Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBR... by Nasim Mavaddat, Debra Frost, Emily Zhao, Daniel R. Barnes, Munaza Ahmed, Julian Barwell, Angela F. Brady, Paul Brennan, Hector Conti, Jackie Cook, Harriet Copeland, Rosemarie Davidson, Alan Donaldson, Emma Douglas, David Gallagher, Rachel Hart, Louise Izatt, Zoe Kemp, Fiona Lalloo, Zosia Miedzybrodzka, Patrick J. Morrison, Jennie E. Murray, Alex Murray, Hannah Musgrave, Claire Searle, Lucy Side, Katie Snape, Vishakha Tripathi, Lisa Walker, Stephanie Archer, D. Gareth Evans, Marc Tischkowitz, Antonis C. Antoniou, Douglas F. Easton

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Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort by Tahzeeb Fatima, Yuan Zhang, Georgios K. Vasileiadis, Araz Rawshani, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Gröndal, Kim Hørslev-Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Mikkel Østergaard, Till Uhlig, Tuulikki Sokka-Isler, Anna Rudin, Cristina Maglio

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Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance by Ruihe Wu, Baochen Li, Rui Su, Xiaoyang Liu, Anqi Gao, Jing Luo, Chong Gao, Xiaofeng Li, Caihong Wang

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Interrelationships Between Inflammatory Score, Delayed Cerebral Ischemia and Unfavorable Outcome in Patients with aSAH: A Four-Way Decomposition by Zhang P, Zhu H, Li X, Qian Y, Zhu Y, Zhang W, Yan Z, Ni H, Lin Z, Lin X, Li Z, Zhuge Q, Zeng B

“…We also further explore the mediation and interaction of DCI within the chain of events using the four-way effect decomposition.Methods: Machine learning algorithms are used for biomarker selection and constructed the inflammatory score. …”
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Identification of Disulfidptosis-Related Genes and Molecular Subgroups in Rheumatoid Arthritis for Diagnostic Model and Patient Stratification by Liu X, Wang S, Du X, Wang Y, Mo L, Li H, Qu Z, Wang X, Sun J, Li Y, Wang J

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Serum TGF-β1 and CD14 Predicts Response to Anti-TNF-α Therapy in IBD by Stepan Coufal, Miloslav Kverka, Jakub Kreisinger, Tomas Thon, Filip Rob, Martin Kolar, Zuzana Reiss, Dagmar Schierova, Klara Kostovcikova, Radka Roubalova, Lukas Bajer, Zuzana Jackova, Martin Mihula, Pavel Drastich, Jana Tresnak Hercogova, Michaela Novakova, Martin Vasatko, Milan Lukas, Helena Tlaskalova-Hogenova, Zuzana Jiraskova Zakostelska

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Risk Factors for Gout in Taiwan Biobank: A Machine Learning Approach by Liu YR, Nfor ON, Zhong JH, Lin CY, Liaw YP

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The Role of PLIN3 in Prognosis and Tumor-Associated Macrophage Infiltration: A Pan-Cancer Analysis by Yang S, Liu H, Zheng Y, Chu H, Lu Z, Yuan J, Xu S

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Developing a Multisensor-Based Machine Learning Technology (Aidar Decompensation Index) for Real-Time Automated Detection of Post–COVID-19 Condition: Protocol for an Observational... by Jenny Mathew, Jaclyn A Pagliaro, Sathyanarayanan Elumalai, Lauren K Wash, Ka Ly, Alison J Leibowitz, Varsha G Vimalananda

“…Information about demographics, symptoms (Medical Research Council Dyspnea Scale and Post-COVID-19 Functional Status Scale), comorbidities, and other clinical characteristics will be tagged and added to the biomarker data. …”
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Bioinformatic Analysis of Apoptosis-Related Genes in Preeclampsia Using Public Transcriptomic and Single-Cell RNA Sequencing Datasets by Liu L, Li X, Yang H, Xu F, Dong X

“…We used scRNA-seq and differential expression analysis, combined with five algorithms from the CytoHubba plugin, to identify ARGs as PE biomarkers. …”
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Early Diagnosis of Knee Osteoarthritis With a Natural Language Processing–Driven Approach Based on Clinician Notes: Development and Validation Study by Narathip Thanyakunsajja, Kulsawasd Jitkajornwanich, Shan Xu, Donghee Shin, Pattama Charoenporn

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Development of a Cohesive Predictive Model for Substance Use Disorder Rehabilitation Using Passive Digital Biomarkers, Psychological Assessments, and Automated Facial Emotion Recog... by Andrea P Garzón-Partida, Kimberly Magaña-Plascencia, Diana Emilia Martínez-Fernández, Joaquín García-Estrada, Sonia Luquin, David Fernández-Quezada

“…ResultsThe study is supported by the Program for the Improvement of Working Conditions for Members of the SNII and SNCA (PROSNII U006EST), and APPAC-VII-CUCS-2025 for Article Publication Fees, from the University of Guadalajara. The research protocol was approved by the University of Guadalajara (reference CI-01225) in January 2025. …”
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Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile by Nicolas M. Viart, Anne-Laure Renault, Séverine Eon-Marchais, Yue Jiao, Laetitia Fuhrmann, Sophia Murat El Houdigui, Dorothée Le Gal, Eve Cavaciuti, Marie-Gabrielle Dondon, Juana Beauvallet, Virginie Raynal, Dominique Stoppa-Lyonnet, Anne Vincent-Salomon, Nadine Andrieu, Melissa C. Southey, Fabienne Lesueur

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Home-Based Intervention Tool for Cardiac Telerehabilitation: Protocol for a Controlled Trial by Francesca Mastorci, Maria Francesca Lodovica Lazzeri, Lamia Ait-Ali, Paolo Marcheschi, Paola Quadrelli, Massimiliano Mariani, Rafik Margaryan, Wanda Pennè, Marco Savino, Giuseppe Prencipe, Alina Sirbu, Paolo Ferragina, Corrado Priami, Alessandro Tommasi, Cesare Zavattari, Pierluigi Festa, Stefano Dalmiani, Alessandro Pingitore

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Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis by Yujia Wang, Zhimin Chen, Kaiqi Huang, Keng Ye, Shiwei He, Yanfang Xu, Hong Chen

“…Early identification and accurate diagnosis of AAV is crucial for improving prognosis. However, research on biomarkers associated with AAV is limited. …”
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Unified Mobile App for Streamlining Verbal Autopsy and Cause of Death Assignment in India: Design and Development Study by Harleen Kaur, Stuti Tripathi, Manjeet Singh Chalga, Sudhir K Benara, Amit Dhiman, Shefali Gupta, Saritha Nair, Geetha Menon, B K Gulati, Sandeep Sharma, Saurabh Sharma

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Developing an Interpretable Machine Learning Model for Early Prediction of Cardiovascular Involvement in Systemic Lupus Erythematosus by Deng Z, Liu H, Chen F, Liu Q, Wang X, Wang C, Lyu C, Li J, Li T

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The Role of EZH2 in Initiating Epigenetic Regulation of CRSwNP by Zeng R, Wang Y, Song X, Wang J

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A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers by Andrés Rodríguez, Olga Calero, Sergio Veiga, Miriam Menacho-Román, Ignacio Arribas, Lluís Cano, Guillermo García-Ribas, Miguel Calero

“…The test’s discriminatory performance was assessed by ROC analysis and two-threshold classification algorithms. Results ApoE4 levels ascertained by the e4Quant test exhibited clear genotype-dependent stratification. …”
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Screening and Risk Analysis of Atrial Fibrillation After Radiotherapy for Breast Cancer: Protocol for the Cross-Sectional Cohort Study “Watch Your Heart (WATCH)” by Laura Saint-Lary, Baptiste Pinel, Loic Panh, Gaelle Jimenez, Julien Geffrelot, Youlia Kirova, Jeremy Camilleri, David Broggio, Marie-Odile Bernier, Corinne Mandin, Christelle Levy, Serge Boveda, Juliette Thariat, Sophie Jacob

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