Inducible knockdown of Plasmodium gene expression using the glmS ribozyme. by Parichat Prommana, Chairat Uthaipibull, Chayaphat Wongsombat, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Ellen Knuepfer, Anthony A Holder, Philip J Shaw

“…Conventional reverse genetic approaches for study of Plasmodium malaria parasite gene function are limited, or not applicable. Hence, new inducible systems are needed. …”
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Role of the individual metabolic syndrome components and heart remodelling progression in women by E. M. Khurs, A. N. Dmitriev, A. V. Poddubnaya, E. M. Futerman

“…In women with various combinations of MS components, heart structure and function changes are different. Insulin resistance facilitates the progression of systolic myocardial stress and myocardial contractility reduction. …”
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Antiplatelet therapy de-escalation in a patient after percutaneous coronary intervention with a high risk of bleeding by A. A. Kassymova, J. A. Mansurova, L. K. Karazhanova, A. A. Chinybayeva

“…A 47-year-old patient of Kazakh nationality was hospitalized with gastrointestinal bleeding.Given bleeding type 3 by BARC (Bleeding Academic Research Consortium) associated with DAPT, it was decided to apply a strategy to de-escalate antiplatelet therapy under the control of platelet function testing (PFT) and genetic testing.In this case, replacement of ticagrelor with the weak P2Y12 receptor inhibitor clopidogrel was not possible as the patient appeared to be a carrier of the CYP2C19*2 polymorphism contributing to loss of function of the cytochrome P-450(CYP) enzyme.…”
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Managing moderate-to-severe paediatric asthma: a scoping review of the efficacy and safety of fluticasone propionate/salmeterol by Sira Nanthapisal, Ana Paula Beltran Moschione Castro, Paulo Marcio Pitrez, Chirag Teli, Abhijith P G

“…Search strategies were developed and refined by authors.Charting methods Selected articles were screened for clinical outcome data (exacerbation reduction, nocturnal awakenings, lung function, symptom control, rescue medication use and safety) and a table of key parameters developed.Results Improvements in asthma outcomes with FP/SAL include reduced risk of asthma-related emergency department visits and hospitalisations, protection against exercise-induced asthma and improvements in measures of lung function. …”
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Exercise enhances cardiomyocyte mitochondrial homeostasis to alleviate left ventricular dysfunction in pressure overload induced remodelling by Zhichao Ma, Yanling Cen, Weiwei Xun, Caiying Mou, Junwen Yu, Yarui Hu, Chen Liu, Jun Sun, Rui Bi, Yanli Qiu, Mingchao Ding, Li Jin

“…In the SC group, a significant increase was observed in cardiomyocyte diameter, cardiac function, autophagy, and apoptosis. After 8 weeks of swimming exercise, there was a substantial reduction in cardiomyocyte diameter, an improvement in cardiac function, a mitigation of mitochondrial fission and autophagy. …”
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Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway by Yiting Deng, Yuanhang He, Juan Xu, Haoting He, Manling Zhang, Guang Li

“…We found that short-term ablation caused a reduction in collagen and Vas_EC density, while long-term ablation may induce compensatory collagen expression without causing heart function reduction. …”
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Integrated PTS fire evacuation path planning algorithm by Zhijun Gao, Meng Zhang, Xin Wang, Hongyan Zhang, Chengcheng Zhang

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Meta-analysis of clinical trials of osteoarthritis treatment effectiveness with Chondroguard by I. Yu. Torshin, A. M. Lila, A. V. Naumov, A. Yu. Kochish, L. I. Alekseeva, E. A. Taskina, I. V. Sarvilina, A. N. Galustyan, A. N. Gromov, A. K. Khadzhidis, L. V. Vasilieva, E. F. Yevstratova, M. I. Udovika, O. A. Gromova

“…There was a significant reduction in pain according to VAS at night (CG: -20.1; control: -9.9; p=0.05018., while sitting or lying down (CG: -15.5; control: -7.6; p=0.01656., when walking (CG: -28.2; control: -17.0; p=0.04957). …”
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Place of imidazoline receptor agonists in the treatment of hypertension by D. V. Nebieridze, A. S. Safaryan

“…Therefore, it contributes to reducing insulin resistance (weight loss) and has organ protective properties (endothelial function improvement, left ventricular hypertrophy regression, microalbuminuria reduction). …”
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Stackelberg Game Based on Trajectory Prediction for Lane Change in Mixed Traffic by Baichuan Shi, Li Zhai, Chang Liu

“…The method develops a utility function for human-driven vehicles incorporating driving styles and safety-comfort-efficiency factors, with a corresponding cost function for autonomous vehicles. …”
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Protective effect of phenolic-rich extract of Anona muricata Linn leaf on renal oxidative stress and inflammation in streptozotocin-induced diabetes in diabetic rats by Benjamin Olusola Omiyale, Bidemi Emmanuel Ekundayo, Makhosazana Siduduzile Mathenjwa-Goqo, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye

“…The rats were randomly distributed into 6 groups of normal control, diabetic control, phenolic rich extract of Anona muricata (EAM) treated at (25, 50 and 100 mg/kg) and metformin (Glucophage). …”
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Three-dimensional Simulation of Wet Combustion of Hydrogen-methane Mixture in the Annular Combustion Chamber of a Microturbine by A. Sohrabi, S. M. Mirsajedi

“…The introduction of humidity levels of 2.5%, 5%, 7.5%, and 10% in the inlet air reduces NOx emissions by 68% in the case where the fuel mixture contains 10% hydrogen, with this reduction occurring at 10% humidity. Additionally, a 48% reduction in CO emissions was observed when the fuel mixture contained 40% hydrogen, and this reduction also occurred at 10% humidity. …”
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Robust Input Shaping Commands with First-Order Actuators by Yoon-Gyung Sung, Seongjun Lee

“…An ideal input shaping command can deviate due to actuator dynamics so that the modified command has a detrimental effect on the performance of oscillation reduction in feedforward control applications. A zero-vibration-derivative (ZVD_F) shaper with first-order actuators is analytically proposed using a phasor–vector approach, an exponential function for the approximation of the dynamic response of first-order actuators and the usage of the ZVD shaper. …”
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Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice. by Alberto Roselló-Díez, Linda Madisen, Sébastien Bastide, Hongkui Zeng, Alexandra L Joyner

“…The systemic effect involved impaired placental function and IGF signalling, revealing bone-placenta communication. …”
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Histological Effects of Aqueous Extract of Carica papaya Seed on the Renal Tissue in Adult Wistar Rats by Ekundina, V.O.* , Ebeye, O.A. and Odigie, B.O.

“…Subsequent studies should evaluate renal function parameters and ultra-structural evaluation to corroborate these findings.…”
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The Effect of Cuscuta chinensis on Mild to Moderate Depression: a Double-Blind Randomized Clinical Trial by Roshanak Mokaberinejad, Gholamreza Bazmandegan, Maryam Hamzeloo-Moghadam, Mohammad Reza Mirzabeigi Abadi, Zahra Kamiab*

“…Results: The mean BDI score at baseline was 19.6±4.22 in the intervention group and 18.4±11.23 in the control group (p=0.091). The interaction effect between group and time was statistically significant, indicating a greater reduction in depression scores in the intervention group compared to the control group (F=6.807, df=2, p=0.001). …”
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The effects of valacyclovir on polyomavirus infection (BKV) in kidney transplant recipients by K. Samadi, M. Ghorbansabbagh, V. Raesi, P. Marouzi, F. Sharifipour, Zeinab Jalambadani

“…Valacyclovir can effectively reduce the serum viral load in BKV-infected kidney transplant recipients. This reduction, however, is not accompanied by an improvement in renal function or prevention of rejection.…”
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ВЛИЯНИЕ АНТАГОНИСТОВ АЛЬДОСТЕРОНА НА ПАРАМЕТРЫ ЭЛЕКТРОКАРДИОГРАММЫ ВЫСОКОГО РАЗРЕШЕНИЯ У ПАЦИЕНТОВ С ПАРОКСИЗМАЛЬНОЙ ФОРМОЙ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙ... by Н. Т. Ватутин, А. Н. Шевелёк, Е. В. Ещенко, И. Н. Кравченко

“…At the baseline ALP were found in 25 (83%) patients of the control group and in 24 (86%) patients of the spironolactone group (р=0.977). …”
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Influence of adapted hip-hop dancing on quality of life and social participation among children/adolescents with cerebral palsy by Joseana Wendling WITHERS, Sandra Baggio MUZZOLON, Marise Bueno ZONTA

“…Methods Pilot study including 18 children/adolescents with CP and Gross Motor Function Classification System levels I and II. Nine participants took part in an adapted hip-hop dance practice (study group; SG), and nine others served as the control group (CG). …”
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The Efficacy of the Mulligan Concept to Treat Meniscal Pathology: A Systematic Review by Nathan C. Reep, Sydney N. Leverett, Rebecca M. Heywood, Russell T. Baker, Darren L. Barnes, Scott W. Cheatham

“… # Conclusion Treatment interventions incorporating MC MWM techniques demonstrated reduction of pain and improvement in function in the short term in patients with clinically diagnosed meniscal pathologies…”
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