Effect of on muscle protein degradation and anti-oxidative capacity in weaned piglets after Lipopolysaccharide challenge by Nianbang Wu, Shunkang Li, Yanling Kuang, Wensheng He, Huiling Zhu, Qingyu Gao, Liping Liu, Shuiyuan Cheng, Yulan Liu, Xin Cong, Dan Wang

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Targeting Toll-like receptor 4 and microbiota dysregulation: a new frontier in nonalcoholic fatty liver disease management by K.B. Kvit

“…Patients with NAFLD exhibited significant gut microbiota changes, characterized by an increased Firmicutes/Bacteroidetes ratio and elevated Actinobacteria levels compared to controls. TLR4 levels were significantly higher in the NAFLD group, correlating positively with liver function tests and systemic inflammatory markers. …”
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One-year outcomes of a digital twin intervention for type 2 diabetes: a retrospective real-world study by Paramesh Shamanna, Ravi Sankar Erukulapati, Ashutosh Shukla, Lisa Shah, Bree Willis, Mohamed Thajudeen, Rajiv Kovil, Rahul Baxi, Mohsin Wali, Suresh Damodharan, Shashank Joshi

“…At baseline, participants were on mean 1.9 (SD 1.4) anti-diabetic medications, which decreased to 0.5 (SD 0.7) at one-year [change: -1.5 (SD 1.3), p < 0.001]. Significant reductions in weight [mean change: -4.8 kg (SD 6.0 kg), p < 0.001], insulin resistance [HOMA2-IR: -0.1 (SD 1.2), p < 0.001], and improvements in β-cell function [HOMA2-B: +21.6 (SD 47.7), p < 0.001] were observed, along with better CGM metrics. …”
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Left ventricular remodelling early after surgical correction of mitral regurgitation: stroke volume maintenance by E. A. Ashikhmina, H. V. Schaff, R. M. Suri, M. Enriquez-Sarano, M. D. Abel

“…The latter group served as controls, in order to assess potential impact of cardiopulmonary bypass and cardioplegic arrest onLV function. …”
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Optimized heat-moisture treatment decreases the starch digestibility of polished maize flour from predominant varieties consumed in Uganda by Finagnon Toyi Kevin Fassinou, Solomon Olum, Lawrence Okidi, Duncan Ongeng

“…It is largely consumed in polished form characterized by high digestibility, rapidly releasing glucose into the bloodstream, making it unsuitable for metabolic health. This calls for the reduction of maize flour digestibility through increasing its slowly-digestible (SDS) and resistant-starch (RS) contents, typical function of Heat-moisture Treatment (HMT). …”
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Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer’s disease and related Tau pathologies by Alice Alessandra Galeotti, Lorenzo Santucci, Jennifer Klimek, Jennifer Klimek, Mohamed Aghyad Al Kabbani, Mohamed Aghyad Al Kabbani, Hans Zempel, Hans Zempel, Vittoria Raffa

“…Alzheimer’s disease (AD) and related tauopathies such as frontotemporal dementia (FTD) or traumatic brain injury (TBI) are neurodegenerative disorders characterized by progressive loss of memory and cognitive function. The main histopathological features of AD are amyloid-β plaques and Tau neurofibrillary tangles, suggested to interfere with neuronal function and to cause microtubule (MT) destabilization. …”
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Plasma Levels of IL-17, VEGF, and Adrenomedullin and S-Cone Dysfunction of the Retina in Children and Adolescents without Signs of Retinopathy and with Varied Duration of Diabetes by Kornel Semeran, Przemysław Pawłowski, Łukasz Lisowski, Izabela Szczepaniak, Jerzy Wójtowicz, Sławomir Ławicki, Alina Bakunowicz-Łazarczyk, Artur Bossowski

“…The study objective was to assess chosen biochemical parameters of blood and bioelectric function of the retina in patients with T1DM. The study group consisted of 41 patients with T1DM with no signs of diabetic retinopathy. …”
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A putative ABC transporter gene, CcT1, is involved in beauvericin synthesis, conidiation, and oxidative stress resistance in Cordyceps chanhua by Zhimin Liu, Jiahua Zhu, Ruixue Gong, Zhiyuan Wen, Yanwen Liu, Yulong Wang, Zengzhi Li, Bo Huang, Fan Peng

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The Potential Effect of Dapagliflozin and Liraglutide in Attenuating Cardio-Renal Injuries in Diabetic Rats by Albanna AA, Ibrahim DA, Shamsher AM, Al-Shawia MA, Halboup A

“…Histological studies also revealed a reduction in cardiorenal tissue injury caused by diabetes. …”
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Chlorogenic acid alleviates the intestinal barrier dysfunction and intestinal microbiota disorder induced by cisplatin by Ruiqi Tian, Yinchuan Ding, Shijie Zhang, Min Li, Yiran Wang, Qi Wu, Huanhuan Ding, Chengjie Song, Ce Shi, Min Xue

“…So, we investigate the protective effect of chlorogenic acid on cisplatin induced intestinal barrier structure and function injury in mice from the perspective of gut microbiota.MethodsC57BL/6J mice were divided into 4 groups, including the control group, a cisplatin group, a chlorogenic acid treatment group receiving intraperitoneal injections alongside cisplatin (Cis + CGA1), and the last group pre-treated with chlorogenic acid before cisplatin administration (Cis + CGA2). …”
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Evaluation of the efficacy of Capacitive Resistive Monopolar Radiofrequency at 448 kHz in the physiotherapeutic treatment of female dyspareunia by Anna Abelló Pla, Anna Andreu-Povar, Laura Fabbi, Jordi Esquirol-Caussa, Judith Lleberia-Juanós, Antonio Gil-Moreno, Mireia Coll Omaña

“…Results: Both groups showed significant improvements in sexual function at the end of treatment. In the GI, improvements were observed in desire, arousal, lubrication, satisfaction, and pain reduction. …”
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Effects of combined exposure to heavy metals on lower respiratory flora and its role of lung injury in rats by Ping Ding, Xiaoxia Wang, Nan Li, Shuxia Yu, Shuxia Yu, Yiwen Zhang, Junpu Yu, Tian Tian, Rentong Chen, Bin Luo, Li Ma, Rongxuan Zhang, Rongxuan Zhang

“…Microbial community structure and function were further analyzed using LEfSe, PICRUSt2, and ecological network analysis.ResultsCompared exposure to Ni, Cu, and As induced dose-dependent lung damage, including inflammation, alveolar deformation, and bronchial thickening, accompanied by significant declines in lung function, including a 21.2% reduction in tidal volume and a 34.5% increase in airway resistance in the high-dose group (P &lt; 0.05). …”
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Cardiometabolic Modulation by Semaglutide Contributes to Cardioprotection in Rats with Myocardial Infarction by Yan H, Yao W, Li Y, Li T, Song K, Yan P, Dang Y

“…Untargeted metabolomic analysis using LC-MS/MS was utilized.Results: Semaglutide treatment was associated with a reduction in body weight, blood glucose, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), as well as an enhancement in the left ventricular ejection fraction (Control vs MI vs SEMA, 69.13± 4.30 vs 30.16± 3.17 vs 39.81± 6.13, P < 0.05). …”
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High Antennal Expression of <i>CYP6K1</i> and <i>CYP4V2</i> Participate in the Recognition of Alarm Pheromones by <i>Solenopsis invicta</i> Buren by Xinyi Jiang, Jiacheng Shen, Peng Lin, Youming Hou

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The protective effect and mechanism of (-)-(S)-B-973B on SH-SY5Y cell injury induced by 1-me-thyl-4-phenyl pyridine by LI Huanhuan, QIAO Zhen, WANG Ji, CAO Xiu, DU Xixun

“…SH-SY5Y cells were divided into control group (group A), MPP+ group (group B), (-)-(S)-B-973B group (group C), (-)-(S)-B-973B+MPP+ group (group D). …”
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Optimization of Sensor Targeting Configuration for Intelligent Tire Force Estimation Based on Global Sensitivity Analysis and RBF Neural Networks by Yu Zhang, Guolin Wang, Haichao Zhou, Jintao Zhang, Xiangliang Li, Xin Wang

“…Tire force is a critical state parameter for vehicle dynamics control systems during vehicle operation. Compared with tire force estimation methods relying on vehicle dynamics or tire models, intelligent tire technology can provide real-time feedback regarding tire–road interactions to the vehicle control system. …”
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Grape seed proanthocyanidins improve lymphatic drainage and blood perfusion in secondary lymphedema models by Hwayeong Cheon, Bumchul Kim, Jae Yong Jeon, Jae Yong Jeon

“…Histological analysis was conducted using hematoxylin and eosin (H&amp;E) staining.ResultsThe treatment group demonstrated a significant reduction of edema in the tail compared to the control group. …”
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Preassembled complexes of hAgo2 and ssRNA delivered by nanoparticles: a novel silencing gene expression approach overcoming the absence of the canonical pathway of siRNA processing... by Shimaa A. E-S. El-Sayed, Mohamed A. Rizk, Hang Li, Uday Kumar Mohanta, Iqra Zafar, Shengwei Ji, Zhuowei Ma, Thom Do, Yongchang Li, Daisuke Kondoh, Jerzy Jaroszewski, Xuenan Xuan

“…In this regard, searching for anti-Babesia gene therapy may facilitate the control of this infection. Following this pattern, small interfering RNAs (siRNAs) are widely used to study gene function and hence open the way to control the parasite. …”
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The effect of motivational interviewing on patients with early post-stroke depression: a quasi-experimental study by Yingjie Fu, Yi Zhang, Qianying Deng, Yuenv Wang, Siyi Su, Zheng Wang, Luyi Xu, Beibei Lin, Yun Li, Jufang Li

“…The intervention group showed a significantly higher rate of decrease in the depression score from T0 to T1 (95% CI: -11.227 to -7.748, p < 0.001) and T0 to T2 (95% CI: -11.683, -6.170, p < 0.001), compared with the control group; the intervention group had a greater reduction in the sleep score from T0 to T1 (95% CI: -2.502 to -0.962, p < 0.001), compared with the control group. …”
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Metagenomic Insight into Cecal Microbiota Shifts in Broiler Chicks Following <i>Eimeria</i> spp. Vaccination by Dimitrios Marinos Karadedos, Tilemachos Mantzios, Despoina Eugenia Kiousi, Margaritis Tsifintaris, Ilias Giannenas, Panagiotis Sakkas, Georgios A. Papadopoulos, Gunther Antonissen, Aglaia Pappa, Alex Galanis, Vasilios Tsiouris

“…<i>p</i> < 0.05), along with a decline in short-chain fatty acid (SCFA)-producing bacteria (<i>Oscillibacter</i> spp. and <i>Eisenbergiella</i> spp.) in groups B and C, respectively, compared to the control. Predictive functional metagenomics indicated disruptions in amino acid metabolism, nucleotide degradation, and lipid metabolism, potentially affecting gut integrity and nutrient absorption. …”
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