Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease by M. Baus-Domínguez, R. Gómez-Díaz, D. Torres-Lagares, J. R. Corcuera-Flores, J. C. Ruiz-Villandiego, G. Machuca-Portillo, J. L. Gutiérrez-Pérez, M. A. Serrera-Figallo

“…Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature. Materials and Methods. Case study and controls on eleven Down Syndrome patients (DS+PD+ vs. …”
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Neurosurgeons’ experiences of conducting and disseminating clinical research in low- and middle-income countries: a qualitative study protocol by Angelos Kolias, Peter J Hutchinson, Tom Bashford, Muhammad Mukhtar Khan, Ignatius N Esene, Claire Karekezi, Charlotte J Whiffin, Brandon G Smith, Davi J Fontoura Solla

“…Therefore, the aim of this study was to understand neurosurgeons’ experiences of, aspirations for and ability to conduct and disseminate clinical research in LMICs.Methods and analysis This is a pragmatic qualitative study situated within the naturalistic paradigm using focus groups and interviews with a purposive sample of neurosurgeons from LMICs. …”
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Cholesterol and triglyceride concentrations following 12–18 months of clinically prescribed elexacaftor-tezacaftor-ivacaftor—PROMISE sub-study by Rosara Bass, Michael Stalvey, George Solomon, Steven Rowe, David Nichols, Sarah Jane Schwarzenberg, Steven Freedman, Rachel Walega, Andrea Kelly

“…Background/Aims: People with CF (PwCF) have low total, high, and low density lipoprotein cholesterol (TC, HDL-C and LDL-C) and historically have had low prevalence of cardiovascular disease. More recently, cases of acute myocardial infarction are reported in PwCF. …”
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Active myofascial trigger points in head and neck muscles of patients with chronic tension-type headache in two primary health care units in Tshwane by K. Joseph, S. A. Hitchcock, H. P. Meyer, M. M. Geyser, P. J. Becker

“…This study therefore aimed to investigate the prevalence of active MTrP’s in specific head and neck muscles/muscle groups in patients with CTTH. Methods: A prospective, cross-sectional and descriptive study was done in two primary health care facilities situated in Tshwane, South Africa. …”
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Impact of COPD and sarcopenia on all-cause and respiratory mortality in US adults: NHANES 1999–2018 by Jiao Xu, Yuehua Ma, Qingyue Zeng, Xingyu Mu, Hu Nie, Shuangqing Li, Qiaoli Su, Hong Fan

“…We estimated the impact of COPD and SAR on all-cause and respiratory mortalities in the US adult population. Methods The study analyzed data from the National Health and Nutrition Examination Surveys (NHANES), a representative sample of the US population. …”
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The relationship between age and physical activity as objectively measured by accelerometers in older adults with and without dementia by Karl Brown, Andrew Shutes-David, Sarah Payne, Adrienne Jankowski, Katie Wilson, Edmund Seto, Debby W Tsuang

“…The study also sought to investigate how these differences vary in magnitude at different ages. Methods Accelerometry data were analyzed from individuals with dementia ( n = 94) and individuals without dementia ( n = 613) who participated in the National Health and Aging Trends Study (NHATS), as well as from individuals with DLB ( n = 12) and AD ( n = 10) who participated in a pilot study. …”
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Features of the water regime and photosynthesis in hybrid forms of cherry plum under the dry wind season conditions by A. V. Grigoriev, R. A. Pilkevich, L. A. Lukicheva, T. B. Gubanova, V. M. Gorina

“…Water retention capacity of leaves and chlorophyll fluorescence were measured under the simulated conditions close to the dry wind season.Materials and methods. The water regime parameters were studied for five cherry plum genotypes in 2021 and 2022. …”
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A pilot project- Causes of hypersegmentation in neutrophils apart from existing causes by Gunjan Bhatia, Namita Goyal, Priyanka Parakh, Shuchi Goyal, Shelesh Kumar Swami, Nitesh Kumar Chauhan

“…We aimed to evaluate causes of hypersegmentation in peripheral smear apart from already known causes. Materials and methods: The study was conducted for three years. …”
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Exploring the Potential Association Between Inhaled Corticosteroid and Face Aging Risk: A Mendelian Randomization Study by Junpeng Li, Yaqiong Liu, Gujie Wu, Shanye Yin, Lin Cheng, Wenjun Deng

“…However, long-term use of ICSs could lead to multiple side effects, including skin changes. <b>Methods</b>: We identified ICS target genes using DrugBank and DGIdb databases and derived genetic instruments from cis-eQTL data in whole-blood samples (n = 31,684). …”
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Evaluating the performance of artificial intelligence in summarizing pre-coded text to support evidence synthesis: a comparison between chatbots and humans by Kim Nordmann, Stefanie Sauter, Mirjam Stein, Johanna Aigner, Marie-Christin Redlich, Michael Schaller, Florian Fischer

“…This study aims to compare the accuracy, completeness and relevance of chatbot-generated responses against human responses in evidence synthesis as part of a scoping review. Methods We employed a structured survey-based research methodology to analyse and compare responses between two human researchers and four chatbots (ZenoChat, ChatGPT 3.5, ChatGPT 4.0, and ChatFlash) to questions based on a pre-coded sample of 407 articles. …”
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Noise-induced Hearing Loss among Non-Medical Workers in a Healthcare Institution by Manju Deena Mammen, Ann Mary Augustine, Anjali Lepcha, Jessie Sophia Sharma, Arockiaraj Arul Prakash, Ajay Philip

“…This study aims to estimate the prevalence of hearing loss among such workers and correlate the degree of hearing loss with age, duration of exposure, and coexisting illnesses. Methods: A retrospective review of 117 clinical records was conducted on 179 employees working in areas of excessive noise in a tertiary care hospital. …”
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Engagement and perspectives regarding the family conference process when considering discontinuation of life-sustaining treatments among critical care specialist nurses: a nationwi... by Akane Kato, Yuta Tanaka, Yoshiyuki Kizawa, Hiroaki Yamase, Asami Tado, Junko Tatsuno, Mitsunori Miyashita

“…We aimed to elucidate how critical care specialist nurses engage in the family conference process in terms of the actual discussions held, the recommended topics, and their perspectives regarding transfer of critical care patients to general wards. Methods This self-administered nationwide survey was conducted between October and December 2020, targeting a random sample of 740 critical care specialist nurses. …”
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Influence of local denture-related factors on the inflammatory marker levels in patients with denture stomatitis by Marija Bradić-Vasić, Ana Pejčić, Milena Kostić, Radmila Obradović, Ivan Minić, Ivana Stanković, Katarina Živadinović, Jelena Bašić, Aleksandra Ignjatović

“…The aim of this research was to examine the effects of local denture factors in the oral mucosa and saliva content that occurred after the DS onset. Materials and methods The study sample comprised 150 adult partial or total denture wearers, 100 of whom were diagnosed with DS, and the remaining 50 had a healthy mucous membrane despite having prosthetic restorations and served as controls. …”
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Development of the barriers to opioid access scale among individuals with chronic pain by Sujith Ramachandran, Stefan Kertesz, Emily Gravlee, Prachi Prajapati, John P. Bentley, Yi Yang

“…Objectives: The aim of this study was to develop an instrument to measure barriers to prescription opioid access among individuals with chronic pain and test its psychometric properties. Methods: This study used a cross-sectional online survey of a convenience sample of adults (>18 years) who reported any type of pain for at least 45 days or more in the previous 3 months. …”
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Genetic association between Class II division 1 and division 2 malocclusions with PAX9 (rs8004560) gene polymorphism in a tertiary care hospital by Monika SHUKLA, Munish REDDY, Kritanjali SINGH, Ruchi SAINI, Pradeep RAGHAV, Kaynat NASSER, Nupur SHARMA, Aastha KAMRANI, Shehla RAFIQUE, Tanjula SHAIR

“…ABSTRACT Objective: To assess whether there is any difference in the genetic association between Class II division 1 (div. 1) and division 2 (div. 2) malocclusions using PAX9 (rs8004560) gene single nucleotide polymorphism (SNP). Material and Methods: Sixty patients from the Orthodontics department of Subharti Dental College and Hospital (Meerut, India) were divided into two groups: Group 1 (Class II div. 1 malocclusion) and Group 2 (Class II div. 2 malocclusion). …”
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Analysis of CA1, CA3, and DG areas of the hippocampus, substance-P, and brain-derived neurotrophic factors expression in the presence of Ocimum sanctum Linn on the brain of the rat... by Made Bagus Auriva Mataram, Ulayatul Kustiati, Hevi Wihadmadyatami, Dwi Aris Agung Nugrahaningsih, Siti Isrina Oktavia Salasia, Dwi Liliek Kusindarta

“…Aim: Using a rat model of AD, this work attempted to determine the effects of an ethanolic extract from Ocimum sanctum on the number and shape of neurons in the CA1, CA3, and DG sections of the hippocampus alongside the expression of neurotrophic factors. Methods: The animal model will be split into five treatment groups, one of which will be a control group. …”
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In-house designed simulation courses versus society-accredited designs by international societies: A comparative analysis by Abramovich, Igor, Beilstein, Jakob, Kornemann, Eva, Berger-Estilita, Joana, Schröder, Torsten

“…Future research should include a broader sample, more rigorous content analysis, longitudinal follow-up, and detailed participant experience data to enhance the depth and applicability of findings.…”
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Chinese herbal medicine (Bu-Shen-Tian-Jing Formula) for outcomes of IVF in Chinese patients with polycystic ovary syndrome: A retrospective cohort study by Xiaoming Pan, Yinger Gu, Xian Zhang, Biwei Shi, Long Cui, Fangfang Wang, Fan Qu

“…We conducted a retrospective cohort study to investigate the effects of CHM (Bu-Shen-Tian-Jing Formula, BSTJF) on the outcomes of IVF in Chinese patients with PCOS and the potential underlying mechanism. Methods: A total of 111 patients with PCOS who undergone IVF between November 2009 and July 2018 were included. …”
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Association between visceral adiposity index and endometriosis: a population-based study by Jiajia Zhang, Qian Zhang, Tianyu Chu, Xian Chen, Hui Zhou, Dewu Xu, Chunlin Dong, Yibo Wu

“…The results of subgroup analyses showed that some specific demographic, lifestyle, and reproductive characteristics were not statistically significant in influencing the correlation between VAI and endometriosis (p &gt; 0.05 for all interactions).ConclusionOur study observed a statistically significant association between VAI and endometriosis. More prospective cohort investigations with large samples are required to further validate these findings because the etiology of endometriosis remains unclear.…”
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Identification of hub genes, diagnostic model, and immune infiltration in preeclampsia by integrated bioinformatics analysis and machine learning by Yihan Zheng, Zhuanji Fang, Xizhu Wu, Huale Zhang, Pengming Sun

“…Abstract Purpose This study aimed to identify novel biomarkers for preeclampsia (PE) diagnosis by integrating Weighted Gene Co-expression Network Analysis (WGCNA) with machine learning techniques. Patients and methods We obtained the PE dataset GSE25906 from the gene expression omnibus (GEO) database. …”
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