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Baseline gut microbiome and metabolites are correlated with changes in alcohol consumption in participants in a randomized Zonisamide clinical trial
Published 2025-03-01“…A positive relationship between baseline fecal GABA levels and percent drinking reduction (R = 0.43, p.adj < 0.07) was identified by microbiome function prediction and confirmed by ELISA and metabolomics. …”
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The influence of the chosen method of anesthesia on the severity of postoperative cognitive dysfunction in patients with ophthalmic surgery
Published 2021-03-01“…Reduction of cognitive functions in the postoperative period is gaining importance in the context of the insurance medicine introduction. …”
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Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia
Published 2023-11-01“…The key elements of hypoxic training in diabetes encompass activities geared toward activating metabolic pathways, enhancing mitochondrial function, and regulating blood glucose levels. Such interventions can potentially lead to improvements in insulin resistance, a reduction in glycemia, and an overall enhancement of cardiorespiratory function. …”
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Greater sage‐grouse and fences: Does marking reduce collisions?
Published 2012-06-01“…We tested a marking method in greater sage‐grouse breeding habitat and modeled collision as a function of fence marking and control covariates, in Idaho (USA) in 2010. …”
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Effects of infrastructure on the adoption of sustainable agricultural practices in sub-Saharan Africa
Published 2025-01-01“…Using a panel dataset from sub-Saharan Africa and advanced econometric techniques—including a correlated random effect with a multivariate probit (CRE-MVP), a control function approach (CRE-CFA), and an ordered probit with endogenous treatment (CRE-OPRETRE) models—this study accounts for potential interrelationships between SAPs and endogeneity due to observed and unobserved heterogeneity. …”
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Cranioplasty as a Catalyst for Neurofunctional and Emotional Restoration in Severe Brain Injury: A Case Report Analysis
Published 2025-06-01“…Cranioplasty restores skull protection and intracranial pressure balance, which has been shown to contribute significantly to neurological improvements, including the reduction of neuropsychological deficits, better control of seizure activity, and partial mitigation of cerebral atrophy. …”
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A novel role of the antidepressant paroxetine in inhibiting neuronal Kv7/M channels to enhance neuronal excitability
Published 2025-04-01“…Abstract The voltage-gated Kv7/KCNQ/M potassium channels exert inhibitory control over neuronal membrane excitability. The reduction of Kv7 channel function can improve neuronal excitability that defines the fundamental mechanism of learning and memory. …”
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Dynamic Changes in Fourth Heart Sound in Type 2 Diabetes: Insights From Visualized Phonocardiography and SGLT2 Inhibitor Adjustment
Published 2025-01-01“…Additionally, S4 correlates with atrial function, which is typically impaired in patients with Type 2 diabetes (T2D) but can improve with sodium–glucose co-transporter-2 inhibitor (SGLT2i) therapy. …”
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Evaluation of Neurobehavioral Effect of Citrullus Lanatus Juice on Albino Mice
Published 2017-06-01“…Animals were randomly assigned into 4 groups A, B, C and D (n=10). Group A was control (normal saline). Group B was treated with Citrullus lanatus juice in a dose of 3 ml/kg, Group C was given 6 ml/kg of juice. …”
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EFFECT OF NETILMICIN ON THE AUDITORY ANALYZER (EXPERIMENTAL STUDY)
Published 2011-10-01“…Auditory function was assessed according to the registration of short stem-evoked potentials (SSEP) and otoacoustic emission distortion product (OEDP). …”
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Cytogenetic abnormalities in thymus cells as a possible side effect of combined skeletal muscle laser therapy (experimental study)
Published 2020-08-01“…Objective: the functional analysis of the thymus during a course of laser therapy of the calf muscles of adult rats. …”
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Resolution of Angina Pectoris and Improvement of the Coronary Flow Reserve after Ranolazine Treatment in a Woman with Isolated Impaired Coronary Microcirculation
Published 2013-01-01“…Ranolazine induces in fact a reduction of the intracellular late sodium current that leads to a reduction of the intracellular calcium concentration thus producing a better myocardial diastolic relaxation process which in its turns enhances the myocardial perfusion. …”
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Precise wind allocation scheme decision based on attraction-repulsion algorithm
Published 2025-04-01“…By employing AROA, the ventilation fan and existing underground ventilation facilities were precisely controlled, and an optimized solution was iteratively generated. …”
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A PRISMA Systematic Review of Sexual Dysfunction and Probiotics with Pathophysiological Mechanisms
Published 2025-03-01“…Significant improvements in Female Sexual Function Index (FSFI) scores were observed, with combined treatments such as Lactofem with Letrozole and Lactofem with selective serotonin reuptake inhibitors (SSRIs) demonstrating a 10% biochemical and clinical pregnancy rate compared to 0% in the control group (<i>p</i> = 0.05). …”
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Sauchinone Ameliorates Senescence Through Reducing Mitochondrial ROS Production
Published 2025-02-01“…Taken together, these studies revealed a novel mechanism by which sauchinone reduces mitochondrial ROS production by regulating mitochondrial function and <i>VAMP8</i> expression. Our results open a new avenue for aging research to control senescence by regulating mitochondrial ROS production.…”
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Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3/HIF-1α
Published 2025-03-01“…Sirt1 overexpression and control lentivirus were administered to the peri-infarct region of mice heart. …”
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Dietary menhaden fish oil supplementation suppresses lipopolysaccharide-induced neuroinflammation and cognitive impairment in diabetic rats
Published 2024-12-01“…Context Menhaden fish oil (FO) is widely recognized for inhibiting neuroinflammatory responses and preserving brain function. Nevertheless, the mechanisms of FO influencing brain cognitive function in diabetic states remain unclear.Objective This study examines the potential role of FO in suppressing LPS-induced neuroinflammation and cognitive impairment in diabetic animals (DA).Materials and methods Thirty male Wistar rats were divided into 5 groups: i) DA received LPS induction (DA-LPS); ii) DA received LPS induction and 1 g/kg FO (DA-LPS-1FO); iii) DA received LPS induction and 3 g/kg FO (DA-LPS-3FO); iv) animals received normal saline and 3 g/kg FO (NS-3FO) and v) control animals received normal saline (CTRL). …”
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An abdominal aortic calcification as a RISK FACTOR FOR cardio -cerebral events in patients with peripheral arterial
Published 2014-07-01“…We have found statistically significant differences between groupsin heart structure and function. A high left ventricular wall thickness (р < 0.01), left atrium dilation (р < 0.01) and enhanced of left ventricular mass (р < 0.05), ejection fraction reduction (р < 0.05) and more common diastolic dysfunction (р < 0.05) were determined inpatients with abdominal aortic calcification. …”
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