Antimicrobial Dosing During Continuous Venovenous Hemodiafiltration in Septic Shock Patients: A Prospective, Multicenter Study Protocol by Alicia Wendy Vega Harwood, Marta Martín Fernández, Carlos Ezquer Garin, Francisco Javier Álvarez, Rocío López Herrero, Eduardo Tamayo, Gerardo Aguilar

“…<b>Objectives:</b> To develop pharmacokinetic/pharmacodynamic models for beta-lactam antibiotics in septic shock patients undergoing continuous renal replacement therapy (CRRT), with the goal of optimizing antibiotic dosing and then improving treatment outcomes. …”
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Current View on the Use of Extracorporeal Detoxification Methods for the Treatment of Rhabdomyolysis (Review) by S. V. Masolitin, D. N. Protsenko, I. N. Tyurin, O. A. Mamontova, M. A. Magomedov

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Clinical and radiographic evaluation of topical vitamin D application on immediate dental implants: a randomized clinical trial by Bassem M. Ayyad, Mohamed Said Hamed, Ahmed Elrody, Pierre A. Hanna, Ahmed Abdelmohsen Younis

“…Methods Twenty-four immediate implants were placed in healthy patients (aged 21–40 years) requiring replacement of single-rooted teeth in the anterior mandible. …”
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Outcomes of dual mobility versus conventional total hip arthroplasty for patients with femoral neck fractures: a systematic review and meta-analysis including registry data by Michael Silveira Santiago, Fatemeh Akbarpoor, Felipe J. Aidar, José Morais Sirqueira Neto, Marcus Vinicius Vieira de Matos Pereira Silva, Sohaib Darwish, Mohammed Ayman Khokar, Zainulabideen Ahmed, Fernanda Valeriano Zamora, Reuthemann Esequias Teixeira Tenorio Albuquerque Madruga, Alfonso López Díaz-de-Durana, María Merino-Fernandez, Leonardo da Costa Lima, Erick Sobral Porto, Davi Teixeira de Souza, Rosana Cipolotti

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Development and validation of an interpretable multi-task model to predict outcomes in patients with rhabdomyolysis: a multicenter retrospective cohort studyResearch in context by Chunli Liu, Jie Shi, Fengjuan Wang, Duo Li, Yu Luo, Bofan Yang, Yunlong Zhao, Li Zhang, Dingwei Yang, Heng Jin, Jie Song, Xiaoqin Guo, Haojun Fan, Qi Lv

“…Early and accurate prediction of acute kidney injury (AKI), disease severity, renal replacement therapy (RRT) requirements, and mortality risk is essential for timely identification of high-risk individuals, personalized treatment planning, and optimal allocation of healthcare resources. …”
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Performance Evaluation of African catfish (<i>Clarias gariepinus</i>) Fed Diets with Varying Dietary Inclusion Levels of Christmas Melon (<i>Laganaria breviflorus</i>) as a Partial... by Oghenefejiro Adagha, Jerimoth Kesena Ekelemu, Oster Francis Nwachi, Arnold Ebuka Irabor

“…In conclusion, the results obtained in this study revealed that Christmas melon (<i>L. breviflorus</i>) could replace wheat offal by up to 10% in the diet of <i>C. gariepinus</i> without negative effects on the obtained optimal growth performance, hematological parameters, or serum biochemistry.…”
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A Higher-Than-Standard-Intensity International Normalized Ratio Goal for Patients Undergoing Mechanical Aortic Valve Replacement With Additional Thrombotic Risk Factors: Protocol f... by Myung-Rho Kim, Taha Shaikh, Shawn Wang, Spencer Taylor, Vidhani Goel, Banveet Kaur Khetarpal, Chowdhury Ahsan, Kavita Batra

“…ConclusionsThis study will provide critical evidence on INR management in high-risk patients with MAVR, potentially informing future updates to clinical guidelines and optimizing the balance between thromboembolic prevention and bleeding risk. …”
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Reliability Analysis of an Extended Shock Model and Its Optimization Application in a Production Line by Renbin Liu

“…Secondly, using supplementary variable method and Laplace transform, some important reliability indices are derived, such as availability, failure frequency, mean vacation period, mean renewal cycle, mean startup period, and replacement frequency. Finally, a production line controlled by two cold-standby computers is modeled to present numerical illustration and its optimal part-time job policy at a maximum profit.…”
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Optimizing carbon sequestration and performance of concrete masonry blocks containing alkaline industrial waste by Jad Bawab, Hilal El-Hassan, Amr El-Dieb, Jamal Khatib

“…This study aims to optimize the carbon sequestration, compressive strength, and water transport properties (i.e., water absorption and volume of permeable voids) of concrete masonry blocks incorporating calcium carbide residue (CCR) as a partial cement replacement. …”
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Optimal intestinal graft selection for reconstruction of extended ureteral stricture: an animal model study by S. V. Kotov, R. I. Guspanov, A. G. Yusufov, O. V. Gaina, A. L. Aprosimov, I. V. Lapin, M. M. Zobnin, N.  O. Larionova, N. V. Trykina, T. Yu. Luskatova, O. V. Bogdanova

“…When it is not possible to perform reconstruction with the tissues of the urinary system, the best solution is intestinal replacement plasty. However, despite the great world experience, the search for the optimal method of intestinal reconstruction does not stop, which determines the relevance of conducting an experimental prospective study.Objective. …”
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Multi-objective Bayesian optimization of eco-friendly gas mixtures for resistive plate chambers by Pit Bechtold, Dario Stocco, Christian M Franck

“…This study presents a novel approach for autonomous optimization of the detector performance and environmental impact of gas mixtures and enabling a more efficient evaluation for finding a suitable replacement for RPCs. …”
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Experimental analysis and gene expression programming optimization of sustainable concrete containing mineral fillers by Ayesha Rauf, Usama Asif, Kennedy Onyelowe, Muhammad Faisal Javed, Hisham Alabduljabbar

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Optimization method for precise control of proportional electromagnetic valve for automatic drive of agricultural machinery by GENG Biao, LI Huan, FANG Hui, ZHANG Shengrong, XU Wei

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The optimization of development process of petrol-gas stations network with the purpose to increase energy efficiency by Larisa Jovanović, Dijana Fedjunina, Milan Radosavljević

“…The use of appropriate indicators according DPSIR methodology enables optimization of processes at oil/gas stations and increase energy efficiency. …”
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RESEARCH ON MAINTENANCE PARAMETER OPTIMIZATION OF DSA200 TYPE PANTOGRAPH BASED ON RELIABILITY ANALYSIS by MAO Yongwen, LI Yong

“…Aiming at the issues of under-maintenance or over-maintenance in preventive maintenance of DSA200 type pantograph, a method was proposed to optimize inspection and maintenance parameters by using pantograph failure data.Firstly, the failure datas of the pantograph components were analyzed by using graph parameter method, which failure time distribution models were fitted.The failure datas were preliminarily determined to obey the exponential distribution，and the Bartlett value method was further used to verify the validity of the failure data obey exponential distribution.Secondly, based on the structure and working characteristics of pantographs, a reliability block diagram model with pantograph components in series was constructed.According to the characteristics of constant failure rate of pantograph components, the failure rate of pantographs was obtained.Thirdly, the minimum cost model of preventive maintenance and replacement of pantographs was established, and the optimal preventive maintenance interval and the optimal number of spare parts were obtained.Finally, the structure importance, probability importance and critical importance of pantograph components were analyzed by using fault tree analysis method, and the failure probability of pantograph and the key components in inspection and maintenance were obtained.The optimized pantograph inspection and maintenance parameters can provide scientific reference for maintenance personnel to improve their maintenance level and reduce maintenance costs.…”
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Early Prediction of Student Suspension and Dropout for Counseling Resource Optimization Using Multilayer Perceptron by Yu-Huei Cheng, Mu-Hsin Shih, Che-Nan Kuo

“…The sub-replacement fertility rate in Taiwan has caused many educational institutions to face significant challenges, making student suspension and dropout critical issues for sustainable operations. …”
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Structural Optimization and Airflow Uniformity Evaluation of Bag Filter Based on Different Diversion Schemes by Hongli Hu, Shuo Ma, Yu Wang, Hongting Ma

“…Furthermore, high velocities at the bottom of the filter bags caused severe wear, complicating bag detection and replacement. Therefore, an optimization approach involving three vertical descending deflectors in the hopper was proposed. …”
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Selecting Energy-Efficient LED Retrofits with Optimal Color Qualities for New and Refurbished Buildings by Irena Fryc, Maciej Listowski, Robert Supronowicz, Christophe Martinsons

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Optimal cropping patterns and intertemporal groundwater usage under extraction constraints in Oklahoma’s panhandle by Lixia H. Lambert, Yiqing Yao, Lucia R. Levers

“…With lower water extraction rates over ten years, dryland sorghum is a suitable replacement for irrigated maize. Higher energy costs did not show a significant influence on optimal cropping patterns and water usage paths when the water extraction rate is low. …”
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Optimized needle configuration for operational seed (ONCOSEED) efficiency and deployment for prostate seed implants by Siddhant Sen, Ethan Stolen, Jaehee Chun, Jin Sung Kim, James J. Sohn

“…ONCOSEED enhances the efficiency of seed replacement in LDR brachytherapy, promoting the adoption of adaptive brachytherapy practices.…”
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