The Immunologic Spectrum of Biostimulators and Its Clinical Importance by Niamh Corduff, MBBS, FRACS, Kate Goldie, MB, BCh

“…Biostimulators elicit a spectrum of immunologic responses dependent on their physicochemical properties, ultimately producing clinical outcomes tending toward replacement or regeneration of native tissue. Understanding their immunologic mechanisms allows for optimal selection and use to achieve desired outcomes. …”
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Managing adherence, exposure, and toxicity in oral anticancer therapies by Kazuo Kobayashi

“…Continued research and collaboration are essential to optimize OAA-based therapy and improve patient care in oncology pharmacy.…”
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Advances and Perspectives in Alkali–Silica Reaction (ASR) Testing: A Critical Review of Reactivity and Mitigation Assessments by Osama Omar, Hussain Al Hatailah, Antonio Nanni

“…A validated framework is suggested to determine the optimal SCM optimal replacement levels for ASR mitigation based on extensive field data, offering direct guidance for mix design decisions involving potentially reactive aggregates. …”
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A Convenient Fluorogenic Detection Strategy for Phosphorothioate Modification of DNA Through Photocatalytic Oligonucleotide-Templated Reaction by Nannan Jing, Yantian Qin, Xinli Fan, Qian Wang, Jing Wang, Fuping You, Xinjing Tang

“…DNA phosphorothioate (PT) modifications, characterized by the replacement of a non-bridging phosphate oxygen atom with a sulfur atom, are widely observed in bacterial genomes. …”
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Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya by Caitlin Greenland-Bews, Sonal Shah, Morine Achieng, Emilie S. Badoum, Yaya Bah, Hellen C. Barsosio, Helena Brazal-Monzó, Jennifer Canizales, Anna Drabko, Alice J. Fraser, Luke Hannan, Sheikh Jarju, Jean-Moise Kaboré, Mariama A. Kujabi, Cristina Leggio, Maia Lesosky, Jarra Manneh, Tegwen Marlais, Julian Matthewman, Issa Nebié, Eric Onyango, Alphonse Ouedraogo, Kephas Otieno, Samuel S. Serme, Sodiomon Sirima, Ben Soulama, Brian Tangara, Alfred Tiono, William Wu, Emily R. Adams, Abdul Karim Sesay, Chris Drakeley, Feiko O. ter Kuile, Issiaka Soulama, Simon Kariuki, David J. Allen, Thomas Edwards

“…We successfully scaled up the HRM-VOC-2 assay to screen a total of 506 samples from which we were able to show the replacement of Alpha with the introduction of Delta and the replacement of Delta by the Omicron variant in this community in Kisumu, Kenya.IMPORTANCEThe rapid evolution of the severe acute respiratory syndrome coronavirus 2 variants of concern (VOCs) demonstrated the need for accessible surveillance tools so all communities can conduct viral surveillance. …”
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Highly durable and energy‐efficient probabilistic bits based on h‐BN/SnS2 interface for integer factorization by Joon‐Kyu Han, Jun‐Young Park, Shania Rehman, Muhammad Farooq Khan, Moon‐Seok Kim, Sungho Kim

“…Abstract As social networks and related data processes have grown exponentially in complexity, the efficient resolution of combinatorial optimization problems has become increasingly crucial. …”
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Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells by Sena Awano-Kim, Satoshi Hosoya, Ryo Yokomizo, Hiroshi Kishi, Aikou Okamoto

“…Currently, treatments such as hysteroscopic adhesiolysis and hormone replacement therapy have demonstrated variable efficacy with limited clinical evidence. …”
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Enhanced RT-DETR with Dynamic Cropping and Legendre Polynomial Decomposition Rockfall Detection on the Moon and Mars by Panpan Zang, Jinxin He, Yongbin Yang, Yu Li, Hanya Zhang

“…While deep learning technologies, particularly object detection models, demonstrate transformative potential, they require specific adaptation to planetary imaging constraints, including low contrast, grayscale inputs, and small-target detection. Our coordinated optimization strategy integrates dynamic cropping optimization with architectural innovations: Kolmogorov–Arnold Network based C3 module (KANC3) replaces RepC3 through Legendre polynomial decomposition to strengthen feature representation, while our dynamic cropping strategy significantly improves small-target detection in low-contrast grayscale imagery by mitigating background and target imbalance. …”
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Application and Analysis of Remote Sensing Image Processing Technology in Robotic Power Inspection by Jie Chen, Hemeng Yang, Rui Xu

“…Without the popularization of manned distribution stations and smart grid methods, replacing manual inspection with electric power inspection robots can improve the inspection quality and inspection efficiency to a certain extent. …”
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Preparation of Chitosan Oleogel from Capillary Suspension and Its Application in Pork Meatballs by Shishuai Wang, Zhongqin Fan, Xinya Huang, Yue Gao, Hongwei Sui, Jun Yang, Bin Li

“…To assess the potential application of the optimized oleogel, it was incorporated into pork meatballs as a replacement for pork fat. …”
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Qualitative and Quantitative Analysis Method of Recombinant Collagen in Complex Matrix Based on HPLC-MS/MS by Jianping Gao, Liping Jia, Zhenhu Guo, Liming Xu, Daidi Fan, Guifeng Zhang

“…The spiking recovery rate was between 80% and 90%. The optimal pretreatment method was Tris-HCl solvent replacement. …”
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Critical key points for anesthesia in experimental research involving sheep (Ovis aries) by Ruxandra Costea, Tiberiu Iancu, Alexandru Duțulescu, Cătălin Nicolae, Florin Leau, Ruxandra Pavel

“…By adhering to these principles, researchers can minimize the number of animals used, reduce any potential discomfort or distress experienced by the animals, and refine procedures to optimize animal welfare while still achieving scientific objectives. …”
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Pressure Management in Water Distribution Networks by Means of Pumps as Turbines: A Case Study in Northern Italy by Lucrezia Manservigi, Valentina Marsili, Filippo Mazzoni, Giulia Anna Maria Castorino, Saverio Farsoni, Enzo Losi, Stefano Alvisi, Marcello Bonfè, Marco Franchini, Pier Ruggero Spina, Mauro Venturini

“…The study reveals that the hydraulic regulation of the optimal PAT allows recovering over 50% of the hydraulic energy available in the WDN.…”
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Basic science review of transcutaneous osseointegration: current status, research gaps and needs, and defining future directions by Bailey V. Fearing, PhD, Ida Leah Gitajn, MD, Sarah M. Romereim, PhD, Jason S. Hoellwarth, MD, Joseph C. Wenke, PhD, Joseph R. Hsu

“…Addressing these challenges is essential for optimizing patient outcomes and advancing this emerging field.…”
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Hypopituitarism and Cardiovascular Risk by Ivana Kraljević MD, PhD, Mirsala Solak MD, PhD, Ante Mandić MD, PhD, Katarina Mlekuš Kozamernik MD, Maja Raičević MD, PhD, Anida Divanović Slato MD, Zlata Kovačević MD, Emir Muzurović MD, PhD

“…While standard hormone replacement therapy (HRT) is crucial for restoring hormonal balance, it can sometimes have adverse metabolic effects that can exacerbate atherosclerosis and CVD. …”
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Context-Aware Dual-Task Deep Network for Concurrent Bone Segmentation and Clinical Assessment to Enhance Shoulder Arthroplasty Preoperative planning by Luca Marsilio, Andrea Moglia, Alfonso Manzotti, Pietro Cerveri

“…<italic>Goal:</italic> Effective preoperative planning for shoulder joint replacement requires accurate glenohumeral joint (GH) digital surfaces and reliable clinical staging. …”
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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model. by Manuel E Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E Crawford, Stuart Bunting, Mika Aoyagi-Scharber

“…Here, we assess the effect of recombinant HexA and HexD3, a newly engineered mimetic of HexA optimized for the treatment of Tay-Sachs disease and Sandhoff disease. …”
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High-Efficiency Wireless Power Transfer System Based on Low-Frequency AlScN Piezoelectric Micromechanical Ultrasonic Transducers for Implantable Medical Devices by Wanyun Cui, Jianwei Zong, Junxiang Li, Qiang Ping, Lei Qiu, Liang Lou

“…However, traditional implanted batteries necessitate periodic surgical replacement and tend to be relatively bulky, posing significant inconvenience to patients. …”
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Bailiffs’ Offices in the North Caucasus in the Last Third of the 18^th — First Half of the 19^th Centuries: Evolution of Activity by A. Kh. Abazov, I. R. Nakhusheva

“…It is concluded that the proposed periodization allows to present the dynamics of the activity of the bailiffs in the North Caucasus in the last third of the 18th — first half of the 19th centuries as a complex phenomenon aimed at finding optimal forms of governance of the peoples included in the political and legal space of the Russian Empire.…”
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Review and comparative analysis of potent individual dosimetric monitoring systems for Ukrainian NPPs by V. V. Chumak, V. M. Volosky

“…Based on the analysis of literature data, international standards and recommendations, information from manufacturers and authors’ own practical experience, a generalization of information on existing and future IDM systems is carried out, a vision of the most optimal choice of systems for re-equipping laboratories for dosimetric monitoring of nuclear power plants good for the next decade is proposed.…”
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