Huntingtin plays an essential role in the adult hippocampus by Jessica C. Barron, Laura J. Dawson, Samantha J. Carew, Mackenzie C. Grace, Kelsie A. Senior, Katelyn C. Ryan, Firoozeh Nafar, Craig S. Moore, Jacqueline Blundell, Matthew P. Parsons

“…Overall, these findings uncover a previously unrecognized role of wtHTT as a critical regulator of hippocampal function in the mature brain, and highlight the hippocampus as a potentially vulnerable region to the adverse effects of non-selective HTT reduction.…”
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EVALUATING THE CLINICAL AND HEMODYNAMICAL ACTION OF NEBIVOLOL IN CHRONIC HEART FAILURE by M. A. Gurevich, N. P. Sanina, T. F. Hohlova, V. I. Buvalcev

“…Patients were treated with the drug in a course of 3 months.A control group(15 people) was treated traditional therapy (by heart glicozides, metabolic preparations, diurethics, if necessary). …”
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Vibration Analysis and Design of a Structure Subjected to Human Walking Excitations by M. Setareh, M. Lovelace

“…Conclusions are made on the validity of each forcing function studied here.…”
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Adjustment of angle error and tolerance allocation methods for RV reducers by ZHANG Bowen, ZHOU Jianxing, CUI Quanwei, LIN Kaihong, ZHOU Yadong, XU Wenqiang

“…Combining with the optimal control theory and comprehensively considering factors such as transmission accuracy, adjustment man-hour cost, and measurement uncertainty, the optimal adjustment amount for each assembly step and the final error state were given. …”
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Simulation of the impact of an additional corrugated structure impedance on the bursting dynamics in an electron storage ring by S. Maier, M. Brosi, A. Mochihashi, M. J. Nasse, M. Schwarz, A.-S. Müller

“…In the case of a single-digit picosecond bunch length, synchrotron light sources produce intense coherent radiation up to the THz range. The reduction of the bunch length by lowering the momentum compaction factor (low-α) gives rise to the microbunching instability, which is on the one hand a crucial roadblock in the x-ray range during to the resulting effective bunch lengthening, but on the other hand also an opportunity for the generation of intense THz radiation if it can be controlled appropriately. …”
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Peroxisomal Import Reduces the Proapoptotic Activity of Deubiquitinating Enzyme USP2. by Katharina Reglinski, Marina Keil, Sabrina Altendorf, Dominic Waithe, Christian Eggeling, Wolfgang Schliebs, Ralf Erdmann

“…Blocking of peroxisomal import did not interfere with the proapoptotic activity of USP2, suggesting that the enzyme performs its critical function outside of this compartment. Instead, increase of the efficiency of USP2 import into peroxisomes either by optimization of its peroxisomal targeting signal or by overexpression of the PTS1 receptor did result in a reduction of the apoptotic rate of transfected cells. …”
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A Resilient micro-payment infrastructure: an approach based on blockchain technology by Soumaya Bel Hadj Youssef, Noureddine Boudriga

“…In addition, its efficiency is improved through the reduction of the verification delay and user waiting time. …”
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Managing the failing renal allograft: navigating a complex topography by Elizabeth A. Kendrick

“…Recipients of kidney transplants often outlive the function of the renal allograft will need ESRD management. …”
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Impact of Various Carbon Sources on the Growth Efficiency, Antioxidant Efficacy, and Immunity of Clariid Catfish Clarias gariepinus (Burchell 1822) by Omoniyi Michal Popoola, Tunde Olowolafe, Ayomide Miracle Oyelade, Blessing Aderonke Oguntokun

“…Fish reared in biofloc systems exhibited significantly higher total cholesterol, total protein, superoxide dismutase (SOD), Lyzosome (LYZ), and Myeloperoxidase (MPO) activities compared with the control group. However, there was a reduction in the activities of ALT, AST, total glucose, and antiprotease in biofloc-treated C. gariepinus compared with the control. …”
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RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. by María Fernández-Velasco, Gema Ruiz-Hurtado, Angélica Rueda, Patricia Neco, Martha Mercado-Morales, Carmen Delgado, Carlo Napolitano, Silvia G Priori, Sylvain Richard, Ana María Gómez, Jean-Pierre Benitah

“…Analyzing the CICR in catecholaminergic polymorphic ventricular tachycardia (CPVT) mice as a model of RyR-generated Ca(2+) leak, we evidence here that increased occurrence of the discrete local SR Ca(2+) releases through the RyRs (Ca(2+) sparks) cause a depolarizing shift in activation and a hyperpolarizing shift in isochronic inactivation of cardiac LTCC current resulting in the reduction of window current. Both increasing fast [Ca(2+)](i) buffer capacity or depleting SR Ca(2+) store blunted these changes, which could be reproduced in WT cells by RyRCa(2+) leak induced with Ryanodol and CaM inhibition.Our results unveiled a new paradigm for CaM-dependent effect on LTCC gating and further the nanodomain Ca(2+) control of LTCC, emphasizing the importance of spatio-temporal relationships between Ca(2+) signals and CaM function.…”
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Small-Signal Stability Analysis and Parameters Optimization of Virtual Synchronous Generator for Low-Inertia Power System by Alaa Altawallbeh, Abdulrahman Alassi, Nader Meskin, Mohammed A. Al-Hitmi, Ahmed M. Massoud

“…We further propose a hybrid Particle Swarm Optimization (PSO) algorithm with a multi-objective cost function to optimize VSG controller gains. The optimized design achieves an 83% reduction in ROCOF, a 90% improvement in frequency deviation, and a non-oscillatory power response. …”
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Growth Performance and Gut Health of Cold-Stressed Broilers in Response to Supplementation with a Combination of Sodium Butyrate and Vitamin D3 by Hang Gao, Yi Wang, Xingkai Zhao, Yaling Yu, Yizhe Guo, Zhendong Li, Zhenlei Zhou

“…Birds were exposed to cold stress at 16 ± 1 °C for 72 h (d 18–21) and 26 ± 1 °C for the control. The results indicated that the SB/VD3 diet could alleviate the reduction in average daily gain (ADG) caused by cold stress (<i>p</i> < 0.05). …”
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Deciphering the angiogenic potential of Zhishi Xiebai Guizhi decoction in coronary heart disease: an in-depth network pharmacology and experimental investigation by Yingli Mo, Yuping Xu, Bei Lu, Xiaojuan Fan, Qingshuang Zhang, Shaowu Cheng, Qinghua Peng

“…In a double-blind RCT (n = 180), ZXGD adjunct therapy significantly improved angina frequency (35% reduction vs. control, p < 0.01) and endothelial function (FMD increase: 2.8% ± 0.5 vs. 1.2% ± 0.4, p < 0.05) over 12 weeks, with no severe adverse events. …”
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Liver Disease and Central Nervous System Dysfunction: Linking the Two - A Narrative Review by Maciej Tenderenda, Bartosz Buczkowski, Piotr Oleksy, Agnieszka Klecza, Aleksandra Broniak, Magdalena Reclik, Karol Zieliński, Aarushi Chourasia, Krzysztof Nowakowski, Martyna Chraścina

“…Conclusions: Addressing HE requires a multifaceted approach, including ammonia reduction, inflammation control, and neurotransmitter balance restoration. …”
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Evaluation of nematode susceptibility and resistance to anthelmintic drugs with a WMicrotracker motility assay by Mélanie Alberich, Marie Garcia, Julie Petermann, Clara Blancfuney, Sophie Jouffroy, Philippe Jacquiet, Anne Lespine

“…The standard method for detecting resistance, the Faecal Egg Count Reduction Test (FECRT), is susceptible to misinterpretation, leading to flawed management decisions that undermine parasite control efforts. …”
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Impact of viscous dissipation, chemical reaction over a Carreau hybrid nanofluids flow across a permeable curved Riga surface by R. Mahesh, U.S. Mahabaleshwar, Basma Souayeh

“…These findings are advantageous for developing strategies applicable to heat control across many industries and biological sectors to enhance energy efficiency and system performance.…”
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Neurobiological Changes Induced by Mindfulness and Meditation: A Systematic Review by Andrea Calderone, Desirée Latella, Federica Impellizzeri, Paolo de Pasquale, Fausto Famà, Angelo Quartarone, Rocco Salvatore Calabrò

“…<b><i>Background and Objectives:</i></b> Meditation and mindfulness, rooted in ancient traditions, enhance mental well-being by cultivating awareness and emotional control. It has been shown to induce neuroplasticity, increase cortical thickness, reduce amygdala reactivity, and improve brain connectivity and neurotransmitter levels, leading to improved emotional regulation, cognitive function, and stress resilience. …”
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Optimal power flow using recent red-tailed hawk optimization algorithm by Ahmed M Nassef, Mohammad Ali Abdelkareem, Mohamed Louzazni

“…The RTH has reduced the cost to $799.0680 in Case 1, with an enhancement ratio of 0.04 % compared to the PSO. The objective function in Case 2 includes cost reduction and voltage deviation. …”
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Effects of Volatile Substances from Trichoderma erinaceum M6-5 on the Cell Membrane and Wall of Alternaria alternata, a Postharvest Pathogen of Korla Fragrant Pear by HUANG Wei, WANG Ning, SONG Bo, LIU Fengjuan, ZHANG Miaomiao,, WANG Suling, WU Longyuan, ZHANG Lijuan, WANG Wei

“…SEM and TEM images showed that the mycelia of A. alternata appeared shriveled, swollen and broken partially after the treatment. A greater reduction in cytoplasmic matrix was noted when compared with the control group, which was accompanied by local plasmolysis. …”
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Experimental Study on Stress Uniformity and Deformation Behavior of Coals with Different Length-to-Diameter Ratios under Dynamic Compression by Qiupeng Yuan, Guangxiang Xie, Lei Wang, Zhenhua Jiao, Peng Zou, Huaiqian Liu, Naseer Muhammad Khan

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