Investigation of the degree of family history of diabetes in different clusters of newly diagnosed type 2 diabetes in Thailand by Watip Tangjittipokin, Tassanee Narkdontri, Nipaporn Teerawattanapong, Sarocha Suthon, Vorthunju Nakhonsri, Rujipat Wasitthankasem, Nirinya Sudtachat, Lukana Preechasuk, Varisara Lapinee, Nuntakorn Thongtang, Sissades Tongsima, Nattachet Plengvidhya

“…This study aimed to determine the evidence of hereditary factors in these type 2 diabetes clusters.Methods A total of 487 subjects who were diagnosed with type 2 diabetes in two years were enrolled in the Siriraj Diabetes Center, Siriraj Hospital Bangkok, Bangkok, Thailand. …”
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Accurate Indentification of Pathogenic Mutations Conferring α1-Antitrypsin Deficiency by a Novel Multiplexed Molecular AssayTake-home Points by Emily K. DeCurtis, BSc, Sharon K. Kuss-Duerkop, PhD, Iara M.P. Machado, PhD, Zoe P. Stewart, BSc, Matt Jackson, MS, Ellie Hasenohr, BSc, Jessica L. Crumby, BSc, Steve D. Groshong, MD, PhD, Claire M. Coeshott, PhD, Ronald J. Harbeck, PhD, James P. Woodrow, MD, Robert A. Sandhaus, MD, PhD, Yongbao Wang, PhD

“…Study Design and Methods: We developed a multiplexed polymerase chain reaction (PCR) assay that that uses mass spectrometry to detect 20 pathogenic SERPINA1 mutations, two normal M allele variants, and an additional variant of unknown significance as an accessible frontline genetic test for AATD. …”
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Geochemical Characteristics and Organic Matter Enrichment Mechanism in Late Paleozoic Mudstone, Eastern Margin of Ordos Basin by Jindong YANG, Zhenfeng YU, Xu GUO, Ruixi ZHAO

“…Although the eastern edge of the Ordos Basin is rich in deep coalbed methane and tight sandstone gas, the enrichment characteristics and controlling factors of organic matter in coal-bearing strata are unclear, which is not conducive to the study on the storage law of resource, evaluation of development potential, and selection of favorable areas.OBJECTIVESTo reveal the organic carbon content and its influencing factors of mudstones in the coal measure strata and guide the efficient development of coal-measure gas in the eastern margin of the Ordos Basin.METHODS(1) Analytical method: A total of 26 mudstone samples from the Shihezi, Shanxi and Taiyuan Formations were collected in the Shixi area. …”
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Measurement of schizophrenia symptoms through speech analysis from PANSS interview recordings by Michelle Worthington, Michelle Worthington, Georgios Efstathiadis, Vijay Yadav, Vijay Yadav, Isaac Galatzer-Levy, Isaac Galatzer-Levy, Isaac Galatzer-Levy, Alan Kott, Emanuel Pintilii, Tejendra Patel, Colin Sauder, Inder Kaul, Stephen Brannan, Anzar Abbas

“…By contrast, negative symptoms were associated with decreased amount of speech, slower speech, and longer, more varied pauses.DiscussionA large sample of PANSS recordings was successfully processed using open source methods for phenotyping and strong relationships between speech characteristics and symptoms from these recordings were observed. …”
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Fate and risks of potentially toxic elements associated with lacustrine groundwater discharge: quantification, modeling, and biogeochemistry by Shen Qu, Juliang Wang, Keyi Zhang, Mengyu Fan, Yuanzhen Zhao, Xu Yang, Zhongli Wang, Helena I. Gomes, Rachel L. Gomes, Limin Duan, Shaogang Dong, Ruihong Yu

“…This multi-method investigation elucidates LGD-driven PTE cycling fluxes and mechanisms, providing critical insights for groundwater-lake management.…”
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Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested... by Raphael S Peter, Alexandra Nieters, Siri Göpel, Uta Merle, Jürgen M Steinacker, Peter Deibert, Birgit Friedmann-Bette, Andreas Nieß, Barbara Müller, Claudia Schilling, Gunnar Erz, Roland Giesen, Veronika Götz, Karsten Keller, Philipp Maier, Lynn Matits, Sylvia Parthé, Martin Rehm, Jana Schellenberg, Ulrike Schempf, Mengyu Zhu, Hans-Georg Kräusslich, Dietrich Rothenbacher, Winfried V Kern, EPILOC Phase 2 Study Group

“…A history of PEM was associated with more severe symptoms and more objective signs of disease and might help stratify cases for disease severity.…”
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Spatial Variability of Soil Acidity and Lime Requirements for Potato Cultivation in the Huánuco Highlands by Kenyi Quispe, Sharon Mejía, Carlos Carbajal, Lidiana Alejandro, Patricia Verástegui, Richard Solórzano

“…The ordinary geostatistical kriging method evaluated the predictive accuracy for 23 soil properties and liming requirements over a 28,463 ha area, at a spatial resolution of 10 m. …”
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Mining Porcine Blood Whole-DNA Sequencing Datasets to Uncover Pig Viromes: An Exploratory Application to Identify Potential Infecting Agents of an Undefined Disease Outbreak by Samuele Bovo, Anisa Ribani, Giuseppina Schiavo, Valeria Taurisano, Matteo Bolner, Francesca Bertolini, Luca Fontanesi

“…In this study, we tested, for the first time for diagnostic purposes in a livestock species, a new method based on whole-genome sequencing of all the DNAs extracted from the blood of nine pigs sampled from a farm where there was a suspected outbreak of Post-weaning Multisystemic Wasting Syndrome. …”
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Study of Oxidative–Reductive Potential Changes in the Enrichment of Oxidized Polymetallic Ores by Alima Mambetaliyeva, Tansholpan Tussupbekova, Leyla Sabirova, Guldana Makasheva, Kanay Rysbekov, Madina Barmenshinova

“…The most effective method for enriching oxidized polymetallic ores is flotation with preliminary sulfidization. …”
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Gender and age-related variations in rumen fermentation and microbiota of Qinchuan cattle by Yueting Pan, Huaxuan Li, Juze Wang, Xiaolei Sun, Entang Liang, Juntao Guo, Jianfang Wang, Ke Zhang, Bingzhi Li, Mengqi Zan, Wucai Yang, Linsen Zan

“…Objective Our study aimed to investigate the gender and age-related variations in rumen fermentation, serum metabolites, and microbiota in Qinchuan cattle. Methods A total of 38 Qinchuan beef cattle were selected and maintained on a uniform diet for three months. …”
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Haptic communication and interpersonal dynamics in hand-by-hand guided locomotion in children and adults by Priscilla Avaltroni, Priscilla Avaltroni, Francesca Sylos-Labini, Francesca Sylos-Labini, Margherita Villani, Germana Cappellini, Germana Cappellini, Francesco Lacquaniti, Francesco Lacquaniti, Yury Ivanenko

“…Here, we studied haptic-guided locomotion in children and adults.MethodsWe examined 11 pairs (adult-adult, child-child [6–8 years old], and adult-child) walking side by side with hand contact toward targets, with one participant leading and one blindfolded follower. …”
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Assessment of Pain, Diet, and Analgesic Use in Orthodontic Patients: An Observational Study by Bianca Maria Negruțiu, Claudia Elena Staniș, Ligia Luminița Vaida, Abel Emanuel Moca, Cristina Paula Costea, Raluca Iurcov, Alexandru Nicolae Pîrvan, Marius Rus

“…The primary aim of this observational study was to assess the influence of orthodontic patients’ age, gender, and living environment on pain duration, diet impairment, and analgesic use one week after their first adjustment visit to the orthodontist. <i>Methods</i>: This observational study included a sample of 194 orthodontic patients who completed a questionnaire consisting of six single-choice questions. …”
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Identification and functional analysis of a novel SMARCC2 splicing variant in a family with syndromic neurodevelopmental disorder by Ming Li, Jingqi Lin, Hongjun Fei, Jinyu Liu, Yiyao Chen, Xu Han, Yanlin Wang, Jian Wang, Renyi Hua, Shuyuan Li, Niu Li

“…Abstract Background To determine the pathogenicity of a novel splicing variant in the SMARCC2 gene identified from a pair of adult male monozygotic twins with neurodevelopmental disorder, and to investigate the genotype-phenotype characteristics associated with SMARCC2 variants. Methods Whole-exome sequencing (WES) was conducted on the proband, and candidate variants were validated using Sanger sequencing within the family. …”
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Response of dissolved organic matter and bacterial community to anthropogenic disturbances in a plateau lake by Yue Meng, Yue Meng, Xin Jiang, Xin Jiang, Yue Li, Chun Qing, Chun Qing, Xingyu Long, Pinhua Xia, Pinhua Xia

“…Similarly, α and β diversity indices for bacterial communities showed no marked variation (P &gt; 0.05) between highly and lightly disturbed areas in both water and sediment samples. Nevertheless, co-occurrence network analysis revealed more negatively correlated links and longer average path length with stronger disturbances. …”
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Archives and Health program for dementia: A pilot study of a non-pharmacological creative arts-based intervention protocol by Sara Uboldi, Lorenza Iannacci, Vanda Menon, Alessandro Bortolotti, Giulia Candeloro, Alessandro Crociata, Valeria Pica, Angelo Romagnoli, Maria Tartari, Andrea Fabbo, Alessandra Marasco, Pier Luigi Sacco

“…Future studies with larger samples are necessary to confirm these findings and explore their clinical implications more robustly.…”
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Fastest Prostate Cancer Prediction on Whole-Mount Pathological Slides Using Self-Reform Multilayer Transformer by Linjie Xu, Xiaotian Yu, Haoming Luo, Jili Wang, Wenjie Liang, Jing Zhang, Zunlei Feng, Cheng Lu, Xiuming Zhang

“…Extensive experiments demonstrate that SMT achieves up to <inline-formula> <tex-math notation="LaTeX">$2.71\times $ </tex-math></inline-formula> faster training and <inline-formula> <tex-math notation="LaTeX">$775\times $ </tex-math></inline-formula> faster inference compared to traditional patch-cropping methods, while maintaining comparable accuracy and requiring less storage compared to existing SOTA methods. …”
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The Longitudinal Effect of Psychological Distress on Internet Addiction Symptoms Among Chinese College Students: Cross-Lagged Panel Network Analysis by Yuxuan Jiang, Chuman Xiao, Xiang Wang, Dongling Yuan, Qian Liu, Yan Han, Jie Fan, Xiongzhao Zhu

“…ObjectiveThis longitudinal study aimed to explore the development of and changes in IA symptoms over time and the directional relationship between IA and various psychological distress symptoms. MethodsThis study followed a sample of 2497 Chinese college students (mean age 19.14, SD 0.72 years) across 3 waves of a data collection span of 2 years. …”
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Understanding household-level risk factors for zero dose immunization in 82 low- and middle-income countries. by Brooke Amara Farrenkopf, Xiaobin Zhou, Anita Shet, Folake Olayinka, Kelly Carr, Bryan Patenaude, Onyema Greg Chido-Amajuoyi, Chizoba Wonodi

“…<h4>Methods</h4>We utilized the most recent DHS and MICS data spanning 2011 to 2020 from low, lower-middle, and upper-middle income countries. …”
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Matrix Metalloproteinases 1 and 3 in Ovarian Cancer: Diagnostic and Prognostic Potential of Genetic Variants and Expression Profiling by Amal Mohamad Husein Mackawy, Hajed Obaid Alharbi, Ahmad Almatroudi, Wanian M. Alwanian, Khaled S. Allemailem

“…This study examines the effects of immunoreactive biomolecule variations of <i>MMPs-1,3</i>, as well as the <i>MMP-1 (1607 1G/2G)</i> and <i>MMP-3 (-1171 5A/6A)</i> genetic variants, on OC risk and progression in Egyptian women. <b>Methods</b>: Tissue specimens embedded in paraffin from 100 OC patients and 60 controls were stained using immunohistochemistry to examine expression of <i>MMPs-1,3</i>. …”
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Genotype distribution of human papillomavirus among women with cervical cancer stratified by HIV status in Tanzania. by Alita Mrema, Mamsau Ngoma, Emmanuel L Lugina, Atukuzwe Kahakwa, Chacha Josiah Mwita, Salama Iddy, Eulade Rugengamizi, Kandali Samwel, John Ngowi, Salum J Lidenge, Charles Wood, Julius Mwaiselage

“…This study aimed to determine the HPV genotype distribution according to HIV status among women with CC in Tanzania.<h4>Methods</h4>This cross-sectional study was done at Ocean Road Cancer Institute (ORCI) in Tanzania among women with histologically confirmed CC. …”
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