Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis by Qianhua Yuan, Wanhan Song, Ya Wang, Yutong Xie, Dazhang Deng, Nageena Qayyum, Huawen Li, Honghui Guo

“…This study evaluated nanoencapsulated roselle anthocyanins extract (Nano-RAE) in mitigating WD-induced metabolic disturbances and lifespan reduction in Drosophila melanogaster. Male flies were divided into three groups: control, WD, and WD + RAE (5 mg/mL Nano-RAE). …”
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Long-Term Effectiveness and Safety of SGLT-2 Inhibitors in an Italian Cohort of Patients with Type 2 Diabetes Mellitus by Maria Mirabelli, Eusebio Chiefari, Patrizia Caroleo, Raffaella Vero, Francesco Saverio Brunetti, Domenica Maria Corigliano, Biagio Arcidiacono, Daniela Patrizia Foti, Luigi Puccio, Antonio Brunetti

“…In our patients’ population, the glycometabolic effects of SGLT-2 inhibitors were durable and comparable to those observed in multicenter randomized controlled trials. This notwithstanding safety concerns must be raised regarding the frequent occurrence of genitourinary infections and the risk of a rapid decline of renal function in patients with evidence of volume depletion and/or receiving other medications which can adversely affect kidney function.…”
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O-GlcNAc transferase plays a non-catalytic role in C. elegans male fertility. by Daniel Konzman, Tetsunari Fukushige, Mesgana Dagnachew, Michael Krause, John A Hanover

“…Though essential in most metazoans, O-GlcNAc transferase (ogt-1) is dispensable in Caenorhabditis elegans, allowing genetic analysis of its physiological roles. Compared to control, ogt-1 males had a four-fold reduction in mean offspring, with nearly two thirds producing zero progeny. …”
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Photobiomodulation reduces hippocampal apoptotic cell death and produces a Raman spectroscopic "signature". by David J Davies, Mohammed Hadis, Valentina Di Pietro, Giuseppe Lazzarino, Mario Forcione, Georgia Harris, Andrew R Stevens, Wai Cheong Soon, Pola Goldberg Oppenheimer, Michael Milward, Antonio Belli, William M Palin

“…Apoptotic cell death within the brain represents a significant contributing factor to impaired post-traumatic tissue function and poor clinical outcome after traumatic brain injury. …”
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Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment by T. Mikalauskas, B. Burnytė

“…However, supportive measures, including physiotherapy and orthotics, can help improve muscle function and mobility, slow the progression of the disease, and control other symptoms. …”
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Dynamic balance optimization method for aero-engine rotor without trial weight by Lingli Jiang, Changzhi Shi, Xuejun Li, Hui Ma, Yiming Cao

“…This approach offers a valuable technical reference for aerospace engine vibration control.…”
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Kalyanak Ghrita Mitigates Ethanol Craving in Ethanol-dependent Mice Model by Tanvi M. Chotai, Sarita Mahendra Kapgate

“…Introduction: Ethanol dependence is characterized by impaired control over alcohol consumption in spite of harmful consequences. …”
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System Identification Methods for Dynamic Testing of Fluid-Film Bearings by Jerzy T. Sawicki, Maurice L. Adams, Russell J. Capaldi

“…Since the coefficient values extracted can vary significantly as a function of the system identification approach used, more attention is needed to treat this issue than is typically included in the rotor dynamics literature. …”
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Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes by Amel Mahmoud Soliman, Ayman Saber Mohamed, Mohamed-Assem Said Marie

“…Echinochrome groups showed reduction in the concentrations of glucose, malondialdehyde, urea, uric acid and creatinine. …”
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Renal protective role of active vitamin D3 supplement in oatients with type 2 diabetes:a meta-analysis by HE Lei, YI Xin, LIN Mei, ZHAO Tian-ya, LI Meng-si, GAO Ping

“…Objective To systematically evaluate the efficacy,safety and the renoprotective effect of active vitamin D3 treatment in patients with type 2 diabetes mellitus(T2DM).Methods Literature searches were performed with PubMed,EMBase,Google scholar,CNKI,VIP,Wanfang Date and CBM from inception to December 2014.Publications of the randomized controlled trials on the treatment of T2 DM with active vitamin D3 were included.The methodology quality of the included studies was assessed and the pooled analysis on therapeutic effect index was performed by two reviewers independently according to the criteria of the Cochrane handbook Results A total of 10 eligible RCT were included.The fixed-effect model was used to analyze urinary albumin creatinine ratio(UACR),and the pooled SMD was- 0.34(95%CI:- 0.55,- 0.12),P = 0.002,which indicated that active vitamin D3-treated group had a statistically significant reduction in UACR.The randomeffect model was used to analyze serum creatinine,and the pooled SMD was-1.27(95%CI:- 3.66,1.12),P = 0.30,which indicated that there was no statistically significant difference between experimental group and control group.In addition,active vitamin D3-treated group was more obvious than control group in terms of lowering insulin resistance,serum cholesterol,triglycerides,systolic pressure,and increasing high-density lipoprotein cholesterol(HDL-C) in patients with T2DM(P<0.05)[SMD or WMD(95%CI) was-2.69(-3.42,-1.97);-0.37(-0.63,-0.11),-0.30(- 0.56,- 0.05);- 5.94(- 9.08,- 2.80);0.33(0.03,0.63),respectively].However,there was no statistically significant difference in hemoglobin A1c(HbAlc) and diastolic pressure between experimental group and control group(P>0.05)[WMD(95%CI) was 0.06(-0.08,0.19);- 1.77(- 3.65,- 0.12),respectively].Conclusions Currently available evidence shows that active vitamin D3 is effective in improving glucose metabolism,and reducing blood lipids and blood pressure in T2 DM patients.It can also reduce proteinuria,and protect renal function to some extent…”
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High-intensity interval training improves blood pressure and adropin plasma levels in elderly with hypertensive treatment by Alireza Ghardashi-Afousi, Abbasali Gaieni

“…Background: Adropin is a newly identified bioactive protein that is important in energy hemostasis and vascular endothelial function.Aim: The purpose of the present study was to investigate plasma levels of adropin and nitrite/nitrate (NO), in elderly treated hypertensive subjects at baseline and follow-up after 6 weeks of high-intensity interval training (HIIT).Material and Methods: Forty-four elderly participants with treated hypertensives (age 61.09±5.82 years, 25 male and 19 female, BMI= 25.7±1.31 kg/m2) were randomly assigned to either the high-intensity interval training (HIIT) or control group. …”
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Ileal mucosal epithelial cell proliferation in old mice and in mice with Alzheimer's disease by Dinić Jovana, Đorđević Isidora, Vuković David, Puškaš Nela

“…Results: In the group of 8-week-old transgenic mice, a highly statistically significant decrease in the perimeter of longitudinally sectioned Lieberkuhn crypts' was shown, compared to the control group. A highly statistically significant reduction in the number of Ki-67-positive cells per 100 mm of the perimeter length was demonstrated in the group of 36-week-old transgenic mice compared to both the corresponding control group and younger transgenic animals. …”
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Epidemiological studies on the health impact of air pollution in Japan: their contribution to the improvement of ambient air quality by Masayuki Shima

“…Thereafter, the concentrations of NOx and PM gradually decreased due to the control measures based on the Automobile NOx/PM Law enforced in 2001. …”
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Strength characteristics in saturation process and rainfall-induced landslide failure mechanism of granite residual soil by Bing Lan, Bangzhong Jia, Yiying Wu, Yiying Wu, Xiaoyu Yi, Wenkai Feng, Yihe Li

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ENDOTHELIAL DYSFUNCTIONS AND THEIR CORRECTION IN WOMEN WITH EARLY POSTMENOPAUSE by S. N. Tolstov, I. A. Salov, A. P. Rebrov

“…Favorable changes in vascular endothelium function were observed during long-term MHT with the fixed combination of Е2 1 mg/DRSP 2 mg.…”
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Clinical impact of quality nursing combined with health education pathway on quality of life and sleep in severe aplastic anemia patients complicated with infection: a randomized c... by Wei Shen, Feng Wei

“…Using the number table method, participants were randomly divided into an observation group (OG) and a control group (CG), with 65 patients in each group. …”
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Application of different approaches in interventional thrombolysis of deep vein thrombosis of lower extremities by YUAN Xiaopu, YANG Lili, WU Hongfang

“…Interventional thrombolysis was conducted via the popliteal vein approach in observation group, and via infrapatellar vein approach in control group. Perioperative indicators and thrombus clearance effects were observed in both groups. …”
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Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium by Garrett Rhodes, Kristen L. Segars, Yoonjoo K. Lee, Audrey E. K. Hutcheon, Celeste B. Rich, Vickery Trinkaus-Randall

“…Epithelial wound healing is essential to repair the corneal barrier function after injury and requires coordinated epithelial sheet movement over the wounded region. …”
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Prediction of Rut Depth in Soil Caused by Wheels Using Artificial Neural Networks by N. Farhadi, A. Mardani, A. Hosainpour, B. Golanbari

“…In this study, two machine learning models, namely the multilayer perceptron (MLP) and the radial basis function (RBF) networks, were employed to predict rut depth.Materials and MethodsExperiments were conducted using a soil bin that allows for precise control of independent parameters, measuring 24 meters in length, 2 meters in width, and 0.8 meters in depth. …”
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Rehabilitation &amp; Sports Medicine by Schmucker A, Jerg A, Schulz SVW, Zorn J, Vollrath S, Steinacker JM

“…Lung function of controls were compared with athletes after COVID-19 and changes in patients with dyspnea (during infection and at time of appointment) and changes over time between infection and examination on lung function were examined. …”
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