIA) with its recently-developed commercial platform.<h4>Methods</h4>In this diagnostic accuracy, retrospective, case-cohort study, we compared the sensitivity, specificity, positive likelihood ratio (LR+) and negative likelihood ratio (LR-) of the commercial Wantai Mp1p EIA versus our in-house Mp1p EIA on paired plasma and urine samples from 424 hospitalized adults with advanced HIV disease, including 224 cases of proven talaromycosis, where Talaromyces marneffei was isolated in culture of blood or other clinical specimens, and 200 controls diagnosed with a range of other opportunistic infections. …”
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Comparative evaluation of oral microbiologic profile in children with Type 1 Diabetes Mellitus versus healthy controls and its relation to oral health status by Wedad M. Nageeb, Asmaa Ali Emam Abo-Elsoud, Mona Karem Amin, Tarek Mohamed Nabil Mohamed Kamel Mahmoud, Noha El-Sayed Fathi Abdou

“…C. dubliniensis and C. tropicalis occurred more frequently in the saliva of children with poor glycemic control. …”
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Features of the coronavirus disease course in young children by N. S. Kosmynina, I. Yu. Avramenko

“…To analyze the features of the coronavirus disease course in young children. Materials and methods. We analyzed case histories of 60 children aged 0 to 3 years who were hospitalized to the Lviv Regional Children’s Clinical Hospital “OHMATDYT” in the period from April to December 2020 with a diagnosis of coronavirus disease. …”
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Pharmacokinetic Analysis of the Bioavailability of AQUATURM^®, a Water-Soluble Curcumin Formulation, in Comparison to a Conventional Curcumin Tablet, in Human Subjects by Lillian Jabur, Rishi Pandey, Meena Mikhael, Garry Niedermayer, Erika Gyengesi, David Mahns, Gerald Münch

“…This study aimed to evaluate and compare the pharmacokinetic profile of AQUATURM®, a novel, water-soluble curcumin formulation, with that of a widely available commercial curcumin supplement. <b>Methods:</b> A randomized, double-blind, two-period crossover study was conducted in 12 healthy adult participants (6 male, 6 female; aged 20–45 years). …”
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Body Weight and Breast Cancer Treatment Experiences: Results From the Share Thoughts on a Breast Cancer Study by Sarah H. Nash, Elizabeth Verhage, Bradley D. McDowell, Joan Neuner, Elizabeth Chrischilles, Ingrid M. Lizarraga, Mary Schroeder

“…Our objective was to evaluate differences in treatments received, patient experiences of care, and treatment decision‐making processes among breast cancer survivors by body size. Methods We used data from the Share Thoughts on Breast Cancer study. …”
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Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis by Kun Wang, Wenchao Ma, Leina Sun, Fangcheng Su

“…Methods: We employed a revised version of the Jadad scale to assess the quality of the research literature following a rigorous screening process. …”
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Effective coverage of antenatal care and associated factors among pregnant women in Tanzania: a multilevel analysis by Amanuel Yosef Gebrekidan, Beshada Zerfu Woldegeorgis, Gizachew Ambaw Kassie, Kirubel Eshetu Haile, Ashenafi Teklay Abrha, Angwach Abrham Asnake, Yordanos Sisay Asgedom

“…Therefore, this study aimed to investigate the effective coverage (quality-adjusted coverage) of ANC and its associated factors among pregnant women in Tanzania.MethodsThis research was based on data from the 2022 Tanzania Demographic and Health Survey. …”
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Costing and cost-effectiveness of Cepheid Xpert HIV -1 Qual Assay using whole blood protocol versus PCR by Abbott Systems in Malawi by Maggie Nyirenda-Nyang'wa, Gerald Manthalu, Matthias Arnold, Dominic Nkhoma, Mina C. Hosseinipour, Maganizo Chagomerana, Precious Chibwe, Kevin Mortimer, Neil Kennedy, Derek Fairley, Victor Mwapasa, Chisomo Msefula, Henry C. Mwandumba, Jobiba Chinkhumba, Nigel Klein, Dagmar Alber, Angela Obasi

“…We assessed whether POCT Cepheid Xpert HIV-1 Qual assay whole blood (XpertHIV) was more cost-effective than PCR. # Methods From July-August 2018, 700 PCR Abbott tests using dried blood spots (DBS) were performed on 680 participants who enrolled on the feasibility, acceptability and performance of the XpertHIV study. …”
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Machine learning-based identification of histone deacetylase-associated prognostic factors and prognostic modeling for low-grade glioma by Keshan Wen, Weijie Zhu, Ziyi Luo, Wei Wang

“…This study aims to develop a prognostic model based on HDAC-related genes to aid in risk stratification and predict therapeutic responses. Methods Expression data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) were analyzed to identify an optimal HDAC-related risk signature from 73 genes using 10 machine learning algorithms. …”
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Role of KLF5 in enhancing ovarian cancer stemness and PARPi resistance: mechanisms and therapeutic targeting by Huimin Xiao, Guiyun Cheng, Haocheng Zhang, Yao Liu, Zhongshao Chen, Yuehan Gao, Feng Gao, Yanling Liu, Shourong Wang, Beihua Kong

“…PARPi-resistant cells formed larger and more numerous spheres and had higher ALDH activity. …”
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Ethnicity as a factor in the subjective experience of loneliness in students by Yu. M. Zabrodin, E. L. Soldatova, O. O. Andronnikova, Yu. M. Perevozkina

“…To conduct the research, the authors used a set of methods to study loneliness, Zung Self-Rating Depression Scale and a questionnaire to identify the level and na­ture of loneliness by G. …”
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Optimizing IoT intrusion detection with cosine similarity based dataset balancing and hybrid deep learning by Arvind Prasad, Wael Mohammad Alenazy, Naved Ahmad, Gauhar Ali, Hanaa A. Abdallah, Sadique Ahmad

“…The proposed model achieved an F1-score of 0.9758 on RT-IoT2022 and 0.9275 on UNSW Bot-IoT, outperforming SMOTE-based methods in accuracy and computational efficiency. …”
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High expression of SOX9 is a diagnostic and prognostic indicator of glioma by Libo Xu, Zhenhao Wang, Mao Li, Qingsong Li

“…In recent years, SOX9 has been reported to play an important role in many diseases and cancers, and is a promising target, but it has been rarely reported in GBM.MethodsRNA sequencing data of GBM were obtained from the Cancer Genome Atlas (TCGA) database and the Genotype-Tissue Expression (GTEx) database for analysis of SOX9 expression and differentially expressed genes (DEGs). …”
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Associations between subjective and objective measures of stress and load: an insight from 45-week prospective study in 189 elite athletes by Kristina Drole, Mojca Doupona, Kathrin Steffen, Kathrin Steffen, Aleš Jerin, Aleš Jerin, Armin Paravlic, Armin Paravlic

“…IntroductionThe aim of this study was to investigate the associations between subjective and objective measures of stress and load in elite male handball players at both the group and individual levels.MethodsIn this 45-week prospective cohort study, 189 elite male handball players weekly reported their perceived stress and load across training, competition, academic, and work domains. …”
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Acceptability of an open-label wait-listed trial design: Experiences from the PROUD PrEP study. by Mitzy Gafos, Elizabeth Brodnicki, Monica Desai, Sheena McCormack, Will Nutland, Sonali Wayal, Ellen White, Gemma Wood, Tristan Barber, Gill Bell, Amanda Clarke, David Dolling, David Dunn, Julie Fox, Lewis Haddow, Charles Lacey, Anthony Nardone, Killian Quinn, Caroline Rae, Iain Reeves, Michael Rayment, David White, Vanessa Apea, Wilbert Ayap, Claire Dewsnap, Yolanda Collaco-Moraes, Gabriel Schembri, Yinka Sowunmi, Rob Horne, PROUD Study Team

“…We report on the acceptability of this open-label wait-listed trial design.<h4>Methods</h4>Participants completed an acceptability questionnaire, which included categorical study acceptability data and free-text data on most and least liked aspects of the study. …”
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Salivary vitamin D levels in children with autism in relation to oral health status and disease severity by Jehan Y Al-Demirchi, Batool H Al-Ghurabi, Waqar AlKubaisy

“…The purpose of this study was to investigate vitamin D levels in relation to oral health status of children with autism, as well as the relationship between vitamin D and disease severity. Materials and  methods: Two groups  were  included  in  this study:  40 institutionalized  autistic children as a study group and 40 apparently healthy children as a control group with  age  range  (3-12)  years.  …”
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Attention Deficit Predicts Intellectual Functioning in Children with Neurofibromatosis Type 1 by Magdalena Heimgärtner, Sofia Granström, Karin Haas-Lude, Robert A. Leark, Victor-Felix Mautner, Karen Lidzba

“…In our study, we investigated if attention deficits are associated with intellectual functioning in NF1 and if children with NF1 plus ADHD differ in their intellectual and attention profiles from children affected by NF1-only or ADHD only. Methods. 111 children aged between 6 and 12 years (53 NF1 plus ADHD, 28 NF1-only, 30 ADHD-only) performed the German version of the intelligence test WISC-IV and a continuous performance test (T.O.V.A.) to assess attention functions. …”
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Using Deep Learning Techniques to Enhance Blood Cell Detection in Patients with Leukemia by Mahwish Ilyas, Muhammad Bilal, Nadia Malik, Hikmat Ullah Khan, Muhammad Ramzan, Anam Naz

“…Conventional leukemia diagnostic methods are time-consuming, manually intensive, and inefficient. …”
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Reliability and Validity of the ActivForce Digital Dynamometer in Assessing Shoulder Muscle Force across Different User Experience Levels by Christos Karagiannopoulos, Sean Griech, Brian Leggin

“… # Design Descriptive observational study. # Methods A convenience sample of 29 healthy adults were assessed twice by each of three testers (two experienced clinicians and a novice PT student) on shoulder external rotation (ER), internal rotation (IR), and forward elevation (FE) using both the AF and MF2 devices. …”
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Testing source elevation versus genotype as predictors of sugar pine performance in a post‐fire restoration planting by Emily V. Moran, Rainbow DeSilva, Courtney Canning, Jessica W. Wright

“…However, further tests with more extensive genomic and performance data may improve the utility of genotype information for seed selection.…”
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