Nuclear IRF-1 expression as a mechanism to assess “Capability” to express PD-L1 and response to PD-1 therapy in metastatic melanoma by Mario Sznol, Harriet M. Kluger, Pok Fai Wong, James W. Smithy, David L. Rimm, Vasiliki Pelekanou, Lauren M. Moore, Jamaal Rehman, Patricia Gaule, Veronique M. Neumeister

“…Specifically, response is seen in tumors that do not express programmed death ligand 1 (PD-L1), highlighting the need for a more sensitive biomarker. We hypothesize that capacity to express PD-L1, as assessed by an assay for a PD-L1 transcription factor, interferon regulatory factor 1 (IRF-1), may better distinguish patients likely to benefit from anti-PD-1 immunotherapy.Methods Samples from 47 melanoma patients that received nivolumab, pembrolizumab, or combination ipilimumab/nivolumab at Yale New Haven Hospital from May 2013 to March 2016 were collected. …”
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Targeted ultra-high performance liquid chromatography-tandem mass spectrometry assay for the quantification of medium-chain phosphatidylcholines in platelets of coronary artery dis... by Tamara Janker, Adrian Brun, Adrian Sievers-Engler, Kristina Dittrich, Meinrad Gawaz, Michael Lämmerhofer

“…Furthermore, an organic solvent and fatty acyl carbon number-corrected response factor approach gave also accuracies within acceptance limits of bioanalytical validation guidelines and has more generic applicability. Compared to the previous untargeted RPLC-ESI-QTOF-MS/MS method, the optimized targeted UHPLC-QTrap-MS/MS assay showed increased sensitivity and selectivity for the detection of medium-chain PCs in platelet samples of CAD (LOQs in the range of 0.5–5 nmol/L). …”
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Fast and Efficient Lunar Finite Element Gravity Model by Giaky Nguyen, Ahmad Bani Younes, Ahmed Atallah

“…In this paper, the finite element method (FEM) is integrated with orthogonal polynomial approximation in high-dimensional spaces to innovatively model the Moon’s surface gravity anomaly. …”
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Evaluation study on gas-phase passivation inhibiting the spontaneous combustion tendency of ferrous sulfide compounds by Yuanyuan Zhang, HaSung Kong, Ruixuan Hao, Qin Xu, Long Zhao

“…The entropy-weight TOPSIS method was then used to evaluate the passivated samples and determine the optimal passivation conditions. …”
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Exploring the diversity of Gardnerella vaginalis in the genitourinary tract microbiota of monogamous couples through subtle nucleotide variation. by A Murat Eren, Marcela Zozaya, Christopher M Taylor, Scot E Dowd, David H Martin, Michael J Ferris

“…<h4>Methodology/principal findings</h4>To explore G. vaginalis diversity, distribution and sexual transmission, we developed a Shannon entropy-based method to analyze low-level sequence variation in 65,710 G. vaginalis 16S rRNA gene segments that were PCR-amplified from vaginal samples of 53 monogamous women and from urethral and penile skin samples of their male partners. …”
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Epidemiological and molecular characterization of Enterobius vermicularis cases in Mersin, Turkey: An analysis based on mitochondrial DNA cox1 gene sequences by Harun Gülbudak, Seda Tezcan Ülger, Taylan Bozok, Gönül Aslan

“…Between January 2017 and December 2023, 1496 samples were examined using the cellophane tape method, and 75 positives were identified. …”
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Between Volga and Ural River basins: concerning family ties of the Abashevo and Sintashta population of the Bronze Age in the context of genetic dat by Mednikova M.B., Kanapin A.A., Samsonova A.A., Morgunova N.L.

“…In a pairwise comparison of Pepkino caster with other samples, the probability of the occurrence of at least one IBD fragment in the genomes was more than 0.9 for both the Maloyldashevo sample, as well for a female (sample POST_131) from Southern Bavaria with close AMS date. …”
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Relationship between time under tension of muscle in resistance training with angiogenesis effective factors in inactive girls by Raziyeh Shiri, Mahsa Abdi, Sadegh Amani Shalamzari

“…Also, the more eccentric component was more associated with more strength in the 2s – 4s training.…”
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Does AI affect job burnout and insecurity differently by gender? A fuzzy-set qualitative comparative analysis (fsQCA) of 26 university faculty cases by Heran Guan, Rossilah Binti Jamil

“…With the development of artificial intelligence technology, university lecturers are experiencing a series of reactions that may occur after changing traditional teaching methods. This study uses 26 Chinese university lecturers as a sample, based on the grounded theory of qualitative research, and uses NVivo 14 and fsQCA 3.0 to explore the differentiated antecedent configuration pathways of job burnout and job insecurity among university lecturers of different genders under the influence of AI. …”
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Gender differences in victims of war torture: Types of torture and psychological consequences by Špirić Željko, Opačić Goran, Jović Vladimir, Samardžić Radomir, Knežević Goran, Mandić-Gajić Gordana, Todorović Milorad

“…The aim of this study was to investigate gender differences in types of torture and psychological consequences in subjects who experienced war torture. Methods. A sample (410 men and 76 women) included clients of 'Centre for rehabilitation of torture victims - IAN, Belgrade' who experienced torture in prisons and concentration camps during civil wars in ex-Yugoslavia 1991-1995 and 1999. …”
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The effect of chronic obstructive pulmonary disease on the level of homocysteinemia and the condition of coronary vessels in patients with myocardial infarction by T. V. Prokofieva, E. A. Lipnitskaya, B. Yu. Kuzmichev, O. S. Polunina, L. P. Voronina, E. A. Polunina

“…Objective: to study and compare the level of homocysteine with the results of coronary angiography in patients with myocardial infarction (MI) and concurrent chronic obstructive pulmonary disease (COPD).Subjects and methods. 246 patients with MI were examined. In 137 (55.7%) people, MI developed on the background of COPD, while in 109 (44.3%) patients MI was a single condition. …”
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Routine Preoperative CT Scanning of Patients with Anorectal Sepsis is not Useful. A Retrospective Cohort Study by Jaro Van Zande, Ward Janssens, Natalie Poortmans, Martijn Schoneveld, Ellen Van Eetvelde, Laura Van Praet, Sarah Violon, David D.E. Zimmerman, Jasper Stijns

“…Patients (Materials) and Methods: All consecutive patients undergoing AA drainage between January 2015 and January 2020 were studied retrospectively. …”
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To what extent do we learn from past epidemics: a mobile phone survey of selected villages in Liberia by Elisa Maria Maffioli, Daisey Yu

“…We ask whether and to what extent individuals learn from past epidemics in Liberia, a country affected by both the 2014-2016 Ebola Virus Disease and COVID-19. # Methods We explored the association between being exposed to the 2014–2016 Ebola epidemic and measures of beliefs, intentions, and behavior during COVID-19. …”
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Epidemiology of respiratory infections during the different levels of non-pharmaceutical interventions by Ting Shi, Linlin Huang, Jianmei Tian

“…Under strict NPIs, inpatients with ARIs were more commonly boy and infants (p < 0.01). However, after the discontinuation of NPIs, they were more commonly children over 6 years of age (p < 0.01). …”
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Environmental education on the European Green Deal. Implications and promotion of the concept through different channels in Romania by Ionel Bran

“…So, in conclusion, people who already knew what the Green Deal meant showed a more sustainable behavior. The results suggest the importance of boosting the promotion of the European Green Deal, sustainability, circular economy, and so on, reaching more people, thus creating a more powerful educational system in this direction. …”
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Health Facts Medication Adherence in Transplantation (H-MAT) Study: A Secondary Analysis of Determinants and Outcomes of Medication Nonadherence in Adult Kidney Transplant Recipien... by Cynthia L. Russell, Heather J. Gotham, An-Lin Cheng, Suman Sahil, Preethi Yerram

“…To explore the relationship between determinants and posttransplant medication nonadherence (MNA) in adult kidney transplant recipients, and to examine the relationship between posttransplant MNA and clinical outcomes. Methods. Using the World Health Organization’s model, this retrospective, multicenter, correlational study examined the relationship between determinants, posttransplant MNA, and clinical outcomes in 16,671 adult kidney transplant recipients from the Cerner Health Facts national data warehouse. …”
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Paediatric cerebellar glioblastoma - long-term survival following surgery and adjuvant chemoradiotherapy: A case report and literature review by Matthew I. Sanders, Daniel Gatt, Victoria Lee, Stephen B. Wharton, Veejay Bagga

“…Material and methods: Tumour histopathology plus retrospective molecular analysis of archived samples, as well treatment strategy and patient characteristics of a six-year-old child with cerebellar glioblastoma and prolonged progression-free survival were assessed. …”
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How and What Do Women Learn About Contraception? A Latent Class Analysis of Adolescents and Adult Women in Delaware by Mónica L. Caudillo, Fatima Zahra, Michael S. Rendall

“…Results: Adolescents are more likely than adults to report having recently acquired any information about contraception (76% vs. 64%), but they are more likely to rely primarily on a single source. …”
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Internalized stigma mediates the relationship between pelvic pain severity and both depression and anxiety in women with chronic pelvic pain by Sarah E. Francis, Jamey T. Brumbaugh, Jeongwi An, Emily J. Bartley, Daniel W. McNeil

“…Design: Quantitative, cross-sectional design. Methods: A sample of 241 adult women with CPP from the United States completed a series of questionnaires via an online survey. …”
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Relationship between vascular age and atherosclerosis-related cardiovascular diseases by R. N. Najafov

“…Pearson's chi-squared test with Monte Carlo simulation showed that within 10-month followup, myocardial infarction (MI) in presented sample was more common in age subgroups of 50-59 (10,0%) and 60-69 (8,3%) years. …”
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