Assessment of the effectiveness and safety of fixed-dose combination of alogliptin and pioglitazone in real clinical practice: results of the PROsperity study by M. V. Shestakova, M. I. Kharakhulakh, Y. A. Belolipetsky

“…The maximum reduction in HbA1C (-2,8%) was seen in patients with baseline HbA1C >9,0% (n=300, which is 15% of the total sample). …”
Get full text

Effect of Dapagliflozin on Glycemic Variability in Patients with Type 2 Diabetes under Insulin Glargine Combined with Other Oral Hypoglycemic Drugs by Menghui Luo, Xiaocen Kong, Huiying Wang, Xiaofang Zhai, Tingting Cai, Bo Ding, Yun Hu, Ting Jing, Xiaofei Su, Huiqin Li, Jianhua Ma

“…Further, a stratified analysis showed that patients with higher pretreatment HbA1c and waist-to-hip ratio (WHR) had greater improvement in glycemic control. Conclusion. Dapagliflozin may reduce blood glucose levels, ameliorate glycemic variability, and improve pancreatic beta-cell function in patients with T2D under insulin glargine combined with other oral hypoglycemic drugs, especially in those with poor glucose control and abdominal obesity.…”
Get full text

High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy by Xin Sun, Yao Chen, Feifei Hu, Yumeng Qiao, He Wu, Yao Su, Yue Hu, Jie Wu, Jie Wu, Mingli Huang

“…This reduction may be related to increased risk of maternal vascular malperfusion and adverse pregnancy outcomes, potentially through mechanisms involving exacerbated oxidative stress and impaired placental vascular function; however, further studies are needed to clarify these associations.…”
Get full text

Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD by Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, Claudio Grassi

“…Methods Nup153-regulated mechanisms contributing to NSC function were investigated: (1) in cultured NSCs isolated from AD and wild type (WT) mice by proteomics; (2) in vivo by lentiviral-mediated delivery of Nup153 or GFP in the hippocampus of AD and control mice analyzing neurogenesis and cognitive function; (3) in human iPSC-derived brain organoids obtained from AD patients and control subjects as a model of neurodevelopment. …”
Get full text

Inhibition of ceramide synthesis improves the outcome of ischemia/reperfusion injury in cardiomyocytes derived from human induced pluripotent stem cell by Pellumb Haxhikadrija, Jasmine M.F. Wu, Sascha Hübner, Katja Grün, Tom Kretzschmar, Tina Müller, Markus H. Gräler, Claudia Backsch, Anja Weise, Elisabeth Klein, P. Christian Schulze, Mohamed M. Bekhite

“…Additionally, in vitro findings show that ceramide reduction improves the outcome of IR injury by lowering intracellular Ca2+ [Ca2+]i concentration and improves mitochondrial function changes during IR.…”
Get full text

Value of Probiotics on Outcome in Patients Following Liver Surgery: A Systematic Review and Meta-Analysis by Robert Karitnig, Andreas Bogner, Nora Jahn, Christos Vlachos, Andri Lederer, Antonia Geisler, Robert Sucher, Hans Michael Hau

“…The results of the meta-analysis demonstrated that the probiotic group exhibited lower rates of postoperative infectious complications (OR = 0.34; 95%CI 0.25 to 0.45; <i>p</i> < 0.0001), hospital stay duration (SMD = −0.13; 95%CI −0.25 to −0.00; <i>p</i> = 0.05), lower serum endotoxin levels (SMD = −0.39%CI −0.59 to −19; <i>p</i> < 0.0001), and white blood cell counts (SMD = −SMD = −0.35; 95%CI −0.56 to −0.13; <i>p</i> = 0.002) compared to the control group. Further, with regard to liver function, we observed significant postoperative differences in alanine aminotransferase (ALT)-levels (SMD = −0.46; 95%CI −0.63 to −0.29; <i>p</i> < 0.0001), aspartate aminotransferase (AST) levels (SMD = −0.53; 95%CI −0.71 to −0.34; <i>p</i> < 0.0001), bilirubin levels (SMD = −0.35; 95%CI −0.50 to −0.19; <i>p</i> < 0.0001), and international ratio (INR) levels (SMD = −0.1; 95%CI −0.12 to −0.08; <i>p</i> ≤ 0.0001), favoring the symbiotic group compared to the control group. …”
Get full text

Optimizing the treatment for gastroesophageal reflux disease in young people: the role and place of rebamipide by I.M. Skrypnyk, I.M. Gorodnytska, G.S. Maslova, B.M. Fylenko

“…Nitrite (NO₂) levels were 2.6-fold higher in erosive GERD (p < 0.0001) and 1.8-fold higher in non-erosive GERD (p = 0.0022) compared to the control group. The normalization of sialic acid and glycosaminoglycan levels after treatment with the PPI + rebamipide complex (p < 0.0001 and p = 0.0001, respectively) is a confirmation of the restorative and protective functions of the esophageal mucosa in both erosive and non-erosive GERD in young patients. …”
Get full text

Effect of combined Kaempferia parviflora extract and fenitrothion treatment on male reproductive parameters in a murine model by Shawn Samson Tze Xian Ong, Phek Jin Kwong, Mun Yee Chan, GimCheong Tan

“…Mice fed with fenitrothion in group 2 displayed an increase in relative testis weight, lipid peroxidation levels and a significant reduction in all sperm parameters (sperm concentration, progressive motility, and viability), as well as serum testosterone levels compared to the control mice in group 1 (P<0.05). …”
Get full text

Statistical Analysis of Lipid Profiles Associated with Coronary Heart Disease in Erbil City-Iraq by Dler Hussein Kadir, Karzan Abdullah, Aziz Muazafar Jafaar, Rebaz Hamza Salih, Shukur Wasman Smail, Gashaw Qasim Rahman, Harem Khdir Awla, Zhikal Omar Khudhur

“…The comparison between the recorded parameters of healthy controls and patients was conducted using the t-test function in GraphPad Prism 6.0. …”
Get full text

Dietary restriction and exercise for diabetic patients with chronic kidney disease: a systematic review. by Liesbeth Van Huffel, Charles R V Tomson, Johannes Ruige, Ionut Nistor, Wim Van Biesen, Davide Bolignano

“…<h4>Outcomes</h4>Death, cardiovascular events, glycaemic control, kidney function, metabolic parameters and body composition.…”
Get full text

Assessing clenbuterol’s modulation of metabolic and inflammatory pathways in Nile tilapia (Oreochromas niloticous) fed high fat diet by Aya G. Rashwan, Doaa H. Assar, Abdallah S. Salah, Muyassar H. Abualreesh, Shimaa M. R. Salem, Norah Althobaiti, Zizy I. Elbialy

“…The results revealed that compared to the control group, HFD exhibited a marked reduction in FBW, BWG, PER, and body protein percent but significantly increased the FCR, IPF, liver fat percent, and body ash percent with altered hematological parameters, raised serum biomarkers of hepatic and renal injury. …”
Get full text

Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis by Kun Wang, Wenchao Ma, Leina Sun, Fangcheng Su

“…Additionally, the trial group exhibited a more pronounced reduction in blood pressure and greater enhancement in cardiac function (OR=5.55, 95%CI). …”
Get full text

Mitochondrial DNA copy number in leukocytes of patients with type 2 diabetes mellitus and chronic kidney disease by Y. A. Saienko, D. S. Krasnenkov, K. K. Midlovets, V. V. Korcheva, Y. E. Rebrova, D. D. Yepishyna, B. M. Mankovsky

“…No statistically significant differences in mtDNA-CN level were observed between patients with T2DM and CKD, patients with T2DM without CKD, and the control group (P > 0.05). No associations between mtDNA-CN and kidney function parameters were identified. …”
Get full text

Efficacy of red ointment in wound cavity repair following non-puerperal mastitis debridement by Jiamei Feng, Zheng Chen, Jiaye Sun, Shijun Shao, Lu Xie, Wenchao Qu, Qingqian Gao, Xueqing Wu, Hua Wan

“…Methods A prospective, randomized controlled trial was conducted, including 88 patients diagnosed with NPM. …”
Get full text

Strain Engineering of Anisotropic Electronic, Transport, and Photoelectric Properties in Monolayer Sn₂Se₂P₄ by Haowen Xu, Yuehua Xu

Get full text

A Bacillus subtilis strain with efficient algaecide of Microcystis aeruginosa and degradation of microcystins by Yuanyuan Chen, Fei Xiong, Ying Zhu, Dongdong Zhai, Hongyan Liu, Lin Zhang, Ming Xia

“…Comparing the bacterial cell incubation system to the control and bacterial cell-free filtrate systems, the assessment of extracellular and intracellular MCs revealed a 95% reduction in MCs. …”
Get full text

Gut microbiome and metabolome interactions in Crohn’s disease: mechanistic insights into exclusive enteral nutrition-induced remission by Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Quan Zhou, Quan Zhou, Mengli Xue, Mengli Xue, Mengli Xue, Mengli Xue, Xing Yu, Xing Yu, Xing Yu, Xing Yu, Xue’e Chen, Xue’e Chen, Xue’e Chen, Xue’e Chen, Jintong Chen, Jintong Chen, Jintong Chen, Jintong Chen, Chengdang Wang, Chengdang Wang, Chengdang Wang, Chengdang Wang

“…Importantly, EEN therapy was associated with a reduction in oxidative stress and an improvement in gut barrier function.ConclusionThis study comprehensively integrates microbiome and metabolome analyses, providing new insights into the mechanism of action of EEN therapy in CD. …”
Get full text

Biomarkers and subclinical left ventricular dysfunction in patients with type 2 diabetes without clinical manifestations of cardiovascular diseases by T. G. Utina, D. U. Akasheva, D. V. Korsunsky, O. N. Dzhioeva, O. M. Drapkina

“…They were divided into three following groups: 1st — with T2D (n=47), 2nd — with prediabetes (n=20), 3rd — control (n=53). All participants underwent transthoracic echocardiography with assessment of the linear and volumetric heart dimensions, systolic and diastolic LV function. …”
Get full text

Selective Brain Hypothermia in the Comprehensive Rehabilitation of Patients with Chronic Consciousness Disorders by M. V. Petrova, O. A. Shevelev, M. Yu. Yuriev, M. A. Zhdanova, I. Z. Kostenkova, M. M. Kanarskii

“…In the control group of patients in MCS the oromotor function improved (P &lt; 0.05), overall CRS-R scores changed insignificantly from 9.1 ± 0.57 to 10.1 ± 0.86 (P &lt; 0.1). …”
Get full text

Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis by Laura Chulenbayeva, Zharkyn Jarmukhanov, Karlygash Kaliyekova, Samat Kozhakhmetov, Almagul Kushugulova

“…Results: Subgroup analyses revealed a significant reduction in fecal SCFA levels—specifically butyrate, acetate, and propionate—in all IBD subgroups compared to healthy controls. …”
Get full text